13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2019-12-31, filed 2020-02-13, with 86 holding rows worth $1,213,436,000.
- Accession
- 0001178913-20-000447
- Filer
- CIK 1496201
- Filed
- 2020-02-13
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2019
A holdings report, 86 entries on the cover page, a total value of $1,213,436,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $1,213,436,000 with VALUE read as thousands by filing date, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerSphera Global Healthcare GP Ltd.028-15864
- included managerSphera Global Healthcare Management LP028-15865
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SPDR SER TR | 78464A870 | S&P BIOTECH | 2,800,000 | $266,308,000 | thousands by filing date | put |
| ISHARES TR | 464287556 | ISHARES BIOTECH | 1,000,000 | $120,510,000 | thousands by filing date | put |
| Johnson & Johnson | 478160104 | COM | 438,653 | $63,986,000 | thousands by filing date | |
| Bristol-Myers Squibb Company | 110122108 | COM | 915,000 | $58,734,000 | thousands by filing date | |
| SANOFI SA SPONSORED ADR | 80105N105 | ADR | 1,140,000 | $57,228,000 | thousands by filing date | |
| Merck & Co.,Inc. | 58933Y105 | COM | 555,000 | $50,477,000 | thousands by filing date | |
| NOVO-NORDISK A S ADR | 670100205 | ADR | 640,000 | $37,043,000 | thousands by filing date | |
| Gilead Sciences,Inc. | 375558103 | COM | 500,000 | $32,490,000 | thousands by filing date | call |
| SEATTLE GENETICS INC | 812578102 | COM | 250,000 | $28,565,000 | thousands by filing date | call |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 2,800,320 | $27,275,000 | thousands by filing date | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 251,382 | $21,254,000 | thousands by filing date | |
| NOVARTIS AG SPONSORED ADR | 66987V109 | ADR | 200,000 | $18,938,000 | thousands by filing date | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 140,000 | $18,066,000 | thousands by filing date | |
| VERINT SYS INC | 92343X100 | COM | 290,699 | $16,093,000 | thousands by filing date | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 357,000 | $15,272,000 | thousands by filing date | |
| ALEXION PHARMACEUTICALS INC | 015351109 | COM | 115,713 | $12,514,000 | thousands by filing date | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 1,220,600 | $11,962,000 | thousands by filing date | call |
| MYLAN NV | N59465109 | SHS EURO | 560,000 | $11,256,000 | thousands by filing date | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 214,736 | $10,314,000 | thousands by filing date | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 73,773 | $10,263,000 | thousands by filing date | |
| UNIQURE NV | N90064101 | SHS | 139,514 | $9,998,000 | thousands by filing date | |
| Microsoft Corp | 594918104 | COM | 58,741 | $9,263,000 | thousands by filing date | |
| BLUEPRINT MEDICINES CORP | 09627Y109 | COM | 106,000 | $8,492,000 | thousands by filing date | |
| EXICURE INC | 30205M101 | COM | 2,888,888 | $8,262,000 | thousands by filing date | |
| ALLOT LTD | M0854Q105 | SHS | 970,666 | $8,251,000 | thousands by filing date | |
| ROCKET PHARMACEUTICALS INC | 77313F106 | COM | 361,888 | $8,237,000 | thousands by filing date | |
| ARVINAS INC | 04335A105 | COM | 198,781 | $8,168,000 | thousands by filing date | |
| GW PHARMACEUTICALS PLC | 36197T103 | ADS | 77,000 | $8,051,000 | thousands by filing date | |
| PROQR THERAPEUTICS NV | N71542109 | SHS EURO | 805,000 | $7,978,000 | thousands by filing date | |
| AUDIOCODES LTD | M15342104 | ORD | 306,053 | $7,863,000 | thousands by filing date | |
| FISERV INC | 337738108 | COM | 67,279 | $7,779,000 | thousands by filing date | |
| X4 Pharmaceuticals, Inc. | 98420X103 | COM | 720,000 | $7,704,000 | thousands by filing date | |
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 200,000 | $7,698,000 | thousands by filing date | |
| PORTOLA PHARMACEUTICALS INC COM | 737010108 | Stock | 317,000 | $7,570,000 | thousands by filing date | |
| IVERIC BIO INC | 46583P102 | COM | 868,200 | $7,449,000 | thousands by filing date | |
| STOKE THERAPEUTICS INC | 86150R107 | COM | 256,380 | $7,261,000 | thousands by filing date | |
| PALO ALTO NETWORKS INC | 697435105 | COM | 30,976 | $7,163,000 | thousands by filing date | |
| ZYMEWORKS INC | 98985W102 | COM | 157,000 | $7,137,000 | thousands by filing date | |
| PRECISION BIOSCIENCES INC | 74019P108 | COM | 493,739 | $6,858,000 | thousands by filing date | |
| Amazon.com, Inc | 023135106 | COM | 3,700 | $6,837,000 | thousands by filing date | |
| Y-mAbs Therapeutics Inc | 984241109 | Common Stock | 213,293 | $6,665,000 | thousands by filing date | |
