13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2021-03-31, filed 2021-05-17, with 170 holding rows worth $1,303,789,000.
- Accession
- 0001178913-21-001758
- Filer
- CIK 1496201
- Filed
- 2021-05-17
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q1 2021
A holdings report, 170 entries on the cover page, a total value of $1,303,789,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $1,303,797,000 with VALUE read as thousands by filing date, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerSphera Global Healthcare GP Ltd.028-15864
- included managerSphera Global Healthcare Management LP028-15865
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| Eli Lilly and Company | 532457108 | COM | 429,200 | $80,183,000 | thousands by filing date | |
| Johnson & Johnson | 478160104 | COM | 453,900 | $74,598,000 | thousands by filing date | |
| AbbVie,Inc. | 00287Y109 | COM | 599,500 | $64,878,000 | thousands by filing date | |
| Merck & Co.,Inc. | 58933Y105 | COM | 808,808 | $62,351,000 | thousands by filing date | |
| SANOFI SA SPONSORED ADR | 80105N105 | ADR | 997,900 | $49,356,000 | thousands by filing date | |
| ASTRAZENECA PLC SPONSORED ADR | 046353108 | ADR | 960,473 | $47,755,000 | thousands by filing date | |
| iShares Russell 2000 ETF | 464287655 | SHS | 210,000 | $46,397,000 | thousands by filing date | put |
| ENPHASE ENERGY INC COM | 29355A107 | Stock | 230,000 | $37,297,000 | thousands by filing date | call |
| GENERAC HLDGS INC | 368736104 | COM | 105,663 | $34,599,000 | thousands by filing date | |
| Johnson & Johnson | 478160104 | COM | 200,000 | $32,870,000 | thousands by filing date | call |
| iShares Expanded Tech-Software Sector ETF | 464287515 | SHS | 70,900 | $24,207,000 | thousands by filing date | put |
| FIVERR INTL LTD ORD SHS | M4R82T106 | Stock | 100,000 | $21,718,000 | thousands by filing date | call |
| KURA ONCOLOGY INC COM | 50127T109 | Stock | 717,751 | $20,291,000 | thousands by filing date | |
| C4 THERAPEUTICS INC | 12529R107 | COM STK | 497,136 | $18,389,000 | thousands by filing date | |
| Microsoft Corp | 594918104 | COM | 67,536 | $15,923,000 | thousands by filing date | |
| KORNIT DIGITAL LTD | M6372Q113 | SHS | 148,381 | $14,708,000 | thousands by filing date | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 638,093 | $14,268,000 | thousands by filing date | |
| LIVEPERSON, INC. | 538146101 | COM | 260,000 | $13,712,000 | thousands by filing date | |
| ESSA PHARMA INC | 29668H708 | COM NEW | 469,241 | $13,631,000 | thousands by filing date | |
| AUDIOCODES LTD | M15342104 | ORD | 475,624 | $12,832,000 | thousands by filing date | |
| Bristol-Myers Squibb Company | 110122108 | COM | 200,000 | $12,626,000 | thousands by filing date | |
| ONCORUS INC | 68236R103 | COM | 903,111 | $12,571,000 | thousands by filing date | |
| CEREVEL THERAPEUTICS HLDNG I | 15678U128 | COM | 912,240 | $12,525,000 | thousands by filing date | |
| MOHAWK GROUP HLDGS INC | 608189106 | COM | 355,600 | $10,490,000 | thousands by filing date | call |
| PALO ALTO NETWORKS INC | 697435105 | COM | 32,300 | $10,403,000 | thousands by filing date | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 888,800 | $10,257,000 | thousands by filing date | call |
| iShares S&P Global Clean Energy Index Fund | 464288224 | COM | 420,000 | $10,206,000 | thousands by filing date | put |
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 137,672 | $10,129,000 | thousands by filing date | |
| CURIS INC | 231269200 | COM | 885,838 | $10,028,000 | thousands by filing date | |
