13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2017-12-31, filed 2018-02-12, with 136 holding rows worth $852,232,000.
- Accession
- 0001178913-18-000471
- Filer
- CIK 1496201
- Filed
- 2018-02-12
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2017
A holdings report, 137 entries on the cover page, a total value of $852,232,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $852,232,000 with VALUE read as thousands by filing date, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerSphera Global Healthcare GP Ltd.028-15864
- included managerSphera Global Healthcare Management LP028-15865
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SPDR SER TR | 78464A870 | S&P BIOTECH | 1,950,000 | $165,497,000 | thousands by filing date | put |
| ISHARES TR | 464287556 | ISHARES BIOTECH | 500,000 | $53,385,000 | thousands by filing date | put |
| CELGENE CORP | 151020104 | COM | 309,000 | $32,247,000 | thousands by filing date | |
| MYLAN NV | N59465109 | SHS EURO | 756,449 | $32,005,000 | thousands by filing date | |
| Merck & Co.,Inc. | 58933Y105 | COM | 425,000 | $23,915,000 | thousands by filing date | |
| BIOGEN INC COM | 09062X103 | Stock | 74,200 | $23,638,000 | thousands by filing date | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 384,997 | $21,421,000 | thousands by filing date | |
| GLAXOSMITHKLINE PLC-ADR | 37733W105 | SPONSORED ADR | 450,000 | $15,962,000 | thousands by filing date | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 1,100,000 | $15,829,000 | thousands by filing date | |
| ALEXION PHARMACEUTICALS INC | 015351109 | COM | 120,000 | $14,351,000 | thousands by filing date | |
| Pfizer Inc. | 717081103 | COM | 390,000 | $14,126,000 | thousands by filing date | |
| CELLCOM ISRAEL LTD | M2196U109 | SHS | 1,359,744 | $14,022,000 | thousands by filing date | |
| SHIRE PLC | 82481R106 | COMMON STOCK-FO | 86,500 | $13,418,000 | thousands by filing date | |
| Vertex Pharmaceuticals Incorporated | 92532F100 | COM | 85,823 | $12,861,000 | thousands by filing date | |
| CLOVIS ONCOLOGY INC | 189464100 | COM | 158,000 | $10,744,000 | thousands by filing date | |
| PORTOLA PHARMACEUTICALS INC COM | 737010108 | Stock | 210,000 | $10,223,000 | thousands by filing date | |
| NICE LTD SPONSORED ADR | 653656108 | ADR | 107,870 | $9,914,000 | thousands by filing date | |
| CELLECTIS ADS | 15117K103 | COM | 339,367 | $9,893,000 | thousands by filing date | |
| ALLERGAN PLC | G0177J108 | SHS | 60,000 | $9,815,000 | thousands by filing date | |
| IGNYTA INC | 451731103 | COM | 344,300 | $9,193,000 | thousands by filing date | |
| VIKING THERAPEUTICS INC | 92686J106 | COM | 2,145,300 | $8,710,000 | thousands by filing date | |
| TESARO INC | 881569107 | COM | 95,000 | $7,873,000 | thousands by filing date | |
| PROTHENA CORP PLC SHS | G72800108 | Stock | 205,000 | $7,685,000 | thousands by filing date | |
| LA JOLLA PHARMACEUTICAL CO | 503459604 | COM PAR $.0001 2 | 225,000 | $7,241,000 | thousands by filing date | |
| EIGER BIOPHARMACEUTICALS INC | 28249U105 | COM | 511,469 | $7,135,000 | thousands by filing date | |
| ALDEYRA THERAPEUTICS INC | 01438T106 | COM | 1,044,131 | $7,100,000 | thousands by filing date | |
| Visa Inc | 92826C839 | COM | 60,401 | $6,887,000 | thousands by filing date | |
| REATA PHARMACEUTICALS INC | 75615P103 | CL A | 225,000 | $6,372,000 | thousands by filing date | |
| Alphabet Inc. Reg. Shares A | 02079K305 | COM | 5,767 | $6,075,000 | thousands by filing date | |