| KARYOPHARM THERAPEUTICS INC | 48576U106 | COM | 330,000 | $6,326,000 | thousands by filing date | |
| ALDEYRA THERAPEUTICS INC | 01438T106 | COM | 1,069,089 | $6,211,000 | thousands by filing date | |
| GALERA THERAPEUTICS EQUICLASS EQUITY | 36338D108 | COMMON STOCK | 471,439 | $6,204,000 | thousands by filing date | |
| MINERVA NEUROSCIENCES INC COM NEW | 603380106 | Stock | 855,000 | $6,079,000 | thousands by filing date | |
| ARQULE INC | 04269E107 | COM | 297,227 | $5,933,000 | thousands by filing date | |
| PROTEOSTASIS THERAPEUTICS IN | 74373B109 | COM | 2,536,600 | $5,783,000 | thousands by filing date | |
| HARPOON THERAPEUTICS INC | 41358P106 | COM | 384,031 | $5,680,000 | thousands by filing date | |
| BLUEBIRD BIO INC | 09609G100 | COM | 64,500 | $5,660,000 | thousands by filing date | |
| FIVERR INTL LTD ORD SHS | M4R82T106 | Stock | 233,805 | $5,494,000 | thousands by filing date | |
| SOLAREDGE TECHNOLOGIES INC | 83417M104 | COM | 56,822 | $5,403,000 | thousands by filing date | |
| CAESARSTONE LTD | M20598104 | ORD SHS | 354,357 | $5,340,000 | thousands by filing date | |
| NEOS THERAPEUTICS INC | 64052L106 | COM | 3,530,731 | $5,331,000 | thousands by filing date | |
| WIX COM LTD SHS | M98068105 | Stock | 41,415 | $5,068,000 | thousands by filing date | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 115,000 | $4,912,000 | thousands by filing date | |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 86,280 | $4,778,000 | thousands by filing date | |
| PRINCIPIA BIOPHARMA INC | 74257L108 | COM | 86,500 | $4,738,000 | thousands by filing date | |
| VIKING THERAPEUTICS INC | 92686J106 | COM | 590,000 | $4,732,000 | thousands by filing date | |
| NEOLEUKIN THERAPEUTICS INC | 64049K104 | COM | 379,998 | $4,682,000 | thousands by filing date | |
| RETROPHIN INC | 761299106 | COM | 317,381 | $4,507,000 | thousands by filing date | |
| FORESCOUT TECHNOLOGIES INC | 34553D101 | COM | 137,021 | $4,494,000 | thousands by filing date | |
| BURLINGTON STORES INC COM | 122017106 | Stock | 19,500 | $4,447,000 | thousands by filing date | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 630,000 | $4,442,000 | thousands by filing date | |
| KORNIT DIGITAL LTD | M6372Q113 | SHS | 101,759 | $3,483,000 | thousands by filing date | |
| NOVA LTD COM | M7516K103 | Stock | 91,466 | $3,460,000 | thousands by filing date | |
| WABTEC COM | 929740108 | Stock | 40,000 | $3,112,000 | thousands by filing date | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 268,747 | $2,851,000 | thousands by filing date | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 16,581 | $2,662,000 | thousands by filing date | |
| KALVISTA PHARMACEUTICALS INC | 483497103 | COM | 147,700 | $2,631,000 | thousands by filing date | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 260,352 | $2,551,000 | thousands by filing date | |
| Allena Pharmaceuticals, Inc. | 018119107 | COM | 917,800 | $2,506,000 | thousands by filing date | |
| IMMUNOVANT INC | 45258J201 | UNIT 12/18/2024 | 100,000 | $2,487,000 | thousands by filing date | |
| ABEONA THERAPEUTICS INC | 00289Y107 | COM | 720,472 | $2,356,000 | thousands by filing date | |
| ARYA SCIENCES ACQUISITION CO | G3165V117 | UNIT 10/04/2023 | 200,000 | $2,300,000 | thousands by filing date | |
| ADMA BIOLOGICS INC | 000899104 | COM | 540,000 | $2,160,000 | thousands by filing date | |
| AXOVANT SCIENCES LTD | G0750W203 | COM | 398,541 | $2,041,000 | thousands by filing date | |
| EVOLUS INC | 30052C107 | COM | 150,000 | $1,826,000 | thousands by filing date | |
| ASSEMBLY BIOSCIENCES INC | 045396108 | COM | 88,248 | $1,806,000 | thousands by filing date | |
| Inflarx Nv | N44821101 | COM | 330,000 | $1,307,000 | thousands by filing date | |
| CONCERT PHARMACEUTICALS INC | 206022105 | COM | 140,000 | $1,292,000 | thousands by filing date | |
| MELLANOX TECHNOLOGIES LTD | M51363113 | COMMON STOCK | 8,452 | $990,000 | thousands by filing date | |
| SUNESIS PHARMACEUTICALS INC | 867328700 | COM | 2,141,800 | $723,000 | thousands by filing date | |
| BELLICUM PHARMACEUTICALS INC | 079481107 | COM | 400,000 | $516,000 | thousands by filing date | |
| ZAFGEN INC | 98885E103 | COM | 347,670 | $386,000 | thousands by filing date | |
| IMMUNOVANT INC | 45258J102 | COM | 20,000 | $317,000 | thousands by filing date | |
| CELLECTAR BIOSCIENCES INC | 15117F500 | COM PAR | 87,500 | $197,000 | thousands by filing date |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001178913-20-000447 | this filing | 2020-02-13 | acceptance time not in the bulk data set |