13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2020-12-31, filed 2021-02-16, with 110 holding rows worth $1,126,784,000.
- Accession
- 0001178913-21-000561
- Filer
- CIK 1496201
- Filed
- 2021-02-16
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2020
A holdings report, 110 entries on the cover page, a total value of $1,126,784,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $1,126,785,000 with VALUE read as thousands by filing date, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerSphera Global Healthcare GP Ltd.028-15864
- included managerSphera Global Healthcare Management LP028-15865
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| Eli Lilly and Company | 532457108 | COM | 410,000 | $69,224,000 | thousands by filing date | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 370,000 | $63,081,000 | thousands by filing date | call |
| Merck & Co.,Inc. | 58933Y105 | COM | 728,808 | $59,616,000 | thousands by filing date | |
| Johnson & Johnson | 478160104 | COM | 338,200 | $53,226,000 | thousands by filing date | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 300,000 | $42,234,000 | thousands by filing date | put |
| NOVARTIS AG SPONSORED ADR | 66987V109 | ADR | 429,000 | $40,510,000 | thousands by filing date | |
| Bristol-Myers Squibb Company | 110122108 | COM | 625,000 | $38,769,000 | thousands by filing date | |
| AbbVie,Inc. | 00287Y109 | COM | 340,000 | $36,431,000 | thousands by filing date | |
| ASTRAZENECA PLC SPONSORED ADR | 046353108 | ADR | 690,473 | $34,517,000 | thousands by filing date | |
| ONCORUS INC | 68236R103 | COM | 903,111 | $28,395,000 | thousands by filing date | |
| SIGILON THERAPEUTICS INC | 82657L107 | COM | 567,460 | $26,061,000 | thousands by filing date | |
| AbbVie,Inc. | 00287Y109 | COM | 225,000 | $24,109,000 | thousands by filing date | call |
| GENERAC HLDGS INC | 368736104 | COM | 105,663 | $24,029,000 | thousands by filing date | |
| NICE LTD SPONSORED ADR | 653656108 | ADR | 74,481 | $21,118,000 | thousands by filing date | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 745,900 | $16,589,000 | thousands by filing date | |
| KURA ONCOLOGY INC COM | 50127T109 | Stock | 471,494 | $15,399,000 | thousands by filing date | |
| C4 THERAPEUTICS INC | 12529R107 | COM STK | 443,824 | $14,601,000 | thousands by filing date | |
| PALO ALTO NETWORKS INC | 697435105 | COM | 37,871 | $13,459,000 | thousands by filing date | |
| CEREVEL THERAPEUTICS HLDNG I | 15678U128 | COM | 811,665 | $13,457,000 | thousands by filing date | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 75,000 | $12,787,000 | thousands by filing date | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 75,000 | $12,787,000 | thousands by filing date | put |
| AUDIOCODES LTD | M15342104 | ORD | 428,971 | $11,818,000 | thousands by filing date | |
| ZYMEWORKS INC | 98985W102 | COM | 245,000 | $11,579,000 | thousands by filing date | |
| ALX ONCOLOGY HOLDINGS INC | 00166B105 | COMMON STOCK | 133,448 | $11,503,000 | thousands by filing date | |
| KORNIT DIGITAL LTD | M6372Q113 | SHS | 128,381 | $11,443,000 | thousands by filing date | |
| NOVARTIS AG SPONSORED ADR | 66987V109 | ADR | 120,000 | $11,332,000 | thousands by filing date | call |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 157,900 | $11,228,000 | thousands by filing date | |
| META PLATFORMS INC CL A | 30303M102 | COM | 39,998 | $10,926,000 | thousands by filing date | |
| Merck & Co.,Inc. | 58933Y105 | COM | 130,000 | $10,634,000 | thousands by filing date | call |
| Microsoft Corp | 594918104 | COM | 47,536 | $10,573,000 | thousands by filing date | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 597,198 | $10,463,000 | thousands by filing date | |
| ZENTALIS PHARMACEUTICALS INC | 98943L107 | COMMON STOCK | 190,796 | $9,910,000 | thousands by filing date | |
