13F-HR filed by ORBIMED ADVISORS LLC
ORBIMED ADVISORS LLC filed this 13F-HR for the quarter ended 2019-12-31, filed 2020-02-14, with 136 holding rows worth $7,004,336,000.
- Accession
- 0001172661-20-000859
- Filer
- CIK 1055951
- Filed
- 2020-02-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2019
A holdings report, 136 entries on the cover page, a total value of $7,004,336,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $7,004,336,000 with VALUE read as thousands by filing date, 13F file number 028-06774. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerORBIMED CAPITAL LLC028-10410
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 3,343,100 | $465,092,000 | thousands by filing date | |
| SYNTHORX INC COM | 87167A103 | Stock | 5,316,355 | $371,560,000 | thousands by filing date | |
| TRICIDA INC | 89610F101 | COM | 9,614,280 | $362,843,000 | thousands by filing date | |
| SPRINGWORKS THERAPEUTICS INC | 85205L107 | COM | 7,406,307 | $285,069,000 | thousands by filing date | |
| PREVAIL THERAPEUTICS INC | 74140Y101 | COM | 13,822,463 | $218,810,000 | thousands by filing date | |
| Boston Scientific Corporation | 101137107 | COM | 4,674,800 | $211,394,000 | thousands by filing date | |
| ALECTOR INC | 014442107 | COMMON STOCK | 10,987,944 | $189,322,000 | thousands by filing date | |
| ALEXION PHARMACEUTICALS INC | 015351109 | COM | 1,662,585 | $179,809,000 | thousands by filing date | |
| Merck & Co.,Inc. | 58933Y105 | COM | 1,954,100 | $177,725,000 | thousands by filing date | |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 1,340,600 | $172,750,000 | thousands by filing date | |
| Vertex Pharmaceuticals Incorporated | 92532F100 | COM | 783,100 | $171,460,000 | thousands by filing date | |
| TURNING PT THERAPEUTICS | 90041T108 | COM | 2,745,327 | $171,006,000 | thousands by filing date | |
| IOVANCE BIOTHERAPEUTICS INC | 462260100 | COM | 5,548,326 | $153,578,000 | thousands by filing date | |
| NEXTCURE INC | 65343E108 | COM | 2,711,013 | $152,711,000 | thousands by filing date | |
| HUMANA INC COM | 444859102 | Stock | 391,900 | $143,639,000 | thousands by filing date | |
| Bristol-Myers Squibb Company | 110122108 | COM | 1,700,000 | $109,123,000 | thousands by filing date | |
| EHEALTH INC | 28238P109 | COM | 1,111,914 | $106,833,000 | thousands by filing date | |
| 89BIO INC | 282559103 | COM | 4,004,442 | $105,277,000 | thousands by filing date | |
| EDWARDS LIFESCIENCES CORP COM | 28176E108 | Stock | 434,900 | $101,458,000 | thousands by filing date | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 935,970 | $100,607,000 | thousands by filing date | |
| Cigna Corporation | 125523100 | COM | 489,700 | $100,139,000 | thousands by filing date | |
| INSPIRE MED SYS INC COM | 457730109 | Stock | 1,347,000 | $99,961,000 | thousands by filing date | |
| ARQULE INC | 04269E107 | COM | 5,000,000 | $99,800,000 | thousands by filing date | |
| Intuitive Surgical,Inc. | 46120E602 | COM | 167,800 | $99,195,000 | thousands by filing date | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 766,049 | $98,851,000 | thousands by filing date | |
| Danaher Corporation | 235851102 | COM | 638,900 | $98,058,000 | thousands by filing date | |
| BAUSCH HEALTH COS INC COM | 071734107 | Stock | 3,183,100 | $95,238,000 | thousands by filing date | |
| DECIPHERA PHARMACEUTICALS IN | 24344T101 | COM | 1,514,171 | $94,242,000 | thousands by filing date | |
| GLAUKOS CORP COM | 377322102 | Stock | 1,547,646 | $84,300,000 | thousands by filing date | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 1,729,200 | $83,053,000 | thousands by filing date | |
