13F-HR filed by Ikarian Capital, LLC
Ikarian Capital, LLC filed this 13F-HR for the quarter ended 2021-12-31, filed 2022-02-14, with 186 holding rows worth $671,295,000.
- Accession
- 0001420506-22-000377
- Filer
- CIK 1778253
- Filed
- 2022-02-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2021
A holdings report, 186 entries on the cover page, a total value of $671,295,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $671,295,000 with VALUE read as thousands by filing date, 13F file number 028-19721. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SPDR SER TR | 78464A870 | S&P BIOTECH | 542,400 | $60,727,000 | thousands by filing date | put |
| BICYCLE THERAPEUTICS PLC-ADR | 088786108 | SPONSORED ADS | 613,126 | $37,321,000 | thousands by filing date | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 399,400 | $35,962,000 | thousands by filing date | call |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 178,300 | $30,237,000 | thousands by filing date | call |
| HORIZON THERAPEUTICS PLC | G46188101 | SHS | 246,900 | $26,607,000 | thousands by filing date | call |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 593,800 | $22,946,000 | thousands by filing date | call |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 451,200 | $17,433,000 | thousands by filing date | put |
| KEZAR LIFE SCIENCES INC | 49372L100 | COM | 1,020,917 | $17,069,000 | thousands by filing date | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 419,216 | $16,198,000 | thousands by filing date | |
| ZENTALIS PHARMACEUTICALS INC | 98943L107 | COMMON STOCK | 191,140 | $16,067,000 | thousands by filing date | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 909,700 | $15,173,000 | thousands by filing date | put |
| KODIAK SCIENCES INC | 50015M109 | COM | 167,900 | $14,235,000 | thousands by filing date | call |
| GOSSAMER BIO INC COM | 38341P102 | Stock | 1,166,933 | $13,199,000 | thousands by filing date | |
| SIERRA ONCOLOGY INC | 82640U404 | CMN | 569,029 | $12,370,000 | thousands by filing date | |
| Milestone Pharmaceuticals Inc | 59935V107 | COM | 1,750,043 | $11,464,000 | thousands by filing date | |
| ATHIRA PHARMA INC | 04746L104 | COM | 860,000 | $11,207,000 | thousands by filing date | call |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 92,400 | $10,345,000 | thousands by filing date | call |
| IMMATICS N.V | N44445109 | SHS | 737,546 | $9,913,000 | thousands by filing date | |
| ZOGENIX INC. | 98978L204 | Common Stock | 590,400 | $9,594,000 | thousands by filing date | call |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 200,000 | $9,455,000 | thousands by filing date | call |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 100,000 | $8,836,000 | thousands by filing date | call |
| ADICET BIO INC | 007002108 | COM | 477,418 | $8,350,000 | thousands by filing date | |
| HORIZON THERAPEUTICS PLC | G46188101 | SHS | 75,661 | $8,153,000 | thousands by filing date | |
| TRACON PHARMACEUTICALS INC | 89237H209 | COM NEW | 2,691,110 | $7,454,000 | thousands by filing date | |
| BIOGEN INC COM | 09062X103 | Stock | 29,533 | $7,087,000 | thousands by filing date | |
