13F-HR filed by Rock Springs Capital Management LP
Rock Springs Capital Management LP filed this 13F-HR for the quarter ended 2021-12-31, filed 2022-02-14, with 136 holding rows worth $4,328,231,000.
- Accession
- 0001172661-22-000578
- Filer
- CIK 1595725
- Filed
- 2022-02-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2021
A holdings report, 136 entries on the cover page, a total value of $4,328,231,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $4,328,231,000 with VALUE read as thousands by filing date, 13F file number 028-16048. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| AGILON HEALTH INC | 00857U107 | COM | 7,495,000 | $202,365,000 | thousands by filing date | |
| HUMANA INC COM | 444859102 | Stock | 349,000 | $161,887,000 | thousands by filing date | |
| ALIGN TECHNOLOGY INC COM | 016255101 | Stock | 200,000 | $131,436,000 | thousands by filing date | |
| Intuitive Surgical,Inc. | 46120E602 | COM | 360,000 | $129,348,000 | thousands by filing date | |
| INSULET CORP COM | 45784P101 | Stock | 463,750 | $123,390,000 | thousands by filing date | |
| UnitedHealth Group Inc | 91324P102 | COM | 240,000 | $120,514,000 | thousands by filing date | |
| IDEXX LABS INC COM | 45168D104 | Stock | 180,000 | $118,523,000 | thousands by filing date | |
| HCA Healthcare Inc | 40412C101 | COM | 450,000 | $115,614,000 | thousands by filing date | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 315,000 | $110,310,000 | thousands by filing date | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 1,105,000 | $94,113,000 | thousands by filing date | |
| BLUEPRINT MEDICINES CORP | 09627Y109 | COM | 859,755 | $92,088,000 | thousands by filing date | |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 2,646,625 | $86,995,000 | thousands by filing date | |
| IMMUNOCORE HLDGS PLC ADS | 45258D105 | ADR | 2,471,555 | $84,626,000 | thousands by filing date | |
| HORIZON THERAPEUTICS PLC | G46188101 | SHS | 746,000 | $80,389,000 | thousands by filing date | |
| EDWARDS LIFESCIENCES CORP COM | 28176E108 | Stock | 582,000 | $75,398,000 | thousands by filing date | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 883,921 | $74,329,000 | thousands by filing date | |
| ZAI LAB LTD ADR | 98887Q104 | ADR | 1,180,700 | $74,207,000 | thousands by filing date | |
| BAXTER INTL INC | 071813109 | COM | 733,803 | $62,990,000 | thousands by filing date | |
| NOVAVAX INC | 670002401 | COM NEW | 425,000 | $60,805,000 | thousands by filing date | |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 410,415 | $60,204,000 | thousands by filing date | |
| PACIRA BIOSCIENCES INC COM | 695127100 | Stock | 1,000,000 | $60,170,000 | thousands by filing date | |
| NEVRO CORP | 64157F103 | COM | 714,000 | $57,884,000 | thousands by filing date | |
| EVOLENT HEALTH INC CL A | 30050B101 | Stock | 2,038,000 | $56,391,000 | thousands by filing date | |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 332,500 | $56,385,000 | thousands by filing date | |
| ACLARIS THERAPEUTICS INC COM | 00461U105 | Stock | 3,861,347 | $56,144,000 | thousands by filing date | |
| KARUNA THERAPEUTICS INC | 48576A100 | COM | 426,843 | $55,916,000 | thousands by filing date | |
| FRESHPET INC COM | 358039105 | Stock | 580,000 | $55,257,000 | thousands by filing date | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 400,000 | $53,812,000 | thousands by filing date | |
| CEREVEL THERAPEUTICS HLDNG I | 15678U128 | COM | 1,648,435 | $53,442,000 | thousands by filing date | |
