13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2019-03-31, filed 2019-05-15, with 102 holding rows worth $1,088,441,000.
- Accession
- 0001178913-19-001480
- Filer
- CIK 1496201
- Filed
- 2019-05-15
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q1 2019
A holdings report, 102 entries on the cover page, a total value of $1,088,441,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $1,088,437,000 with VALUE read as thousands by filing date, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerSphera Global Healthcare GP Ltd.028-15864
- included managerSphera Global Healthcare Management LP028-15865
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SPDR SER TR | 78464A870 | S&P BIOTECH | 3,335,000 | $301,951,000 | thousands by filing date | put |
| Bristol-Myers Squibb Company | 110122108 | COM | 879,900 | $41,980,000 | thousands by filing date | |
| Johnson & Johnson | 478160104 | COM | 265,000 | $37,044,000 | thousands by filing date | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 2,488,078 | $33,838,000 | thousands by filing date | |
| ALEXION PHARMACEUTICALS INC | 015351109 | COM | 247,300 | $33,430,000 | thousands by filing date | |
| Merck & Co.,Inc. | 58933Y105 | COM | 377,000 | $31,355,000 | thousands by filing date | |
| Gilead Sciences,Inc. | 375558103 | COM | 480,000 | $31,205,000 | thousands by filing date | |
| MYLAN NV | N59465109 | SHS EURO | 1,002,307 | $28,405,000 | thousands by filing date | |
| CELGENE CORP | 151020104 | COM | 300,000 | $28,302,000 | thousands by filing date | put |
| ASTRAZENECA PLC SPONSORED ADR | 046353108 | ADR | 700,000 | $28,301,000 | thousands by filing date | |
| CELGENE CORP | 151020104 | COM | 250,000 | $23,585,000 | thousands by filing date | |
| NOVO-NORDISK A S ADR | 670100205 | ADR | 400,000 | $20,924,000 | thousands by filing date | |
| GLAXOSMITHKLINE PLC-ADR | 37733W105 | SPONSORED ADR | 430,000 | $17,970,000 | thousands by filing date | |
| VERINT SYS INC | 92343X100 | COM | 263,926 | $15,799,000 | thousands by filing date | |
| BIOGEN INC COM | 09062X103 | Stock | 60,000 | $14,183,000 | thousands by filing date | put |
| BLUEBIRD BIO INC | 09609G100 | COM | 83,796 | $13,184,000 | thousands by filing date | |
| UNIQURE NV | N90064101 | SHS | 200,000 | $11,930,000 | thousands by filing date | call |
| UROGEN PHARMA LTD | M96088105 | COMMON STOCK | 308,377 | $11,391,000 | thousands by filing date | |
| INTERCEPT PHARMACEUTICALS IN | 45845P108 | COM | 100,000 | $11,186,000 | thousands by filing date | |
| RETROPHIN INC | 761299106 | COM | 435,678 | $9,859,000 | thousands by filing date | |
| ALDEYRA THERAPEUTICS INC | 01438T106 | COM | 1,069,089 | $9,654,000 | thousands by filing date | |
| NOVARTIS AG SPONSORED ADR | 66987V109 | ADR | 100,000 | $9,614,000 | thousands by filing date | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 73,405 | $8,749,000 | thousands by filing date | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 220,500 | $8,300,000 | thousands by filing date | |
| CELLECTIS ADS | 15117K103 | COM | 447,970 | $8,216,000 | thousands by filing date | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 68,273 | $8,036,000 | thousands by filing date | |
| AEGLEA BIOTHERAPEUTICS INC | 00773J103 | COM | 975,000 | $7,849,000 | thousands by filing date | |
| ALLOT LTD | M0854Q105 | SHS | 965,931 | $7,669,000 | thousands by filing date | |
| PALO ALTO NETWORKS INC | 697435105 | COM | 30,754 | $7,470,000 | thousands by filing date | |
| CAESARSTONE LTD | M20598104 | ORD SHS | 478,114 | $7,463,000 | thousands by filing date | |
| Microsoft Corp | 594918104 | COM | 61,397 | $7,241,000 | thousands by filing date | |