| VAXCYTE INC COM | 92243G108 | Stock | 295,111 | $7,021,000 | thousands by filing date | |
| SERES THERAPEUTICS INC | 81750R102 | COM | 795,903 | $6,630,000 | thousands by filing date | |
| PARDES BIOSCIENCES INC | 69945Q105 | COM | 400,000 | $6,547,000 | thousands by filing date | |
| INHIBRX INC | 45720L107 | COM | 149,850 | $6,542,000 | thousands by filing date | |
| AYALA PHARMACEUTICALS INC | 05465V108 | COM | 669,271 | $5,696,000 | thousands by filing date | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 179,138 | $5,597,000 | thousands by filing date | |
| REATA PHARMACEUTICALS INC | 75615P103 | CL A | 200,000 | $5,274,000 | thousands by filing date | call |
| X4 Pharmaceuticals, Inc. | 98420X103 | COM | 2,264,491 | $5,186,000 | thousands by filing date | |
| CHIMERIX INC COM | 16934W106 | Stock | 795,410 | $5,114,000 | thousands by filing date | |
| ARCUS BIOSCIENCES INC | 03969F109 | COM | 124,600 | $5,044,000 | thousands by filing date | put |
| LAKEFRONT BIOTHERAPEUTICS NV | 36315X101 | SPON ADR | 86,865 | $4,861,000 | thousands by filing date | |
| GLOBAL BLOOD THERAPEUTICS USD | 37890U108 | COM | 164,082 | $4,803,000 | thousands by filing date | |
| WHITEHAWK THERAPEUTICS INC | 00032Q104 | CMN | 196,408 | $4,744,000 | thousands by filing date | |
| SCPHARMACEUTICALS INC | 810648105 | COM | 901,362 | $4,525,000 | thousands by filing date | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 126,900 | $4,341,000 | thousands by filing date | call |
| IOVANCE BIOTHERAPEUTICS INC | 462260100 | COM | 196,000 | $3,742,000 | thousands by filing date | put |
| CABALETTA BIO INC | 12674W109 | COMMON STOCK | 970,398 | $3,678,000 | thousands by filing date | |
| ISHARES TR | 464287556 | ISHARES BIOTECH | 24,022 | $3,666,000 | thousands by filing date | |
| INHIBRX INC | 45720L107 | COM | 80,800 | $3,529,000 | thousands by filing date | call |
| ADICET BIO INC | 007002108 | COM | 200,000 | $3,498,000 | thousands by filing date | call |
| NEKTAR THERAPEUTICS | 640268108 | COM | 250,000 | $3,378,000 | thousands by filing date | call |
| IOVANCE BIOTHERAPEUTICS INC | 462260100 | COM | 172,521 | $3,294,000 | thousands by filing date | |
| FINCH THERAPEUTICS GROUP INC | 31773D101 | COM | 315,732 | $3,148,000 | thousands by filing date | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 993,481 | $3,119,000 | thousands by filing date | |
| CLOVIS ONCOLOGY INC | 189464100 | COM | 1,112,669 | $3,016,000 | thousands by filing date | |
| SATSUMA PHARMACEUTICALS INC | 80405P107 | COM | 629,384 | $2,831,000 | thousands by filing date | |
| KEZAR LIFE SCIENCES INC | 49372L100 | COM | 169,300 | $2,830,000 | thousands by filing date | call |
| AUTOLUS THERAPEUTICS PLC SPON | 05280R100 | COM | 544,819 | $2,827,000 | thousands by filing date | |
| RENOVACOR INC | 75989E106 | COM | 342,902 | $2,641,000 | thousands by filing date | |
| REATA PHARMACEUTICALS INC | 75615P103 | CL A | 100,000 | $2,637,000 | thousands by filing date | put |
| MACROGENICS INC | 556099109 | COM | 156,047 | $2,506,000 | thousands by filing date | |
| VIKING THERAPEUTICS INC | 92686J106 | COM | 500,642 | $2,303,000 | thousands by filing date | |
| OVID THERAPEUTICS INC | 690469101 | COMMON STOCK | 705,082 | $2,264,000 | thousands by filing date | |