| IRHYTHM HOLDINGS INC COM | 450056106 | Stock | 433,000 | $50,960,000 | thousands by filing date | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 742,065 | $47,114,000 | thousands by filing date | |
| ACADIA HEALTHCARE COMPANY INC COM | 00404A109 | Stock | 748,500 | $45,434,000 | thousands by filing date | |
| EXACT SCIENCES CORP COM | 30063P105 | Stock | 570,000 | $44,363,000 | thousands by filing date | |
| INVITAE CORP | 46185L103 | COM | 2,800,243 | $42,760,000 | thousands by filing date | |
| PENUMBRA INC COM | 70975L107 | Stock | 148,500 | $42,667,000 | thousands by filing date | |
| SHOCKWAVE MED INC | 82489T104 | COM | 222,500 | $39,678,000 | thousands by filing date | |
| SEAGEN INC | 81181C104 | COM | 256,000 | $39,578,000 | thousands by filing date | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 424,000 | $38,181,000 | thousands by filing date | |
| ARVINAS INC | 04335A105 | COM | 457,200 | $37,554,000 | thousands by filing date | |
| CYTOKINETICS INC | 23282WAA8 | NOTE 4.000%11/1 | 8,000,000 | $35,665,000 | thousands by filing date | principal |
| WARBY PARKER INC | 93403J106 | CL A COM | 724,000 | $33,709,000 | thousands by filing date | |
| HEALTH CATALYST INC | 42225T107 | COM | 850,200 | $33,685,000 | thousands by filing date | |
| VERVE THERAPEUTICS INC | 92539P101 | COM | 902,926 | $33,291,000 | thousands by filing date | |
| COVETRUS INC | 22304C100 | COM | 1,661,700 | $33,184,000 | thousands by filing date | |
| ENCOMPASS HEALTH CORP COM | 29261A100 | Stock | 502,500 | $32,793,000 | thousands by filing date | |
| PHREESIA INC | 71944F106 | COM | 770,000 | $32,078,000 | thousands by filing date | |
| PROTHENA CORP PLC SHS | G72800108 | Stock | 647,730 | $31,998,000 | thousands by filing date | |
| ACCOLADE INC | 00437E102 | COM | 1,197,000 | $31,553,000 | thousands by filing date | |
| DEXCOM INC COM | 252131107 | Stock | 56,750 | $30,472,000 | thousands by filing date | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 951,650 | $29,539,000 | thousands by filing date | |
| ABCAM PLC | 000380204 | ADR USD | 1,252,500 | $29,496,000 | thousands by filing date | |
| CONMED CORP COM | 207410101 | Stock | 202,500 | $28,706,000 | thousands by filing date | |
| GRAPHITE BIO INC | 38870X104 | COM | 2,078,910 | $25,841,000 | thousands by filing date | |
| SIERRA ONCOLOGY INC | 82640U404 | CMN | 1,184,793 | $25,757,000 | thousands by filing date | |
| INTERSECT ENT INC | 46071F103 | COM | 940,000 | $25,671,000 | thousands by filing date | |
| MIRUM PHARMACEUTICALS INC | 604749101 | COM | 1,538,814 | $24,544,000 | thousands by filing date | |
| PROMETHEUS BIOSCIENCES INC | 74349U108 | COM | 618,407 | $24,452,000 | thousands by filing date | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 771,367 | $24,098,000 | thousands by filing date | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 264,000 | $23,324,000 | thousands by filing date | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 269,400 | $22,829,000 | thousands by filing date | |
| PULMONX CORP | 745848101 | COM | 700,000 | $22,449,000 | thousands by filing date | |
| DYNAVAX TECHNOLOGIES CORP | 268158201 | COM NEW | 1,576,894 | $22,187,000 | thousands by filing date | |
| WEST PHARMACEUTICAL SVSC INC COM | 955306105 | Stock | 45,500 | $21,340,000 | thousands by filing date | |
| Mersana Therapeutics Inc | 59045L106 | Common Stock | 3,248,950 | $20,208,000 | thousands by filing date | |
| GUARDANT HEALTH INC COM | 40131M109 | Stock | 200,000 | $20,004,000 | thousands by filing date | |
| Xilio Therapeutics Inc. | 98422T100 | COM | 1,191,094 | $19,058,000 | thousands by filing date | |
