13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2015-12-31, filed 2016-02-11, with 118 holding rows worth $682,986,000.
- Accession
- 0001178913-16-004256
- Filer
- CIK 1496201
- Filed
- 2016-02-11
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2015
A holdings report, 119 entries on the cover page, a total value of $682,986,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $682,991,000 with VALUE read as thousands by filing date, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerSphera Global Healthcare GP Ltd.028-15864
- included managerSphera Global Healthcare Management LP028-15865
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SPDR S&P 500 ETF TR | 78462F953 | PUT | 400,000 | $81,548,000 | thousands by filing date | put |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 784,850 | $51,517,000 | thousands by filing date | |
| ORMAT TECHNOLOGIES INC | 686688102 | COM | 272,462 | $38,744,000 | thousands by filing date | |
| Pfizer Inc. | 717081103 | COM | 1,176,612 | $37,981,000 | thousands by filing date | |
| BIOGEN INC COM | 09062X103 | Stock | 123,850 | $37,941,000 | thousands by filing date | |
| ALLERGAN PLC | G0177J108 | SHS | 100,000 | $31,250,000 | thousands by filing date | |
| SPDR SERIES TRUST | 78464A950 | PUT | 329,800 | $23,152,000 | thousands by filing date | put |
| AbbVie,Inc. | 00287Y109 | COM | 362,000 | $21,445,000 | thousands by filing date | |
| CELGENE CORP | 151020104 | COM | 147,200 | $17,629,000 | thousands by filing date | |
| MYLAN N V | N59465909 | CALL | 300,000 | $16,221,000 | thousands by filing date | call |
| Gilead Sciences,Inc. | 375558103 | COM | 142,700 | $14,440,000 | thousands by filing date | |
| ALEXION PHARMACEUTICALS INC | 015351109 | COM | 59,164 | $11,286,000 | thousands by filing date | |
| Bristol-Myers Squibb Company | 110122108 | COM | 121,500 | $8,358,000 | thousands by filing date | |
| SHIRE PLC | 82481R106 | COMMON STOCK-FO | 40,000 | $8,200,000 | thousands by filing date | |
| ACORDA THERAPEUTICS INC | 00484M106 | COM | 143,000 | $6,118,000 | thousands by filing date | |
| Vertex Pharmaceuticals Incorporated | 92532F100 | COM | 48,400 | $6,090,000 | thousands by filing date | |
| FIVE PRIME THERAPEUTICS INC. | 33830X104 | Common Stock | 145,000 | $6,018,000 | thousands by filing date | |
| 38259p508 | COM | 7,409 | $5,764,000 | thousands by filing date | ||
| INCYTE CORP COM | 45337C102 | Stock | 51,621 | $5,598,000 | thousands by filing date | |
| SAGE THERAPEUTICS INC | 78667J108 | COM | 93,000 | $5,422,000 | thousands by filing date | |
| CELLCOM ISRAEL LTD | M2196U109 | SHS | 212,300 | $5,144,000 | thousands by filing date | |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 81,200 | $5,029,000 | thousands by filing date | |
| OPKO HEALTH INC | 68375N103 | COM | 500,000 | $5,025,000 | thousands by filing date | |
| MACROGENICS INC | 556099109 | COM | 153,000 | $4,738,000 | thousands by filing date | |
| BELLICUM PHARMACEUTICALS INC | 079481107 | COM | 231,515 | $4,693,000 | thousands by filing date | |
| CHECK POINT SOFTWARE TECH LTD ORD | M22465104 | Stock | 55,857 | $4,546,000 | thousands by filing date | |
| PORTOLA PHARMACEUTICALS INC COM | 737010108 | Stock | 85,500 | $4,399,000 | thousands by filing date | |
| MARINUS PHARMACEUTICALS INC | 56854Q101 | COM | 570,908 | $4,362,000 | thousands by filing date | |
| RADIUS HEALTH INC | 750469207 | COM NEW | 70,000 | $4,308,000 | thousands by filing date | |
| VANDA PHARMACEUTICALS INC | 921659108 | COM | 462,051 | $4,302,000 | thousands by filing date | |
| ADAMAS PHARMACEUTICALS INC | 00548A106 | COM | 150,000 | $4,248,000 | thousands by filing date | |
| Rocket Pharmaceuticals Inc | 45780V102 | SHS | 360,000 | $4,079,000 | thousands by filing date | |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 40,000 | $3,766,000 | thousands by filing date | |
| ALDER BIOPHARMACEUTICALS INC | 014339105 | COM | 112,500 | $3,716,000 | thousands by filing date | |
| ORBOTECH LTD | M75253100 | ORD | 167,619 | $3,709,000 | thousands by filing date | |
| KEMPHARM INC COM NEW | 488445107 | Stock | 183,954 | $3,653,000 | thousands by filing date | |
