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13F-HR filed by Ikarian Capital, LLC

Ikarian Capital, LLC filed this 13F-HR for the quarter ended 2021-09-30, filed 2021-11-15, with 209 holding rows worth $1,420,104,000.

Accession
0001420506-21-001587
Filed
2021-11-15
Accepted by EDGAR
acceptance time not in the bulk data set
Ingested
Source
SEC quarterly data set

Original filing

13F report for Q3 2021

A holdings report, 209 entries on the cover page, a total value of $1,420,104,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $1,420,104,000 with VALUE read as thousands by filing date, 13F file number 028-19721. The quarter's positions are built on this report. The resolved quarter.

The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).

Issuer as filedCUSIPClassAmountValueValue read asType
SPY78462F103SHS300,000$128,741,000thousands by filing dateput
SPDR SER TR78464A870S&P BIOTECH650,000$81,713,000thousands by filing dateput
REATA PHARMACEUTICALS INC75615P103CL A471,400$47,423,000thousands by filing dateput
BIOGEN INC COM09062X103Stock167,500$47,402,000thousands by filing datecall
HORIZON THERAPEUTICS PLCG46188101SHS421,900$46,212,000thousands by filing datecall
CELLDEX THERAPEUTICS INC NEW15117B202COM NEW791,600$42,741,000thousands by filing datecall
UnitedHealth Group Inc91324P102COM100,000$39,074,000thousands by filing datecall
SPDR SER TR78464A870S&P BIOTECH300,000$37,712,000thousands by filing datecall
ALNYLAM PHARMACEUTICALS INC COM02043Q107Stock179,800$33,949,000thousands by filing datecall
SAREPTA THERAPEUTICS INC803607100COM361,700$33,449,000thousands by filing datecall
CELLDEX THERAPEUTICS INC NEW15117B202COM NEW520,200$28,084,000thousands by filing dateput
COMPASS PATHWAYS PLC20451W101SPONSORED ADS848,100$25,330,000thousands by filing datecall
CRISPR THERAPEUTICS AG NAMEN AKTH17182108Stock197,300$22,084,000thousands by filing dateput
BICYCLE THERAPEUTICS PLC-ADR088786108SPONSORED ADS526,500$21,897,000thousands by filing date
Rafael Holdings Inc Class B75062E106COM580,400$17,833,000thousands by filing datecall
GOSSAMER BIO INC COM38341P102Stock1,351,933$16,995,000thousands by filing date
KODIAK SCIENCES INC50015M109COM167,900$16,115,000thousands by filing datecall
ALLAKOS INC01671P100COM150,800$15,964,000thousands by filing datecall
KRYSTAL BIOTECH INC COM501147102Stock292,500$15,272,000thousands by filing dateput
KRYSTAL BIOTECH INC COM501147102Stock282,300$14,740,000thousands by filing datecall
CELLDEX THERAPEUTICS INC NEW15117B202COM NEW270,431$14,600,000thousands by filing date
NOVAVAX INC670002401COM NEW70,000$14,511,000thousands by filing datecall
CABALETTA BIO INC12674W109COMMON STOCK1,187,898$14,445,000thousands by filing date
X4 Pharmaceuticals, Inc.98420X103COM2,539,917$13,437,000thousands by filing date
ZENTALIS PHARMACEUTICALS INC98943L107COMMON STOCK200,000$13,328,000thousands by filing datecall
CORTEXYME INC22053A107COM142,100$13,024,000thousands by filing datecall
Rafael Holdings Inc Class B75062E106COM413,800$12,716,000thousands by filing dateput
SIERRA ONCOLOGY INC82640U404CMN573,380$12,569,000thousands by filing date
MIRATI THERAPEUTICS INC60468T105COM70,000$12,384,000thousands by filing datecall
IMMATICS N.VN44445109SHS883,046$11,479,000thousands by filing date
APELLIS PHARMACEUTICALS INC03753U106COM347,545$11,455,000thousands by filing date
APELLIS PHARMACEUTICALS INC03753U106COM345,400$11,385,000thousands by filing dateput
Merck & Co.,Inc.58933Y105COM150,000$11,266,000thousands by filing datecall