| AERIE PHARMACEUTICALS INC | 00771V108 | COM | 150,000 | $7,125,000 | thousands by filing date | |
| BIOGEN INC COM | 09062X103 | Stock | 30,000 | $7,091,000 | thousands by filing date | |
| REATA PHARMACEUTICALS INC | 75615P103 | CL A | 81,769 | $6,989,000 | thousands by filing date | |
| ARQULE INC | 04269E107 | COM | 1,432,643 | $6,862,000 | thousands by filing date | |
| AXOVANT SCIENCES LTD | G0750W104 | COM | 5,108,333 | $6,794,000 | thousands by filing date | |
| IMMUNOMEDICS INC | 452907108 | COM | 326,660 | $6,275,000 | thousands by filing date | |
| CAMTEK LTD ORD | M20791105 | Stock | 700,574 | $6,249,000 | thousands by filing date | |
| AUTOLUS THERAPEUTICS PLC SPON | 05280R100 | COM | 192,994 | $6,074,000 | thousands by filing date | |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 181,625 | $5,975,000 | thousands by filing date | |
| CARA THERAPEUTICS INC | 140755109 | COM | 303,930 | $5,963,000 | thousands by filing date | |
| Alphabet Inc. Reg. Shares A | 02079K305 | COM | 5,000 | $5,884,000 | thousands by filing date | |
| MYOKARDIA INC | 62857M105 | COM | 113,000 | $5,875,000 | thousands by filing date | |
| MELLANOX TECHNOLOGIES LTD | M51363113 | COMMON STOCK | 49,394 | $5,846,000 | thousands by filing date | |
| NEOS THERAPEUTICS INC | 64052L106 | COM | 2,201,697 | $5,746,000 | thousands by filing date | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 533,655 | $5,422,000 | thousands by filing date | |
| Amazon.com, Inc | 023135106 | COM | 3,000 | $5,342,000 | thousands by filing date | |
| ANAPTYSBIO INC | 032724106 | COM | 70,000 | $5,114,000 | thousands by filing date | |
| ROCKET PHARMACEUTICALS INC | 77313F106 | COM | 290,001 | $5,087,000 | thousands by filing date | |
| MINERVA NEUROSCIENCES INC COM NEW | 603380106 | Stock | 642,018 | $5,046,000 | thousands by filing date | |
| SUTRO BIOPHARMA INC | 869367102 | COM | 437,889 | $4,988,000 | thousands by filing date | |
| STRONGBRIDGE BIOPHARMA PLC | G85347105 | SHS USD | 951,600 | $4,739,000 | thousands by filing date | |
| MOHAWK INDS INC | 608190104 | COM | 37,000 | $4,668,000 | thousands by filing date | |
| UNIQURE NV | N90064101 | SHS | 77,349 | $4,614,000 | thousands by filing date | |
| CYMABAY THERAPEUTICS INC | 23257D103 | COM | 345,535 | $4,589,000 | thousands by filing date | |
| MELLANOX TECHNOLOGIES LTD | M51363113 | COMMON STOCK | 38,500 | $4,557,000 | thousands by filing date | put |
| BIOHAVEN PHARMACEUTICAL HOLDIN | G11196105 | COM | 88,015 | $4,530,000 | thousands by filing date | |
| SOLAREDGE TECHNOLOGIES INC | 83417M104 | COM | 119,067 | $4,486,000 | thousands by filing date | |
| TRANSPORTATION & LOGISTI | 438083107 | COM | 161,000 | $4,465,000 | thousands by filing date | |
| GLOBAL BLOOD THERAPEUTICS USD | 37890U108 | COM | 80,000 | $4,234,000 | thousands by filing date | |
| MACROGENICS INC | 556099109 | COM | 235,000 | $4,225,000 | thousands by filing date | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 33,581 | $4,192,000 | thousands by filing date | |
| SPDR S&P Homebuilders ETF | 78464A888 | SHS | 107,934 | $4,161,000 | thousands by filing date | |
| LOGICBIO THERAPEUTICS INC | 54142F102 | COM | 417,625 | $4,126,000 | thousands by filing date | |
| KADMON HLDGS INC | 48283N106 | COM | 1,490,000 | $3,934,000 | thousands by filing date | |
| NICE LTD SPONSORED ADR | 653656108 | ADR | 31,771 | $3,892,000 | thousands by filing date | |
| GLYCOMIMETICS INC | 38000Q102 | COM | 311,013 | $3,875,000 | thousands by filing date | |
| ISHARES TR | 464287432 | 20 YR TR BD ETF | 30,000 | $3,793,000 | thousands by filing date | |