| HERON THERAPEUTICS INC | 427746102 | COM | 135,000 | $3,605,000 | thousands by filing date | |
| GOOGLE INC-CL A | 38259P908 | COM | 4,600 | $3,579,000 | thousands by filing date | call |
| CATALYST PHARMACEUTICALS INC | 14888U101 | COM | 1,455,000 | $3,565,000 | thousands by filing date | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 100,000 | $3,565,000 | thousands by filing date | |
| RAPTOR PHARMACEUTICAL CORP | 75382F106 | COM | 685,000 | $3,562,000 | thousands by filing date | |
| GW PHARMACEUTICALS PLC | 36197T903 | CALL | 50,000 | $3,472,000 | thousands by filing date | call |
| VALEANT PHARMACEUTICALS INTL | 91911K102 | COM | 33,750 | $3,431,000 | thousands by filing date | |
| CONCERT PHARMACEUTICALS INC | 206022105 | COM | 180,000 | $3,415,000 | thousands by filing date | |
| TJX Companies Inc | 872540109 | COM | 47,961 | $3,401,000 | thousands by filing date | |
| ANACOR PHARMACEUTICALS INC | 032420101 | COM | 30,000 | $3,389,000 | thousands by filing date | |
| CHINOOK THERAPEUTICS INC. | 00739L101 | Common Stock | 120,000 | $3,377,000 | thousands by filing date | |
| NOVAVAX INC | 670002104 | COMMON STOCK | 400,000 | $3,356,000 | thousands by filing date | |
| CARA THERAPEUTICS INC | 140755109 | COM | 197,820 | $3,335,000 | thousands by filing date | |
| CLOVIS ONCOLOGY INC | 189464100 | COM | 94,500 | $3,308,000 | thousands by filing date | |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 50,000 | $3,246,000 | thousands by filing date | |
| EGALET CORP | 28226B104 | COM | 292,500 | $3,223,000 | thousands by filing date | |
| SEATTLE GENETICS INC | 812578102 | COM | 70,000 | $3,142,000 | thousands by filing date | |
| KITE PHARMA INC | 49803L109 | COM | 50,000 | $3,081,000 | thousands by filing date | |
| Mondelez International,Inc. Class A | 609207105 | COM | 68,625 | $3,077,000 | thousands by filing date | |
| IMMUNE DESIGN CORP. | 45252L103 | Common Stock | 153,000 | $3,072,000 | thousands by filing date | |
| ARROWHEAD RESEARCH CORP | 042797209 | COM | 486,000 | $2,989,000 | thousands by filing date | |
| MasterCard, Inc | 57636Q104 | COM | 30,605 | $2,980,000 | thousands by filing date | |
| ACCELERON PHARMA INC | 00434H108 | COM | 60,000 | $2,926,000 | thousands by filing date | |
| GENOCEA BIOSCIENCES INC | 372427104 | COM | 540,490 | $2,848,000 | thousands by filing date | |
| Visa Inc | 92826C839 | COM | 36,600 | $2,838,000 | thousands by filing date | |
| Starbucks Corporation | 855244109 | COM | 46,828 | $2,811,000 | thousands by filing date | |
| FOAMIX PHARMACEUTICALS LTD | M46135105 | SHS | 342,000 | $2,774,000 | thousands by filing date | |
| BIOTIE THERAPIES OYJ | 09074D103 | SPONSORED ADR | 193,646 | $2,740,000 | thousands by filing date | |
| PARTNER COMMUNICATIONS CO LT | 70211M109 | ADR | 617,951 | $2,700,000 | thousands by filing date | |
| Honeywell Technologies | 438516106 | COM | 25,595 | $2,651,000 | thousands by filing date | |
| RETROPHIN INC | 761299106 | COM | 135,000 | $2,604,000 | thousands by filing date | |
| INTRA-CELLULAR THERAPIES INC | 46116X101 | COMMON STOCK | 48,400 | $2,603,000 | thousands by filing date | |
| UNIQURE NV | N90064101 | SHS | 153,500 | $2,539,000 | thousands by filing date | |
| EXELIXIS INC COM | 30161Q104 | Stock | 450,000 | $2,538,000 | thousands by filing date | |
| COLUCID PHARMACEUTICALS INC | 19716T101 | COM | 285,525 | $2,390,000 | thousands by filing date | |
| ADVANCE AUTO PARTS INC | 00751Y106 | COM | 15,555 | $2,341,000 | thousands by filing date | |
| HALOZYME THERAPEUTICS INC COM | 40637H109 | Stock | 135,000 | $2,340,000 | thousands by filing date | |
| SUMMIT THERAPEUTICS INC COM | 86627R102 | Stock | 202,220 | $2,321,000 | thousands by filing date | |
| FORWARD PHARMA A/S | 34986J105 | SPONSORED ADR | 121,500 | $2,309,000 | thousands by filing date | |
| DIMENSION THERAPEUTICS INC | 25433V105 | COM | 200,000 | $2,256,000 | thousands by filing date | |
| MEDICINES CO | 584688105 | COM | 60,000 | $2,240,000 | thousands by filing date | |
| COGNIZANT TECHNOLOGY SOLUTIONS CL A | 192446102 | Stock | 36,600 | $2,197,000 | thousands by filing date | |
