13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2018-09-30, filed 2018-11-14, with 113 holding rows worth $871,050,000.
- Accession
- 0001178913-18-002945
- Filer
- CIK 1496201
- Filed
- 2018-11-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q3 2018
A holdings report, 113 entries on the cover page, a total value of $871,050,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $871,052,000 with VALUE read as thousands by filing date, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerSphera Global Healthcare GP Ltd.028-15864
- included managerSphera Global Healthcare Management LP028-15865
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SPDR SER TR | 78464A870 | S&P BIOTECH | 1,100,000 | $105,457,000 | thousands by filing date | putThe filing omitted confidential holdings, a later amendment may add them. |
| Merck & Co.,Inc. | 58933Y105 | COM | 780,000 | $55,333,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MYLAN NV | N59465109 | SHS EURO | 1,325,000 | $48,495,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Johnson & Johnson | 478160104 | COM | 325,000 | $44,905,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| GLAXOSMITHKLINE PLC-ADR | 37733W105 | SPONSORED ADR | 865,000 | $34,747,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Bristol-Myers Squibb Company | 110122108 | COM | 540,000 | $33,523,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Gilead Sciences,Inc. | 375558103 | COM | 420,000 | $32,428,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 1,787,994 | $21,617,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ALEXION PHARMACEUTICALS INC | 015351109 | COM | 141,700 | $19,698,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ALDEYRA THERAPEUTICS INC | 01438T106 | COM | 1,142,089 | $15,761,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| VIKING THERAPEUTICS INC | 92686J106 | COM | 859,727 | $14,976,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| IMMUNOMEDICS INC | 452907108 | COM | 699,039 | $14,561,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CELLECTIS ADS | 15117K103 | COM | 447,970 | $12,642,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 76,116 | $12,293,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| BLUEBIRD BIO INC | 09609G100 | COM | 78,396 | $11,446,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ARQULE INC | 04269E107 | COM | 2,005,243 | $11,350,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MINERVA NEUROSCIENCES INC COM NEW | 603380106 | Stock | 842,391 | $10,572,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CAESARSTONE LTD | M20598104 | ORD SHS | 561,311 | $10,412,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 136,381 | $10,343,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| PTC THERAPEUTICS INC | 69366J200 | COM | 210,000 | $9,870,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| RETROPHIN INC | 761299106 | COM | 325,678 | $9,357,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AUTOLUS THERAPEUTICS PLC SPON | 05280R100 | COM | 296,251 | $8,935,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 88,000 | $8,533,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SAGE THERAPEUTICS INC | 78667J108 | COM | 60,000 | $8,475,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Microsoft Corp | 594918104 | COM | 69,656 | $7,967,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| PROQR THERAPEUTICS NV | N71542109 | SHS EURO | 398,749 | $7,716,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 296,856 | $7,644,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| REATA PHARMACEUTICALS INC | 75615P103 | CL A | 92,719 | $7,581,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| VERINT SYS INC | 92343X100 | COM | 150,126 | $7,521,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CLEARSIDE BIOMEDICAL INC | 185063104 | COM | 1,154,690 | $7,101,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 92,673 | $6,567,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| UNIQURE NV | N90064101 | SHS | 177,849 | $6,472,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MELINTA THERAPEUTICS INC | 58549G100 | COM | 1,616,867 | $6,387,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AEGLEA BIOTHERAPEUTICS INC | 00773J103 | COM | 653,112 | $6,250,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CARA THERAPEUTICS INC | 140755109 | COM | 255,930 | $6,130,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Visa Inc | 92826C839 | COM | 40,401 | $6,064,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ARRAY BIOPHARMA INC COM | 04269X105 | Stock | 395,000 | $6,004,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| BIOHAVEN PHARMACEUTICAL HOLDIN | G11196105 | COM | 155,515 | $5,840,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| STRONGBRIDGE BIOPHARMA PLC | G85347105 | SHS USD | 1,179,010 | $5,718,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SOLAREDGE TECHNOLOGIES INC | 83417M104 | COM | 150,817 | $5,678,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| TRANSPORTATION & LOGISTI | 438083107 | COM | 245,104 | $5,603,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| WABTEC COM | 929740108 | Stock | 53,114 | $5,571,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 112,908 | $5,318,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| INTERNATIONAL FLAVORS&FRAGRANC COM | 459506101 | Stock | 36,450 | $5,071,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MasterCard, Inc | 57636Q104 | COM | 22,760 | $5,067,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| PIERIS PHARMACEUTICALS INC | 720795103 | COM | 904,686 | $5,066,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ZAFGEN INC | 98885E103 | COM | 430,000 | $5,027,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 379,484 | $5,009,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| KADMON HLDGS INC | 48283N106 | COM | 1,490,000 | $4,977,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Cisco Systems,Inc. | 17275R102 | COM | 100,000 | $4,865,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AUDENTES THERAPEUTICS INC. | 05070R104 | Common Stock | 120,000 | $4,751,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| FORESCOUT TECHNOLOGIES INC | 34553D101 | COM | 124,463 | $4,700,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| KEZAR LIFE SCIENCES INC | 49372L100 | COM | 212,000 | $4,539,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ObsEva SA | H5861P103 | COM | 243,669 | $4,393,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 233,151 | $4,313,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ABEONA