| LIFESTANCE HEALTH GROUP INC | 53228F101 | COM | 2,000,000 | $19,040,000 | thousands by filing date | |
| LEGEND BIOTECH CORP | 52490G102 | SPONSORED ADS | 403,584 | $18,811,000 | thousands by filing date | |
| ANAPTYSBIO INC | 032724106 | COM | 538,700 | $18,720,000 | thousands by filing date | |
| RELAY THERAPEUTICS INC COM | 75943R102 | Stock | 597,767 | $18,357,000 | thousands by filing date | |
| IMMUNEERING CORP | 45254E107 | CLASS A COM | 1,089,816 | $17,622,000 | thousands by filing date | |
| AURA BIOSCIENCES INC | 05153U107 | COMMON STOCK | 1,008,114 | $17,118,000 | thousands by filing date | |
| COMPASS THERAPEUTICS INC | 20454B104 | COM | 5,328,088 | $16,890,000 | thousands by filing date | |
| ICOSAVAX INC | 45114M109 | COM | 735,504 | $16,828,000 | thousands by filing date | |
| SPERO THERAPEUTICS INC | 84833T103 | COM | 945,313 | $15,134,000 | thousands by filing date | |
| GOSSAMER BIO INC | 38341PAA0 | NOTE 5.000% 6/0 | 15,373,000 | $15,066,000 | thousands by filing date | principal |
| AMARIN CORP PLC | 023111206 | SPONS ADR NEW | 4,419,700 | $14,894,000 | thousands by filing date | |
| AMRYT PHARMA LTD - SPNR ADR | 03217L106 | COMMON EQUITY | 1,305,825 | $14,103,000 | thousands by filing date | |
| MACROGENICS INC | 556099109 | COM | 857,205 | $13,758,000 | thousands by filing date | |
| COLLEGIUM PHARMACEUTICAL INC | 19459J104 | COM | 725,000 | $13,543,000 | thousands by filing date | |
| NOVOCURE LTD | G6674U108 | ORD SHS | 175,000 | $13,139,000 | thousands by filing date | |
| WHITEHAWK THERAPEUTICS INC | 00032Q104 | CMN | 538,835 | $13,013,000 | thousands by filing date | |
| RIGEL PHARMACEUTICALS INC | 766559603 | COMMON STOCK | 4,860,200 | $12,880,000 | thousands by filing date | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 587,101 | $12,417,000 | thousands by filing date | |
| CHINOOK THERAPEUTICS INC | 16961L106 | COM | 720,349 | $11,749,000 | thousands by filing date | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 1,012,506 | $11,694,000 | thousands by filing date | |
| LEAP THERAPEUTICS INC | 52187K101 | COM | 3,520,570 | $11,407,000 | thousands by filing date | |
| ACUMEN PHARMACEUTICALS INC | 00509G209 | CMN | 1,571,918 | $10,626,000 | thousands by filing date | |
| AURINIA PHARMACEUTICALS INC COM | 05156V102 | Stock | 457,173 | $10,456,000 | thousands by filing date | |
| CULLINAN THERAPEUTICS INC | 230031106 | COM | 646,078 | $9,969,000 | thousands by filing date | |
| ORION ACQUISITION CORP | 68626A207 | UNIT 02/19/2026 | 1,000,000 | $9,850,000 | thousands by filing date | |
| RENEO PHARMACEUTICALS INC | 75974E103 | COM | 1,143,185 | $9,774,000 | thousands by filing date | |
| EPIZYME INC | 29428V104 | COM | 3,807,662 | $9,519,000 | thousands by filing date | |
| OLINK HLDG AB | 680710100 | ADR | 515,000 | $9,373,000 | thousands by filing date | |
| NURIX THERAPEUTICS INC | 67080M103 | COMMON STOCK | 321,050 | $9,294,000 | thousands by filing date | |
| MEREO BIOPHARMA GROUP PLC | 589492107 | CMN | 5,585,621 | $8,937,000 | thousands by filing date | |
| BIOMEA FUSION INC | 09077A106 | CMN | 1,165,582 | $8,684,000 | thousands by filing date | |
| ADAPTIMMUNE THERAPEUTICS PLC | 00653A107 | SPONDS ADR | 2,215,588 | $8,308,000 | thousands by filing date | |
| VINCERX PHARMA INC | 92731L106 | COM NEW | 809,195 | $8,246,000 | thousands by filing date | |
| FULCRUM THERAPEUTICS INC | 359616109 | COMMON STOCK | 456,990 | $8,084,000 | thousands by filing date | |
| NKARTA INC | 65487U108 | COMMON STOCK | 507,248 | $7,786,000 | thousands by filing date | |
| PARATEK PHARMACEUTICALS INC | 699374302 | Equity | 1,697,105 | $7,620,000 | thousands by filing date | |
