13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2018-12-31, filed 2019-02-14, with 100 holding rows worth $887,207,000.
- Accession
- 0001178913-19-000472
- Filer
- CIK 1496201
- Filed
- 2019-02-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2018
A holdings report, 100 entries on the cover page, a total value of $887,207,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $887,206,000 with VALUE read as thousands by filing date, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerSphera Global Healthcare GP Ltd.028-15864
- included managerSphera Global Healthcare Management LP028-15865
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SPDR SER TR | 78464A870 | S&P BIOTECH | 2,700,000 | $193,725,000 | thousands by filing date | putThe filing omitted confidential holdings, a later amendment may add them. |
| MYLAN NV | N59465109 | SHS EURO | 1,677,241 | $45,956,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Merck & Co.,Inc. | 58933Y105 | COM | 472,000 | $36,066,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Bristol-Myers Squibb Company | 110122108 | COM | 630,000 | $32,747,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CELGENE CORP | 151020104 | COM | 465,000 | $29,802,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CAESARSTONE LTD | M20598104 | ORD SHS | 469,160 | $23,808,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| VERINT SYS INC | 92343X100 | COM | 149,100 | $23,573,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 2,447,994 | $23,452,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Gilead Sciences,Inc. | 375558103 | COM | 350,000 | $21,893,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ASTRAZENECA PLC SPONSORED ADR | 046353108 | ADR | 515,000 | $19,560,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Microsoft Corp | 594918104 | COM | 46,998 | $17,838,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| PALO ALTO NETWORKS INC | 697435105 | COM | 24,885 | $17,514,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ALEXION PHARMACEUTICALS INC | 015351109 | COM | 168,100 | $16,366,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ITURAN LOCATION AND CONTROL SHS | M6158M104 | Stock | 122,177 | $14,637,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| BLUEBIRD BIO INC | 09609G100 | COM | 138,796 | $13,769,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ALLOT LTD | M0854Q105 | SHS | 595,764 | $13,513,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 116,517 | $12,716,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| REATA PHARMACEUTICALS INC | 75615P103 | CL A | 221,269 | $12,413,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| PTC THERAPEUTICS INC | 69366J200 | COM | 345,500 | $11,858,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| GLAXOSMITHKLINE PLC-ADR | 37733W105 | SPONSORED ADR | 310,000 | $11,845,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 704,500 | $10,863,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ALDEYRA THERAPEUTICS INC | 01438T106 | COM | 1,232,089 | $10,226,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| IMMUNOMEDICS INC | 452907108 | COM | 706,539 | $10,082,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SAGE THERAPEUTICS INC | 78667J108 | COM | 103,500 | $9,914,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MELLANOX TECHNOLOGIES LTD | M51363113 | COMMON STOCK | 28,351 | $9,787,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 87,081 | $8,366,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AXOVANT SCIENCES LTD | G0750W104 | COM | 8,200,000 | $8,167,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| GW PHARMACEUTICALS PLC | 36197T103 | ADS | 77,000 | $7,499,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CELLECTIS ADS | 15117K103 | COM | 447,970 | $7,459,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| RETROPHIN INC | 761299106 | COM | 325,678 | $7,370,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| RVL PHARMACEUTICALS PLC | G6S41R101 | COM | 922,200 | $7,147,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| UNIQURE NV | N90064101 | SHS | 232,849 | $6,711,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AUTOLUS THERAPEUTICS PLC SPON | 05280R100 | COM | 202,994 | $6,666,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| GLOBAL BLOOD THERAPEUTICS USD | 37890U108 | COM | 147,000 | $6,034,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ORCHARD THERAPEUTICS PLC | 68570P101 | ADR | 370,000 | $5,820,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| FORESCOUT TECHNOLOGIES INC | 34553D101 | COM | 59,169 | $5,746,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| VIKING THERAPEUTICS INC | 92686J106 | COM | 745,727 | $5,705,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Gilat Satellite Network | M51474118 | COM | 166,663 | $5,705,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ARQULE INC | 04269E107 | COM | 2,032,643 | $5,630,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| PROQR THERAPEUTICS NV | N71542109 | SHS EURO | 340,000 | $5,365,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MINERVA NEUROSCIENCES INC COM NEW | 603380106 | Stock | 782,018 | $5,271,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| BIOHAVEN PHARMACEUTICAL HOLDIN | G11196105 | COM | 133,015 | $4,919,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MOHAWK INDS INC | 608190104 | COM | 10,661 | $4,659,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| EPIZYME INC | 29428V104 | COM | 749,502 | $4,617,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AEGLEA BIOTHERAPEUTICS INC | 00773J103 | COM | 600,000 | $4,494,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| LOGICBIO THERAPEUTICS INC | 54142F102 | COM | 417,625 | $4,343,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ROCKET PHARMACEUTICALS INC | 77313F106 | COM | 290,001 | $4,298,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| STRONGBRIDGE