13F-HR filed by ORBIMED ADVISORS LLC
ORBIMED ADVISORS LLC filed this 13F-HR for the quarter ended 2023-12-31, filed 2024-02-14, with 110 holding rows worth $5,007,244,053.
- Accession
- 0001172661-24-001461
- Filer
- CIK 1055951
- Filed
- 2024-02-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2023
A holdings report, 111 entries on the cover page, a total value of $5,007,244,053 stated on the cover page (in dollars after the unit check, H1), rows summing to $5,007,244,053 with VALUE read as dollars as filed, 13F file number 028-06774. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerORBIMED CAPITAL LLC028-10410
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SINOVAC BIOTECH LTD | P8696W104 | SHS | 2,718,735 | $340,000,000 | dollars as filed | |
| BIOGEN INC COM | 09062X103 | Stock | 827,600 | $214,158,052 | dollars as filed | |
| Eli Lilly and Company | 532457108 | COM | 365,400 | $212,998,968 | dollars as filed | |
| Boston Scientific Corporation | 101137107 | COM | 3,306,800 | $191,166,108 | dollars as filed | |
| Intuitive Surgical,Inc. | 46120E602 | COM | 499,000 | $168,342,640 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 14,567,176 | $159,364,905 | dollars as filed | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 1,571,410 | $151,515,352 | dollars as filed | |
| RAYZEBIO INC | 75525N107 | COM | 2,365,213 | $147,045,292 | dollars as filed | |
| ENLIVEN THERAPEUTICS INC COM | 29337E102 | Stock | 8,998,338 | $124,536,998 | dollars as filed | |
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 3,219,359 | $117,506,604 | dollars as filed | |
| Merck & Co.,Inc. | 58933Y105 | COM | 1,055,000 | $115,016,100 | dollars as filed | |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 2,064,797 | $104,458,080 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 1,702,237 | $98,321,209 | dollars as filed | |
| GRACELL BIOTECHNOLOGIES INC | 38406L103 | ADR | 9,308,726 | $93,459,609 | dollars as filed | |
| TENET HEALTHCARE CORP COM NEW | 88033G407 | Stock | 1,224,400 | $92,527,908 | dollars as filed | |
| EVOLENT HEALTH INC CL A | 30050B101 | Stock | 2,746,532 | $90,717,952 | dollars as filed | |
| UNITED THERAPEUTICS CORP DEL COM | 91307C102 | Stock | 386,100 | $84,899,529 | dollars as filed | |
| XTANT MED HLDGS INC | 98420P308 | COM NEW | 73,114,592 | $82,619,489 | dollars as filed | |
| Stryker Corporation | 863667101 | COM | 269,000 | $80,554,740 | dollars as filed | |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 4,245,000 | $79,806,000 | dollars as filed | |
| Thermo Fisher Scientific Inc. | 883556102 | COM | 143,800 | $76,327,602 | dollars as filed | |
| VERONA PHARMA PLC | 925050106 | SPONSORED ADS | 3,777,778 | $75,102,227 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 1,153,091 | $72,414,115 | dollars as filed | |
| THESEUS PHARMACEUTICALS INC | 88369M101 | COM | 17,713,600 | $71,740,080 | dollars as filed | |
| Vertex Pharmaceuticals Incorporated | 92532F100 | COM | 175,200 | $71,287,128 | dollars as filed | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 519,279 | $68,420,201 | dollars as filed | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 697,500 | $67,259,925 | dollars as filed | |
| Elevance Health, Inc. | 036752103 | COM | 141,500 | $66,725,740 | dollars as filed | |
| THIRD HARMONIC BIO INC | 88427A107 | COM | 5,779,071 | $63,396,409 | dollars as filed | |
| NATERA INC COM | 632307104 | Stock | 954,481 | $59,788,690 | dollars as filed | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 1,667,360 | $59,324,669 | dollars as filed | |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 922,200 | $55,202,892 | dollars as filed | |