| AEGLEA BIOTHERAPEUTICS INC | 00773J103 | COM | 1,577,296 | $7,492,000 | thousands by filing date | |
| ESSA PHARMA INC | 29668H708 | COM NEW | 511,044 | $7,257,000 | thousands by filing date | |
| SPRUCE BIOSCIENCES INC | 85209E109 | COM | 1,622,689 | $7,237,000 | thousands by filing date | |
| ATHIRA PHARMA INC | 04746L104 | COM | 552,252 | $7,196,000 | thousands by filing date | |
| DESIGN THERAPEUTICS INC | 25056L103 | COM | 335,247 | $7,178,000 | thousands by filing date | |
| PHASEBIO PHARMACEUTICALS INC | 717224109 | COM | 2,581,299 | $6,737,000 | thousands by filing date | |
| FATE THERAPEUTICS INC | 31189P102 | COM | 110,000 | $6,436,000 | thousands by filing date | |
| Day One Biopharmaceuticals Inc | 23954D109 | Common Stock | 381,939 | $6,436,000 | thousands by filing date | |
| Applied Therapeutics Inc | 03828A101 | Common Stock | 701,680 | $6,280,000 | thousands by filing date | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 627,180 | $6,259,000 | thousands by filing date | |
| KINNATE BIOPHARMA INC | 49705R105 | COM | 339,846 | $6,022,000 | thousands by filing date | |
| INOZYME PHARMA INC | 45790W108 | COM | 868,466 | $5,923,000 | thousands by filing date | |
| COMPUGEN LTD | M25722105 | ORD | 1,289,990 | $5,547,000 | thousands by filing date | |
| THESEUS PHARMACEUTICALS INC | 88369M101 | COM | 437,329 | $5,545,000 | thousands by filing date | |
| GAMIDA CELL LTD | M47364100 | SHS | 2,154,300 | $5,472,000 | thousands by filing date | |
| PRELUDE THERAPEUTICS INC | 74065P101 | CMN | 368,959 | $4,594,000 | thousands by filing date | |
| EDAP TMS S A | 268311107 | SPONSORED ADR | 760,900 | $4,558,000 | thousands by filing date | |
| Tempest Therapeutics, Inc. | 87978U108 | Common Stock | 823,654 | $4,349,000 | thousands by filing date | |
| FUSION PHARMACEUTICALS INC | 36118A100 | COM | 948,327 | $3,955,000 | thousands by filing date | |
| F-STAR THERAPEUTICS INC | 30315R107 | COM | 751,889 | $3,774,000 | thousands by filing date | |
| TRAVERE THERAPEUTICS INC | 761299AB2 | NOTE 2.500% 9/1 | 3,250,000 | $3,589,000 | thousands by filing date | principal |
| ACELRX PHARMACEUTICALS INC | 00444T100 | COM | 6,325,902 | $3,544,000 | thousands by filing date | |
| BCLS ACQUISITION CORP | G0904B105 | CMN | 309,000 | $3,028,000 | thousands by filing date | |
| SHATTUCK LABS INC | 82024L103 | COMMON STOCK | 313,499 | $2,668,000 | thousands by filing date | |
| JIYA ACQUISITION CORP | 47760M102 | CMN | 206,200 | $2,015,000 | thousands by filing date | |
| POSEIDA THERAPEUTICS INC | 73730P108 | COM | 289,754 | $1,973,000 | thousands by filing date | |
| IMARA INC | 45249V107 | COM | 842,302 | $1,895,000 | thousands by filing date | |
| RADIUS HEALTH INC | 750469AA6 | NOTE | 1,500,000 | $1,459,000 | thousands by filing date | principal |
| THERAVANCE BIOPHARMA | 88339KAA0 | NOTE 3.250%11/0 | 1,500,000 | $1,456,000 | thousands by filing date | principal |
| ATRECA INC | 04965G109 | COM | 462,530 | $1,401,000 | thousands by filing date | |
| NEUROCRINE BIOSCIENCES INC | 64125CAD1 | NOTE 2.250% 5/1 | 1,000,000 | $1,257,000 | thousands by filing date | principal |
| PACIRA BIOSCIENCES | 695127AD2 | NOTE 2.375% 4/0 | 1,000,000 | $1,029,000 | thousands by filing date | principal |
| NEVRO CORP | 64157FAC7 | NOTE 2.750% 4/0 | 500,000 | $556,000 | thousands by filing date | principal |
| NUVATION BIO INC | 67080N119 | WARR | 134,028 | $253,000 | thousands by filing date |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001172661-22-000578 | this filing | 2022-02-14 | acceptance time not in the bulk data set |