13F-HR filed by ORBIMED ADVISORS LLC
ORBIMED ADVISORS LLC filed this 13F-HR for the quarter ended 2021-12-31, filed 2022-02-14, with 158 holding rows worth $7,778,455,000.
- Accession
- 0001172661-22-000795
- Filer
- CIK 1055951
- Filed
- 2022-02-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2021
A holdings report, 159 entries on the cover page, a total value of $7,778,455,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $7,778,455,000 with VALUE read as thousands by filing date, 13F file number 028-06774. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerORBIMED CAPITAL LLC028-10410
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 6,028,307 | $373,634,000 | thousands by filing date | |
| Bristol-Myers Squibb Company | 110122108 | COM | 4,339,800 | $270,587,000 | thousands by filing date | |
| HORIZON THERAPEUTICS PLC | G46188101 | SHS | 2,500,055 | $269,406,000 | thousands by filing date | |
| Boston Scientific Corporation | 101137107 | COM | 5,552,300 | $235,862,000 | thousands by filing date | |
| THESEUS PHARMACEUTICALS INC | 88369M101 | COM | 16,838,668 | $213,514,000 | thousands by filing date | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 13,944,680 | $213,075,000 | thousands by filing date | |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 1,426,400 | $209,239,000 | thousands by filing date | |
| PMV PHARMACEUTICALS INC | 69353Y103 | COM | 7,330,423 | $169,333,000 | thousands by filing date | |
| Pfizer Inc. | 717081103 | COM | 2,615,400 | $154,439,000 | thousands by filing date | |
| 0 | 000000000 | 0 | 11,895,652 | $148,660,000 | thousands by filing date | Value about 1/1,000 of the price other filers imply, kept as filed and left out of ratios. |
| HUMANA INC COM | 444859102 | Stock | 318,300 | $147,647,000 | thousands by filing date | |
| AbbVie,Inc. | 00287Y109 | COM | 1,068,800 | $144,716,000 | thousands by filing date | |
| Vertex Pharmaceuticals Incorporated | 92532F100 | COM | 658,100 | $144,519,000 | thousands by filing date | |
| EDWARDS LIFESCIENCES CORP COM | 28176E108 | Stock | 1,076,200 | $139,422,000 | thousands by filing date | |
| Merck & Co.,Inc. | 58933Y105 | COM | 1,779,300 | $136,366,000 | thousands by filing date | |
| UnitedHealth Group Inc | 91324P102 | COM | 271,000 | $136,080,000 | thousands by filing date | |
| Intuitive Surgical,Inc. | 46120E602 | COM | 373,800 | $134,306,000 | thousands by filing date | |
| NATERA INC COM | 632307104 | Stock | 1,413,985 | $132,052,000 | thousands by filing date | |
| ADICET BIO INC | 007002108 | COM | 7,447,141 | $130,250,000 | thousands by filing date | |
| ARCUTIS BIOTHERAPEUTICS INC | 03969K108 | COM | 6,073,850 | $125,972,000 | thousands by filing date | |
| PRELUDE THERAPEUTICS INC | 74065P101 | CMN | 10,039,691 | $124,994,000 | thousands by filing date | |
| Stryker Corporation | 863667101 | COM | 465,300 | $124,431,000 | thousands by filing date | |
| GUARDANT HEALTH INC COM | 40131M109 | Stock | 1,227,400 | $122,765,000 | thousands by filing date | |
| IOVANCE BIOTHERAPEUTICS INC | 462260100 | COM | 6,337,700 | $120,987,000 | thousands by filing date | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 1,009,700 | $113,046,000 | thousands by filing date | |
| SEAGEN INC | 81181C104 | COM | 655,600 | $101,356,000 | thousands by filing date | |