| ALEXION PHARMACEUTICALS INC | 015351109 | COM | 60,000 | $9,374,000 | thousands by filing date | |
| TRILLIUM THERAPEUTICS INC COM NEW | 89620X506 | Stock | 626,759 | $9,220,000 | thousands by filing date | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 147,700 | $9,157,000 | thousands by filing date | |
| BURLINGTON STORES INC COM | 122017106 | Stock | 35,000 | $9,154,000 | thousands by filing date | |
| TECTONIC THERAPEUTIC INC COM | 05455M100 | Stock | 655,874 | $9,143,000 | thousands by filing date | |
| VARONIS SYS INC | 922280102 | COM | 55,225 | $9,035,000 | thousands by filing date | |
| IMMATICS N.V | N44445109 | SHS | 823,391 | $8,884,000 | thousands by filing date | |
| CAMTEK LTD ORD | M20791105 | Stock | 400,000 | $8,764,000 | thousands by filing date | |
| NOVABRIDGE BIOSCIENCES | 44975P103 | CMN | 181,820 | $8,573,000 | thousands by filing date | |
| VERINT SYS INC | 92343X100 | COM | 127,000 | $8,532,000 | thousands by filing date | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 735,434 | $8,259,000 | thousands by filing date | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 174,261 | $8,075,000 | thousands by filing date | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 832,878 | $8,037,000 | thousands by filing date | |
| IMMUNOVANT INC | 45258J102 | COM | 170,000 | $7,852,000 | thousands by filing date | |
| UNIQURE NV | N90064101 | SHS | 216,000 | $7,804,000 | thousands by filing date | |
| REPARE THERAPEUTICS INC | 760273102 | COM | 224,300 | $7,693,000 | thousands by filing date | |
| FATE THERAPEUTICS INC | 31189P102 | COM | 82,000 | $7,456,000 | thousands by filing date | |
| BEYONDSPRING INC | G10830100 | SHS | 598,000 | $7,296,000 | thousands by filing date | |
| VERONA PHARMA PLC | 925050106 | SPONSORED ADS | 1,033,603 | $7,235,000 | thousands by filing date | |
| BCLS ACQUISITION CORP | G0904B105 | CMN | 625,000 | $6,891,000 | thousands by filing date | |
| Amazon.com, Inc | 023135106 | COM | 2,061 | $6,713,000 | thousands by filing date | |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 29,779 | $6,541,000 | thousands by filing date | |
| Y-mAbs Therapeutics Inc | 984241109 | Common Stock | 131,016 | $6,487,000 | thousands by filing date | |
| ORIC PHARMACEUTICALS INC | 68622P109 | COM | 182,200 | $6,167,000 | thousands by filing date | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 265,753 | $6,136,000 | thousands by filing date | |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 101,044 | $6,063,000 | thousands by filing date | |
| DECIPHERA PHARMACEUTICALS IN | 24344T101 | COM | 103,565 | $5,910,000 | thousands by filing date | |
| IOVANCE BIOTHERAPEUTICS INC | 462260100 | COM | 127,289 | $5,906,000 | thousands by filing date | |
| ALLOT LTD | M0854Q105 | SHS | 533,192 | $5,609,000 | thousands by filing date | |
| NOVA LTD COM | M7516K103 | Stock | 78,113 | $5,515,000 | thousands by filing date | |
| PRAXIS PRECISION MEDICINES I | 74006W108 | COM | 100,000 | $5,502,000 | thousands by filing date | |
| ARKO CORP | 041242108 | COMMON STOCK | 600,000 | $5,400,000 | thousands by filing date | |
| VISTAGEN THERAPEUTICS INC | 92840H202 | COM | 2,725,000 | $5,287,000 | thousands by filing date | |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 91,800 | $5,190,000 | thousands by filing date | |
| CONCERT PHARMACEUTICALS INC | 206022105 | COM | 384,039 | $4,854,000 | thousands by filing date | |
| GALERA THERAPEUTICS EQUICLASS EQUITY | 36338D108 | COMMON STOCK | 467,662 | $4,784,000 | thousands by filing date | |
| DICERNA PHARMACEUTICALS INC | 253031108 | COM | 216,980 | $4,780,000 | thousands by filing date | |
| GALECTO INC | 36322Q107 | COM | 391,787 | $4,669,000 | thousands by filing date | |
| ESSA PHARMA INC | 29668H708 | COM NEW | 390,200 | $4,655,000 | thousands by filing date | |
| KALVISTA PHARMACEUTICALS INC | 483497103 | COM | 240,140 | $4,560,000 | thousands by filing date | |