| ORCHARD THERAPEUTICS PLC | 68570P101 | ADR | 1,366,564 | $9,921,000 | thousands by filing date | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 247,527 | $9,619,000 | thousands by filing date | |
| ALX ONCOLOGY HOLDINGS INC | 00166B105 | COMMON STOCK | 130,351 | $9,612,000 | thousands by filing date | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 832,878 | $9,611,000 | thousands by filing date | |
| FATE THERAPEUTICS INC | 31189P102 | COM | 109,807 | $9,054,000 | thousands by filing date | |
| VISTAGEN THERAPEUTICS INC | 92840H202 | COM | 4,177,158 | $8,897,000 | thousands by filing date | |
| ZAI LAB LTD ADR | 98887Q104 | ADR | 65,788 | $8,778,000 | thousands by filing date | |
| NICE LTD SPONSORED ADR | 653656108 | ADR | 39,481 | $8,606,000 | thousands by filing date | |
| Amazon.com, Inc | 023135106 | COM | 2,761 | $8,543,000 | thousands by filing date | |
| PERRIGO CO PLC SHS | G97822103 | Stock | 210,000 | $8,499,000 | thousands by filing date | call |
| ONTO INNOVATION INC COM | 683344105 | Stock | 125,000 | $8,214,000 | thousands by filing date | |
| ISHARES TR | 464287432 | 20 YR TR BD ETF | 60,000 | $8,127,000 | thousands by filing date | put |
| SIGILON THERAPEUTICS INC | 82657L107 | COM | 362,239 | $8,072,000 | thousands by filing date | |
| AFFIMED N V | N01045108 | COM | 1,018,965 | $8,060,000 | thousands by filing date | |
| BOLT BIOTHERAPEUTICS INC | 097702104 | COM | 241,000 | $7,931,000 | thousands by filing date | |
| REPARE THERAPEUTICS INC | 760273102 | COM | 248,100 | $7,614,000 | thousands by filing date | |
| ZENTALIS PHARMACEUTICALS INC | 98943L107 | COMMON STOCK | 175,140 | $7,599,000 | thousands by filing date | |
| THERAPEUTICS ACQUISITION COR | 88339T103 | COM CL A | 720,000 | $7,567,000 | thousands by filing date | |
| MOHAWK GROUP HLDGS INC | 608189106 | COM | 251,015 | $7,405,000 | thousands by filing date | |
| CAESARSTONE LTD | M20598104 | ORD SHS | 535,148 | $7,348,000 | thousands by filing date | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 167,799 | $7,321,000 | thousands by filing date | |
| BEONE MEDICINES LTD SPONSORED ADS | 07725L102 | ADR | 20,900 | $7,275,000 | thousands by filing date | |
| BCLS ACQUISITION CORP | G0904B105 | CMN | 687,900 | $7,271,000 | thousands by filing date | |
| TRILLIUM THERAPEUTICS INC COM NEW | 89620X506 | Stock | 670,459 | $7,201,000 | thousands by filing date | |
| VARONIS SYS INC | 922280102 | COM | 138,675 | $7,120,000 | thousands by filing date | |
| CYBERARK SOFTWARE LTD SHS | M2682V108 | Stock | 55,000 | $7,114,000 | thousands by filing date | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 450,064 | $6,989,000 | thousands by filing date | |
| ALLOT LTD | M0854Q105 | SHS | 420,205 | $6,711,000 | thousands by filing date | |
| SUTRO BIOPHARMA INC | 869367102 | COM | 294,825 | $6,710,000 | thousands by filing date | |
| VERONA PHARMA PLC | 925050106 | SPONSORED ADS | 801,256 | $6,699,000 | thousands by filing date | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 762,569 | $6,695,000 | thousands by filing date | |
| NURIX THERAPEUTICS INC | 67080M103 | COMMON STOCK | 215,076 | $6,687,000 | thousands by filing date | |
| KALVISTA PHARMACEUTICALS INC | 483497103 | COM | 258,880 | $6,651,000 | thousands by filing date | |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 145,476 | $6,541,000 | thousands by filing date | |
| RESEARCH ALLIANCE CORP II | 760873109 | CMN | 600,000 | $6,150,000 | thousands by filing date | |
| STOKE THERAPEUTICS INC | 86150R107 | COM | 150,729 | $5,854,000 | thousands by filing date | |
