13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.
SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2015-03-31, filed 2015-05-11, with 147 holding rows worth $960,518,000.
- Accession
- 0001178913-15-001551
- Filer
- CIK 1496201
- Filed
- 2015-05-11
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q1 2015
A holdings report, 148 entries on the cover page, a total value of $960,518,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $960,518,000 with VALUE read as thousands by filing date, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerSphera Global Healthcare GP Ltd.028-15864
- included managerSphera Global Healthcare Management LP028-15865
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| ISHARES TR | 464287955 | PUT | 8,000 | $99,496,000 | thousands by filing date | put |
| SPDR S&P 500 ETF TR | 78462F953 | PUT | 3,500 | $72,251,000 | thousands by filing date | put |
| ACTAVIS PLC | G0083B108 | SHS | 192,100 | $57,173,000 | thousands by filing date | |
| Pfizer Inc. | 717081103 | COM | 1,024,013 | $35,625,000 | thousands by filing date | |
| SPDR SERIES TRUST | 78464A950 | PUT | 1,500 | $33,063,000 | thousands by filing date | put |
| Gilead Sciences,Inc. | 375558103 | COM | 320,000 | $31,402,000 | thousands by filing date | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 402,819 | $25,096,000 | thousands by filing date | |
| AbbVie,Inc. | 00287Y109 | COM | 407,000 | $23,826,000 | thousands by filing date | |
| TEVA PHARMACEUTICAL INDS LTD | 881624909 | CALL | 3,500 | $21,805,000 | thousands by filing date | call |
| Merck & Co.,Inc. | 58933Y105 | COM | 375,000 | $21,555,000 | thousands by filing date | |
| Amgen Inc. | 031162100 | COM | 120,200 | $19,214,000 | thousands by filing date | |
| ENDO INTL PLC | G30401106 | SHS | 210,000 | $18,837,000 | thousands by filing date | |
| MYLAN NV | N59465109 | SHS EURO | 272,100 | $16,149,000 | thousands by filing date | |
| AUSPEX PHARMACE | 05211J102 | Common Stock | 125,074 | $12,541,000 | thousands by filing date | |
| ORMAT TECHNOLOGIES INC | 686688102 | COM | 80,092 | $12,054,000 | thousands by filing date | |
| AMAG PHARMACEUTICALS INC | 00163U106 | COM | 200,230 | $10,945,000 | thousands by filing date | |
| ISHARES TR | 464287956 | ISHARES BIOTECH | 300 | $10,303,000 | thousands by filing date | put |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 80,000 | $9,970,000 | thousands by filing date | |
| NOVARTIS AG SPONSORED ADR | 66987V109 | ADR | 100,000 | $9,861,000 | thousands by filing date | |
| SELECT SECTOR SPDR TR | 81369Y959 | PUT | 1,300 | $9,425,000 | thousands by filing date | put |
| VALEANT PHARMACEUTICALS INTL | 91911K102 | COM | 45,750 | $9,087,000 | thousands by filing date | |
| UNITED THERAPEUTICS CORP DEL COM | 91307C102 | Stock | 48,840 | $8,422,000 | thousands by filing date | |
| CLOVIS ONCOLOGY INC | 189464100 | COM | 112,455 | $8,348,000 | thousands by filing date | |
| CELGENE CORP | 151020104 | COM | 70,000 | $8,070,000 | thousands by filing date | |
| VERINT SYS INC | 92343X100 | COM | 122,304 | $7,574,000 | thousands by filing date | |
| SHIRE PLC | 82481R106 | COMMON STOCK-FO | 134,751 | $7,229,000 | thousands by filing date | |
| SEATTLE GENETICS INC | 812578102 | COM | 200,000 | $7,070,000 | thousands by filing date | |
| iShares Russell 2000 ETF | 464287655 | SHS | 56,100 | $6,977,000 | thousands by filing date | |
| ARRAY BIOPHARMA INC COM | 04269X105 | Stock | 923,922 | $6,809,000 | thousands by filing date | |
| Bristol-Myers Squibb Company | 110122108 | COM | 100,000 | $6,450,000 | thousands by filing date | |
| DYAX CORP | 26746E103 | COM | 367,556 | $6,158,000 | thousands by filing date | |
| ASTRAZENECA PLC SPONSORED ADR | 046353108 | ADR | 86,637 | $5,929,000 | thousands by filing date | |
