13F-HR filed by ORBIMED ADVISORS LLC
ORBIMED ADVISORS LLC filed this 13F-HR for the quarter ended 2021-03-31, filed 2021-05-17, with 158 holding rows worth $10,694,926,000.
- Accession
- 0001172661-21-001345
- Filer
- CIK 1055951
- Filed
- 2021-05-17
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q1 2021
A holdings report, 159 entries on the cover page, a total value of $10,694,926,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $10,694,926,000 with VALUE read as thousands by filing date, 13F file number 028-06774. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerORBIMED CAPITAL LLC028-10410
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 6,186,307 | $455,127,000 | thousands by filing date | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 13,944,680 | $453,202,000 | thousands by filing date | |
| PRELUDE THERAPEUTICS INC | 74065P101 | CMN | 10,039,691 | $435,020,000 | thousands by filing date | |
| 0 | 000000000 | 0 | 11,895,652 | $421,709,000 | thousands by filing date | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 8,740,887 | $381,365,000 | thousands by filing date | |
| HORIZON THERAPEUTICS PLC | G46188101 | SHS | 3,144,355 | $289,406,000 | thousands by filing date | |
| Merck & Co.,Inc. | 58933Y105 | COM | 3,732,400 | $287,731,000 | thousands by filing date | |
| Bristol-Myers Squibb Company | 110122108 | COM | 4,515,400 | $285,057,000 | thousands by filing date | |
| ABCELLERA BIOLOGICS INC COM | 00288U106 | Stock | 8,200,768 | $278,498,000 | thousands by filing date | |
| Boston Scientific Corporation | 101137107 | COM | 6,920,600 | $267,481,000 | thousands by filing date | |
| Vertex Pharmaceuticals Incorporated | 92532F100 | COM | 1,135,900 | $244,094,000 | thousands by filing date | |
| PMV PHARMACEUTICALS INC | 69353Y103 | COM | 7,330,423 | $241,098,000 | thousands by filing date | |
| TURNING PT THERAPEUTICS | 90041T108 | COM | 2,361,327 | $223,358,000 | thousands by filing date | |
| NATERA INC COM | 632307104 | Stock | 2,195,900 | $222,972,000 | thousands by filing date | |
| IOVANCE BIOTHERAPEUTICS INC | 462260100 | COM | 6,645,100 | $210,384,000 | thousands by filing date | |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 1,221,200 | $209,192,000 | thousands by filing date | |
| ARCUTIS BIOTHERAPEUTICS INC | 03969K108 | COM | 6,073,850 | $175,716,000 | thousands by filing date | |
| XTANT MED HLDGS INC | 98420P308 | COM NEW | 72,873,494 | $171,981,000 | thousands by filing date | |
| UnitedHealth Group Inc | 91324P102 | COM | 403,000 | $149,944,000 | thousands by filing date | |
| GUARDANT HEALTH INC COM | 40131M109 | Stock | 977,400 | $149,200,000 | thousands by filing date | |
| HUMANA INC COM | 444859102 | Stock | 313,600 | $131,477,000 | thousands by filing date | |
| AbbVie,Inc. | 00287Y109 | COM | 1,213,200 | $131,293,000 | thousands by filing date | |
| THERAVANCE BIOPHARMA INC | G8807B106 | COM | 6,219,110 | $126,932,000 | thousands by filing date | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 1,301,715 | $126,592,000 | thousands by filing date | |
| PASSAGE BIO INC | 702712100 | COM | 6,962,899 | $121,711,000 | thousands by filing date | |
| GRACELL BIOTECHNOLOGIES INC | 38406L103 | ADR | 7,884,870 | $121,427,000 | thousands by filing date | |
| KINNATE BIOPHARMA INC | 49705R105 | COM | 3,847,929 | $119,901,000 | thousands by filing date | |