| PIERIS PHARMACEUTICALS INC | 720795103 | COM | 800,000 | $6,040,000 | thousands by filing date | |
| META PLATFORMS INC CL A | 30303M102 | COM | 34,067 | $6,011,000 | thousands by filing date | |
| NOMAD FOODS LTD USD ORD SHS | G6564A105 | Stock | 340,162 | $5,752,000 | thousands by filing date | |
| FIBROGEN INC | 31572Q808 | COM | 119,779 | $5,678,000 | thousands by filing date | |
| GLYCOMIMETICS INC | 38000Q102 | COM | 325,000 | $5,457,000 | thousands by filing date | |
| ObsEva SA | H5861P103 | COM | 547,697 | $5,346,000 | thousands by filing date | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 129,474 | $5,187,000 | thousands by filing date | |
| ARRAY BIOPHARMA INC COM | 04269X105 | Stock | 405,000 | $5,184,000 | thousands by filing date | |
| SPARK THERAPEUTICS INC | 84652J103 | COM | 100,000 | $5,142,000 | thousands by filing date | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 170,000 | $5,119,000 | thousands by filing date | |
| DECIPHERA PHARMACEUTICALS IN | 24344T101 | COM | 224,154 | $5,008,000 | thousands by filing date | |
| SAGE THERAPEUTICS INC | 78667J108 | COM | 30,000 | $4,941,000 | thousands by filing date | |
| ADAMAS PHARMACEUTICALS INC | 00548A106 | COM | 140,500 | $4,762,000 | thousands by filing date | |
| MELLANOX TECHNOLOGIES LTD | M51363113 | COMMON STOCK | 73,446 | $4,752,000 | thousands by filing date | |
| INCYTE CORP COM | 45337C102 | Stock | 50,000 | $4,736,000 | thousands by filing date | |
| INCYTE CORP COM | 45337C102 | Stock | 50,000 | $4,736,000 | thousands by filing date | put |
| MINERVA NEUROSCIENCES INC COM NEW | 603380106 | Stock | 775,000 | $4,689,000 | thousands by filing date | |
| STEMLINE THERAPEUTICS INC | 85858C107 | COM | 300,000 | $4,680,000 | thousands by filing date | |
| WIX COM LTD SHS | M98068105 | Stock | 78,180 | $4,499,000 | thousands by filing date | |
| FLEX PHARMA INC | 33938A105 | COM | 241,211 | $4,339,000 | thousands by filing date | |
| Financial Select Sector SPDR Fund | 81369Y605 | SHS | 155,000 | $4,326,000 | thousands by filing date | |
| Honeywell Technologies | 438516106 | COM | 26,750 | $4,102,000 | thousands by filing date | |
| KADMON HLDGS INC | 48283N106 | COM | 1,100,000 | $3,982,000 | thousands by filing date | |
| GLOBAL BLOOD THERAPEUTICS USD | 37890U108 | COM | 100,000 | $3,935,000 | thousands by filing date | |
| COGNIZANT TECHNOLOGY SOLUTIONS CL A | 192446102 | Stock | 55,086 | $3,912,000 | thousands by filing date | |
| CHARTER COMMUNICATIONS INC N | 16119P108 | COM | 11,629 | $3,907,000 | thousands by filing date | |
| IMMUNOMEDICS INC | 452907108 | COM | 230,000 | $3,717,000 | thousands by filing date | |
| AVEO PHARMACEUTICALS INC | 053588109 | COM | 1,300,000 | $3,627,000 | thousands by filing date | |
| ANAPTYSBIO INC | 032724106 | COM | 35,000 | $3,525,000 | thousands by filing date | |
| PUMA BIOTECHNOLOGY INC | 74587V107 | COMMON STOCK | 35,000 | $3,460,000 | thousands by filing date | |
| Arsanis Inc | 042873109 | COM | 269,268 | $3,436,000 | thousands by filing date | |
| VBI VACCINES INC | 91822J103 | COM NEW | 800,000 | $3,416,000 | thousands by filing date | |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 160,000 | $3,378,000 | thousands by filing date | |
| ABEONA THERAPEUTICS INC | 00289Y107 | COM | 210,000 | $3,329,000 | thousands by filing date | |
| Allena Pharmaceuticals, Inc. | 018119107 | COM | 325,000 | $3,270,000 | thousands by filing date | |
| IMMUNOGEN INC | 45253H101 | COMMON STOCK | 500,000 | $3,205,000 | thousands by filing date | |