| TURNING PT THERAPEUTICS | 90041T108 | COM | 2,106,450 | $100,478,000 | thousands by filing date | |
| HCA Healthcare Inc | 40412C101 | COM | 389,500 | $100,070,000 | thousands by filing date | |
| TRICIDA INC | 89610F101 | COM | 10,280,947 | $98,286,000 | thousands by filing date | |
| KEROS THERAPEUTICS INC COM | 492327101 | Stock | 1,679,417 | $98,263,000 | thousands by filing date | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 3,196,876 | $90,823,000 | thousands by filing date | |
| MEIRAGTX HOLDINGS PLC | G59665102 | COMMON STOCK | 3,727,466 | $88,490,000 | thousands by filing date | |
| DEXCOM INC COM | 252131107 | Stock | 152,900 | $82,100,000 | thousands by filing date | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 931,915 | $79,371,000 | thousands by filing date | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 860,880 | $76,059,000 | thousands by filing date | |
| SINOVAC BIOTECH LTD | P8696W104 | SHS | 2,839,500 | $72,700,000 | thousands by filing date | |
| ZIMMER BIOMET HOLDINGS INC COM | 98956P102 | Stock | 564,300 | $71,689,000 | thousands by filing date | |
| REPARE THERAPEUTICS INC | 760273102 | COM | 3,322,488 | $70,071,000 | thousands by filing date | |
| COMPASS THERAPEUTICS INC | 20454B104 | COM | 21,642,975 | $68,608,000 | thousands by filing date | |
| KINNATE BIOPHARMA INC | 49705R105 | COM | 3,847,929 | $68,185,000 | thousands by filing date | |
| THERAVANCE BIOPHARMA INC | G8807B106 | COM | 5,974,535 | $66,019,000 | thousands by filing date | |
| Thermo Fisher Scientific Inc. | 883556102 | COM | 94,700 | $63,188,000 | thousands by filing date | |
| ABCELLERA BIOLOGICS INC COM | 00288U106 | Stock | 4,180,768 | $59,785,000 | thousands by filing date | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 8,740,887 | $58,214,000 | thousands by filing date | |
| ALPINE IMMUNE SCIENCES INC | 02083G100 | COM | 4,081,592 | $56,530,000 | thousands by filing date | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 2,836,386 | $55,962,000 | thousands by filing date | |
| BIOGEN INC COM | 09062X103 | Stock | 230,200 | $55,230,000 | thousands by filing date | |
| SI BONE INC | 825704109 | COM | 2,305,300 | $51,201,000 | thousands by filing date | |
| 89BIO INC | 282559103 | COM | 3,729,442 | $48,744,000 | thousands by filing date | |
| GRACELL BIOTECHNOLOGIES INC | 38406L103 | ADR | 7,884,870 | $47,625,000 | thousands by filing date | |
| PASSAGE BIO INC | 702712100 | COM | 6,962,899 | $44,214,000 | thousands by filing date | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 1,981,300 | $43,371,000 | thousands by filing date | |
| OAK STR HEALTH INC | 67181A107 | COM | 1,290,300 | $42,761,000 | thousands by filing date | |
| XTANT MED HLDGS INC | 98420P308 | COM NEW | 72,873,494 | $40,809,000 | thousands by filing date | |
| NEUROPACE INC | 641288105 | COMMON STOCK | 4,012,281 | $40,444,000 | thousands by filing date | |
| LAKEFRONT BIOTHERAPEUTICS NV | 36315X101 | SPON ADR | 717,257 | $39,542,000 | thousands by filing date | |
| TELA BIO INC | 872381108 | COM | 3,027,542 | $38,753,000 | thousands by filing date | |
| VERONA PHARMA PLC | 925050106 | SPONSORED ADS | 5,694,841 | $38,269,000 | thousands by filing date | |
| IKENA ONCOLOGY INC | 45175G108 | COM | 2,933,941 | $36,792,000 | thousands by filing date | |
