13F-HR filed by ORBIMED ADVISORS LLC
ORBIMED ADVISORS LLC filed this 13F-HR for the quarter ended 2018-12-31, filed 2019-02-14, with 131 holding rows worth $5,407,812,000.
- Accession
- 0001172661-19-000868
- Filer
- CIK 1055951
- Filed
- 2019-02-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2018
A holdings report, 131 entries on the cover page, a total value of $5,407,812,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $5,407,812,000 with VALUE read as thousands by filing date, 13F file number 028-06774. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerORBIMED CAPITAL LLC028-10410
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| TRICIDA INC | 89610F101 | COM | 10,889,280 | $256,769,000 | thousands by filing date | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 4,087,373 | $256,074,000 | thousands by filing date | |
| BIOGEN INC COM | 09062X103 | Stock | 835,249 | $251,343,000 | thousands by filing date | |
| CELGENE CORP | 151020104 | COM | 3,256,700 | $208,722,000 | thousands by filing date | |
| Boston Scientific Corporation | 101137107 | COM | 5,790,400 | $204,633,000 | thousands by filing date | |
| ALEXION PHARMACEUTICALS INC | 015351109 | COM | 2,047,400 | $199,335,000 | thousands by filing date | |
| Merck & Co.,Inc. | 58933Y105 | COM | 2,495,000 | $190,643,000 | thousands by filing date | |
| Vertex Pharmaceuticals Incorporated | 92532F100 | COM | 1,133,200 | $187,783,000 | thousands by filing date | |
| WRIGHT MED GROUP N V | N96617118 | ORD SHS | 4,905,899 | $133,539,000 | thousands by filing date | |
| ALLERGAN PLC | G0177J108 | SHS | 957,000 | $127,913,000 | thousands by filing date | |
| CLEMENTIA PHARMACEUTICALS IN | 185575107 | COM | 10,425,225 | $122,601,000 | thousands by filing date | |
| MYLAN NV | N59465109 | SHS EURO | 3,986,200 | $109,222,000 | thousands by filing date | |
| Thermo Fisher Scientific Inc. | 883556102 | COM | 437,500 | $97,908,000 | thousands by filing date | |
| SYNTHORX INC COM | 87167A103 | Stock | 5,316,355 | $92,398,000 | thousands by filing date | |
| Cigna Corporation | 125523100 | COM | 482,700 | $91,674,000 | thousands by filing date | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 781,000 | $85,231,000 | thousands by filing date | |
| REGENERON PHARMACEUTICALS COM | 75886F107 | Stock | 222,100 | $82,954,000 | thousands by filing date | |
| Intuitive Surgical,Inc. | 46120E602 | COM | 170,500 | $81,656,000 | thousands by filing date | |
| Elevance Health, Inc. | 036752103 | COM | 305,400 | $80,207,000 | thousands by filing date | |
| INSPIRE MED SYS INC COM | 457730109 | Stock | 1,829,449 | $77,294,000 | thousands by filing date | |
| ILLUMINA INC | 452327109 | COM | 245,900 | $73,753,000 | thousands by filing date | |
| PRINCIPIA BIOPHARMA INC | 74257L108 | COM | 2,605,713 | $71,370,000 | thousands by filing date | |
| EDWARDS LIFESCIENCES CORP COM | 28176E108 | Stock | 465,600 | $71,316,000 | thousands by filing date | |
| IMMUNOMEDICS INC | 452907108 | COM | 4,967,403 | $70,885,000 | thousands by filing date | |
| LOGICBIO THERAPEUTICS INC | 54142F102 | COM | 6,466,783 | $67,255,000 | thousands by filing date | |
| BAUSCH HEALTH COS INC COM | 071734107 | Stock | 3,600,300 | $66,498,000 | thousands by filing date | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 647,600 | $62,215,000 | thousands by filing date | |
| HUMANA INC COM | 444859102 | Stock | 206,500 | $59,158,000 | thousands by filing date | |
