13F-HR filed by ORBIMED ADVISORS LLC
ORBIMED ADVISORS LLC filed this 13F-HR for the quarter ended 2022-12-31, filed 2023-02-14, with 115 holding rows worth $5,227,458,389.
- Accession
- 0001172661-23-001310
- Filer
- CIK 1055951
- Filed
- 2023-02-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2022
A holdings report, 116 entries on the cover page, a total value of $5,227,458,389 stated on the cover page (in dollars after the unit check, H1), rows summing to $5,227,458,389 with VALUE read as dollars as filed, 13F file number 028-06774. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerORBIMED CAPITAL LLC028-10410
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SINOVAC BIOTECH LTD | P8696W104 | SHS | 2,718,735 | $340,000,000 | dollars as filed | |
| UnitedHealth Group Inc | 91324P102 | COM | 380,500 | $201,733,490 | dollars as filed | |
| Bristol-Myers Squibb Company | 110122108 | COM | 2,584,900 | $185,983,555 | dollars as filed | |
| Boston Scientific Corporation | 101137107 | COM | 3,898,200 | $180,369,714 | dollars as filed | |
| HUMANA INC COM | 444859102 | Stock | 348,700 | $178,600,653 | dollars as filed | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 1,615,210 | $167,158,083 | dollars as filed | |
| Intuitive Surgical,Inc. | 46120E602 | COM | 620,500 | $164,649,675 | dollars as filed | |
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 5,250,000 | $136,552,500 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 14,567,176 | $130,230,553 | dollars as filed | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 972,300 | $125,990,634 | dollars as filed | |
| VERONA PHARMA PLC | 925050106 | SPONSORED ADS | 4,572,289 | $119,473,912 | dollars as filed | |
| Stryker Corporation | 863667101 | COM | 481,000 | $117,599,690 | dollars as filed | |
| SEAGEN INC | 81181C104 | COM | 913,812 | $117,433,980 | dollars as filed | |
| COMPASS THERAPEUTICS INC | 20454B104 | COM | 22,362,850 | $112,485,136 | dollars as filed | |
| Thermo Fisher Scientific Inc. | 883556102 | COM | 202,200 | $111,349,518 | dollars as filed | |
| THESEUS PHARMACEUTICALS INC | 88369M101 | COM | 17,233,668 | $85,823,667 | dollars as filed | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 687,700 | $82,138,888 | dollars as filed | |
| KEROS THERAPEUTICS INC COM | 492327101 | Stock | 1,679,417 | $80,645,604 | dollars as filed | |
| EVOLENT HEALTH INC CL A | 30050B101 | Stock | 2,824,832 | $79,321,283 | dollars as filed | |
| Vertex Pharmaceuticals Incorporated | 92532F100 | COM | 271,500 | $78,403,770 | dollars as filed | |
| NATERA INC COM | 632307104 | Stock | 1,946,353 | $78,185,000 | dollars as filed | |
| TERNS PHARMACEUTICALS INC COM | 880881107 | Stock | 7,619,135 | $77,562,794 | dollars as filed | |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 1,993,600 | $75,298,272 | dollars as filed | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 8,740,887 | $74,559,766 | dollars as filed | |
| BIOGEN INC COM | 09062X103 | Stock | 258,200 | $71,500,744 | dollars as filed | |
| Pfizer Inc. | 717081103 | COM | 1,393,600 | $71,408,064 | dollars as filed | |
| ADICET BIO INC | 007002108 | COM | 7,447,140 | $66,577,432 | dollars as filed | |
| EDWARDS LIFESCIENCES CORP COM | 28176E108 | Stock | 860,500 | $64,201,905 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 1,283,126 | $61,525,892 | dollars as filed | |
| VECTIVBIO HLDG AG | H9060V101 | COM | 7,006,861 | $60,714,451 | dollars as filed | |
| PRELUDE THERAPEUTICS INC | 74065P101 | CMN | 10,039,691 | $60,639,734 | dollars as filed | |
| TENET HEALTHCARE CORP COM NEW | 88033G407 | Stock | 1,220,300 | $59,538,437 | dollars as filed | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 3,196,876 | $58,502,831 | dollars as filed | |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 1,283,692 | $58,164,085 | dollars as filed | |