| ARYA SCIENCES ACQUISITION CO | G3166W106 | COM CL A | 400,000 | $5,512,000 | thousands by filing date | |
| BAIDU INC SPON ADR REP A | 056752108 | ADR | 25,000 | $5,439,000 | thousands by filing date | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 202,134 | $5,235,000 | thousands by filing date | |
| ARYA SCIENCES ACQU CORP IV | G31659108 | COM | 500,000 | $5,200,000 | thousands by filing date | |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 29,779 | $5,101,000 | thousands by filing date | |
| ACHILLES THERAPEUTICS PL-ADR | 00449L102 | COM | 300,000 | $4,965,000 | thousands by filing date | |
| RADA ELECTR INDS LTD | M81863124 | CMN | 407,925 | $4,899,000 | thousands by filing date | |
| IDEAYA BIOSCIENCES INC COM | 45166A102 | Stock | 201,984 | $4,747,000 | thousands by filing date | |
| REINVENT TECHNOLOGY PARTNERS | G74847107 | SHS CL A | 468,012 | $4,685,000 | thousands by filing date | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 220,320 | $4,539,000 | thousands by filing date | |
| MEREO BIOPHARMA GROUP PLC | 589492107 | CMN | 1,312,415 | $4,423,000 | thousands by filing date | |
| GLOBAL X FDS | 37954Y442 | CLOUD COMPUTNG | 170,600 | $4,391,000 | thousands by filing date | put |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 284,224 | $4,343,000 | thousands by filing date | |
| FARFETCH LTD | 30744W107 | ORD SH CL A | 80,000 | $4,242,000 | thousands by filing date | |
| ORIC PHARMACEUTICALS INC | 68622P109 | COM | 169,900 | $4,163,000 | thousands by filing date | |
| FORESIGHT ACQUISITION CORP UNI | 34552y205 | COM | 420,000 | $4,162,000 | thousands by filing date | |
| SHATTUCK LABS INC | 82024L103 | COMMON STOCK | 140,665 | $4,113,000 | thousands by filing date | |
| ARKO CORP | 041242108 | COMMON STOCK | 408,000 | $4,056,000 | thousands by filing date | |
| HEALTHCARE CAPITAL CORP | 42228c200 | COM | 400,000 | $3,948,000 | thousands by filing date | |
| Inflarx Nv | N44821101 | COM | 1,000,000 | $3,900,000 | thousands by filing date | |
| YUMANITY THERAPEUTICS INC | 98872L102 | COM | 208,609 | $3,776,000 | thousands by filing date | |
| CATABASIS PHARMACEUTICALS IN | 14875P206 | COM NEW | 1,294,000 | $3,740,000 | thousands by filing date | |
| CYCLACEL PHARMACE 6percent PFDCONV | 23254L603 | Stock | 508,322 | $3,614,000 | thousands by filing date | |
| NKARTA INC | 65487U108 | COMMON STOCK | 101,006 | $3,323,000 | thousands by filing date | |
| GRACELL BIOTECHNOLOGIES INC | 38406L103 | ADR | 212,600 | $3,274,000 | thousands by filing date | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 100,000 | $3,250,000 | thousands by filing date | |
| LAVA THERAPEUTICS NV | N51517105 | SHS | 213,894 | $3,249,000 | thousands by filing date | |
| LONGVIEW ACQUISITION CORP II | 54319Q204 | UNIT 99/99/9999 | 300,000 | $3,012,000 | thousands by filing date | |
| EUCRATES BIOMEDICAL ACQU COR | G3141W106 | CMN | 304,025 | $3,007,000 | thousands by filing date | |
| CLARIM ACQUISITION CORP | 18049C207 | UNIT 99/99/9999 | 300,000 | $2,985,000 | thousands by filing date | |
| GALERA THERAPEUTICS EQUICLASS EQUITY | 36338D108 | COMMON STOCK | 323,348 | $2,852,000 | thousands by filing date | |
| GALECTO INC | 36322Q107 | COM | 448,016 | $2,722,000 | thousands by filing date | |
| NOVABRIDGE BIOSCIENCES | 44975P103 | CMN | 54,962 | $2,664,000 | thousands by filing date | |
| PHASEBIO PHARMACEUTICALS INC | 717224109 | COM | 750,000 | $2,595,000 | thousands by filing date | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 9,249 | $2,547,000 | thousands by filing date | |
| IMMUNOVANT INC | 45258J102 | COM | 158,500 | $2,542,000 | thousands by filing date | |