| GUARDANT HEALTH INC COM | 40131M109 | Stock | 1,534,464 | $57,681,000 | thousands by filing date | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 1,914,282 | $57,409,000 | thousands by filing date | |
| EXELIXIS INC COM | 30161Q104 | Stock | 2,801,900 | $55,113,000 | thousands by filing date | |
| PUMA BIOTECHNOLOGY INC | 74587V107 | COMMON STOCK | 2,598,883 | $52,887,000 | thousands by filing date | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 1,519,700 | $52,156,000 | thousands by filing date | |
| CVS Health Corporation | 126650100 | COM | 793,800 | $52,010,000 | thousands by filing date | |
| DECIPHERA PHARMACEUTICALS IN | 24344T101 | COM | 2,442,200 | $51,262,000 | thousands by filing date | |
| AGILENT TECHNOLOGIES INC COM | 00846U101 | Stock | 753,000 | $50,797,000 | thousands by filing date | |
| CLOVIS ONCOLOGY INC | 189464100 | COM | 2,752,200 | $49,430,000 | thousands by filing date | |
| IOVANCE BIOTHERAPEUTICS INC | 462260100 | COM | 5,548,326 | $49,103,000 | thousands by filing date | |
| CENTENE CORP DEL COM | 15135B101 | Stock | 417,400 | $48,126,000 | thousands by filing date | |
| UnitedHealth Group Inc | 91324P102 | COM | 186,500 | $46,461,000 | thousands by filing date | |
| EHEALTH INC | 28238P109 | COM | 1,100,000 | $42,262,000 | thousands by filing date | |
| RESTORBIO INC | 76133L103 | COM | 4,830,387 | $41,638,000 | thousands by filing date | |
| ZAI LAB LTD ADR | 98887Q104 | ADR | 1,753,538 | $40,717,000 | thousands by filing date | |
| AUDENTES THERAPEUTICS INC. | 05070R104 | Common Stock | 1,893,500 | $40,369,000 | thousands by filing date | |
| BEONE MEDICINES LTD SPONSORED ADS | 07725L102 | ADR | 282,500 | $39,623,000 | thousands by filing date | |
| BLUEBIRD BIO INC | 09609G100 | COM | 387,200 | $38,410,000 | thousands by filing date | |
| HERON THERAPEUTICS INC | 427746102 | COM | 1,400,300 | $36,324,000 | thousands by filing date | |
| TANDEM DIABETES CARE INC | 875372203 | COM NEW | 948,000 | $35,996,000 | thousands by filing date | |
| MOLINA HEALTHCARE INC | 60855R100 | COM | 305,000 | $35,447,000 | thousands by filing date | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 494,200 | $35,291,000 | thousands by filing date | |
| ARVINAS INC | 04335A105 | COM | 2,678,810 | $34,423,000 | thousands by filing date | |
| ObsEva SA | H5861P103 | COM | 2,605,531 | $32,986,000 | thousands by filing date | |
| Abbott Laboratories | 002824100 | COM | 448,400 | $32,433,000 | thousands by filing date | |
| AERIE PHARMACEUTICALS INC | 00771V108 | COM | 872,100 | $31,483,000 | thousands by filing date | |
| Viewra, Inc | 92672L107 | COM | 5,149,019 | $31,255,000 | thousands by filing date | |
| IRONWOOD PHARMACEUTICALS INC | 46333X108 | COMMON STOCK | 2,878,000 | $29,816,000 | thousands by filing date | |
| Gilead Sciences,Inc. | 375558103 | COM | 443,800 | $27,760,000 | thousands by filing date | |
| DAVITA INC COM | 23918K108 | Stock | 534,000 | $27,480,000 | thousands by filing date | |
| Bristol-Myers Squibb Company | 110122108 | COM | 505,900 | $26,297,000 | thousands by filing date | |
| Pfizer Inc. | 717081103 | COM | 602,200 | $26,286,000 | thousands by filing date | |
| SHIRE PLC | 82481R106 | COMMON STOCK-FO | 150,000 | $26,106,000 | thousands by filing date | call |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 928,500 | $24,958,000 | thousands by filing date | |