| NATERA INC COM | 632307104 | Stock | 2,440,613 | $82,224,000 | thousands by filing date | |
| REGENERON PHARMACEUTICALS COM | 75886F107 | Stock | 209,300 | $78,588,000 | thousands by filing date | |
| ARVINAS INC | 04335A105 | COM | 1,898,800 | $78,022,000 | thousands by filing date | |
| UNIQURE NV | N90064101 | SHS | 1,081,765 | $77,519,000 | thousands by filing date | |
| Thermo Fisher Scientific Inc. | 883556102 | COM | 220,500 | $71,634,000 | thousands by filing date | |
| MEIRAGTX HOLDINGS PLC | G59665102 | COMMON STOCK | 3,453,020 | $69,129,000 | thousands by filing date | |
| TANDEM DIABETES CARE INC | 875372203 | COM NEW | 1,141,390 | $68,038,000 | thousands by filing date | |
| EXELIXIS INC COM | 30161Q104 | Stock | 3,753,700 | $66,140,000 | thousands by filing date | |
| Abbott Laboratories | 002824100 | COM | 715,100 | $62,114,000 | thousands by filing date | |
| HORIZON THERAPEUTICS PLC | G46188101 | SHS | 1,582,300 | $57,279,000 | thousands by filing date | |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 994,808 | $55,092,000 | thousands by filing date | |
| BELLUS HEALTH INC NEW | 07987C204 | COM | 7,025,832 | $53,137,000 | thousands by filing date | |
| DEXCOM INC COM | 252131107 | Stock | 234,900 | $51,382,000 | thousands by filing date | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 2,039,282 | $51,166,000 | thousands by filing date | |
| Adverum Biotechnologies, Inc. | 00773U108 | Common Stock | 4,342,190 | $50,022,000 | thousands by filing date | |
| AURINIA PHARMACEUTICALS INC COM | 05156V102 | Stock | 2,345,447 | $47,519,000 | thousands by filing date | |
| CRISPR THERAPEUTICS AG NAMEN AKT | H17182108 | Stock | 766,378 | $46,676,000 | thousands by filing date | |
| LOGICBIO THERAPEUTICS INC | 54142F102 | COM | 6,466,783 | $46,561,000 | thousands by filing date | |
| PROTHENA CORP PLC SHS | G72800108 | Stock | 2,902,239 | $45,942,000 | thousands by filing date | |
| ATHENEX INC | 04685N103 | COM | 2,772,221 | $42,332,000 | thousands by filing date | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 256,300 | $41,141,000 | thousands by filing date | |
| TELA BIO INC | 872381108 | COM | 3,027,542 | $39,207,000 | thousands by filing date | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 6,767,584 | $36,816,000 | thousands by filing date | |
| HARPOON THERAPEUTICS INC | 41358P106 | COM | 2,446,409 | $36,182,000 | thousands by filing date | |
| Elevance Health, Inc. | 036752103 | COM | 106,600 | $32,196,000 | thousands by filing date | |
| Amgen Inc. | 031162100 | COM | 122,100 | $29,435,000 | thousands by filing date | |
| HCA Healthcare Inc | 40412C101 | COM | 190,000 | $28,084,000 | thousands by filing date | |
| IQVIA HLDGS INC COM | 46266C105 | Stock | 175,000 | $27,039,000 | thousands by filing date | |
| Applied Therapeutics Inc | 03828A101 | Common Stock | 987,186 | $26,930,000 | thousands by filing date | |
| ZIMMER BIOMET HOLDINGS INC COM | 98956P102 | Stock | 178,700 | $26,748,000 | thousands by filing date | |
| VERRICA PHARMACEUTICALS INC | 92511W108 | COM | 1,479,733 | $23,513,000 | thousands by filing date | |
| BIOMX INC | 09090D103 | COM | 2,313,489 | $22,406,000 | thousands by filing date | |
| AEGLEA BIOTHERAPEUTICS INC | 00773J103 | COM | 2,865,524 | $21,893,000 | thousands by filing date | |
| ZAI LAB LTD ADR | 98887Q104 | ADR | 514,000 | $21,377,000 | thousands by filing date | |
| Gilead Sciences,Inc. | 375558103 | COM | 326,100 | $21,190,000 | thousands by filing date | |