| MELINTA THERAPEUTICS INC | 58549G100 | COM | 200,000 | $3,160,000 | thousands by filing date | |
| CLEARSIDE BIOMEDICAL INC | 185063104 | COM | 450,000 | $3,150,000 | thousands by filing date | |
| EDGE THERAPEUTICS INC | 279870109 | COM | 333,737 | $3,127,000 | thousands by filing date | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 35,000 | $3,121,000 | thousands by filing date | |
| CLEMENTIA PHARMACEUTICALS IN | 185575107 | COM | 163,000 | $3,094,000 | thousands by filing date | |
| LAM RESEARCH CORP | 512807108 | COM | 16,580 | $3,052,000 | thousands by filing date | |
| AUDENTES THERAPEUTICS INC. | 05070R104 | Common Stock | 95,000 | $2,969,000 | thousands by filing date | |
| SAVARA INC | 805111101 | COM | 200,000 | $2,968,000 | thousands by filing date | |
| THERAPEUTICSMD INC | 88338N107 | COM | 479,980 | $2,899,000 | thousands by filing date | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 37,000 | $2,871,000 | thousands by filing date | |
| OREILLY AUTOMOTIVE INC COM | 67103H107 | Stock | 11,650 | $2,802,000 | thousands by filing date | |
| EXPEDIA GROUP INC COM NEW | 30212P303 | Stock | 22,950 | $2,749,000 | thousands by filing date | |
| CORBUS PHARMACEUTICALS HLDGS | 21833P103 | COM | 375,000 | $2,663,000 | thousands by filing date | |
| PHAXIAM THERAPEUTICS S A | 29604W108 | SPONSORED ADR | 120,000 | $2,642,000 | thousands by filing date | |
| MACROGENICS INC | 556099109 | COM | 138,700 | $2,635,000 | thousands by filing date | |
| CASCADIAN THERAPEUTICS INC | 14740B606 | COM NEW | 681,210 | $2,520,000 | thousands by filing date | |
| SUMMIT THERAPEUTICS INC COM | 86627R102 | Stock | 212,018 | $2,349,000 | thousands by filing date | |
| PALO ALTO NETWORKS INC | 697435105 | COM | 16,055 | $2,327,000 | thousands by filing date | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 221,430 | $2,294,000 | thousands by filing date | |
| ARDELYX INC | 039697107 | COM | 345,000 | $2,277,000 | thousands by filing date | |
| CATALYST PHARMACEUTICALS INC | 14888U101 | COM | 576,825 | $2,255,000 | thousands by filing date | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 118,750 | $2,250,000 | thousands by filing date | |
| SELECTA BIOSCIENCES INC | 816212104 | COM | 228,534 | $2,242,000 | thousands by filing date | |
| CTI BIOPHARMA CORP | 12648L601 | COM | 833,633 | $2,234,000 | thousands by filing date | |
| CYMABAY THERAPEUTICS INC | 23257D103 | COM | 240,000 | $2,208,000 | thousands by filing date | |
| ORBOTECH LTD | M75253100 | ORD | 43,488 | $2,185,000 | thousands by filing date | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 248,472 | $2,177,000 | thousands by filing date | |
| GALMED PHARMACEUTICALS LTD | M47238106 | SHS | 238,095 | $2,164,000 | thousands by filing date | |
| MYLAN NV | N59465109 | SHS EURO | 50,000 | $2,116,000 | thousands by filing date | call |
| ADVANCE AUTO PARTS INC | 00751Y106 | COM | 21,000 | $2,093,000 | thousands by filing date | call |
| SIERRA ONCOLOGY INC | 82640U107 | COM | 550,000 | $2,052,000 | thousands by filing date | |
| Comcast Corp | 20030N101 | COM | 46,905 | $1,879,000 | thousands by filing date | |
| KALA BIO INC COM | 483119103 | Stock | 100,000 | $1,849,000 | thousands by filing date | |
| OVID THERAPEUTICS INC | 690469101 | COMMON STOCK | 180,674 | $1,783,000 | thousands by filing date | |
| MasterCard, Inc | 57636Q104 | COM | 11,525 | $1,744,000 | thousands by filing date | |
| EVOKE PHARMA INC | 30049G104 | COM | 769,149 | $1,738,000 | thousands by filing date | |