| GOSSAMER BIO INC COM | 38341P102 | Stock | 200,000 | $2,262,000 | thousands by filing date | call |
| ALLAKOS INC | 01671P100 | COM | 218,000 | $2,135,000 | thousands by filing date | call |
| ARENA PHARMACEUTICALS INC | 040047607 | COM NEW | 22,300 | $2,072,000 | thousands by filing date | call |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 23,700 | $2,008,000 | thousands by filing date | |
| CLENE INC | 185634102 | COM | 489,321 | $2,006,000 | thousands by filing date | |
| TG THERAPEUTICS INC COM | 88322Q108 | Stock | 100,739 | $1,914,000 | thousands by filing date | |
| SAVARA INC | 805111101 | COM | 1,539,691 | $1,910,000 | thousands by filing date | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 164,174 | $1,896,000 | thousands by filing date | |
| PROTARA THERAPEUTICS INC | 74365U107 | COM STK | 279,256 | $1,885,000 | thousands by filing date | |
| AURINIA PHARMACEUTICALS INC COM | 05156V102 | Stock | 82,335 | $1,883,000 | thousands by filing date | |
| TG THERAPEUTICS INC COM | 88322Q108 | Stock | 98,600 | $1,873,000 | thousands by filing date | put |
| CHEMOMAB THERAPEUTICS LTD | 16385C104 | SPONSORED ADS | 265,264 | $1,829,000 | thousands by filing date | |
| ODONATE THERAPEUTICS INC | 676079106 | COM | 1,340,631 | $1,810,000 | thousands by filing date | |
| LYRA THERAPEUTICS INC | 55234L105 | COM | 394,536 | $1,719,000 | thousands by filing date | |
| NUVATION BIO INC COM CL A | 67080N101 | Stock | 200,000 | $1,700,000 | thousands by filing date | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 100,000 | $1,668,000 | thousands by filing date | call |
| MERUS N V | N5749R100 | COM | 50,907 | $1,619,000 | thousands by filing date | |
| CABALETTA BIO INC | 12674W109 | COMMON STOCK | 423,000 | $1,603,000 | thousands by filing date | call |
| LIQUIDIA CORPORATION COM NEW | 53635D202 | Stock | 325,445 | $1,583,000 | thousands by filing date | |
| Inflarx Nv | N44821101 | COM | 331,048 | $1,577,000 | thousands by filing date | |
| VASCULAR BIOGENICS LTD | M96883109 | COM | 790,838 | $1,558,000 | thousands by filing date | |
| AILERON THERAPEUTICS INC COM NEW | 00887A105 | Stock | 2,763,583 | $1,556,000 | thousands by filing date | |
| ELEDON PHARMACEUTICALS INC | 28617k101 | COM | 344,578 | $1,519,000 | thousands by filing date | |
| RENEO PHARMACEUTICALS INC | 75974E103 | COM | 175,000 | $1,497,000 | thousands by filing date | |
| PHATHOM PHARMACEUTICALS INC | 71722W107 | COMMON STOCK | 74,560 | $1,467,000 | thousands by filing date | |
| CONNECT BIOPHARMA HLDGS LTD | 207523101 | SHS | 262,237 | $1,350,000 | thousands by filing date | |
| MAXCYTE INC | 57777K106 | COM | 130,000 | $1,325,000 | thousands by filing date | |
| VERASTEM INC | 92337C104 | COM | 637,371 | $1,308,000 | thousands by filing date | |
| SYNAPTOGENIX INC | 87167T201 | COM NEW | 145,629 | $1,239,000 | thousands by filing date | |
| GEMINI THERAPEUTICS INC | 36870G105 | CMN | 421,050 | $1,225,000 | thousands by filing date | |
| AVALO THERAPEUTICS INC | 05338F108 | CMN | 718,705 | $1,223,000 | thousands by filing date | |
| VALLON PHARMACEUTICALS INC | 92023M101 | COM | 198,085 | $1,184,000 | thousands by filing date | |