| LIFESCI ACQUISITION II CORP | 53229E103 | COM | 244,000 | $2,474,000 | thousands by filing date | |
| FINCH THERAPEUTICS GROUP INC | 31773D101 | COM | 150,000 | $2,387,000 | thousands by filing date | |
| CAMTEK LTD ORD | M20791105 | Stock | 79,746 | $2,384,000 | thousands by filing date | |
| Instil Bio, Inc. | 45783C101 | Common Stock | 95,000 | $2,383,000 | thousands by filing date | |
| INHIBRX INC | 45720L107 | COM | 114,643 | $2,301,000 | thousands by filing date | |
| TURMERIC ACQUISITION CORP | G9127T108 | CMN | 219,440 | $2,144,000 | thousands by filing date | |
| ALPINE IMMUNE SCIENCES INC | 02083G100 | COM | 198,260 | $2,102,000 | thousands by filing date | |
| HIGHCAPE CAP ACQUISITION COR | 42984L105 | COM CL A | 172,396 | $2,055,000 | thousands by filing date | |
| FOLEY TRASIMENE ACQUISTN COR | 34431F104 | COM CL A | 200,000 | $2,008,000 | thousands by filing date | |
| HEALTHCOR CATALIO ACQU CORP | G44125105 | CL A SHS | 200,000 | $2,000,000 | thousands by filing date | |
| JIYA ACQUISITION CORP | 47760M102 | CMN | 199,028 | $1,958,000 | thousands by filing date | |
| BIOGEN INC COM | 09062X103 | Stock | 6,800 | $1,902,000 | thousands by filing date | |
| EQUILLIUM INC | 29446K106 | COM | 254,184 | $1,817,000 | thousands by filing date | |
| VINCERX PHARMA INC | 92731L106 | COM NEW | 93,708 | $1,809,000 | thousands by filing date | |
| GIGCAPITAL4 INC | 37518G200 | UNIT 99/99/9999 | 175,000 | $1,727,000 | thousands by filing date | |
| SPRING VALEY ACQUISTION III CL A ORD | 85521J109 | COM | 170,937 | $1,697,000 | thousands by filing date | |
| PIERIS PHARMACEUTICALS INC | 720795103 | COM | 650,000 | $1,671,000 | thousands by filing date | |
| DFP HEALTHCARE ACQUISITNS CO | 23343Q100 | COM CL A | 162,759 | $1,621,000 | thousands by filing date | |
| MERUS N V | N5749R100 | COM | 76,992 | $1,608,000 | thousands by filing date | |
| WIX COM LTD SHS | M98068105 | Stock | 5,700 | $1,592,000 | thousands by filing date | |
| CHINOOK THERAPEUTICS INC | 16961L106 | COM | 101,666 | $1,580,000 | thousands by filing date | |
| NORTHERN STAR INVSTMNT CORP | 66573W107 | COM | 155,367 | $1,554,000 | thousands by filing date | |
| TERNS PHARMACEUTICALS INC COM | 880881107 | Stock | 70,000 | $1,540,000 | thousands by filing date | |
| IMMUNOCORE HLDGS PLC ADS | 45258D105 | ADR | 36,000 | $1,533,000 | thousands by filing date | |
| APOLLO STRATEGIC GROWTH CAPITAL | G0411R106 | COMMON STOCK-FO | 150,000 | $1,485,000 | thousands by filing date | |
| LANDCADIA HOLDINGS IV INC | 51477A203 | UNIT 05/01/2025 | 150,000 | $1,485,000 | thousands by filing date | |
| FORUM MERGER IV CORP | 349875203 | UNIT 03/15/2028 | 150,000 | $1,485,000 | thousands by filing date | |
| TAILWIND INTERNATNAL ACQ COR | G8662F127 | UNIT 99/99/9999 | 150,000 | $1,484,000 | thousands by filing date | |
| ARK GLOBAL ACQUISITION CORP | 66981N202 | COM | 150,000 | $1,482,000 | thousands by filing date | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 23,890 | $1,472,000 | thousands by filing date | |
| LARIMAR THERAPEUTICS INC | 517125100 | COM | 100,000 | $1,461,000 | thousands by filing date | |
| GAMIDA CELL LTD | M47364100 | SHS | 178,450 | $1,444,000 | thousands by filing date | |
| PMV PHARMACEUTICALS INC | 69353Y103 | COM | 43,356 | $1,426,000 | thousands by filing date | |
| FRAZIER LIFESCIENCES ACQU CO | G3710A105 | CMN | 126,687 | $1,261,000 | thousands by filing date | |
| Vertex Pharmaceuticals Incorporated | 92532F100 | COM | 5,530 | $1,188,000 | thousands by filing date | |
| LEFTERIS ACQUISITION CORP | 52470X109 | COM CL A | 120,000 | $1,181,000 | thousands by filing date | |