| ALCON AG ORD SHS | H01301128 | Stock | 351,380 | $19,925,000 | thousands by filing date | |
| SCPHARMACEUTICALS INC | 810648105 | COM | 3,409,865 | $19,300,000 | thousands by filing date | |
| BIOGEN INC COM | 09062X103 | Stock | 64,500 | $19,139,000 | thousands by filing date | |
| NOVO-NORDISK A S ADR | 670100205 | ADR | 330,000 | $19,100,000 | thousands by filing date | |
| AVANTOR INC COM | 05352A100 | Stock | 1,012,800 | $18,382,000 | thousands by filing date | |
| SINOVAC BIOTECH LTD | P8696W104 | SHS | 2,839,500 | $17,151,000 | thousands by filing date | |
| XTANT MED HLDGS INC | 98420P308 | COM NEW | 9,207,012 | $14,731,000 | thousands by filing date | |
| ALPINE IMMUNE SCIENCES INC | 02083G100 | COM | 3,670,955 | $14,096,000 | thousands by filing date | |
| TECTONIC THERAPEUTIC INC COM | 05455M100 | Stock | 634,700 | $12,777,000 | thousands by filing date | |
| KALA BIO INC COM | 483119103 | Stock | 3,447,840 | $12,723,000 | thousands by filing date | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 127,200 | $12,098,000 | thousands by filing date | |
| KARYOPHARM THERAPEUTICS INC | 48576U106 | COM | 621,900 | $11,922,000 | thousands by filing date | |
| Mersana Therapeutics Inc | 59045L106 | Common Stock | 2,073,319 | $11,880,000 | thousands by filing date | |
| X4 Pharmaceuticals, Inc. | 98420X103 | COM | 1,086,493 | $11,625,000 | thousands by filing date | |
| Health Care Select Sector SPDR Fund | 81369Y209 | SHS | 113,200 | $11,531,000 | thousands by filing date | |
| NEOLEUKIN THERAPEUTICS INC | 64049K104 | COM | 900,000 | $11,088,000 | thousands by filing date | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 110,000 | $10,462,000 | thousands by filing date | call |
| ObsEva SA | H5861P103 | COM | 2,605,531 | $9,953,000 | thousands by filing date | |
| FOAMIX PHARMACEUTICALS LTD | M46135105 | SHS | 2,577,982 | $8,585,000 | thousands by filing date | |
| IVERIC BIO INC | 46583P102 | COM | 1,000,000 | $8,580,000 | thousands by filing date | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 634,812 | $8,322,000 | thousands by filing date | |
| ESSA PHARMA INC | 29668H708 | COM NEW | 1,471,853 | $8,095,000 | thousands by filing date | |
| CTI BIOPHARMA CORP | 12648L601 | COM | 5,000,000 | $7,900,000 | thousands by filing date | |
| RESTORBIO INC | 76133L103 | COM | 4,830,387 | $7,197,000 | thousands by filing date | |
| VERONA PHARMA PLC | 925050106 | SPONSORED ADS | 1,250,396 | $7,190,000 | thousands by filing date | |
| SELECTA BIOSCIENCES INC | 816212104 | COM | 2,879,064 | $6,852,000 | thousands by filing date | |
| PFENEX INC | 717071104 | COM | 614,868 | $6,751,000 | thousands by filing date | |
| APTOSE BIOSCIENCES INC COM | 03835T200 | Stock | 1,150,000 | $6,521,000 | thousands by filing date | |
| ZOGENIX INC. | 98978L204 | Common Stock | 125,000 | $6,516,000 | thousands by filing date | call |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 106,900 | $6,458,000 | thousands by filing date | |
| HEALTH CATALYST INC | 42225T107 | COM | 179,598 | $6,232,000 | thousands by filing date | |
| NABRIVA THERAPEUTICS PLC | G63637105 | SHS | 4,644,600 | $6,131,000 | thousands by filing date | |
| ANAPTYSBIO INC | 032724106 | COM | 375,800 | $6,107,000 | thousands by filing date | |
| Milestone Pharmaceuticals Inc | 59935V107 | COM | 364,206 | $5,831,000 | thousands by filing date | |
| ACCELERON PHARMA INC | 00434H108 | COM | 107,500 | $5,700,000 | thousands by filing date | |
| ATRICURE INC | 04963C209 | COM | 168,621 | $5,482,000 | thousands by filing date | |