| SYNLOGIC INC | 87166L100 | COM | 483,818 | $1,171,000 | thousands by filing date | |
| PLIANT THERAPEUTICS INC | 729139105 | COM | 86,712 | $1,170,000 | thousands by filing date | |
| RIGEL PHARMACEUTICALS INC | 766559603 | COMMON STOCK | 439,356 | $1,164,000 | thousands by filing date | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 482,610 | $1,163,000 | thousands by filing date | |
| BRAINSTORM CELL THERAPEUTICS | 10501E201 | COM | 289,550 | $1,159,000 | thousands by filing date | |
| QUANTUM SI INC | 74765K105 | COM CL A | 144,406 | $1,136,000 | thousands by filing date | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 8,400 | $1,130,000 | thousands by filing date | |
| DBV TECHNOLOGIES S A | 23306J101 | ADR | 310,110 | $1,078,000 | thousands by filing date | |
| ANEBULO PHARMACEUTICALS INC | 034569103 | COM | 172,309 | $1,071,000 | thousands by filing date | |
| ATEA PHARMACEUTICALS INC | 04683R106 | COMMON STOCK | 116,600 | $1,043,000 | thousands by filing date | call |
| CASI PHARMACEUTICALS INC | 14757U109 | COM | 1,223,067 | $978,000 | thousands by filing date | |
| VISTAGEN THERAPEUTICS INC | 92840H202 | COM | 475,693 | $927,000 | thousands by filing date | |
| SOLID BIOSCIENCES INC COM NEW | 83422E105 | Stock | 521,155 | $911,000 | thousands by filing date | |
| CYCLERION THERAPEUTICS INC | 23255M105 | COM | 502,627 | $866,000 | thousands by filing date | |
| HARPOON THERAPEUTICS INC | 41358P106 | COM | 111,292 | $840,000 | thousands by filing date | |
| MUSTANG BIO INC | 62818Q104 | COM | 506,033 | $840,000 | thousands by filing date | |
| NEXTCURE INC | 65343E108 | COM | 134,055 | $804,000 | thousands by filing date | |
| BLACK DIAMOND THERAPEUTICS I | 09203E105 | COM | 150,484 | $801,000 | thousands by filing date | |
| DIAMEDICA THERAPEUTICS INC | 25253X207 | COMMON STOCK | 209,082 | $779,000 | thousands by filing date | |
| IVERIC BIO INC | 46583P102 | COM | 46,519 | $778,000 | thousands by filing date | |
| MYMD PHARMACEUTICALS INC | 62856X102 | COMMON | 124,000 | $751,000 | thousands by filing date | |
| APPLIED GENETIC TECHNOL CORP | 03820J100 | COM | 390,394 | $742,000 | thousands by filing date | |
| BELLICUM PHARMACEUTICALS INC COM NEW | 079481404 | Stock | 496,756 | $739,000 | thousands by filing date | |
| BCLS ACQUISITION CORP | G0904B105 | CMN | 73,789 | $728,000 | thousands by filing date | |
| TENAX THERAPEUTICS INC | 88032L209 | COM | 694,195 | $722,000 | thousands by filing date | |
| VTV THERAPEUTICS INC CL A | 918385105 | Stock | 700,000 | $697,000 | thousands by filing date | |
| YUMANITY THERAPEUTICS INC | 98872L102 | COM | 228,761 | $678,000 | thousands by filing date | |
| HEPION PHARMACEUTICALS INC | 426897104 | COM | 553,273 | $630,000 | thousands by filing date | |
| ZAI LAB LTD ADR | 98887Q104 | ADR | 9,600 | $603,000 | thousands by filing date | call |
| PANBELA THERAPEUTICS INC | 69833Q100 | COM | 338,382 | $592,000 | thousands by filing date | |
| CORBUS PHARMACEUTICALS HLDGS | 21833P103 | COM | 948,526 | $584,000 | thousands by filing date | |
| INTERCEPT PHARMACEUTICALS IN | 45845P108 | COM | 34,565 | $562,000 | thousands by filing date | |