REATA PHARMACEUTICALS INC75615P103CL A109,600$11,027,000thousands by filing datecall
EDITAS MEDICINE INC28106W103COM254,100$10,438,000thousands by filing dateput
TRACON PHARMACEUTICALS INC89237H209COM NEW2,691,110$10,415,000thousands by filing date
CHEMOCENTRYX INC16383L106COM600,000$10,261,000thousands by filing dateput
CHEMOCENTRYX INC16383L106COM600,000$10,260,000thousands by filing datecall
Milestone Pharmaceuticals Inc59935V107COM1,750,043$9,993,000thousands by filing date
DICERNA PHARMACEUTICALS INC253031108COM493,600$9,952,000thousands by filing datecall
INHIBRX INC45720L107COM289,850$9,654,000thousands by filing date
MACROGENICS INC556099109COM446,000$9,340,000thousands by filing datecall
BIOGEN INC COM09062X103Stock32,243$9,123,000thousands by filing date
ZOGENIX INC.98978L204Common Stock590,400$8,968,000thousands by filing datecall
ARENA PHARMACEUTICALS INC040047607COM NEW148,700$8,854,000thousands by filing datecall
XENON PHARMACEUTICALS INC COM98420N105Stock546,700$8,353,000thousands by filing datecall
INTRA-CELLULAR THERAPIES INC46116X101COMMON STOCK211,670$7,890,000thousands by filing date
APELLIS PHARMACEUTICALS INC03753U106COM233,000$7,680,000thousands by filing datecall
VAXCYTE INC COM92243G108Stock295,111$7,486,000thousands by filing date
COMPASS PATHWAYS PLC20451W101SPONSORED ADS229,202$6,846,000thousands by filing date
INCYTE CORP COM45337C102Stock98,700$6,789,000thousands by filing datecall
IGM BIOSCIENCES INC449585108COM100,000$6,576,000thousands by filing datecall
ELANCO ANIMAL HEALTH INC COM28414H103Stock200,000$6,378,000thousands by filing datecall
ZENTALIS PHARMACEUTICALS INC98943L107COMMON STOCK92,344$6,152,000thousands by filing date
AYALA PHARMACEUTICALS INC05465V108COM538,939$6,112,000thousands by filing date
ASTRAZENECA PLC SPONSORED ADR046353108ADR100,000$6,006,000thousands by filing datecall
SCPHARMACEUTICALS INC810648105COM901,362$5,994,000thousands by filing date
FATE THERAPEUTICS INC31189P102COM100,000$5,928,000thousands by filing dateput
BIOATLA INC09077B104COM196,400$5,782,000thousands by filing date
XENON PHARMACEUTICALS INC COM98420N105Stock377,438$5,767,000thousands by filing date
BICYCLE THERAPEUTICS PLC-ADR088786108SPONSORED ADS130,000$5,408,000thousands by filing datecall
ODONATE THERAPEUTICS INC676079106COM1,840,631$5,357,000thousands by filing date
ALDEYRA THERAPEUTICS INC01438T106COM600,000$5,268,000thousands by filing datecall
ATYR PHARMA INC002120202COM NEW562,246$5,105,000thousands by filing date
CLOVIS ONCOLOGY INC189464100COM1,112,669$4,963,000thousands by filing date
CHIMERIX INC COM16934W106Stock801,308$4,960,000thousands by filing date
OCULAR THERAPEUTIX INC67576A100COM493,200$4,932,000thousands by filing datecall
WAVE LIFE SCIENCES LTD SHSY95308105Stock993,481$4,867,000thousands by filing date
IOVANCE BIOTHERAPEUTICS INC462260100COM196,000$4,833,000thousands by filing dateput
ACADIA PHARMACEUTICALS INC004225108COM281,765$4,681,000thousands by filing date
BELLUS HEALTH INC NEW07987C204COM744,616$4,572,000thousands by filing date
LAKEFRONT BIOTHERAPEUTICS NV36315X101SPON ADR86,865$4,544,000thousands by filing date
AURINIA PHARMACEUTICALS INC COM05156V102Stock200,000$4,426,000thousands by filing datecall
IOVANCE BIOTHERAPEUTICS INC462260100COM172,521$4,254,000thousands by filing date
SERES THERAPEUTICS INC81750R102COM606,554$4,222,000thousands by filing date
FINCH THERAPEUTICS GROUP INC31773D101COM315,732$4,106,000thousands by filing date