| Amgen Inc. | 031162100 | COM | 122,100 | $23,769,000 | thousands by filing date | |
| PROQR THERAPEUTICS NV | N71542109 | SHS EURO | 1,437,731 | $22,687,000 | thousands by filing date | |
| ASSEMBLY BIOSCIENCES INC | 045396108 | COM | 996,123 | $22,532,000 | thousands by filing date | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 5,967,584 | $21,901,000 | thousands by filing date | |
| SI BONE INC | 825704109 | COM | 985,368 | $20,584,000 | thousands by filing date | |
| Stryker Corporation | 863667101 | COM | 130,200 | $20,409,000 | thousands by filing date | |
| SPECTRUM PHARMACEUTICALS INC | 84763A108 | COM | 2,265,500 | $19,823,000 | thousands by filing date | |
| SINOVAC BIOTECH LTD | P8696W104 | SHS | 2,839,500 | $19,706,000 | thousands by filing date | |
| FOAMIX PHARMACEUTICALS LTD | M46135105 | SHS | 5,195,330 | $18,651,000 | thousands by filing date | |
| KALA BIO INC COM | 483119103 | Stock | 3,447,840 | $16,860,000 | thousands by filing date | |
| DEXCOM INC COM | 252131107 | Stock | 138,700 | $16,616,000 | thousands by filing date | |
| MYOKARDIA INC | 62857M105 | COM | 335,100 | $16,373,000 | thousands by filing date | |
| AEGLEA BIOTHERAPEUTICS INC | 00773J103 | COM | 2,165,524 | $16,220,000 | thousands by filing date | |
| NOVO-NORDISK A S ADR | 670100205 | ADR | 330,000 | $15,203,000 | thousands by filing date | |
| XTANT MED HLDGS INC | 98420P308 | COM NEW | 9,207,012 | $14,823,000 | thousands by filing date | |
| SYNLOGIC INC | 87166L100 | COM | 2,029,996 | $14,230,000 | thousands by filing date | |
| AC IMMUNE SA | H00263105 | SHS | 1,440,000 | $13,608,000 | thousands by filing date | |
| SCPHARMACEUTICALS INC | 810648105 | COM | 3,409,865 | $12,821,000 | thousands by filing date | |
| ALPINE IMMUNE SCIENCES INC | 02083G100 | COM | 3,298,516 | $12,139,000 | thousands by filing date | |
| VERONA PHARMA PLC | 925050106 | SPONSORED ADS | 1,250,396 | $12,066,000 | thousands by filing date | |
| VERRICA PHARMACEUTICALS INC | 92511W108 | COM | 1,479,733 | $12,060,000 | thousands by filing date | |
| INSMED INC | 457669AA7 | NOTE 1.750% 1/1 | 16,952,000 | $12,006,000 | thousands by filing date | principal |
| TENET HEALTHCARE CORP COM NEW | 88033G407 | Stock | 562,785 | $9,646,000 | thousands by filing date | |
| NATERA INC COM | 632307104 | Stock | 684,086 | $9,550,000 | thousands by filing date | |
| HCA Healthcare Inc | 40412C101 | COM | 75,900 | $9,446,000 | thousands by filing date | |
| ALLAKOS INC | 01671P100 | COM | 175,000 | $9,147,000 | thousands by filing date | |
| INVITAE CORP | 46185L103 | COM | 824,549 | $9,120,000 | thousands by filing date | |
| Boston Scientific Corporation | 101137107 | COM | 250,000 | $8,835,000 | thousands by filing date | call |
| AERPIO PHARMACEUTICALS INC | 00810B105 | COM | 5,193,946 | $8,830,000 | thousands by filing date | |
| ADAPTIMMUNE THERAPEUTICS PLC | 00653A107 | SPONDS ADR | 1,350,655 | $7,766,000 | thousands by filing date | |
| DERMIRA INC | 24983L104 | COM | 1,031,596 | $7,417,000 | thousands by filing date | |
| NABRIVA THERAPEUTICS PLC | G63637105 | SHS | 4,644,600 | $6,781,000 | thousands by filing date | |
| INTERCEPT PHARMACEUTICALS IN | 45845P108 | COM | 66,000 | $6,652,000 | thousands by filing date | call |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 76,500 | $6,514,000 | thousands by filing date | |
| CELGENE CORP | 151020104 | COM | 100,000 | $6,409,000 | thousands by filing date | call |