| CODIAK BIOSCIENCES INC | 192010106 | COM | 49,680 | $554,000 | thousands by filing date | |
| ALTAMIRA THERAPEUTICS LTD | G0360L100 | SHS | 304,791 | $553,000 | thousands by filing date | |
| FATE THERAPEUTICS INC | 31189P102 | COM | 9,038 | $528,000 | thousands by filing date | |
| LARIMAR THERAPEUTICS INC | 517125100 | COM | 47,193 | $510,000 | thousands by filing date | |
| Rafael Holdings Inc Class B | 75062E106 | COM | 100,000 | $510,000 | thousands by filing date | put |
| ASSEMBLY BIOSCIENCES INC | 045396108 | COM | 214,861 | $501,000 | thousands by filing date | |
| KALVISTA PHARMACEUTICALS INC | 483497103 | COM | 36,576 | $484,000 | thousands by filing date | |
| ASTRIA THERAPEUTICS INC COM | 04635X102 | Stock | 87,580 | $473,000 | thousands by filing date | |
| RELMADA THERAPEUTICS INC | 75955J402 | COMMON STOCK | 20,743 | $467,000 | thousands by filing date | |
| ONCTERNAL THERAPEUTICS INC | 68236P107 | COM | 199,180 | $451,000 | thousands by filing date | |
| OPUS GENETICS INC | 67577R102 | COMMON STOCK | 118,063 | $442,000 | thousands by filing date | |
| OTONOMY INC | 68906L105 | COM | 208,306 | $433,000 | thousands by filing date | |
| PASSAGE BIO INC | 702712100 | COM | 67,849 | $431,000 | thousands by filing date | |
| CATALYST BIOSCIENCES INC | 14888D208 | COM | 454,346 | $416,000 | thousands by filing date | |
| BELLUS HEALTH INC NEW | 07987C204 | COM | 50,000 | $402,000 | thousands by filing date | |
| SEELOS THERAPEUTICS INC | 81577F109 | COM | 244,171 | $398,000 | thousands by filing date | |
| STEALTH BIOTHERAPEUTICS CORP SPONSORED ADS | 85789A105 | Stock | 478,561 | $397,000 | thousands by filing date | |
| IMMUNOPRECISE ANTIBODIES LTDCOM NEW | 45257F200 | cs | 73,882 | $395,000 | thousands by filing date | |
| REGULUS THERAPEUTICS INC | 75915K200 | COM NEW | 1,228,416 | $388,000 | thousands by filing date | |
| CYCLACEL PHARMACE 6percent PFDCONV | 23254L603 | Stock | 99,422 | $385,000 | thousands by filing date | |
| ENVERIC BIOSCIENCES INC | 29405E109 | COM NEW | 400,000 | $372,000 | thousands by filing date | |
| Rafael Holdings Inc Class B | 75062E106 | COM | 72,515 | $370,000 | thousands by filing date | |
| ALLAKOS INC | 01671P100 | COM | 37,400 | $366,000 | thousands by filing date | put |
| AGENUS INC | 00847G705 | COM NEW | 103,192 | $332,000 | thousands by filing date | |
| BRIGHT MINDS BIOSCIENCES INC | 10919W108 | COM | 100,000 | $317,000 | thousands by filing date | |
| Tempest Therapeutics, Inc. | 87978U108 | Common Stock | 58,803 | $310,000 | thousands by filing date | |
| MEREO BIOPHARMA GROUP PLC | 589492107 | CMN | 853,680 | $307,000 | thousands by filing date | |
| DECIPHERA PHARMACEUTICALS IN | 24344T101 | COM | 29,800 | $291,000 | thousands by filing date | call |
| EYEPOINT INC COM NEW | 30233G209 | Stock | 21,427 | $262,000 | thousands by filing date | |
| ATYR PHARMA INC | 002120202 | COM NEW | 35,048 | $262,000 | thousands by filing date | |
| GENOCEA BIOSCIENCES INC | 372427401 | COMMON STOCK | 196,821 | $228,000 | thousands by filing date | |
| COMPASS THERAPEUTICS INC | 20454B104 | COM | 70,000 | $222,000 | thousands by filing date | |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 1,195 | $204,000 | thousands by filing date | |