| INTRA-CELLULAR THERAPIES INC | 46116X101 | COMMON STOCK | 300,000 | $3,654,000 | thousands by filing date | call |
| FISERV INC | 337738108 | COM | 40,365 | $3,563,000 | thousands by filing date | |
| ORCHARD THERAPEUTICS PLC | 68570P101 | ADR | 197,786 | $3,536,000 | thousands by filing date | |
| FORESCOUT TECHNOLOGIES INC | 34553D101 | COM | 75,625 | $3,169,000 | thousands by filing date | |
| RVL PHARMACEUTICALS PLC | G6S41R101 | COM | 864,006 | $3,110,000 | thousands by filing date | |
| Allena Pharmaceuticals, Inc. | 018119107 | COM | 431,193 | $3,027,000 | thousands by filing date | |
| ADVANCE AUTO PARTS INC | 00751Y106 | COM | 17,400 | $2,967,000 | thousands by filing date | |
| WABTEC COM | 929740108 | Stock | 40,000 | $2,949,000 | thousands by filing date | |
| ARVINAS INC | 04335A105 | COM | 198,053 | $2,923,000 | thousands by filing date | |
| DECIPHERA PHARMACEUTICALS IN | 24344T101 | COM | 115,033 | $2,670,000 | thousands by filing date | |
| PROQR THERAPEUTICS NV | N71542109 | SHS EURO | 190,000 | $2,635,000 | thousands by filing date | |
| AUDIOCODES LTD | M15342104 | ORD | 187,045 | $2,589,000 | thousands by filing date | |
| VISTAGEN THERAPEUTICS INC | 92840H202 | COM | 2,022,066 | $2,588,000 | thousands by filing date | |
| RADWARE LTD | M81873107 | COMMON STOCK | 82,277 | $2,150,000 | thousands by filing date | |
| ARYA SCIENCES ACQUISITION CORP SHS CL A | G3165V109 | COM | 200,000 | $2,070,000 | thousands by filing date | |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 183,151 | $1,969,000 | thousands by filing date | |
| Gilat Satellite Network | M51474118 | COM | 176,406 | $1,482,000 | thousands by filing date | |
| KORNIT DIGITAL LTD | M6372Q113 | SHS | 61,404 | $1,461,000 | thousands by filing date | |
| TOCAGEN INC | 888846102 | COM | 120,000 | $1,304,000 | thousands by filing date | |
| ACER THERAPEUTICS INC | 00444P108 | CMN | 50,000 | $1,215,000 | thousands by filing date | |
| DELEK US HLDGS INC NEW COM | 24665A103 | Stock | 30,157 | $1,098,000 | thousands by filing date | |
| Mersana Therapeutics Inc | 59045L106 | Common Stock | 200,000 | $1,052,000 | thousands by filing date | |
| COHERUS ONCOLOGY INC | 19249H103 | COM | 75,600 | $1,031,000 | thousands by filing date | |
| PHAXIAM THERAPEUTICS S A | 29604W108 | SPONSORED ADR | 120,000 | $912,000 | thousands by filing date | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 53,834 | $844,000 | thousands by filing date | |
| MEIRAGTX HOLDINGS PLC | G59665102 | COMMON STOCK | 36,159 | $623,000 | thousands by filing date | |
| CONSTELLATION PHARMACEUTICALS INC. | 210373106 | Common Stock | 40,162 | $544,000 | thousands by filing date | |
| SPRING BK PHARMACEUTICALS IN | 849431101 | COM | 51,015 | $535,000 | thousands by filing date | |
| CUE BIOPHARMA INC | 22978P106 | COM | 50,000 | $387,000 | thousands by filing date | |
| NICE SYS INC | 65366HAB9 | BOND | 250,000 | $376,000 | thousands by filing date | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 83,607 | $336,000 | thousands by filing date | |
| MAGIC SOFTWARE ENTERPRISES LTD ORD | 559166103 | Stock | 38,784 | $324,000 | thousands by filing date | |
| BENITEC BIOPHARMA LTD | 082053307 | SPONS ADR NEW | 120,000 | $228,000 | thousands by filing date | |
| CELLECTAR BIOSCIENCES INC | 15117F500 | COM PAR | 87,500 | $206,000 | thousands by filing date |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001178913-19-001480 | this filing | 2019-05-15 | acceptance time not in the bulk data set | |
| 13F-HR/A 0001178913-19-001740 | added | 2019-06-20 | acceptance time not in the bulk data set |