| DYNAVAX TECHNOLOGIES CORP | 268158201 | COM NEW | 90,000 | $2,174,000 | thousands by filing date | |
| VITAE PHARMACEUTICALS INC | 92847N103 | COM | 120,000 | $2,172,000 | thousands by filing date | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 66,020 | $2,139,000 | thousands by filing date | |
| PALATIN TECHNOLOGIES INC | 696077403 | COM PAR $ .01 | 3,132,926 | $2,080,000 | thousands by filing date | |
| CYNAPSUS THERAPEUTICS INC | 23257Y859 | COM PAR NO PAR | 134,037 | $2,070,000 | thousands by filing date | |
| Arbutus Biopharma Corp | 03879J100 | Common Shares, without par value | 454,500 | $2,023,000 | thousands by filing date | |
| ABEONA THERAPEUTICS INC | 00289Y107 | COM | 600,000 | $2,016,000 | thousands by filing date | |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 220,000 | $2,009,000 | thousands by filing date | |
| EDGE THERAPEUTICS INC | 279870109 | COM | 155,000 | $1,938,000 | thousands by filing date | |
| SCYNEXIS INC COM NEW | 811292101 | Common Stock | 304,600 | $1,892,000 | thousands by filing date | |
| TOBIRA THERAPEUTICS INC COM | 88883P101 | COM | 187,622 | $1,886,000 | thousands by filing date | |
| PIERIS PHARMACEUTICALS INC | 720795103 | COM | 810,000 | $1,855,000 | thousands by filing date | |
| NIVALIS THERAPEUTICS INC | 65481J109 | COM | 231,548 | $1,792,000 | thousands by filing date | |
| OCERA THERAPEUTICS INC COM | 67552A108 | COM | 550,000 | $1,716,000 | thousands by filing date | |
| TRILLIUM THERAPEUTICS INC COM NEW | 89620X506 | Stock | 132,300 | $1,668,000 | thousands by filing date | |
| GW PHARMACEUTICALS PLC | 36197T103 | ADS | 23,790 | $1,652,000 | thousands by filing date | |
| ALDEYRA THERAPEUTICS INC | 01438T106 | COM | 238,500 | $1,617,000 | thousands by filing date | |
| TESARO INC | 881569107 | COM | 30,686 | $1,605,000 | thousands by filing date | |
| NOVARTIS AG SPONSORED ADR | 66987V109 | ADR | 18,000 | $1,549,000 | thousands by filing date | |
| NABRIVA THERAPEUTICS AG | 62957M104 | SPONSORED ADR | 157,500 | $1,504,000 | thousands by filing date | |
| AXALTA COATING SYS LTD COM | G0750C108 | Stock | 56,173 | $1,497,000 | thousands by filing date | |
| NXP SEMICONDUCTORS N V COM | N6596X109 | Stock | 16,920 | $1,426,000 | thousands by filing date | |
| STRONGBRIDGE BIOPHARMA PLC | G85347105 | SHS USD | 181,818 | $1,382,000 | thousands by filing date | |
| Carbylan Therapeutics Inc. | 141384107 | COM | 360,000 | $1,303,000 | thousands by filing date | |
| PROQR THERAPEUTICS NV | N71542109 | SHS EURO | 150,000 | $1,302,000 | thousands by filing date | |
| LOXO ONCOLOGY INC | 548862101 | COM | 45,000 | $1,280,000 | thousands by filing date | |
| MANNKIND CORP | 56400P901 | Option | 760,000 | $1,102,000 | thousands by filing date | call |
| WABTEC COM | 929740108 | Stock | 12,761 | $908,000 | thousands by filing date | |
| ARRAY BIOPHARMA INC COM | 04269X105 | Stock | 215,000 | $907,000 | thousands by filing date | |
| DELPHI AUTOMOTIVE PLC | G27823106 | COMMON STOCK-FO | 10,065 | $863,000 | thousands by filing date | |
| ELLOMAY CAPITAL LIMITED | M39927120 | SHS | 95,653 | $824,000 | thousands by filing date | |
| WIX COM LTD SHS | M98068105 | Stock | 35,460 | $807,000 | thousands by filing date | |
| CHARTER COMMUNICATION - A | 16117M305 | COM | 4,026 | $737,000 | thousands by filing date | |
| CATABASIS PHARMACEUTICALS IN | 14875P107 | COM | 80,742 | $640,000 | thousands by filing date | |
| EZCHIP SEMICONDUCTOR LIMITED | M4146Y108 | ORD | 20,447 | $505,000 | thousands by filing date | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 3,700 | $388,000 | thousands by filing date | |
| ATYR PHARMA INC | 002120103 | COM | 36,450 | $358,000 | thousands by filing date | |
| GENVEC INC NEW | 37246C307 | cs | 186,500 | $343,000 | thousands by filing date | |
| ICL GROUP LTD ILS1 | M5920A109 | Common Stock | 69,083 | $280,000 | thousands by filing date | |
| SMITH A O CORP COM | 831865209 | Stock | 2,700 | $207,000 | thousands by filing date |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001178913-16-004256 | this filing | 2016-02-11 | acceptance time not in the bulk data set |