| CHECK POINT SOFTWARE TECH LTD ORD | M22465104 | Stock | 71,927 | $5,896,000 | thousands by filing date | |
| INSYS THERAPEUTICS INC | 45824V209 | COMMON STOCK | 100,000 | $5,813,000 | thousands by filing date | |
| BELLICUM PHARMACEUTICALS INC | 079481107 | COM | 249,567 | $5,693,000 | thousands by filing date | |
| CONCERT PHARMACEUTICALS INC | 206022105 | COM | 375,000 | $5,679,000 | thousands by filing date | |
| Apple Inc | 037833100 | COM | 42,733 | $5,317,000 | thousands by filing date | |
| TEKMIRA PHARMACEUTICALS COR | 87911B209 | COM NEW | 298,486 | $5,212,000 | thousands by filing date | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 250,000 | $5,200,000 | thousands by filing date | |
| KAMADA LTD | M6240T109 | SHS | 293,727 | $5,167,000 | thousands by filing date | |
| FORWARD PHARMA A/S | 34986J105 | SPONSORED ADR | 180,000 | $5,098,000 | thousands by filing date | |
| TOWERS WATSON & CO | 891894107 | CL A | 38,300 | $5,063,000 | thousands by filing date | |
| VANDA PHARMACEUTICALS INC | 921659108 | COM | 543,390 | $5,054,000 | thousands by filing date | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 450,000 | $4,896,000 | thousands by filing date | |
| RELYPSA INC | 759531106 | Common Stock | 135,000 | $4,869,000 | thousands by filing date | |
| CATALYST PHARMACEUTICALS INC | 14888U101 | COM | 1,100,000 | $4,763,000 | thousands by filing date | |
| APPLIED GENETIC TECHNOL CORP | 03820J100 | COM | 235,124 | $4,700,000 | thousands by filing date | |
| IMPAX LABORATORIES INC | 45256B101 | COM | 100,000 | $4,687,000 | thousands by filing date | |
| MEDIVATION INC | 58501N101 | COM | 36,115 | $4,661,000 | thousands by filing date | |
| KYTHERA BIOPHARMACEUTICALS I | 501570105 | COM | 90,000 | $4,514,000 | thousands by filing date | |
| DEPOMED INC | 249908104 | COM | 200,000 | $4,482,000 | thousands by filing date | |
| BROADCOM CORP | 111320107 | CL A | 100,800 | $4,364,000 | thousands by filing date | |
| CVS Health Corporation | 126650100 | COM | 42,260 | $4,362,000 | thousands by filing date | |
| Health Care Select Sector SPDR Fund | 81369Y209 | SHS | 59,853 | $4,339,000 | thousands by filing date | |
| ALEXION PHARMACEUTICALS INC | 015351109 | COM | 25,000 | $4,333,000 | thousands by filing date | |
| ALDER BIOPHARMACEUTICALS INC | 014339105 | COM | 150,000 | $4,329,000 | thousands by filing date | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 70,000 | $4,260,000 | thousands by filing date | |
| INTERCEPT PHARMACEUTICALS IN | 45845P108 | COM | 15,000 | $4,230,000 | thousands by filing date | |
| BIOGEN INC COM | 09062X103 | Stock | 10,000 | $4,222,000 | thousands by filing date | |
| Starbucks Corporation | 855244109 | COM | 87,308 | $4,134,000 | thousands by filing date | |
| SMITH A O CORP COM | 831865209 | Stock | 61,600 | $4,045,000 | thousands by filing date | |
| KITE PHARMA INC | 49803L109 | COM | 65,970 | $3,805,000 | thousands by filing date | |
| PORTOLA PHARMACEUTICALS INC COM | 737010108 | Stock | 100,023 | $3,797,000 | thousands by filing date | |
| ARIAD PHARMACEUTICALS INC | 04033A100 | COM | 445,000 | $3,667,000 | thousands by filing date | |
| PTC THERAPEUTICS INC | 69366J900 | COM | 600 | $3,651,000 | thousands by filing date | call |
| SPDR INDEX SHS FDS | 78463X202 | EURO STOXX 50 | 94,000 | $3,649,000 | thousands by filing date | |
| INTRA-CELLULAR THERAPIES INC | 46116X101 | COMMON STOCK | 150,000 | $3,582,000 | thousands by filing date | |
| PROTHENA CORP PLC SHS | G72800108 | Stock | 88,133 | $3,361,000 | thousands by filing date | |
| DYAX CORP | 26746E953 | Cmn | 2,000 | $3,351,000 | thousands by filing date | put |
| ESPERION THERAPEUTICS INC NEW COM | 29664W105 | Stock | 36,000 | $3,334,000 | thousands by filing date | |
| TJX Companies Inc | 872540109 | COM | 47,330 | $3,315,000 | thousands by filing date | |