| ARENA PHARMACEUTICALS INC | 040047607 | COM NEW | 2,161 | $200,000 | thousands by filing date | |
| INVENTIVA SA | 46124U107 | ADS | 14,748 | $197,000 | thousands by filing date | |
| ORCHARD THERAPEUTICS PLC | 68570P101 | ADR | 148,131 | $195,000 | thousands by filing date | |
| SAGE THERAPEUTICS INC | 78667J108 | COM | 4,500 | $192,000 | thousands by filing date | call |
| OCULAR THERAPEUTIX INC | 67576A100 | COM | 27,551 | $191,000 | thousands by filing date | |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 1,300 | $191,000 | thousands by filing date | put |
| ASLAN PHARMACEUTICALS LTD | 04522R101 | ADR | 917,348 | $187,000 | thousands by filing date | |
| NOVAVAX INC | 670002401 | COM NEW | 1,283 | $183,000 | thousands by filing date | |
| ACLARIS THERAPEUTICS INC COM | 00461U105 | Stock | 10,785 | $156,000 | thousands by filing date | |
| PUMA BIOTECHNOLOGY INC | 74587V107 | COMMON STOCK | 49,843 | $152,000 | thousands by filing date | |
| MIND MEDICINE (MINDMED) INC | 60255C109 | COMMON STOCK-FO | 100,000 | $138,000 | thousands by filing date | |
| APTOSE BIOSCIENCES INC COM | 03835T200 | Stock | 102,089 | $138,000 | thousands by filing date | |
| BIOXCEL THERAPEUTICS INC | 09075P105 | COM | 5,167 | $104,000 | thousands by filing date | |
| ATHENEX INC | 04685N103 | COM | 76,139 | $103,000 | thousands by filing date | |
| GAMIDA CELL LTD | M47364100 | SHS | 31,029 | $79,000 | thousands by filing date | |
| AMRYT PHARMA LTD - SPNR ADR | 03217L106 | COMMON EQUITY | 34,131 | $72,000 | thousands by filing date | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 5,180 | $56,000 | thousands by filing date | |
| SOLENO THERAPEUTIVS, INC. | 834203200 | COMM | 121,694 | $50,000 | thousands by filing date | |
| IGM BIOSCIENCES INC | 449585108 | COM | 1,500 | $44,000 | thousands by filing date | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 1,765 | $42,000 | thousands by filing date | |
| TRAWS PHARMA INC COM NEW | 68232V801 | Stock | 15,063 | $37,000 | thousands by filing date | |
| KINNATE BIOPHARMA INC | 49705R105 | COM | 1,990 | $35,000 | thousands by filing date | |
| PDS BIOTECHNOLOGY CORP | 70465T107 | COM | 3,495 | $28,000 | thousands by filing date | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 1,500 | $25,000 | thousands by filing date | |
| BAUDAX BIO INC | 07160F107 | COM | 95,059 | $21,000 | thousands by filing date | |
| INTERCEPT PHARMACEUTICALS IN | 45845P108 | COM | 1,100 | $18,000 | thousands by filing date | put |
| FRAZIER LIFESCIENCES ACQU CORP UNIT EXP 120925 | G3710A121 | Stock | 941 | $9,000 | thousands by filing date | |
| DECIPHERA PHARMACEUTICALS IN | 24344T101 | COM | 800 | $8,000 | thousands by filing date | put |
| KARYOPHARM THERAPEUTICS INC | 48576U106 | COM | 785 | $5,000 | thousands by filing date | |
| BLUEBIRD BIO INC | 09609G100 | COM | 287 | $2,000 | thousands by filing date | |
| 2SEVENTY BIO INC COMMON STOCK | 901384107 | Stock | 93 | $2,000 | thousands by filing date |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001420506-22-000377 | this filing | 2022-02-14 | acceptance time not in the bulk data set |