ATEA PHARMACEUTICALS INC04683R106COMMON STOCK116,600$4,088,000thousands by filing datecall
RENOVACOR INC75989E106COM442,902$4,008,000thousands by filing date
ALLAKOS INC01671P100COM37,400$3,960,000thousands by filing dateput
AMICUS THERAPEUTICS INC03152W109COM414,174$3,954,000thousands by filing date
MACROGENICS INC556099109COM188,478$3,947,000thousands by filing date
AMICUS THERAPEUTICS INC03152W109COM403,500$3,854,000thousands by filing dateput
VERASTEM INC92337C104COM1,227,371$3,780,000thousands by filing date
OVID THERAPEUTICS INC690469101COMMON STOCK1,105,082$3,715,000thousands by filing date
LYRA THERAPEUTICS INC55234L105COM403,450$3,688,000thousands by filing date
CORVUS PHARMACEUTICALS INC221015100COM757,545$3,666,000thousands by filing date
BIOCRYST PHARMACEUTICALS INC COM09058V103Stock250,000$3,592,000thousands by filing datecall
AUTOLUS THERAPEUTICS PLC SPON05280R100COM544,819$3,568,000thousands by filing date
IVERIC BIO INC46583P102COM216,519$3,516,000thousands by filing date
XENON PHARMACEUTICALS INC COM98420N105Stock230,000$3,515,000thousands by filing dateput
TRILLIUM THERAPEUTICS INC COM NEW89620X506Stock198,400$3,484,000thousands by filing datecall
NEXTCURE INC65343E108COM509,155$3,431,000thousands by filing date
IGM BIOSCIENCES INC449585108COM51,500$3,387,000thousands by filing date
CLENE INC185634102COM489,321$3,342,000thousands by filing date
ALLAKOS INC01671P100COM31,526$3,337,000thousands by filing date
PROTARA THERAPEUTICS INC74365U107COM STK479,995$3,321,000thousands by filing date
TG THERAPEUTICS INC COM88322Q108Stock98,600$3,282,000thousands by filing dateput
IVERIC BIO INC46583P102COM200,000$3,248,000thousands by filing datecall
VINCERX PHARMA INC92731L106COM NEW199,057$3,219,000thousands by filing date
PHATHOM PHARMACEUTICALS INC71722W107COMMON STOCK99,560$3,196,000thousands by filing date
CHEMOMAB THERAPEUTICS LTD16385C104SPONSORED ADS285,264$3,160,000thousands by filing date
VIKING THERAPEUTICS INC92686J106COM500,642$3,144,000thousands by filing date
CRISPR THERAPEUTICS AG NAMEN AKTH17182108Stock27,968$3,131,000thousands by filing date
TRICIDA INC89610F101COM670,771$3,113,000thousands by filing date
DBV TECHNOLOGIES S A23306J101ADR310,110$3,109,000thousands by filing date
ADICET BIO INC007002108COM392,418$3,077,000thousands by filing date
ARK ETF TR00214Q302GENOMIC REV ETF40,961$3,061,000thousands by filing date
SATSUMA PHARMACEUTICALS INC80405P107COM629,384$2,934,000thousands by filing date
AMICUS THERAPEUTICS INC03152W109COM300,000$2,865,000thousands by filing datecall
AILERON THERAPEUTICS INC COM NEW00887A105Stock2,763,583$2,818,000thousands by filing date
HORIZON THERAPEUTICS PLCG46188101SHS25,661$2,811,000thousands by filing date
OCULAR THERAPEUTIX INC67576A100COM277,551$2,775,000thousands by filing date
SUTRO BIOPHARMA INC869367102COM134,575$2,541,000thousands by filing date
RELAY THERAPEUTICS INC COM75943R102Stock80,000$2,522,000thousands by filing dateput
RELAY THERAPEUTICS INC COM75943R102Stock80,000$2,522,000thousands by filing datecall
LIQUIDIA CORPORATION COM NEW53635D202Stock884,893$2,442,000thousands by filing date
SYNAPTOGENIX INC87167T201COM NEW245,629$2,441,000thousands by filing date
SYNLOGIC INC87166L100COM788,818$2,406,000thousands by filing date
YUMANITY THERAPEUTICS INC98872L102COM228,761$2,360,000thousands by filing date
GOSSAMER BIO INC COM38341P102Stock185,400$2,330,000thousands by filing datecall
INCYTE CORP COM45337C102Stock32,666$2,247,000thousands by filing date