| SAGE THERAPEUTICS INC | 78667J108 | COM | 65,724 | $3,301,000 | thousands by filing date | |
| PUMA BIOTECHNOLOGY INC | 74587V107 | COMMON STOCK | 13,796 | $3,257,000 | thousands by filing date | |
| ISHARES INC MSCI GERMANY ETF | 464286806 | MSCI GERMANY ETF | 108,000 | $3,223,000 | thousands by filing date | |
| GW PHARMACEUTICALS PLC | 36197T103 | ADS | 35,000 | $3,190,000 | thousands by filing date | |
| SUNESIS PHARMACEUTICALS INC | 867328601 | COM NEW | 1,300,000 | $3,185,000 | thousands by filing date | |
| V F CORP COM | 918204108 | Stock | 42,170 | $3,176,000 | thousands by filing date | |
| ORBOTECH LTD | M75253100 | ORD | 196,622 | $3,152,000 | thousands by filing date | |
| AEGERION PHARMACEUTICALS INC | 00767E102 | COM | 120,000 | $3,140,000 | thousands by filing date | |
| PERRIGO CO PLC SHS | G97822103 | Stock | 18,400 | $3,046,000 | thousands by filing date | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 75,000 | $2,978,000 | thousands by filing date | |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 100,000 | $2,932,000 | thousands by filing date | |
| KERYX BIOPHARMACEUTICALS | 492515101 | COMMON STOCK | 230,000 | $2,928,000 | thousands by filing date | |
| CELLDEX THERAPEUTICS INC NEW | 15117B103 | COM | 105,000 | $2,926,000 | thousands by filing date | |
| RECEPTOS, INC. | 756207106 | COMMON STOCK | 17,500 | $2,886,000 | thousands by filing date | |
| AERIE PHARMACEUTICALS INC | 00771V108 | COM | 90,000 | $2,821,000 | thousands by filing date | |
| EPIZYME INC | 29428V104 | COM | 150,000 | $2,817,000 | thousands by filing date | |
| MEDICINES CO | 584688105 | COM | 100,000 | $2,802,000 | thousands by filing date | |
| MEDICINES COMPANY | 584688905 | COM | 1,000 | $2,802,000 | thousands by filing date | call |
| TETRAPHASE PHARMACEUTICALS INC | 88165N105 | COMMON STOCK | 75,000 | $2,748,000 | thousands by filing date | |
| IMMUNE DESIGN CORP. | 45252L103 | Common Stock | 129,440 | $2,732,000 | thousands by filing date | |
| RETROPHIN INC | 761299106 | COM | 111,392 | $2,669,000 | thousands by filing date | |
| ATARA BIOTHERAPEUTICS INC COM NEW | 046513107 | Stock | 63,579 | $2,643,000 | thousands by filing date | |
| VERIFONE SYS INC | 92342Y109 | COM | 75,545 | $2,636,000 | thousands by filing date | |
| TREVENA INC | 89532E109 | COM | 391,811 | $2,555,000 | thousands by filing date | |
| UNIQURE NV | N90064101 | SHS | 102,415 | $2,491,000 | thousands by filing date | |
| OTONOMY INC | 68906L105 | COM | 70,000 | $2,475,000 | thousands by filing date | |
| AVALANCHE BIOT | 05337G107 | Common Stock | 60,000 | $2,431,000 | thousands by filing date | |
| SNAP ON INC COM | 833034101 | Stock | 15,340 | $2,256,000 | thousands by filing date | |
| THERAPEUTICSMD INC | 88338N107 | COM | 365,000 | $2,208,000 | thousands by filing date | |
| SANGAMO THERAPEUTICS INC | 800677106 | COM | 140,000 | $2,195,000 | thousands by filing date | |
| SUMMIT THERAPEUTICS INC COM | 86627R102 | Stock | 175,000 | $2,168,000 | thousands by filing date | |
| Rocket Pharmaceuticals Inc | 45780V102 | SHS | 400,000 | $2,168,000 | thousands by filing date | |
| ISHARES TR | 464288752 | US HOME CONS ETF | 76,000 | $2,145,000 | thousands by filing date | |
| PRICELINE GRP INC | 741503403 | COM NEW | 1,820 | $2,119,000 | thousands by filing date | |
| WABTEC COM | 929740108 | Stock | 21,500 | $2,043,000 | thousands by filing date | |
| STERICYCLE INC | 858912108 | COM | 14,500 | $2,036,000 | thousands by filing date | |
| TRILLIUM THERAPEUTICS INC COM NEW | 89620X506 | Stock | 95,000 | $1,922,000 | thousands by filing date | |
| MARINUS PHARMACEUTICALS INC | 56854Q101 | COM | 213,533 | $1,920,000 | thousands by filing date | |
| Union Pacific Corporation | 907818108 | COM | 17,489 | $1,894,000 | thousands by filing date | |