| PMV PHARMACEUTICALS INC | 69353Y103 | COM | 6,563,077 | $57,098,770 | dollars as filed | |
| CHINOOK THERAPEUTICS INC | 16961L106 | COM | 2,029,300 | $53,167,660 | dollars as filed | |
| Mersana Therapeutics Inc | 59045L106 | Common Stock | 9,011,437 | $52,807,021 | dollars as filed | |
| 0 | 000000000 | 0 | 12,147,877 | $51,512,381 | dollars as filed | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 2,006,500 | $51,065,425 | dollars as filed | |
| REPARE THERAPEUTICS INC | 760273102 | COM | 3,322,488 | $48,873,798 | dollars as filed | |
| XTANT MED HLDGS INC | 98420P308 | COM NEW | 73,114,592 | $48,255,631 | dollars as filed | |
| 89BIO INC | 282559103 | COM | 3,658,869 | $46,577,402 | dollars as filed | |
| SI BONE INC | 825704109 | COM | 3,368,000 | $45,804,800 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 1,149,100 | $45,309,013 | dollars as filed | |
| ACLARIS THERAPEUTICS INC COM | 00461U105 | Stock | 2,758,434 | $43,445,336 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 2,160,941 | $42,981,116 | dollars as filed | |
| ABCELLERA BIOLOGICS INC COM | 00288U106 | Stock | 4,180,768 | $42,351,180 | dollars as filed | |
| SCPHARMACEUTICALS INC | 810648105 | COM | 5,559,528 | $39,861,816 | dollars as filed | |
| UNIQURE NV | N90064101 | SHS | 1,747,555 | $39,617,072 | dollars as filed | |
| BELLUS HEALTH INC NEW | 07987C204 | COM | 4,708,900 | $38,658,842 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 2,836,386 | $37,355,204 | dollars as filed | |
| ARCUTIS BIOTHERAPEUTICS INC | 03969K108 | COM | 2,460,108 | $36,409,598 | dollars as filed | |
| TELA BIO INC | 872381108 | COM | 3,027,542 | $34,816,733 | dollars as filed | |
| ALX ONCOLOGY HOLDINGS INC | 00166B105 | COMMON STOCK | 2,871,000 | $32,356,170 | dollars as filed | |
| KEZAR LIFE SCIENCES INC | 49372L100 | COM | 4,584,322 | $32,273,627 | dollars as filed | |
| PROGYNY INC COM | 74340E103 | Stock | 1,035,000 | $32,240,250 | dollars as filed | |
| Ventyx Biosciences Inc | 92332V107 | Common Stock | 925,000 | $30,330,750 | dollars as filed | |
| ALPINE IMMUNE SCIENCES INC | 02083G100 | COM | 4,081,592 | $29,999,701 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 1,253,130 | $26,353,324 | dollars as filed | |
| THIRD HARMONIC BIO INC | 88427A107 | COM | 5,779,071 | $24,850,005 | dollars as filed | |
| RAPT THERAPEUTICS INC | 75382E109 | COM | 1,251,070 | $24,771,186 | dollars as filed | |
| KINNATE BIOPHARMA INC | 49705R105 | COM | 4,043,629 | $24,666,137 | dollars as filed | |
| CINCOR PHARMA INC | 17240Y109 | COM | 1,906,000 | $23,424,740 | dollars as filed | |
| AEROVATE THERAPEUTICS INC | 008064107 | COM | 759,540 | $22,254,522 | dollars as filed | |
| HORIZON THERAPEUTICS PLC | G46188101 | SHS | 171,000 | $19,459,800 | dollars as filed | |
| GRACELL BIOTECHNOLOGIES INC | 38406L103 | ADR | 7,884,870 | $18,135,201 | dollars as filed | |
| IMARA INC | 45249V107 | COM | 4,386,568 | $17,941,063 | dollars as filed | |
| GH RESEARCH PLC ORDINARY SHARES | G3855L106 | Stock | 1,622,060 | $15,766,423 | dollars as filed | |
| RXSIGHT INC | 78349D107 | COM | 1,202,833 | $15,239,894 | dollars as filed | |
| MODERNA INC | 60770K107 | COM | 82,550 | $14,827,631 | dollars as filed | |
| IOVANCE BIOTHERAPEUTICS INC | 462260100 | COM | 2,007,458 | $12,827,657 | dollars as filed | |
| Bridgebio Pharma Inc Note 2.250 percent 2/0 | 10806XAD4 | Convertible | 30,000,000 | $12,600,000 | dollars as filed | principal |
| PASSAGE BIO INC | 702712100 | COM | 8,931,999 | $12,326,159 | dollars as filed | |
| FUSION PHARMACEUTICALS INC | 36118A100 | COM | 3,224,770 | $10,158,026 | dollars as filed | |
| DECIBEL THERAPEUTICS INC | 24343R106 | COM | 4,945,192 | $10,137,644 | dollars as filed | |