ELEDON PHARMACEUTICALS INC28617k101COM344,578$2,129,000thousands by filing date
SAVARA INC805111101COM1,539,691$2,126,000thousands by filing date
NEKTAR THERAPEUTICS640268108COM114,800$2,062,000thousands by filing datecall
EDITAS MEDICINE INC28106W103COM50,000$2,054,000thousands by filing datecall
CODIAK BIOSCIENCES INC192010106COM119,895$1,958,000thousands by filing date
HEALTH SCIENCES ACQ CORP 2G4411D109ORD SHS197,173$1,950,000thousands by filing date
MADRIGAL PHARMACEUTICALS INC COM558868105Stock23,700$1,890,000thousands by filing date
CATALYST BIOSCIENCES INC14888D208COM454,346$1,867,000thousands by filing date
CORTEXYME INC22053A107COM20,160$1,848,000thousands by filing date
MAXCYTE INC57777K106COM150,000$1,831,000thousands by filing date
GEMINI THERAPEUTICS INC36870G105CMN421,050$1,701,000thousands by filing date
KALVISTA PHARMACEUTICALS INC483497103COM96,576$1,685,000thousands by filing date
VISTAGEN THERAPEUTICS INC92840H202COM600,693$1,647,000thousands by filing date
Inflarx NvN44821101COM631,048$1,634,000thousands by filing date
VASCULAR BIOGENICS LTDM96883109COM790,838$1,622,000thousands by filing date
CEREVEL THERAPEUTICS HLDNG I15678U128COM53,370$1,573,000thousands by filing date
AVALO THERAPEUTICS INC05338F108CMN718,705$1,566,000thousands by filing date
CYCLERION THERAPEUTICS INC23255M105COM502,627$1,543,000thousands by filing date
PLIANT THERAPEUTICS INC729139105COM86,712$1,464,000thousands by filing date
CASI PHARMACEUTICALS INC14757U109COM1,223,067$1,456,000thousands by filing date
BELLICUM PHARMACEUTICALS INC COM NEW079481404Stock496,756$1,451,000thousands by filing date
VALLON PHARMACEUTICALS INC92023M101COM198,085$1,440,000thousands by filing date
ATHIRA PHARMA INC04746L104COM150,000$1,407,000thousands by filing datecall
MUSTANG BIO INC62818Q104COM506,033$1,360,000thousands by filing date
ASCENDIS PHARMA A/S DKK 1.0 AD04351P101SPONSORED ADR8,400$1,339,000thousands by filing datecall
RENEO PHARMACEUTICALS INC75974E103COM175,000$1,303,000thousands by filing date
BLACK DIAMOND THERAPEUTICS I09203E105COM150,484$1,272,000thousands by filing date
DIAMEDICA THERAPEUTICS INC25253X207COMMON STOCK311,041$1,247,000thousands by filing date
SOLID BIOSCIENCES INC COM NEW83422E105Stock521,155$1,246,000thousands by filing date
QUANTUM SI INC74765K105COM CL A144,406$1,204,000thousands by filing date
APPLIED GENETIC TECHNOL CORP03820J100COM390,394$1,175,000thousands by filing date
ANEBULO PHARMACEUTICALS INC034569103COM172,309$1,160,000thousands by filing date
MERUS N VN5749R100COM50,907$1,120,000thousands by filing date
PROTAGONIST THERAPEUTICS74366E102COM61,100$1,083,000thousands by filing datecall
DECIPHERA PHARMACEUTICALS IN24344T101COM29,800$1,012,000thousands by filing datecall
CORBUS PHARMACEUTICALS HLDGS21833P103COM948,526$968,000thousands by filing date
BRAINSTORM CELL THERAPEUTICS10501E201COM289,550$955,000thousands by filing date
HARPOON THERAPEUTICS INC41358P106COM111,292$879,000thousands by filing date
Tempest Therapeutics, Inc.87978U108Common Stock58,803$851,000thousands by filing date
REGULUS THERAPEUTICS INC75915K200COM NEW1,228,416$849,000thousands by filing date
HEPION PHARMACEUTICALS INC426897104COM553,273$847,000thousands by filing date
ONCTERNAL THERAPEUTICS INC68236P107COM199,180$830,000thousands by filing date
TENAX THERAPEUTICS INC88032L209COM466,261$826,000thousands by filing date
ALTAMIRA THERAPEUTICS LTDG0360L100SHS399,148$803,000thousands by filing date