| DEXCOM INC COM | 252131107 | Stock | 297,400 | $106,883,000 | thousands by filing date | |
| REPARE THERAPEUTICS INC | 760273102 | COM | 3,426,325 | $105,154,000 | thousands by filing date | |
| KEROS THERAPEUTICS INC COM | 492327101 | Stock | 1,679,417 | $103,368,000 | thousands by filing date | |
| Intuitive Surgical,Inc. | 46120E602 | COM | 139,600 | $103,156,000 | thousands by filing date | |
| Elevance Health, Inc. | 036752103 | COM | 286,600 | $102,875,000 | thousands by filing date | |
| ADICET BIO INC | 007002108 | COM | 7,232,856 | $94,606,000 | thousands by filing date | |
| HAEMONETICS CORP MASS COM | 405024100 | Stock | 852,000 | $94,581,000 | thousands by filing date | |
| EDWARDS LIFESCIENCES CORP COM | 28176E108 | Stock | 1,126,400 | $94,212,000 | thousands by filing date | |
| 89BIO INC | 282559103 | COM | 3,729,442 | $88,313,000 | thousands by filing date | |
| PROGYNY INC COM | 74340E103 | Stock | 1,925,260 | $85,693,000 | thousands by filing date | |
| TERNS PHARMACEUTICALS INC COM | 880881107 | Stock | 3,791,204 | $83,406,000 | thousands by filing date | |
| IKENA ONCOLOGY INC | 45175G108 | COM | 2,933,941 | $82,884,000 | thousands by filing date | |
| Stryker Corporation | 863667101 | COM | 337,400 | $82,184,000 | thousands by filing date | |
| GEMINI THERAPEUTICS INC | 36870G105 | CMN | 5,826,224 | $78,945,000 | thousands by filing date | |
| AURINIA PHARMACEUTICALS INC COM | 05156V102 | Stock | 6,069,032 | $78,806,000 | thousands by filing date | |
| CHEMOMAB THERAPEUTICS LTD | 16385C104 | SPONSORED ADS | 2,578,174 | $74,019,000 | thousands by filing date | |
| IMMUNOGEN INC | 45253H101 | COMMON STOCK | 9,131,822 | $73,968,000 | thousands by filing date | |
| ACUTUS MED INC | 005111109 | COM | 5,477,958 | $73,240,000 | thousands by filing date | |
| SINOVAC BIOTECH LTD | P8696W104 | SHS | 2,839,500 | $72,000,000 | thousands by filing date | |
| CRISPR THERAPEUTICS AG NAMEN AKT | H17182108 | Stock | 552,500 | $67,322,000 | thousands by filing date | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 505,159 | $65,105,000 | thousands by filing date | |
| DECIPHERA PHARMACEUTICALS IN | 24344T101 | COM | 1,380,900 | $61,920,000 | thousands by filing date | |
| LOGICBIO THERAPEUTICS INC | 54142F102 | COM | 8,466,783 | $61,638,000 | thousands by filing date | |
| MEIRAGTX HOLDINGS PLC | G59665102 | COMMON STOCK | 4,102,925 | $59,205,000 | thousands by filing date | |
| MEREO BIOPHARMA GROUP PLC | 589492107 | CMN | 17,264,763 | $58,183,000 | thousands by filing date | principal |
| ORIC PHARMACEUTICALS INC | 68622P109 | COM | 2,337,574 | $57,271,000 | thousands by filing date | |
| DECIBEL THERAPEUTICS INC | 24343R106 | COM | 4,945,192 | $56,177,000 | thousands by filing date | |
| Adverum Biotechnologies, Inc. | 00773U108 | Common Stock | 5,501,144 | $54,241,000 | thousands by filing date | |
| OAK STR HEALTH INC | 67181A107 | COM | 967,000 | $52,479,000 | thousands by filing date | |
| BURNING ROCK BIOTECH LTD | 12233L107 | SPONSORED ADS | 1,897,663 | $51,085,000 | thousands by filing date | |
| TRICIDA INC | 89610F101 | COM | 9,614,280 | $50,860,000 | thousands by filing date | |
| Thermo Fisher Scientific Inc. | 883556102 | COM | 110,300 | $50,339,000 | thousands by filing date | |