| 2SEVENTY BIO INC COMMON STOCK | 901384107 | Stock | 1,041,300 | $9,756,981 | dollars as filed | |
| ORIC PHARMACEUTICALS INC | 68622P109 | COM | 1,607,568 | $9,468,576 | dollars as filed | |
| CHEMOMAB THERAPEUTICS LTD | 16385C104 | SPONSORED ADS | 2,578,174 | $8,250,157 | dollars as filed | |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 879,003 | $7,954,977 | dollars as filed | |
| MEREO BIOPHARMA GROUP PLC | 589492107 | CMN | 10,605,522 | $7,954,142 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806XAB8 | NOTE 2.500% 3/1 | 20,000,000 | $7,950,000 | dollars as filed | principal |
| INVIVYD INC | 00534A102 | COMMON STOCK | 5,270,400 | $7,905,600 | dollars as filed | |
| IKENA ONCOLOGY INC | 45175G108 | COM | 2,933,941 | $7,804,283 | dollars as filed | |
| CULLINAN THERAPEUTICS INC | 230031106 | COM | 637,287 | $6,723,378 | dollars as filed | |
| VERASTEM INC | 92337C104 | COM | 16,503,237 | $6,642,553 | dollars as filed | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 76,400 | $6,341,200 | dollars as filed | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 516,000 | $6,300,360 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 16,200 | $6,137,046 | dollars as filed | |
| NEUROPACE INC | 641288105 | COMMON STOCK | 4,012,281 | $5,978,299 | dollars as filed | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 6,943,654 | $5,902,106 | dollars as filed | |
| X4 Pharmaceuticals, Inc. | 98420X103 | COM | 5,817,726 | $5,777,002 | dollars as filed | |
| VIGIL NEUROSCIENCE INC | 92673K108 | COM | 448,891 | $5,611,138 | dollars as filed | |
| BIONTECH SE SPONSORED ADS | 09075V102 | ADR | 36,300 | $5,452,986 | dollars as filed | |
| SANOFI SA SPONSORED ADR | 80105N105 | ADR | 100,000 | $4,843,000 | dollars as filed | call |
| GALECTO INC | 36322Q107 | COM | 4,090,937 | $4,704,578 | dollars as filed | |
| SYNLOGIC INC | 87166L100 | COM | 6,029,995 | $4,582,796 | dollars as filed | |
| NEXTCURE INC | 65343E108 | COM | 2,711,013 | $3,822,528 | dollars as filed | |
| AMNEAL PHARMACEUTICALS INC | 03168L105 | COM STK CL A | 1,583,490 | $3,151,145 | dollars as filed | |
| ACUTUS MED INC | 005111109 | COM | 2,648,386 | $3,045,644 | dollars as filed | |
| BIOATLA INC | 09077B104 | COM | 332,372 | $2,742,069 | dollars as filed | |
| Applied Therapeutics Inc | 03828A101 | Common Stock | 3,050,921 | $2,318,700 | dollars as filed | |
| PROTARA THERAPEUTICS INC | 74365U107 | COM STK | 830,641 | $2,226,118 | dollars as filed | |
| GRAYBUG VISION INC COM | 38942Q103 | SHS | 4,163,347 | $2,081,674 | dollars as filed | |
| GOODRX HLDGS INC | 38246G108 | COM CL A | 387,567 | $1,806,062 | dollars as filed | |
| EYEPOINT INC COM NEW | 30233G209 | Stock | 487,642 | $1,706,747 | dollars as filed | |
| CYBIN INC | 23256X100 | COM | 5,386,299 | $1,651,629 | dollars as filed | |
| PYXIS ONCOLOGY INC COMMON STOCK | 747324101 | Stock | 848,252 | $1,136,658 | dollars as filed | |
| HARPOON THERAPEUTICS INC | 41358P106 | COM | 1,516,496 | $1,100,521 | dollars as filed | |
| SINGULAR GENOMICS SYSTEMS IN | 82933R100 | COM | 540,697 | $1,086,801 | dollars as filed | |
| BOLT BIOTHERAPEUTICS INC | 097702104 | COM | 771,059 | $1,002,377 | dollars as filed | |
| ESSA PHARMA INC | 29668H708 | COM NEW | 365,300 | $920,556 | dollars as filed | |
| Merrimack Pharmaceuticals Inc | 590328209 | Common / Ordinary Stock | 73,600 | $843,456 | dollars as filed | |
| AEGLEA BIOTHERAPEUTICS INC | 00773J103 | COM | 1,797,221 | $808,570 | dollars as filed | |
| BIOMX INC | 09090D103 | COM | 2,813,489 | $525,278 | dollars as filed | |
| MONTE ROSA THERAPEUTICS INC | 61225M102 | COM | 27,369 | $208,278 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001172661-23-001310 | this filing | 2023-02-14 | acceptance time not in the bulk data set |