ATEA PHARMACEUTICALS INC04683R106COMMON STOCK22,800$799,000thousands by filing dateput
ASTRIA THERAPEUTICS INC COM04635X102Stock87,580$775,000thousands by filing date
ACLARIS THERAPEUTICS INC COM00461U105Stock42,712$770,000thousands by filing date
ASSEMBLY BIOSCIENCES INC045396108COM214,861$747,000thousands by filing date
SHATTUCK LABS INC82024L103COMMON STOCK36,240$739,000thousands by filing date
BCLS ACQUISITION CORPG0904B105CMN73,789$739,000thousands by filing date
PANBELA THERAPEUTICS INC69833Q100COM338,382$734,000thousands by filing date
FRAZIER LIFESCIENCES ACQU CORP UNIT EXP 120925G3710A121Stock73,118$725,000thousands by filing date
IMMUNOVANT INC45258J102COM83,046$722,000thousands by filing date
KINIKSA PHARMACEUTICALS LTDG5269C101COM CL A59,422$677,000thousands by filing date
PASSAGE BIO INC702712100COM67,849$677,000thousands by filing date
STEALTH BIOTHERAPEUTICS CORP SPONSORED ADS85789A105Stock478,561$651,000thousands by filing date
OPUS GENETICS INC67577R102COMMON STOCK118,063$608,000thousands by filing date
SAREPTA THERAPEUTICS INC803607100COM6,496$602,000thousands by filing date
SEELOS THERAPEUTICS INC81577F109COM244,171$589,000thousands by filing date
KALEIDO BIOSCIENCES INC483347100COM100,000$546,000thousands by filing date
LARIMAR THERAPEUTICS INC517125100COM47,193$545,000thousands by filing date
RELMADA THERAPEUTICS INC75955J402COMMON STOCK20,743$544,000thousands by filing date
AGENUS INC00847G705COM NEW103,192$542,000thousands by filing date
CYCLACEL PHARMACE 6percent PFDCONV23254L603Stock99,422$524,000thousands by filing date
INMUNE BIO INC45782T105COM26,632$517,000thousands by filing date
INTERCEPT PHARMACEUTICALS IN45845P108COM34,565$513,000thousands by filing date
DELCATH SYSTEMS INC24661P807COMMON STOCK44,857$468,000thousands by filing date
IMMUNOPRECISE ANTIBODIES LTDCOM NEW45257F200cs73,882$459,000thousands by filing date
OTONOMY INC68906L105COM208,306$399,000thousands by filing date
EYEPOINT INC COM NEW30233G209Stock36,427$380,000thousands by filing date
GENOCEA BIOSCIENCES INC372427401COMMON STOCK196,821$377,000thousands by filing date
PUMA BIOTECHNOLOGY INC74587V107COMMON STOCK49,843$349,000thousands by filing date
ORCHARD THERAPEUTICS PLC68570P101ADR148,131$341,000thousands by filing date
WHITEHAWK THERAPEUTICS INC00032Q104CMN11,408$335,000thousands by filing date
MEREO BIOPHARMA GROUP PLC589492107CMN903,680$322,000thousands by filing date
ASLAN PHARMACEUTICALS LTD04522R101ADR1,417,348$288,000thousands by filing date
ALNYLAM PHARMACEUTICALS INC COM02043Q107Stock1,461$276,000thousands by filing date
NOVAVAX INC670002401COM NEW1,283$266,000thousands by filing date
COGENT BIOSCIENCES INC19240Q201COM30,727$258,000thousands by filing date
MIRATI THERAPEUTICS INC60468T105COM1,300$231,000thousands by filing dateput
ATHENEX INC04685N103COM76,139$228,000thousands by filing date
APTOSE BIOSCIENCES INC COM03835T200Stock102,089$224,000thousands by filing date
INVENTIVA SA46124U107ADS14,748$202,000thousands by filing date
GAMIDA CELL LTDM47364100SHS31,029$122,000thousands by filing date
SOLENO THERAPEUTIVS, INC.834203200COMM121,694$112,000thousands by filing date
AMRYT PHARMA LTD - SPNR ADR03217L106COMMON EQUITY34,131$81,000thousands by filing date
TRAWS PHARMA INC COM NEW68232V801Stock15,063$57,000thousands by filing date
BAUDAX BIO INC07160F107COM95,059$53,000thousands by filing date

Amendment chain

FilingRoleFiledAcceptedIngested
13F-HR 0001420506-21-001587this filing2021-11-15acceptance time not in the bulk data set