| R1 RCM INC | 77634L105 | COM | 4,803,200 | $50,769,824 | dollars as filed | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 9,240,887 | $50,640,061 | dollars as filed | |
| KEROS THERAPEUTICS INC COM | 492327101 | Stock | 1,268,734 | $50,444,864 | dollars as filed | |
| HUMANA INC COM | 444859102 | Stock | 109,900 | $50,313,319 | dollars as filed | |
| TERNS PHARMACEUTICALS INC COM | 880881107 | Stock | 7,619,135 | $49,448,186 | dollars as filed | |
| ALPINE IMMUNE SCIENCES INC | 02083G100 | COM | 2,535,245 | $48,321,770 | dollars as filed | |
| SI BONE INC | 825704109 | COM | 2,292,531 | $48,120,226 | dollars as filed | |
| PRELUDE THERAPEUTICS INC | 74065P101 | CMN | 10,909,256 | $46,582,523 | dollars as filed | |
| ALX ONCOLOGY HOLDINGS INC | 00166B105 | COMMON STOCK | 3,095,000 | $46,084,550 | dollars as filed | |
| NEUROPACE INC | 641288105 | COMMON STOCK | 4,003,967 | $41,280,900 | dollars as filed | |
| IOVANCE BIOTHERAPEUTICS INC | 462260100 | COM | 4,707,458 | $38,271,634 | dollars as filed | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 1,749,000 | $37,795,890 | dollars as filed | |
| ICON PUB LTD CO SHS | G4705A100 | Stock | 132,200 | $37,421,854 | dollars as filed | |
| UnitedHealth Group Inc | 91324P102 | COM | 70,000 | $36,852,900 | dollars as filed | |
| 0 | 000000000 | 0 | 12,048,773 | $36,800,510 | dollars as filed | |
| Amgen Inc. | 031162100 | COM | 127,300 | $36,664,946 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 1,277,901 | $35,704,554 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 3,317,927 | $35,601,357 | dollars as filed | |
| COMPASS THERAPEUTICS INC | 20454B104 | COM | 22,362,850 | $34,886,046 | dollars as filed | |
| SCPHARMACEUTICALS INC | 810648105 | COM | 5,559,528 | $34,858,241 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 84,600 | $32,184,378 | dollars as filed | |
| FUSION PHARMACEUTICALS INC | 36118A100 | COM | 3,122,770 | $30,009,820 | dollars as filed | |
| ACELYRIN INC | 00445A100 | COM | 4,001,711 | $29,852,764 | dollars as filed | |
| NEUMORA THERAPEUTICS INC. | 640979100 | COM | 1,500,000 | $25,575,000 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 550,000 | $25,333,000 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 536,642 | $24,669,433 | dollars as filed | |
| REPARE THERAPEUTICS INC | 760273102 | COM | 3,322,488 | $24,254,162 | dollars as filed | |
| ABCELLERA BIOLOGICS INC COM | 00288U106 | Stock | 4,180,768 | $23,872,185 | dollars as filed | |
| VERA THERAPEUTICS INC | 92337R101 | COMMON STOCK | 1,518,115 | $23,348,609 | dollars as filed | |
| PMV PHARMACEUTICALS INC | 69353Y103 | COM | 6,475,291 | $20,073,402 | dollars as filed | |
| KINNATE BIOPHARMA INC | 49705R105 | COM | 8,009,729 | $18,983,058 | dollars as filed | |
| TELA BIO INC | 872381108 | COM | 2,835,542 | $18,771,288 | dollars as filed | |
| AEROVATE THERAPEUTICS INC | 008064107 | COM | 756,930 | $17,129,326 | dollars as filed | |
| INVIVYD INC | 00534A102 | COMMON STOCK | 4,127,565 | $16,262,606 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 1,543,407 | $16,252,076 | dollars as filed | |
| ADICET BIO INC | 007002108 | COM | 8,322,140 | $15,728,845 | dollars as filed | |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 79,400 | $15,197,954 | dollars as filed | |
| Pfizer Inc. | 717081103 | COM | 500,000 | $14,395,000 | dollars as filed | call |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 103,700 | $12,865,022 | dollars as filed | |