| ARCTURUS THERAPEUTICS HLDGS | 03969T109 | COM | 1,206,886 | $49,844,000 | thousands by filing date | |
| CURIS INC | 231269200 | COM | 4,366,494 | $49,429,000 | thousands by filing date | |
| APTOSE BIOSCIENCES INC COM | 03835T200 | Stock | 8,030,000 | $47,979,000 | thousands by filing date | |
| HARPOON THERAPEUTICS INC | 41358P106 | COM | 2,285,704 | $47,817,000 | thousands by filing date | |
| CULLINAN THERAPEUTICS INC | 230031106 | COM | 1,146,145 | $47,760,000 | thousands by filing date | |
| VERONA PHARMA PLC | 925050106 | SPONSORED ADS | 5,694,841 | $47,609,000 | thousands by filing date | |
| TELA BIO INC | 872381108 | COM | 3,027,542 | $45,110,000 | thousands by filing date | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 2,497,917 | $44,713,000 | thousands by filing date | |
| Applied Therapeutics Inc | 03828A101 | Common Stock | 2,257,387 | $42,337,000 | thousands by filing date | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 2,753,567 | $42,075,000 | thousands by filing date | |
| SI BONE INC | 825704109 | COM | 1,305,300 | $41,522,000 | thousands by filing date | |
| NANOSTRING TECHNOLOGIES INC | 63009R109 | COM | 622,900 | $40,931,000 | thousands by filing date | |
| MOLINA HEALTHCARE INC | 60855R100 | COM | 162,400 | $37,963,000 | thousands by filing date | |
| KALA BIO INC COM | 483119103 | Stock | 5,465,030 | $36,834,000 | thousands by filing date | |
| VOR BIOPHARMA INC | 929033108 | COM | 833,333 | $35,917,000 | thousands by filing date | |
| FUSION PHARMACEUTICALS INC | 36118A100 | COM | 3,224,770 | $34,570,000 | thousands by filing date | |
| TRILLIUM THERAPEUTICS INC COM NEW | 89620X506 | Stock | 3,165,200 | $33,994,000 | thousands by filing date | |
| UNIQURE NV | N90064101 | SHS | 969,079 | $32,648,000 | thousands by filing date | |
| ALPINE IMMUNE SCIENCES INC | 02083G100 | COM | 3,070,955 | $32,552,000 | thousands by filing date | |
| SCPHARMACEUTICALS INC | 810648105 | COM | 4,797,148 | $31,901,000 | thousands by filing date | |
| AEGLEA BIOTHERAPEUTICS INC | 00773J103 | COM | 4,015,524 | $31,803,000 | thousands by filing date | |
| PANDION THERAPEUTICS INC | 698340106 | COM | 528,229 | $31,720,000 | thousands by filing date | |
| Mersana Therapeutics Inc | 59045L106 | Common Stock | 1,892,500 | $30,621,000 | thousands by filing date | |
| 9 METERS BIOPHARMA INC | 654405109 | COM | 25,716,755 | $30,089,000 | thousands by filing date | |
| NOVAVAX INC | 670002401 | COM NEW | 155,833 | $28,254,000 | thousands by filing date | |
| NEXTCURE INC | 65343E108 | COM | 2,711,013 | $27,137,000 | thousands by filing date | |
| ACHILLES THERAPEUTICS PL-ADR | 00449L102 | COM | 1,584,845 | $26,229,000 | thousands by filing date | |
| SIERRA ONCOLOGY INC | 82640U404 | CMN | 1,477,320 | $25,454,000 | thousands by filing date | |
| GALECTO INC | 36322Q107 | COM | 4,090,937 | $24,852,000 | thousands by filing date | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 8,053,298 | $24,804,000 | thousands by filing date | |
| GRAYBUG VISION INC COM | 38942Q103 | SHS | 4,163,347 | $23,107,000 | thousands by filing date | |
| IMARA INC | 45249V107 | COM | 2,719,902 | $22,956,000 | thousands by filing date | |
| BIOGEN INC COM | 09062X103 | Stock | 82,000 | $22,940,000 | thousands by filing date | |
| ALEXION PHARMACEUTICALS INC | 015351109 | COM | 150,000 | $22,937,000 | thousands by filing date | call |