BIOPHARMA PLC | G85347105 | SHS USD | 931,600 | $4,174,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 273,151 | $4,125,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 175,511 | $4,031,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CARA THERAPEUTICS INC | 140755109 | COM | 303,930 | $3,951,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SANGAMO THERAPEUTICS INC | 800677106 | COM | 340,000 | $3,903,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SUTRO BIOPHARMA INC | 869367102 | COM | 407,889 | $3,679,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 58,273 | $3,651,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| NEOS THERAPEUTICS INC | 64052L106 | COM | 2,201,697 | $3,633,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 174,625 | $3,629,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| TRANSPORTATION & LOGISTI | 438083107 | COM | 161,000 | $3,600,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| EVOKE PHARMA INC | 30049G104 | COM | 1,410,946 | $3,499,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ARVINAS INC | 04335A105 | COM | 271,053 | $3,483,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 45,000 | $3,228,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 67,500 | $3,112,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| KADMON HLDGS INC | 48283N106 | COM | 1,490,000 | $3,099,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ALLOGENE THERAPEUTICS INC | 019770106 | COM | 113,437 | $3,055,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AC IMMUNE SA | H00263105 | SHS | 310,613 | $2,935,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| PORTOLA PHARMACEUTICALS INC COM | 737010108 | Stock | 147,000 | $2,869,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 449,484 | $2,836,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| DECIPHERA PHARMACEUTICALS IN | 24344T101 | COM | 115,033 | $2,415,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| GLYCOMIMETICS INC | 38000Q102 | COM | 251,013 | $2,377,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SAGE THERAPEUTICS INC | 78667J108 | COM | 24,500 | $2,347,000 | thousands by filing date | putThe filing omitted confidential holdings, a later amendment may add them. |
| TRANSLATE BIO INC. | 89374L104 | Common Stock | 309,400 | $2,321,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| VISTAGEN THERAPEUTICS INC | 92840H202 | COM | 1,473,918 | $2,211,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| KORNIT DIGITAL LTD | M6372Q113 | SHS | 30,342 | $2,122,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ARYA SCIENCES ACQUISITION CORP SHS CL A | G3165V109 | COM | 200,000 | $2,048,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ABEONA THERAPEUTICS INC | 00289Y107 | COM | 270,036 | $1,928,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AERPIO PHARMACEUTICALS INC | 00810B105 | COM | 1,131,819 | $1,924,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ZAFGEN INC | 98885E103 | COM | 380,000 | $1,881,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Allena Pharmaceuticals, Inc. | 018119107 | COM | 345,199 | $1,881,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| PIERIS PHARMACEUTICALS INC | 720795103 | COM | 700,000 | $1,862,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ARRAY BIOPHARMA INC COM | 04269X105 | Stock | 125,000 | $1,781,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MOLECULAR TEMPLATES INC | 608550109 | COM | 400,000 | $1,616,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 117,000 | $1,543,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| UROVANT SCIENCES | G9381B108 | COMMON STOCK | 214,030 | $1,410,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| DOVA PHARMACEUTICALS INC | 25985T102 | COM | 185,000 | $1,402,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| NICE SYS INC | 65366HAB9 | BOND | 250,000 | $1,286,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MELINTA THERAPEUTICS INC | 58549G100 | COM | 1,616,867 | $1,282,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CLEARSIDE BIOMEDICAL INC | 185063104 | COM | 1,185,124 | $1,268,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| IDERA PHARMACEUTICALS INC | 45168K405 | COM PAR | 445,558 | $1,234,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 321,430 | $1,180,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SAVARA INC | 805111101 | COM | 110,000 | $833,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| PHAXIAM THERAPEUTICS S A | 29604W108 | SPONSORED ADR | 120,000 | $796,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| VERRICA PHARMACEUTICALS INC | 92511W108 | COM | 97,000 | $791,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MEIRAGTX HOLDINGS PLC | G59665102 | COMMON STOCK | 71,159 | $686,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SPRING BK PHARMACEUTICALS IN | 849431101 | COM | 51,015 | $530,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| KEZAR LIFE SCIENCES INC | 49372L100 | COM | 20,000 | $472,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SIERRA ONCOLOGY INC | 82640U107 | COM | 258,510 | $341,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CONSTELLATION PHARMACEUTICALS INC. | 210373106 | Common Stock | 70,162 | $281,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CUE BIOPHARMA INC | 22978P106 | COM | 50,000 | $235,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Adverum Biotechnologies, Inc. | 00773U108 | Common Stock | 63,355 | $200,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| BENITEC BIOPHARMA LTD | 082053307 | SPONS ADR NEW | 120,000 | $180,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CELLECTAR BIOSCIENCES INC | 15117F500 | COM PAR | 87,500 | $136,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001178913-19-000472 | this filing | 2019-02-14 | acceptance time not in the bulk data set |