13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2018-06-30, filed 2018-08-13, with 109 holding rows worth $725,360,000.
- Accession
- 0001178913-18-002380
- Filer
- CIK 1496201
- Filed
- 2018-08-13
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q2 2018
A holdings report, 110 entries on the cover page, a total value of $725,360,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $725,363,000 with VALUE read as thousands by filing date, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerSphera Global Healthcare GP Ltd.028-15864
- included managerSphera Global Healthcare Management LP028-15865
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SPDR SERIES TRUST | 78464A950 | PUT | 750,000 | $71,393,000 | thousands by filing date | putThe filing omitted confidential holdings, a later amendment may add them. |
| Merck & Co.,Inc. | 58933Y105 | COM | 680,000 | $41,276,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MYLAN NV | N59465109 | SHS EURO | 854,000 | $30,864,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| GLAXOSMITHKLINE PLC-ADR | 37733W105 | SPONSORED ADR | 765,000 | $30,837,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Gilead Sciences,Inc. | 375558103 | COM | 355,000 | $25,148,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ISHARES TR | 464287955 | PUT | 150,000 | $24,566,000 | thousands by filing date | putThe filing omitted confidential holdings, a later amendment may add them. |
| SHIRE PLC | 82481R106 | COMMON STOCK-FO | 126,500 | $21,353,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ALEXION PHARMACEUTICALS INC | 015351109 | COM | 160,544 | $19,932,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 195,232 | $19,228,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 145,096 | $19,179,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 1,189,056 | $18,573,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Amgen Inc. | 031162100 | COM | 100,000 | $18,459,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| BIOGEN INC COM | 09062X103 | Stock | 50,000 | $14,512,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Pfizer Inc. | 717081103 | COM | 390,000 | $14,149,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CLEARSIDE BIOMEDICAL INC | 185063104 | COM | 1,068,720 | $11,425,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| BLUEBIRD BIO INC | 09609G100 | COM | 72,483 | $11,376,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ALLERGAN PLC | G0177J108 | SHS | 60,000 | $10,003,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CELLECTIS ADS | 15117K103 | COM | 351,874 | $9,955,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| RETROPHIN INC | 761299106 | COM | 353,072 | $9,625,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ARQULE INC | 04269E107 | COM | 1,497,683 | $8,282,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| INNOVATE BIOPHARMACEUTICLS I | 45782F105 | COM PAR | 980,502 | $7,844,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| VIKING THERAPEUTICS INC | 92686J106 | COM | 782,424 | $7,425,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Microsoft Corp | 594918104 | COM | 74,435 | $7,340,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| IMMUNOMEDICS INC | 452907108 | COM | 306,655 | $7,259,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MELLANOX TECHNOLOGIES LTD | M51363113 | COMMON STOCK | 85,954 | $7,246,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MINERVA NEUROSCIENCES INC COM NEW | 603380106 | Stock | 820,120 | $6,766,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ALDEYRA THERAPEUTICS INC | 01438T106 | COM | 846,935 | $6,733,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| KURA ONCOLOGY INC COM | 50127T109 | Stock | 351,953 | $6,406,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SODASTREAM INTERNATIONAL | M9068E105 | LTD | 73,762 | $6,292,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MELINTA THERAPEUTICS INC | 58549G100 | COM | 984,492 | $6,252,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| NICE LTD SPONSORED ADR | 653656108 | ADR | 60,043 | $6,231,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| KADMON HLDGS INC | 48283N106 | COM | 1,552,846 | $6,196,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| UNIQURE NV | N90064101 | SHS | 152,490 | $5,764,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ARRAY BIOPHARMA INC COM | 04269X105 | Stock | 339,804 | $5,702,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ADAMAS PHARMACEUTICALS INC | 00548A106 | COM | 213,625 | $5,518,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| BIOHAVEN PHARMACEUTICAL HOLDIN | G11196105 | COM | 137,388 | $5,430,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AEGLEA BIOTHERAPEUTICS INC | 00773J103 | COM | 509,118 | $5,386,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Visa Inc | 92826C839 | COM | 40,401 | $5,351,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 78,048 | $5,192,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ZAFGEN INC | 98885E103 | COM | 480,000 | $4,910,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| REATA PHARMACEUTICALS INC | 75615P103 | CL A | 136,044 | $4,757,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AUTOLUS THERAPEUTICS PLC SPON | 05280R100 | COM | 176,045 | $4,716,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SESEN BIO INC | 817763105 | COM | 2,377,068 | $4,635,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| WABTEC COM | 929740108 | Stock | 46,564 | $4,590,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AERPIO PHARMACEUTICALS INC | 00810B105 | COM | 1,103,554 | $4,580,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| LEAP THERAPEUTICS INC | 52187K101 | COM | 499,137 | $4,492,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MasterCard, Inc | 57636Q104 | COM | 22,760 | $4,473,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 283,997 | $4,430,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CTI BIOPHARMA CORP | 12648L601 | COM | 874,407 | $4,355,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Cisco Systems,Inc. | 17275R102 | COM | 100,000 | $4,303,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| PIERIS PHARMACEUTICALS INC | 720795103 | COM | 842,632 | $4,272,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| EPIZYME INC | 29428V104 | COM | 307,154 | $4,162,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| STRONGBRIDGE