| SELECT MED HLDGS CORP | 81619Q105 | COM | 1,233,600 | $36,268,000 | thousands by filing date | |
| INVIVYD INC | 00534A102 | COMMON STOCK | 4,983,500 | $36,180,000 | thousands by filing date | |
| ORIC PHARMACEUTICALS INC | 68622P109 | COM | 2,337,574 | $34,362,000 | thousands by filing date | |
| NANOSTRING TECHNOLOGIES INC | 63009R109 | COM | 807,100 | $34,084,000 | thousands by filing date | |
| GH RESEARCH PLC ORDINARY SHARES | G3855L106 | Stock | 1,428,732 | $33,332,000 | thousands by filing date | |
| SIERRA ONCOLOGY INC | 82640U404 | CMN | 1,477,320 | $32,117,000 | thousands by filing date | |
| CYTEK BIOSCIENCES INC | 23285D109 | COMMON STOCK | 1,923,139 | $31,386,000 | thousands by filing date | |
| IMMUNOGEN INC | 45253H101 | COMMON STOCK | 3,868,786 | $28,706,000 | thousands by filing date | |
| MEREO BIOPHARMA GROUP PLC | 589492107 | CMN | 17,264,764 | $27,624,000 | thousands by filing date | principal |
| TERNS PHARMACEUTICALS INC COM | 880881107 | Stock | 3,791,204 | $26,804,000 | thousands by filing date | |
| VAXCYTE INC COM | 92243G108 | Stock | 1,096,700 | $26,090,000 | thousands by filing date | |
| ERASCA INC COM | 29479A108 | Stock | 1,667,693 | $25,983,000 | thousands by filing date | |
| EVOLENT HEALTH INC CL A | 30050B101 | Stock | 938,000 | $25,954,000 | thousands by filing date | |
| VECTIVBIO HLDG AG | H9060V101 | COM | 5,223,804 | $25,649,000 | thousands by filing date | |
| Ventyx Biosciences Inc | 92332V107 | Common Stock | 1,289,280 | $25,605,000 | thousands by filing date | |
| VISTAGEN THERAPEUTICS INC | 92840H202 | COM | 12,909,283 | $25,173,000 | thousands by filing date | |
| TENET HEALTHCARE CORP COM NEW | 88033G407 | Stock | 299,000 | $24,425,000 | thousands by filing date | |
| SINGULAR GENOMICS SYSTEMS IN | 82933R100 | COM | 2,104,359 | $24,326,000 | thousands by filing date | |
| SCPHARMACEUTICALS INC | 810648105 | COM | 4,797,148 | $24,082,000 | thousands by filing date | |
| JOUNCE THERAPEUTICS INC | 481116101 | COM | 2,859,900 | $23,880,000 | thousands by filing date | |
| CHINOOK THERAPEUTICS INC | 16961L106 | COM | 1,418,300 | $23,132,000 | thousands by filing date | |
| DECIBEL THERAPEUTICS INC | 24343R106 | COM | 4,945,192 | $22,995,000 | thousands by filing date | |
| HARPOON THERAPEUTICS INC | 41358P106 | COM | 2,903,508 | $21,921,000 | thousands by filing date | |
| Gilead Sciences,Inc. | 375558103 | COM | 287,600 | $20,883,000 | thousands by filing date | |
| Applied Therapeutics Inc | 03828A101 | Common Stock | 2,313,681 | $20,707,000 | thousands by filing date | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 631,000 | $19,712,000 | thousands by filing date | |
| LOGICBIO THERAPEUTICS INC | 54142F102 | COM | 8,466,783 | $19,558,000 | thousands by filing date | |
| GRAPHITE BIO INC | 38870X104 | COM | 1,565,812 | $19,463,000 | thousands by filing date | |
| Mersana Therapeutics Inc | 59045L106 | Common Stock | 2,888,847 | $17,969,000 | thousands by filing date | |
| CHEMOMAB THERAPEUTICS LTD | 16385C104 | SPONSORED ADS | 2,578,174 | $17,789,000 | thousands by filing date | |
| DANAHER CORPORATION | 235851409 | CONV | 10,000 | $17,382,000 | thousands by filing date | principal |
| CURIS INC | 231269200 | COM | 3,634,800 | $17,302,000 | thousands by filing date | |
| ILLUMINA INC | 452327109 | COM | 45,100 | $17,158,000 | thousands by filing date | |