| JFROG LTD ORD SHS | M6191J100 | Stock | 72,377 | $4,547,000 | thousands by filing date | |
| SUTRO BIOPHARMA INC | 869367102 | COM | 201,600 | $4,377,000 | thousands by filing date | |
| ARYA SCIENCES ACQUISITION CO | G3166W106 | COM CL A | 400,000 | $4,340,000 | thousands by filing date | |
| ROCKET PHARMACEUTICALS INC | 77313F106 | COM | 75,000 | $4,113,000 | thousands by filing date | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 23,599 | $3,936,000 | thousands by filing date | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 414,959 | $3,266,000 | thousands by filing date | |
| CHINOOK THERAPEUTICS INC | 16961L106 | COM | 201,666 | $3,198,000 | thousands by filing date | |
| SHATTUCK LABS INC | 82024L103 | COMMON STOCK | 55,300 | $2,898,000 | thousands by filing date | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 9,249 | $2,720,000 | thousands by filing date | |
| ALPINE IMMUNE SCIENCES INC | 02083G100 | COM | 198,260 | $2,498,000 | thousands by filing date | |
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 31,300 | $2,270,000 | thousands by filing date | |
| YUMANITY THERAPEUTICS INC | 98872L102 | COM | 130,434 | $2,217,000 | thousands by filing date | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 100,000 | $2,100,000 | thousands by filing date | |
| ALIGOS THERAPEUTICS INC COM NEW | 01626L105 | Stock | 74,000 | $2,046,000 | thousands by filing date | |
| ATHIRA PHARMA INC | 04746L104 | COM | 53,900 | $1,846,000 | thousands by filing date | |
| LEAP THERAPEUTICS INC | 52187K101 | COM | 800,000 | $1,800,000 | thousands by filing date | |
| ION ACQUISITION CORP 1 LTD | G49392106 | SHS CL A | 150,000 | $1,766,000 | thousands by filing date | |
| 89BIO INC | 282559103 | COM | 69,939 | $1,704,000 | thousands by filing date | |
| BIOATLA INC | 09077B104 | COM | 50,000 | $1,701,000 | thousands by filing date | |
| INHIBRX INC | 45720L107 | COM | 43,182 | $1,424,000 | thousands by filing date | |
| PIERIS PHARMACEUTICALS INC | 720795103 | COM | 550,000 | $1,375,000 | thousands by filing date | |
| BIOXCEL THERAPEUTICS INC | 09075P105 | COM | 28,093 | $1,298,000 | thousands by filing date | |
| HEALTH SCIENCES ACQ CORP 2 | G4411D109 | ORD SHS | 100,000 | $1,281,000 | thousands by filing date | |
| LIFESCI ACQUISITION II CORP | 53229E103 | COM | 100,000 | $1,062,000 | thousands by filing date | |
| KRONOS BIO INC | 50107A104 | COM | 35,000 | $1,045,000 | thousands by filing date | |
| VINCERX PHARMA INC | 92731L106 | COM NEW | 46,465 | $972,000 | thousands by filing date | |
| ACLARIS THERAPEUTICS INC COM | 00461U105 | Stock | 150,000 | $971,000 | thousands by filing date | |
| CEREVEL THERAPEUTICS HLDNG I | 15678U102 | *W EXP 06/09/202 | 166,332 | $940,000 | thousands by filing date | |
| NICE SYS INC | 65366HAB9 | BOND | 250,000 | $856,000 | thousands by filing date | |
| SAGE THERAPEUTICS INC | 78667J108 | COM | 8,554 | $740,000 | thousands by filing date | |
| OLEMA PHARMACEUTICALS INC | 68062P106 | COM | 15,200 | $731,000 | thousands by filing date | |
| MIRAGEN THERAPEUTICS INC | 60463E103 | COM | 30,497 | $502,000 | thousands by filing date | |
| GAMIDA CELL LTD | M47364100 | SHS | 40,000 | $336,000 | thousands by filing date | |
| IMMATICS N.V | N44445117 | *W EXP 07/01/202 | 100,000 | $288,000 | thousands by filing date | |
| THERAPEUTICS ACQUISITION COR | 88339T103 | COM CL A | 20,000 | $279,000 | thousands by filing date | |
| CELLECTAR BIOSCIENCES INC | 15117F500 | COM PAR | 87,500 | $182,000 | thousands by filing date | |
| ORGENESIS INC | 68619K204 | COM | 35,712 | $161,000 | thousands by filing date | |
| OUTLOOK THERAPEUTICS INC | 69012T115 | *W EXP 02/18/202 | 129,500 | $29,000 | thousands by filing date |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001178913-21-000561 | this filing | 2021-02-16 | acceptance time not in the bulk data set |