BIOPHARMA PLC | G85347105 | SHS USD | 673,996 | $4,044,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 439,034 | $4,039,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| KEZAR LIFE SCIENCES INC | 49372L100 | COM | 227,900 | $3,943,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| GLYCOMIMETICS INC | 38000Q102 | COM | 239,933 | $3,870,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| META PLATFORMS INC CL A | 30303M102 | COM | 19,100 | $3,712,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Alphabet Inc. Reg. Shares A | 02079K305 | COM | 3,269 | $3,691,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 335,987 | $3,689,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ObsEva SA | H5861P103 | COM | 243,669 | $3,689,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| FLEX LTD ORD | Y2573F102 | Stock | 259,824 | $3,666,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| DECIPHERA PHARMACEUTICALS IN | 24344T101 | COM | 93,031 | $3,661,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| PROQR THERAPEUTICS NV | N71542109 | SHS EURO | 493,749 | $3,604,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ABEONA THERAPEUTICS INC | 00289Y107 | COM | 223,172 | $3,571,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| EVOKE PHARMA INC | 30049G104 | COM | 1,410,946 | $3,527,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CAESARSTONE LTD | M20598104 | ORD SHS | 230,816 | $3,485,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Allena Pharmaceuticals, Inc. | 018119107 | COM | 267,349 | $3,484,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Vertex Pharmaceuticals Incorporated | 92532F100 | COM | 20,000 | $3,399,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SIERRA ONCOLOGY INC | 82640U107 | COM | 1,075,806 | $3,184,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| OREILLY AUTOMOTIVE INC COM | 67103H107 | Stock | 10,844 | $2,967,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| WIX COM LTD SHS | M98068105 | Stock | 29,542 | $2,963,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| TRANSPORTATION & LOGISTI | 438083107 | COM | 141,836 | $2,893,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ELOXX PHARMACEUTICALS INC | 29014R103 | COM | 167,474 | $2,859,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| FORESCOUT TECHNOLOGIES INC | 34553D101 | COM | 76,400 | $2,617,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| LAM RESEARCH CORP | 512807108 | COM | 14,597 | $2,523,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| VERRICA PHARMACEUTICALS INC | 92511W108 | COM | 125,800 | $2,482,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| APTINYX INC | 03836N103 | COM | 102,474 | $2,477,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 110,803 | $2,438,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MARVELL TECHNOLOGY GROUP LTD | G5876H105 | ORD | 109,842 | $2,355,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SOLAREDGE TECHNOLOGIES INC | 83417M104 | COM | 48,948 | $2,342,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| KORNIT DIGITAL LTD | M6372Q113 | SHS | 130,831 | $2,329,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| NEOS THERAPEUTICS INC | 64052L106 | COM | 352,142 | $2,201,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 83,142 | $1,901,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| VISTAGEN THERAPEUTICS INC | 92840H202 | COM | 1,371,892 | $1,879,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| TRANSLATE BIO INC. | 89374L104 | Common Stock | 130,000 | $1,645,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Gilat Satellite Network | M51474118 | COM | 163,367 | $1,501,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| PORTOLA PHARMACEUTICALS INC COM | 737010108 | Stock | 120,000 | $1,385,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| DELEK US HLDGS INC NEW COM | 24665A103 | Stock | 24,533 | $1,231,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ZYMEWORKS INC | 98985W102 | COM | 73,800 | $1,091,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| Radcom Ltd | M81865111 | COM | 52,760 | $1,042,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| TEVA PHARMACEUTICAL FIN LLC | 88163VAE9 | DBCV 0.250% 2/0 | 2,135 | $970,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ADVANCE AUTO PARTS INC | 00751Y106 | COM | 5,336 | $724,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 14,335 | $707,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AQUINOX PHARMACEUTICALS INC | 03842B101 | COM | 257,613 | $683,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| ROCKET PHARMACEUTICALS INC | 77313F106 | COM | 34,475 | $677,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| TRICIDA INC | 89610F101 | COM | 20,410 | $610,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 6,250 | $589,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SERVICEMASTER GLOBAL HOLDING | 81761R109 | COMMON STOCK | 9,500 | $565,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| UnitedHealth Group Inc | 91324P102 | COM | 2,000 | $491,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| AUDIOCODES LTD | M15342104 | ORD | 59,226 | $461,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| RADWARE LTD | M81873107 | COMMON STOCK | 17,527 | $443,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CHARTER COMMUNICATIONS INC N | 16119P108 | COM | 1,419 | $416,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SITEONE LANDSCAPE SUPPLY INC | 82982L103 | COM | 3,000 | $252,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| MOHAWK INDS INC | 608190104 | COM | 1,100 | $236,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| CISION LTD | G1992S109 | SHS | 15,000 | $224,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| SNAP ON INC COM | 833034101 | Stock | 1,366 | $220,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| EIDOS THERAPEUTICS INC. | 28249H104 | Common Stock | 10,828 | $220,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| THE ULTIMATE SOFTWARE GROUP IN | 90385D107 | COM | 800 | $206,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
| KEMPHARM INC COM NEW | 488445107 | Stock | 22,622 | $147,000 | thousands by filing date | The filing omitted confidential holdings, a later amendment may add them. |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001178913-18-002380 | this filing | 2018-08-13 | acceptance time not in the bulk data set |