| Amgen Inc. | 031162100 | COM | 91,500 | $22,766,000 | thousands by filing date | |
| VERRICA PHARMACEUTICALS INC | 92511W108 | COM | 1,479,733 | $22,418,000 | thousands by filing date | |
| CTI BIOPHARMA CORP | 12648L601 | COM | 7,520,600 | $21,885,000 | thousands by filing date | |
| OLEMA PHARMACEUTICALS INC | 68062P106 | COM | 656,126 | $21,770,000 | thousands by filing date | |
| STANDARD BIOTOOLS INC | 34385P108 | COM | 4,599,571 | $20,790,000 | thousands by filing date | |
| FLEXION THERAPEUTICS INC | 33938J106 | COM | 2,308,083 | $20,657,000 | thousands by filing date | |
| CHINOOK THERAPEUTICS INC | 16961L106 | COM | 1,250,001 | $19,425,000 | thousands by filing date | |
| JOUNCE THERAPEUTICS INC | 481116101 | COM | 1,823,600 | $18,728,000 | thousands by filing date | |
| Gilead Sciences,Inc. | 375558103 | COM | 287,600 | $18,588,000 | thousands by filing date | |
| VISTAGEN THERAPEUTICS INC | 92840H202 | COM | 8,604,000 | $18,327,000 | thousands by filing date | |
| LAKEFRONT BIOTHERAPEUTICS NV | 36315X101 | SPON ADR | 230,905 | $17,800,000 | thousands by filing date | |
| ALIGNMENT HEALTHCARE INC COM | 01625V104 | Stock | 800,000 | $17,544,000 | thousands by filing date | |
| BIOMX INC | 09090D103 | COM | 2,313,489 | $16,472,000 | thousands by filing date | |
| ALEXION PHARMACEUTICALS INC | 015351109 | COM | 102,100 | $15,612,000 | thousands by filing date | |
| BELLUS HEALTH INC NEW | 07987C204 | COM | 3,954,800 | $15,100,000 | thousands by filing date | |
| Milestone Pharmaceuticals Inc | 59935V107 | COM | 2,583,821 | $14,960,000 | thousands by filing date | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 200,278 | $14,927,000 | thousands by filing date | |
| SYROS PHARMACEUTICALS INC | 87184Q107 | COM | 1,837,500 | $13,745,000 | thousands by filing date | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 528,100 | $13,187,000 | thousands by filing date | |
| SILVER SPIKE ACQUISITION COR | G8136L106 | CL A SHS | 700,400 | $12,859,000 | thousands by filing date | |
| VAXCYTE INC COM | 92243G108 | Stock | 648,774 | $12,813,000 | thousands by filing date | |
| ALECTOR INC | 014442107 | COMMON STOCK | 611,478 | $12,315,000 | thousands by filing date | |
| RELAY THERAPEUTICS INC COM | 75943R102 | Stock | 350,000 | $12,100,000 | thousands by filing date | |
| X4 Pharmaceuticals, Inc. | 98420X103 | COM | 1,373,849 | $11,829,000 | thousands by filing date | |
| DIANTHUS THERAPEUTICS INC COM | 55910K108 | Stock | 949,048 | $11,237,000 | thousands by filing date | |
| ALX ONCOLOGY HOLDINGS INC | 00166B105 | COMMON STOCK | 150,000 | $11,061,000 | thousands by filing date | |
| ONCOCYTE CORP | 68235C107 | COM | 2,100,000 | $10,899,000 | thousands by filing date | |
| OLINK HLDG AB | 680710100 | ADR | 300,000 | $10,800,000 | thousands by filing date | |
| CATALYST BIOSCIENCES INC | 14888D208 | COM | 2,118,600 | $10,678,000 | thousands by filing date | |
| NURIX THERAPEUTICS INC | 67080M103 | COMMON STOCK | 300,000 | $9,327,000 | thousands by filing date | |
| LARIMAR THERAPEUTICS INC | 517125100 | COM | 617,245 | $9,018,000 | thousands by filing date | |
| ASLAN PHARMACEUTICALS LTD | 04522R101 | ADR | 2,520,000 | $8,442,000 | thousands by filing date | |
| HEALTH CATALYST INC | 42225T107 | COM | 179,598 | $8,400,000 | thousands by filing date | |