| HEALTH SCIENCES ACQ CORP 2 | G4411D109 | ORD SHS | 100,000 | $1,123,000 | thousands by filing date | |
| REVOLUTION ACCELERTN ACQU CO | 76156P106 | COM CL A | 109,994 | $1,115,000 | thousands by filing date | |
| SWITCHBACK II CORPORATION | G8633T115 | COM CL A | 103,698 | $1,019,000 | thousands by filing date | |
| HIGHCAPE CAP ACQUISITION COR | 42984L105 | COM CL A | 85,000 | $1,013,000 | thousands by filing date | call |
| FALCON CAPITAL ACQUISITN COR | 30606L108 | COM CL A | 100,010 | $997,000 | thousands by filing date | |
| MCAP ACQUISITION CORP | 55282t208 | COM | 100,000 | $995,000 | thousands by filing date | |
| OMEGA ALPHA SPAC | G6749V107 | CL A | 100,000 | $990,000 | thousands by filing date | |
| VPC IMPACT ACQU HOLDI III IN | 91835J207 | UNIT 99/99/9999 | 100,000 | $987,000 | thousands by filing date | |
| VPC IMPACT ACQUISITION HLDG | G9460L100 | UNIT 03/05/2026 | 100,000 | $986,000 | thousands by filing date | |
| 890 5TH AVE PARTNERS INC | 28250A204 | UNIT 01/12/2026 | 98,828 | $983,000 | thousands by filing date | |
| MSP RECOVERY INC COM CL A | 53625R104 | Stock | 100,000 | $982,000 | thousands by filing date | |
| E MERGE TECHNOLOGY ACQUISITI | 26873Y104 | CMN | 100,000 | $975,000 | thousands by filing date | |
| CONNECT BIOPHARMA HLDGS LTD | 207523101 | SHS | 50,000 | $925,000 | thousands by filing date | |
| GLASS HOUSES ACQUISITION COR | 37714P202 | UNIT 03/25/2028 | 89,884 | $902,000 | thousands by filing date | |
| NOVA LTD COM | M7516K103 | Stock | 8,556 | $779,000 | thousands by filing date | |
| LIVE OAK MOBILITY ACQUISI CO | 538126202 | UNIT 03/01/2028 | 75,000 | $749,000 | thousands by filing date | |
| CEREVEL THERAPEUTICS HLDNG I | 15678U102 | *W EXP 06/09/202 | 166,332 | $702,000 | thousands by filing date | |
| LANDOS BIOPHARMA INC | 515069102 | CMN | 70,000 | $674,000 | thousands by filing date | |
| NICE SYS INC | 65366HAB9 | BOND | 250,000 | $666,000 | thousands by filing date | |
| SPARTAN ACQUISITION CORP II | 846775104 | COM | 50,000 | $523,000 | thousands by filing date | |
| VECTOIQ ACQUISITION CORP II | 92244F208 | UNIT 99/99/9999 | 50,000 | $507,000 | thousands by filing date | |
| STRATIM CLOUD ACQUISITION CO | 86309R206 | UNIT 03/05/2026 | 50,000 | $500,000 | thousands by filing date | |
| Z-WORK ACQUISITION CORP | 98880C201 | UNIT 99/99/9999 | 50,000 | $498,000 | thousands by filing date | |
| EJF ACQUISITION CORP | G2955B117 | UNIT 03/10/2026 | 49,900 | $497,000 | thousands by filing date | |
| AGILE GROWTH CORP | G01202129 | UNIT 03/09/2026 | 50,000 | $496,000 | thousands by filing date | |
| MDH ACQUISITION CORP | 55283P205 | UNIT 99/99/9999 | 31,000 | $308,000 | thousands by filing date | |
| CM LIFE SCIENCES INC | 18978W109 | COM CL A | 20,000 | $298,000 | thousands by filing date | |
| IMMATICS N.V | N44445117 | *W EXP 07/01/202 | 100,000 | $295,000 | thousands by filing date | |
| NORTHERN REVIVAL ACQUISITION | G6546R127 | UNIT 01/31/2028 | 28,000 | $277,000 | thousands by filing date | |
| FINTECH EVOLUTION ACQUIS GRO | G3R19A112 | UNIT 99/99/9999 | 25,000 | $247,000 | thousands by filing date | |
| SARISSA CAPITAL ACQUISITN CO | G7823W102 | CMN | 23,900 | $242,000 | thousands by filing date | |
| Ohr Pharmaceutical Inc | 64132K102 | COM | 31,900 | $236,000 | thousands by filing date | |
| OUTLOOK THERAPEUTICS INC | 69012T115 | *W EXP 02/18/202 | 129,500 | $131,000 | thousands by filing date |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001178913-21-001758 | this filing | 2021-05-17 | acceptance time not in the bulk data set |