| NUVECTRA CORP | 67075N108 | COM | 350,000 | $5,719,000 | thousands by filing date | |
| ATHENEX INC | 04685N103 | COM | 430,000 | $5,457,000 | thousands by filing date | |
| INTELLIA THERAPEUTICS INC | 45826J105 | COM | 377,600 | $5,154,000 | thousands by filing date | |
| INTERCEPT PHARMACEUTICALS IN | 45845P108 | COM | 47,800 | $4,818,000 | thousands by filing date | |
| MEIRAGTX HOLDINGS PLC | G59665102 | COMMON STOCK | 469,953 | $4,530,000 | thousands by filing date | |
| Arsanis Inc | 042873109 | COM | 1,868,966 | $4,336,000 | thousands by filing date | |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 327,000 | $4,313,000 | thousands by filing date | |
| SELECTA BIOSCIENCES INC | 816212104 | COM | 1,579,064 | $4,200,000 | thousands by filing date | |
| TECTONIC THERAPEUTIC INC COM | 05455M100 | Stock | 249,900 | $4,161,000 | thousands by filing date | |
| NOVUS THERAPEUTICS INC | 67011N105 | COM | 2,537,110 | $4,059,000 | thousands by filing date | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 634,812 | $4,006,000 | thousands by filing date | |
| CTI BIOPHARMA CORP | 12648L601 | COM | 5,000,000 | $3,668,000 | thousands by filing date | |
| SAGE THERAPEUTICS INC | 78667J108 | COM | 36,300 | $3,477,000 | thousands by filing date | |
| CONSTELLATION PHARMACEUTICALS INC. | 210373106 | Common Stock | 835,842 | $3,352,000 | thousands by filing date | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 323,009 | $3,094,000 | thousands by filing date | |
| 111 INC | 68247Q102 | ADR | 500,000 | $3,070,000 | thousands by filing date | |
| RA MED SYS INC | 74933X104 | COM | 350,000 | $2,783,000 | thousands by filing date | |
| ELECTROCORE INC | 28531P103 | COM | 397,826 | $2,490,000 | thousands by filing date | |
| REALM THERAPEUTICS PLC | 75606L103 | SPONSORED ADS | 1,021,484 | $1,890,000 | thousands by filing date | |
| AEGERION PHARMACEUTICALS INC | 00767EAB8 | NOTE 2.000 8/1 | 2,000,000 | $1,676,000 | thousands by filing date | principal |
| MARINUS PHARMACEUTICALS INC | 56854Q101 | COM | 498,101 | $1,430,000 | thousands by filing date | |
| IMMUNOMEDICS INC | 452907108 | COM | 100,000 | $1,427,000 | thousands by filing date | call |
| AMARIN CORP PLC | 023111206 | SPONS ADR NEW | 81,000 | $1,102,000 | thousands by filing date | |
| MEDICINES CO | 584688105 | COM | 54,600 | $1,045,000 | thousands by filing date | |
| AFFIMED N V | N01045108 | COM | 326,650 | $1,016,000 | thousands by filing date | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 212,000 | $943,000 | thousands by filing date | |
| ADAMAS PHARMACEUTICALS INC | 00548A106 | COM | 100,000 | $854,000 | thousands by filing date | call |
| SOCIETAL CDMO INC | 75629F109 | COM | 107,357 | $762,000 | thousands by filing date | |
| SIERRA ONCOLOGY INC | 82640U107 | COM | 417,104 | $551,000 | thousands by filing date | |
| BIOLINERX LTD-SPONS ADR | 09071M106 | SPON | 1,038,600 | $454,000 | thousands by filing date | |
| REDHILL BIOPHARMA LTD | 757468103 | ADR | 54,600 | $303,000 | thousands by filing date | |
| ALIMERA SCIENCES INC | 016259103 | COM | 250,000 | $180,000 | thousands by filing date | |
| WRIGHT MED GROUP N V | N96617126 | RIGHT 03/01/2019 | 8,746,583 | $109,000 | thousands by filing date | |
| MEDIGUS LTD SPON ADS NEW | 58471G300 | ADR | 15,000 | $39,000 | thousands by filing date |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001172661-19-000868 | this filing | 2019-02-14 | acceptance time not in the bulk data set |