| GEMINI THERAPEUTICS INC | 36870G105 | CMN | 5,826,224 | $16,954,000 | thousands by filing date | |
| Milestone Pharmaceuticals Inc | 59935V107 | COM | 2,583,821 | $16,924,000 | thousands by filing date | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 6,943,654 | $16,734,000 | thousands by filing date | |
| NEXTCURE INC | 65343E108 | COM | 2,711,013 | $16,266,000 | thousands by filing date | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 406,100 | $15,692,000 | thousands by filing date | |
| RXSIGHT INC | 78349D107 | COM | 1,383,500 | $15,564,000 | thousands by filing date | |
| STANDARD BIOTOOLS INC | 34385P108 | COM | 3,819,348 | $14,972,000 | thousands by filing date | |
| SYNLOGIC INC | 87166L100 | COM | 6,029,995 | $14,593,000 | thousands by filing date | |
| ACLARIS THERAPEUTICS INC COM | 00461U105 | Stock | 985,900 | $14,335,000 | thousands by filing date | |
| AEGLEA BIOTHERAPEUTICS INC | 00773J103 | COM | 2,956,124 | $14,042,000 | thousands by filing date | |
| PULMONX CORP | 745848101 | COM | 435,000 | $13,950,000 | thousands by filing date | |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 3,214,509 | $13,919,000 | thousands by filing date | |
| BURNING ROCK BIOTECH LTD | 12233L107 | SPONSORED ADS | 1,452,402 | $13,841,000 | thousands by filing date | |
| FUSION PHARMACEUTICALS INC | 36118A100 | COM | 3,224,770 | $13,447,000 | thousands by filing date | |
| Amgen Inc. | 031162100 | COM | 57,100 | $12,846,000 | thousands by filing date | |
| CYBIN INC | 23256X100 | COM | 10,524,300 | $12,481,000 | thousands by filing date | |
| CULLINAN THERAPEUTICS INC | 230031106 | COM | 805,041 | $12,422,000 | thousands by filing date | |
| GALECTO INC | 36322Q107 | COM | 4,090,937 | $12,396,000 | thousands by filing date | |
| UNIQURE NV | N90064101 | SHS | 585,574 | $12,145,000 | thousands by filing date | |
| BELLUS HEALTH INC NEW | 07987C204 | COM | 1,454,800 | $11,698,000 | thousands by filing date | |
| SONENDO INC | 835431107 | Common Stocks | 1,968,180 | $11,337,000 | thousands by filing date | |
| 9 METERS BIOPHARMA INC | 654405109 | COM | 10,275,887 | $10,057,000 | thousands by filing date | |
| DIANTHUS THERAPEUTICS INC COM | 55910K108 | Stock | 2,250,953 | $9,972,000 | thousands by filing date | |
| PROMETHEUS BIOSCIENCES INC | 74349U108 | COM | 250,000 | $9,885,000 | thousands by filing date | |
| IMARA INC | 45249V107 | COM | 4,386,568 | $9,870,000 | thousands by filing date | |
| VOR BIOPHARMA INC | 929033108 | COM | 833,333 | $9,683,000 | thousands by filing date | |
| ACUTUS MED INC | 005111109 | COM | 2,648,386 | $9,031,000 | thousands by filing date | |
| CVRX INC | 126638105 | COMMON STOCK | 723,055 | $8,843,000 | thousands by filing date | |
| RAPT THERAPEUTICS INC | 75382E109 | COM | 217,000 | $7,970,000 | thousands by filing date | |
| ACHILLES THERAPEUTICS PL-ADR | 00449L102 | COM | 1,584,845 | $7,940,000 | thousands by filing date | |
| GOSSAMER BIO INC COM | 38341P102 | Stock | 683,000 | $7,725,000 | thousands by filing date | |
| GRAYBUG VISION INC COM | 38942Q103 | SHS | 4,163,347 | $7,619,000 | thousands by filing date | |
| ONCOCYTE CORP | 68235C107 | COM | 3,493,800 | $7,582,000 | thousands by filing date | |
| NAUTILUS BIOTECHNOLOGY INC | 63909J108 | COM | 1,452,774 | $7,525,000 | thousands by filing date | |