| ELLOMAY CAPITAL LIMITED | M39927120 | SHS | 221,678 | $1,884,000 | thousands by filing date | |
| MACROGENICS INC | 556099109 | COM | 60,000 | $1,882,000 | thousands by filing date | |
| Adobe Systems Inc | 98979H103 | COM | 184,619 | $1,866,000 | thousands by filing date | |
| Transition Therapeutics, Inc. | 893716209 | COM | 272,906 | $1,864,000 | thousands by filing date | |
| FOAMIX PHARMACEUTICALS LTD | M46135105 | SHS | 200,000 | $1,850,000 | thousands by filing date | |
| GENTHERM INC | 37253A103 | COM | 34,550 | $1,745,000 | thousands by filing date | |
| CELLECTIS ADS | 15117K103 | COM | 50,000 | $1,729,000 | thousands by filing date | |
| TOKAI PHARMACEUTICALS INC COM | 88907J107 | Stock | 146,341 | $1,654,000 | thousands by filing date | |
| CONATUS PHARMACEUTICALS INC | 20600T108 | COM | 220,000 | $1,566,000 | thousands by filing date | |
| MANNKIND CORP COMMON STOCK | 56400P951 | Cmn | 3,000 | $1,560,000 | thousands by filing date | put |
| GENVEC INC NEW | 37246C307 | cs | 528,325 | $1,559,000 | thousands by filing date | |
| OCERA THERAPEUTICS INC COM | 67552A108 | COM | 321,254 | $1,513,000 | thousands by filing date | |
| GALECTIN THERAPEUTICS INC | 363225202 | COMMON STOCK | 450,000 | $1,508,000 | thousands by filing date | |
| GENOCEA BIOSCIENCES INC | 372427104 | COM | 124,200 | $1,473,000 | thousands by filing date | |
| Medgenics Inc New | 58436Q203 | COM NEW | 175,000 | $1,411,000 | thousands by filing date | |
| NEWLINK GENETICS CORP | 651511107 | COM | 25,000 | $1,368,000 | thousands by filing date | |
| ASSEMBLY BIOSCIENCES INC | 045396108 | COM | 100,000 | $1,324,000 | thousands by filing date | |
| EXELIXIS INC COM | 30161Q104 | Stock | 500,000 | $1,285,000 | thousands by filing date | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 70,000 | $1,215,000 | thousands by filing date | |
| ALDEYRA THERAPEUTICS INC | 01438T106 | COM | 115,000 | $1,194,000 | thousands by filing date | |
| STEMLINE THERAPEUTICS INC | 85858C107 | COM | 80,957 | $1,171,000 | thousands by filing date | |
| HERON THERAPEUTICS INC | 427746102 | COM | 79,900 | $1,163,000 | thousands by filing date | |
| SAGENT PHARMACEUTICALS INC | 786692103 | COM | 50,000 | $1,163,000 | thousands by filing date | |
| IMMUNOMEDICS INC | 452907108 | COM | 300,000 | $1,149,000 | thousands by filing date | |
| CYMABAY THERAPEUTICS INC | 23257D103 | COM | 157,179 | $1,088,000 | thousands by filing date | |
| PALATIN TECHNOLOGIES INC | 696077403 | COM PAR $ .01 | 1,040,266 | $1,061,000 | thousands by filing date | |
| AURIS MED HLDG AG | H03579101 | COM | 186,300 | $997,000 | thousands by filing date | |
| JUNO THERAPEUTICS INC | 48205A109 | COM | 15,000 | $910,000 | thousands by filing date | |
| SESEN BIO, INC. | 286221106 | COM | 87,110 | $777,000 | thousands by filing date | |
| MAST THERAPEUTICS INC | 576314108 | COM | 1,374,900 | $667,000 | thousands by filing date | |
| ACHILLION PHARMACEUTICALS IN | 00448Q201 | COM | 65,538 | $646,000 | thousands by filing date | |
| OHR PHARMACEUTICAL INC | 67778H200 | COMMON STOCK | 187,500 | $476,000 | thousands by filing date | |
| SAPIENS INTERNATIONAL CORP | N7716A151 | SHS | 56,420 | $463,000 | thousands by filing date | |
| BIOLINERX LTD-SPONS ADR | 09071M106 | SPON | 193,284 | $408,000 | thousands by filing date | |
| SPECTRUM PHARMACEUTICALS INC | 84763A108 | COM | 50,000 | $304,000 | thousands by filing date | |
| Alcobra Ltd | M2239P109 | SHS | 200 | $1,000 | thousands by filing date | |
| LUMENIS LTD | M6778Q121 | SHS CL B | 245 | $0 | thousands by filing date | Value filed as zero, left out of ratios. |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001178913-15-001551 | this filing | 2015-05-11 | acceptance time not in the bulk data set |