| VERASTEM INC | 92337C203 | COMMON STOCK | 1,529,115 | $12,446,996 | dollars as filed | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 6,943,654 | $12,220,831 | dollars as filed | |
| REGENERON PHARMACEUTICALS COM | 75886F107 | Stock | 13,500 | $11,856,915 | dollars as filed | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 806,000 | $11,437,140 | dollars as filed | |
| PASSAGE BIO INC | 702712100 | COM | 10,124,576 | $10,225,822 | dollars as filed | |
| HERON THERAPEUTICS INC | 427746102 | COM | 5,928,591 | $10,078,605 | dollars as filed | |
| ARROWHEAD PHARMACEUTICALS IN | 04280A100 | COM | 319,651 | $9,781,321 | dollars as filed | |
| UNIQURE NV | N90064101 | SHS | 1,347,900 | $9,125,283 | dollars as filed | |
| DEXCOM INC COM | 252131107 | Stock | 73,200 | $9,083,388 | dollars as filed | |
| APOLLOMICS INC | G0411D107 | COM | 8,565,456 | $8,265,665 | dollars as filed | |
| Gilead Sciences,Inc. | 375558103 | COM | 100,000 | $8,101,000 | dollars as filed | |
| MORPHIC HLDG INC | 61775R105 | COM | 273,400 | $7,895,792 | dollars as filed | |
| TURNSTONE BIOLOGICS CORP | 90042W100 | COM | 3,099,265 | $7,887,629 | dollars as filed | |
| RAPT THERAPEUTICS INC | 75382E109 | COM | 281,413 | $6,993,113 | dollars as filed | |
| IKENA ONCOLOGY INC | 45175G108 | COM | 3,539,358 | $6,972,535 | dollars as filed | |
| INSPIREMD INC | 45779A846 | COM | 2,133,405 | $5,994,868 | dollars as filed | |
| X4 Pharmaceuticals, Inc. | 98420X103 | COM | 7,133,515 | $5,981,452 | dollars as filed | |
| CULLINAN THERAPEUTICS INC | 230031106 | COM | 544,848 | $5,552,001 | dollars as filed | |
| ORIC PHARMACEUTICALS INC | 68622P109 | COM | 522,968 | $4,811,306 | dollars as filed | |
| ILLUMINA INC | 452327109 | COM | 30,300 | $4,218,972 | dollars as filed | |
| AMBRX BIOPHARMA INC | 641871108 | COM | 296,000 | $4,215,040 | dollars as filed | |
| NEXTCURE INC | 65343E108 | COM | 2,711,013 | $3,090,555 | dollars as filed | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 58,800 | $2,332,008 | dollars as filed | |
| ARCUS BIOSCIENCES INC | 03969F109 | COM | 117,000 | $2,234,700 | dollars as filed | |
| 10X GENOMICS INC CL A COM | 88025U109 | Stock | 39,800 | $2,227,208 | dollars as filed | |
| FATE THERAPEUTICS INC | 31189P102 | COM | 528,080 | $1,975,019 | dollars as filed | |
| KEZAR LIFE SCIENCES INC | 49372L100 | COM | 1,927,000 | $1,825,640 | dollars as filed | |
| BOLT BIOTHERAPEUTICS INC | 097702104 | COM | 1,541,000 | $1,725,920 | dollars as filed | |
| LAKESHORE BIOPHARMA CO LTD | G9845F109 | COM | 3,236,311 | $1,653,755 | dollars as filed | |
| VIGIL NEUROSCIENCE INC | 92673K108 | COM | 448,891 | $1,517,252 | dollars as filed | |
| BIOMX INC | 09090D103 | COM | 4,517,589 | $1,264,925 | dollars as filed | |
| CHEMOMAB THERAPEUTICS LTD | 16385C104 | SPONSORED ADS | 2,241,274 | $1,143,050 | dollars as filed | |
| GERON CORP | 374163103 | COM | 485,000 | $1,023,350 | dollars as filed | |
| VIR BIOTECHNOLOGY INC | 92764N102 | COM | 101,000 | $1,016,060 | dollars as filed | |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 45,000 | $1,002,150 | dollars as filed | |
| CALCIMEDICA INC | 38942Q202 | COM NEW | 297,380 | $850,507 | dollars as filed | |
| ELEVATION ONCOLOGY INC COM | 28623U101 | Stock | 1,500,000 | $805,500 | dollars as filed | |
| ACUTUS MED INC | 005111109 | COM | 2,648,386 | $534,709 | dollars as filed | |
| SINGULAR GENOMICS SYSTEMS IN | 82933R100 | COM | 540,697 | $248,775 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001172661-24-001461 | this filing | 2024-02-14 | acceptance time not in the bulk data set |