| NEOS THERAPEUTICS INC | 64052L106 | COM | 170,032 | $1,734,000 | thousands by filing date | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 210,000 | $1,712,000 | thousands by filing date | |
| PROQR THERAPEUTICS NV | N71542109 | SHS EURO | 530,000 | $1,709,000 | thousands by filing date | |
| VTV THERAPEUTICS INC CL A | 918385105 | Stock | 281,679 | $1,693,000 | thousands by filing date | |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 301,000 | $1,686,000 | thousands by filing date | |
| VISTAGEN THERAPEUTICS INC | 92840H202 | COM | 1,247,251 | $1,384,000 | thousands by filing date | |
| AILERON THERAPEUTICS INC COM NEW | 00887A105 | Stock | 125,000 | $1,318,000 | thousands by filing date | |
| Radcom Ltd | M81865111 | COM | 65,760 | $1,305,000 | thousands by filing date | |
| SNAP ON INC COM | 833034101 | Stock | 7,292 | $1,271,000 | thousands by filing date | |
| ACORDA THERAPEUTICS INC | 00484M106 | COM | 50,000 | $1,073,000 | thousands by filing date | |
| Rocket Pharmaceuticals Inc | 45780V102 | SHS | 100,441 | $1,049,000 | thousands by filing date | |
| SPRING BK PHARMACEUTICALS IN | 849431101 | COM | 74,309 | $999,000 | thousands by filing date | |
| ALBIREO PHARMA INC | 01345P106 | COMMON STOCK | 35,431 | $907,000 | thousands by filing date | |
| AQUINOX PHARMACEUTICALS INC | 03842B101 | COM | 75,535 | $888,000 | thousands by filing date | |
| ADVANCE AUTO PARTS INC | 00751Y106 | COM | 8,336 | $831,000 | thousands by filing date | |
| TEVA PHARMACEUTICAL FIN LLC | 88163VAE9 | DBCV 0.250% 2/0 | 2,135 | $758,000 | thousands by filing date | Value about 1,000 times the price other filers imply, kept as filed and left out of ratios. |
| REGENXBIO INC | 75901B107 | COM | 22,107 | $735,000 | thousands by filing date | |
| CATABASIS PHARMACEUTICALS IN | 14875P107 | COM | 328,030 | $489,000 | thousands by filing date | |
| TJX Companies Inc | 872540109 | COM | 5,800 | $443,000 | thousands by filing date | |
| UnitedHealth Group Inc | 91324P102 | COM | 2,000 | $441,000 | thousands by filing date | |
| SERVICEMASTER GLOBAL HOLDING | 81761R109 | COMMON STOCK | 8,000 | $410,000 | thousands by filing date | |
| SAGE THERAPEUTICS INC | 78667J108 | COM | 2,400 | $395,000 | thousands by filing date | put |
| WATSCO INC COM | 942622200 | Stock | 2,100 | $357,000 | thousands by filing date | |
| MOHAWK INDS INC | 608190104 | COM | 1,100 | $303,000 | thousands by filing date | |
| ECOLAB INC COM | 278865100 | Stock | 2,000 | $268,000 | thousands by filing date | |
| Lowes Companies,Inc. | 548661107 | COM | 2,600 | $242,000 | thousands by filing date | |
| SEALED AIR CORP NEW | 81211K100 | COM | 4,500 | $222,000 | thousands by filing date | |
| THE ULTIMATE SOFTWARE GROUP IN | 90385D107 | COM | 800 | $175,000 | thousands by filing date | |
| DENTSPLY SIRONA INC | 24906P109 | COM | 2,500 | $165,000 | thousands by filing date | |
| LIBERTY INTERACTIVE CORP | 53071M856 | LBT VEN COM A NE | 3,000 | $163,000 | thousands by filing date | |
| TRIPADVISOR INC | 896945201 | COM | 4,000 | $138,000 | thousands by filing date | |
| CHIPOTLEMEXICANGRILLI | 169656105 | STOK | 400 | $116,000 | thousands by filing date | |
| VISTA OUTDOOR INC | 928377100 | COM | 6,000 | $87,000 | thousands by filing date | |
| CIDARA THERAPEUTICS INC COM NEW | 171757107 | Stock | 800 | $5,000 | thousands by filing date | |
| ATHERSYS INC | 04744L106 | COM | 773 | $1,000 | thousands by filing date |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001178913-18-000471 | this filing | 2018-02-12 | acceptance time not in the bulk data set |