| NUVATION BIO INC COM CL A | 67080N101 | Stock | 800,000 | $8,360,000 | thousands by filing date | |
| OTONOMY INC | 68906L105 | COM | 3,250,000 | $8,288,000 | thousands by filing date | |
| SUTRO BIOPHARMA INC | 869367102 | COM | 350,000 | $7,966,000 | thousands by filing date | |
| NANOBIOTIX | 63009J107 | SPONSORED ADS | 500,000 | $7,520,000 | thousands by filing date | |
| SYNLOGIC INC | 87166L100 | COM | 2,029,996 | $7,267,000 | thousands by filing date | |
| PROTARA THERAPEUTICS INC | 74365U107 | COM STK | 450,000 | $7,083,000 | thousands by filing date | |
| AERPIO PHARMACEUTICALS INC | 00810B105 | COM | 5,193,946 | $6,700,000 | thousands by filing date | |
| SIGNIFY HEALTH INC | 82671G100 | COM | 225,000 | $6,584,000 | thousands by filing date | |
| LANDOS BIOPHARMA INC | 515069102 | CMN | 681,000 | $6,558,000 | thousands by filing date | |
| INTELLIA THERAPEUTICS INC | 45826J105 | COM | 72,500 | $5,818,000 | thousands by filing date | |
| PULMONX CORP | 745848101 | COM | 125,000 | $5,718,000 | thousands by filing date | |
| HEALTH SCIENCES ACQ CORP 2 | G4411D109 | ORD SHS | 500,000 | $5,595,000 | thousands by filing date | |
| TCR2 THERAPEUTICS INC | 87808K106 | COM | 249,279 | $5,504,000 | thousands by filing date | |
| FORTE BIOSCIENCES INC | 34962G109 | COM | 159,664 | $5,472,000 | thousands by filing date | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 350,000 | $5,436,000 | thousands by filing date | |
| INNOVAGE HLDG CORP | 45784A104 | COM | 200,000 | $5,158,000 | thousands by filing date | |
| ADAGENE INC | 005329107 | CMN | 275,000 | $4,936,000 | thousands by filing date | |
| LONGBOARD PHARMACEUTICALS IN | 54300N103 | COM | 300,000 | $4,914,000 | thousands by filing date | |
| STRONGBRIDGE BIOPHARMA PLC | G85347105 | SHS USD | 1,744,669 | $4,815,000 | thousands by filing date | |
| COMPASS PATHWAYS PLC | 20451W101 | SPONSORED ADS | 127,816 | $4,706,000 | thousands by filing date | |
| PROMETHEUS BIOSCIENCES INC | 74349U108 | COM | 250,000 | $4,565,000 | thousands by filing date | |
| Inflarx Nv | N44821101 | COM | 1,064,118 | $4,150,000 | thousands by filing date | |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 50,000 | $2,831,000 | thousands by filing date | put |
| STANDARD BIOTOOLS INC | 34385P108 | COM | 500,000 | $2,260,000 | thousands by filing date | call |
| SANA BIOTECHNOLOGY INC | 799566104 | COM | 60,000 | $2,008,000 | thousands by filing date | |
| SELECTA BIOSCIENCES INC | 816212104 | COM | 339,169 | $1,535,000 | thousands by filing date | |
| CEL-SCI CORP | 150837607 | COM PAR NEW | 100,000 | $1,521,000 | thousands by filing date | put |
| SILVER SPIKE ACQUISITION COR | G8136L114 | *W EXP 08/02/202 | 150,200 | $1,057,000 | thousands by filing date | |
| NOVABRIDGE BIOSCIENCES | 44975P103 | CMN | 18,565 | $900,000 | thousands by filing date | |
| ARYA SCIENCES ACQUISITION CO | G3166W106 | COM CL A | 49,375 | $680,000 | thousands by filing date | |
| PURPLE BIOTECH LTD SPONSORED ADR | 74638P109 | ADR | 31,418 | $130,000 | thousands by filing date | |
| TRILLIUM THERAPEUTICS INC COM NEW | 89620X506 | Stock | 1,700 | $18,000 | thousands by filing date | call |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001172661-21-001345 | this filing | 2021-05-17 | acceptance time not in the bulk data set |