| NANOSTRING TECHNOLOGIES INC | 63009RAD1 | BOND | 6,000,000 | $7,172,000 | thousands by filing date | principal |
| AEROVATE THERAPEUTICS INC | 008064107 | COM | 535,714 | $6,316,000 | thousands by filing date | |
| INTELLIA THERAPEUTICS INC | 45826J105 | COM | 53,200 | $6,290,000 | thousands by filing date | |
| SYROS PHARMACEUTICALS INC | 87184Q107 | COM | 1,837,500 | $5,990,000 | thousands by filing date | |
| PROTARA THERAPEUTICS INC | 74365U107 | COM STK | 830,641 | $5,607,000 | thousands by filing date | |
| NURIX THERAPEUTICS INC | 67080M103 | COMMON STOCK | 184,468 | $5,340,000 | thousands by filing date | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 58,700 | $5,286,000 | thousands by filing date | |
| NOVABRIDGE BIOSCIENCES | 44975P103 | CMN | 111,120 | $5,266,000 | thousands by filing date | |
| HEALTH SCIENCES ACQ CORP 2 | G4411D109 | ORD SHS | 500,000 | $5,040,000 | thousands by filing date | |
| CENTURY THERAPEUTICS INC | 15673T100 | COM | 307,047 | $4,870,000 | thousands by filing date | |
| BIOMX INC | 09090D103 | COM | 2,813,489 | $4,502,000 | thousands by filing date | |
| ALX ONCOLOGY HOLDINGS INC | 00166B105 | COMMON STOCK | 207,600 | $4,461,000 | thousands by filing date | |
| Inflarx Nv | N44821101 | COM | 875,297 | $4,166,000 | thousands by filing date | |
| TALARIS THERAPEUTICS INC | 87410C104 | COM | 247,240 | $3,780,000 | thousands by filing date | |
| FIELD TRIP HEALTH LTD | 31656R102 | COM | 1,538,470 | $3,722,000 | thousands by filing date | |
| INOZYME PHARMA INC | 45790W108 | COM | 526,600 | $3,591,000 | thousands by filing date | |
| SIGHT SCIENCES INC | 82657M105 | COMMON STOCK | 200,000 | $3,514,000 | thousands by filing date | |
| X4 Pharmaceuticals, Inc. | 98420X103 | COM | 1,373,849 | $3,146,000 | thousands by filing date | |
| WHITEHAWK THERAPEUTICS INC | 00032Q104 | CMN | 127,600 | $3,082,000 | thousands by filing date | |
| EXSCIENTIA PLC | 30223G102 | ADS | 125,000 | $2,470,000 | thousands by filing date | |
| SURFACE ONCOLOGY INC | 86877M209 | COM | 467,945 | $2,237,000 | thousands by filing date | |
| ASLAN PHARMACEUTICALS LTD | 04522R101 | ADR | 1,970,000 | $2,206,000 | thousands by filing date | |
| BRIGHT MINDS BIOSCIENCES INC | 10919W108 | COM | 660,600 | $2,131,000 | thousands by filing date | |
| ADAGENE INC | 005329107 | CMN | 263,176 | $2,123,000 | thousands by filing date | |
| APTINYX INC | 03836N103 | COM | 749,500 | $2,001,000 | thousands by filing date | |
| CATALYST BIOSCIENCES INC | 14888D208 | COM | 1,729,402 | $1,581,000 | thousands by filing date | |
| PYXIS ONCOLOGY INC COMMON STOCK | 747324101 | Stock | 143,640 | $1,576,000 | thousands by filing date | |
| LANDOS BIOPHARMA INC | 515069102 | CMN | 283,217 | $1,359,000 | thousands by filing date | |
| CABALETTA BIO INC | 12674W109 | COMMON STOCK | 302,509 | $1,147,000 | thousands by filing date | |
| LONGBOARD PHARMACEUTICALS IN | 54300N103 | COM | 113,500 | $554,000 | thousands by filing date | |
| AUGMEDIX INC | 05105P107 | COM | 88,363 | $278,000 | thousands by filing date | |
| OWLET INC | 69120X115 | *W EXP 09/14/202 | 220,704 | $86,000 | thousands by filing date |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001172661-22-000795 | this filing | 2022-02-14 | acceptance time not in the bulk data set |