THERAPEUTICS INC | 00289Y107 | COM | 336,939 | $4,313,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 200,000 | $4,308,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| DECIPHERA PHARMACEUTICALS IN | 24344T101 | COM | 110,033 | $4,260,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| EPIZYME INC | 29428V104 | COM | 399,502 | $4,235,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| EVOKE PHARMA INC | 30049G104 | COM | 1,410,946 | $4,205,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SUTRO BIOPHARMA INC | 869367102 | COM | 275,000 | $4,125,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ARVINAS INC | 04335A105 | COM | 240,000 | $4,049,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| NEOS THERAPEUTICS INC | 64052L106 | COM | 831,697 | $4,034,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AC IMMUNE SA | H00263105 | SHS | 503,563 | $4,029,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SNAP ON INC COM | 833034101 | Stock | 21,666 | $3,978,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| IDERA PHARMACEUTICALS INC | 45168K306 | COM | 445,558 | $3,970,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Alphabet Inc. Reg. Shares A | 02079K305 | COM | 3,269 | $3,946,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| PORTOLA PHARMACEUTICALS INC COM | 737010108 | Stock | 147,000 | $3,915,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 212,470 | $3,778,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| OREILLY AUTOMOTIVE INC COM | 67103H107 | Stock | 10,844 | $3,766,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ASSEMBLY BIOSCIENCES INC | 045396108 | COM | 100,431 | $3,730,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MELLANOX TECHNOLOGIES LTD | M51363113 | COMMON STOCK | 50,093 | $3,679,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| GLYCOMIMETICS INC | 38000Q102 | COM | 251,013 | $3,615,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 40,000 | $3,501,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AERPIO PHARMACEUTICALS INC | 00810B105 | COM | 1,131,819 | $3,497,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Allena Pharmaceuticals, Inc. | 018119107 | COM | 295,199 | $3,170,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| TRANSLATE BIO INC. | 89374L104 | Common Stock | 276,639 | $2,766,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 321,430 | $2,758,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| LEAP THERAPEUTICS INC | 52187K101 | COM | 332,525 | $2,590,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| DOVA PHARMACEUTICALS INC | 25985T102 | COM | 120,000 | $2,516,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| VISTAGEN THERAPEUTICS INC | 92840H202 | COM | 1,673,918 | $2,427,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SAVARA INC | 805111101 | COM | 209,596 | $2,339,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ALLOT LTD | M0854Q105 | SHS | 376,451 | $2,326,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MOLECULAR TEMPLATES INC | 608550109 | COM | 400,000 | $2,156,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| FLEX LTD ORD | Y2573F102 | Stock | 159,549 | $2,093,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| UROVANT SCIENCES | G9381B108 | COMMON STOCK | 164,030 | $1,968,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| VERRICA PHARMACEUTICALS INC | 92511W108 | COM | 117,000 | $1,901,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SIERRA ONCOLOGY INC | 82640U107 | COM | 1,022,759 | $1,739,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AQUESTIVE THERAPEUTICS INC COM | 03843E104 | Stock | 95,300 | $1,669,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Gilat Satellite Network | M51474118 | COM | 163,367 | $1,398,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SESEN BIO INC | 817763105 | COM | 630,000 | $1,355,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ZYMEWORKS INC | 98985W102 | COM | 73,800 | $1,159,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| PHAXIAM THERAPEUTICS S A | 29604W108 | SPONSORED ADR | 120,000 | $1,046,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ADVANCE AUTO PARTS INC | 00751Y106 | COM | 5,336 | $898,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| TEVA PHARMACEUTICAL FIN LLC | 88163VAE9 | DBCV 0.250% 2/0 | 2,135 | $862,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AUDIOCODES LTD | M15342104 | ORD | 59,226 | $596,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| UnitedHealth Group Inc | 91324P102 | COM | 2,000 | $532,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| RADWARE LTD | M81873107 | COMMON STOCK | 17,527 | $464,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CHARTER COMMUNICATIONS INC N | 16119P108 | COM | 1,419 | $462,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Adverum Biotechnologies, Inc. | 00773U108 | Common Stock | 75,000 | $454,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| VIKING THERAPEUTICS INC | 92686J106 | COM | 23,900 | $416,000 | thousands by filing date | callThe filing omitted confidential holdings, a later amendment may add them. |
| SERVICEMASTER GLOBAL HOLDING | 81761R109 | COMMON STOCK | 9,500 | $395,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Arbutus Biopharma Corp | 03879J100 | Common Shares, without par value | 40,000 | $378,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| NICE SYS INC | 65366HAB9 | BOND | 250,000 | $359,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| EIDOS THERAPEUTICS INC. | 28249H104 | Common Stock | 31,522 | $315,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| BENITEC BIOPHARMA LTD | 082053307 | SPONS ADR NEW | 120,000 | $294,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Lowes Companies,Inc. | 548661107 | COM | 2,500 | $287,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CELLECTAR BIOSCIENCES INC | 15117F500 | COM PAR | 87,500 | $263,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| THE ULTIMATE SOFTWARE GROUP IN | 90385D107 | COM | 800 | $258,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CISION LTD | G1992S109 | SHS | 15,000 | $252,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SITEONE LANDSCAPE SUPPLY INC | 82982L103 | COM | 3,000 | $226,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Comcast Corp | 20030N101 | COM | 5,993 | $212,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CUE BIOPHARMA INC | 22978P106 | COM | 20,000 | $181,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001178913-18-002945 | this filing | 2018-11-14 | acceptance time not in the bulk data set |