| AMARIN CORP PLC | 023111206 | SPONS ADR NEW | 249,600 | $5,351,000 | thousands by filing date | |
| PERSONALIS INC | 71535D106 | COMMON STOCK | 483,842 | $5,274,000 | thousands by filing date | |
| SYNLOGIC INC | 87166L100 | COM | 2,029,996 | $5,237,000 | thousands by filing date | |
| INCYTE CORP COM | 45337C102 | Stock | 59,500 | $5,196,000 | thousands by filing date | |
| ARENA PHARMACEUTICALS INC | 040047607 | COM NEW | 110,000 | $4,996,000 | thousands by filing date | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 96,143 | $4,113,000 | thousands by filing date | |
| INTELLIA THERAPEUTICS INC | 45826J105 | COM | 262,100 | $3,845,000 | thousands by filing date | |
| DERMIRA INC | 24983L104 | COM | 250,000 | $3,790,000 | thousands by filing date | call |
| ASTRAZENECA PLC SPONSORED ADR | 046353108 | ADR | 69,600 | $3,470,000 | thousands by filing date | |
| SANOFI SA SPONSORED ADR | 80105N105 | ADR | 68,400 | $3,434,000 | thousands by filing date | |
| AERPIO PHARMACEUTICALS INC | 00810B105 | COM | 5,193,946 | $3,238,000 | thousands by filing date | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 34,700 | $2,934,000 | thousands by filing date | |
| KALVISTA PHARMACEUTICALS INC | 483497103 | COM | 160,541 | $2,859,000 | thousands by filing date | |
| INTERCEPT PHARMACEUTICALS IN | 45845P108 | COM | 22,800 | $2,825,000 | thousands by filing date | |
| FLEXION THERAPEUTICS INC | 33938J106 | COM | 133,000 | $2,753,000 | thousands by filing date | |
| CURIS INC | 231269200 | COM | 1,358,363 | $2,309,000 | thousands by filing date | |
| MYOKARDIA INC | 62857M105 | COM | 27,900 | $2,033,000 | thousands by filing date | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 212,000 | $1,861,000 | thousands by filing date | |
| NOVUS THERAPEUTICS INC | 67011N105 | COM | 3,183,314 | $1,846,000 | thousands by filing date | |
| MIRUM PHARMACEUTICALS INC | 604749101 | COM | 71,300 | $1,748,000 | thousands by filing date | |
| ADAPTIMMUNE THERAPEUTICS PLC | 00653A107 | SPONDS ADR | 1,350,655 | $1,621,000 | thousands by filing date | |
| IMMUNOGEN INC | 45253H101 | COMMON STOCK | 286,800 | $1,464,000 | thousands by filing date | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 59,000 | $1,409,000 | thousands by filing date | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 191,209 | $1,348,000 | thousands by filing date | |
| OTONOMY INC | 68906L105 | COM | 350,700 | $1,343,000 | thousands by filing date | |
| SPERO THERAPEUTICS INC | 84833T103 | COM | 131,653 | $1,266,000 | thousands by filing date | |
| SUTRO BIOPHARMA INC | 869367102 | COM | 104,800 | $1,153,000 | thousands by filing date | |
| REGENXBIO INC | 75901B107 | COM | 26,800 | $1,098,000 | thousands by filing date | |
| BRISTOL-MYERS SQUIBB CO | 110122157 | RIGHT 99/99/9999 | 350,000 | $1,054,000 | thousands by filing date | |
| MUSTANG BIO INC | 62818Q104 | COM | 251,685 | $1,027,000 | thousands by filing date | |
| RUBIUS THERAPEUTICS INC | 78116T103 | COM | 100,000 | $950,000 | thousands by filing date | put |
| ZAFGEN INC | 98885E103 | COM | 821,000 | $911,000 | thousands by filing date | |
| APTINYX INC | 03836N103 | COM | 143,000 | $489,000 | thousands by filing date | |
| NULL | 09071M205 | NULL | 69,240 | $156,000 | thousands by filing date | |
| MEDIGUS LTD SPON ADS NEW | 58471G300 | ADR | 15,000 | $26,000 | thousands by filing date |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001172661-20-000859 | this filing | 2020-02-14 | acceptance time not in the bulk data set |