13F-HR filed by ORBIMED ADVISORS LLC
ORBIMED ADVISORS LLC filed this 13F-HR for the quarter ended 2016-12-31, filed 2017-02-14, with 132 holding rows worth $7,848,022,000.
- Accession
- 0001172661-17-000766
- Filer
- CIK 1055951
- Filed
- 2017-02-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2016
A holdings report, 132 entries on the cover page, a total value of $7,848,022,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $7,848,022,000 with VALUE read as thousands by filing date, 13F file number 028-06774. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerORBIMED CAPITAL LLC028-10410
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| ALEXION PHARMACEUTICALS INC | 015351109 | COM | 3,388,386 | $414,569,000 | thousands by filing date | |
| BIOGEN INC COM | 09062X103 | Stock | 1,281,200 | $363,323,000 | thousands by filing date | |
| CELGENE CORP | 151020104 | COM | 3,106,777 | $359,609,000 | thousands by filing date | |
| Boston Scientific Corporation | 101137107 | COM | 16,506,900 | $357,044,000 | thousands by filing date | |
| Amgen Inc. | 031162100 | COM | 2,331,800 | $340,932,000 | thousands by filing date | |
| Merck & Co.,Inc. | 58933Y105 | COM | 4,615,200 | $271,697,000 | thousands by filing date | |
| INCYTE CORP COM | 45337C102 | Stock | 2,082,800 | $208,842,000 | thousands by filing date | |
| SHIRE PLC | 82481R106 | COMMON STOCK-FO | 1,203,351 | $205,027,000 | thousands by filing date | |
| Eli Lilly and Company | 532457108 | COM | 2,739,000 | $201,453,000 | thousands by filing date | |
| AbbVie,Inc. | 00287Y109 | COM | 2,925,000 | $183,164,000 | thousands by filing date | |
| WRIGHT MED GROUP N V | N96617118 | ORD SHS | 7,584,334 | $174,288,000 | thousands by filing date | |
| HUMANA INC COM | 444859102 | Stock | 836,400 | $170,651,000 | thousands by filing date | |
| Pfizer Inc. | 717081103 | COM | 5,167,900 | $167,853,000 | thousands by filing date | |
| AGILENT TECHNOLOGIES INC COM | 00846U101 | Stock | 3,629,900 | $165,378,000 | thousands by filing date | |
| ALLERGAN PLC | G0177J108 | SHS | 769,690 | $161,643,000 | thousands by filing date | |
| Vertex Pharmaceuticals Incorporated | 92532F100 | COM | 2,159,400 | $159,083,000 | thousands by filing date | |
| HCA Healthcare Inc | 40412C101 | COM | 2,002,200 | $148,203,000 | thousands by filing date | |
| Elevance Health, Inc. | 036752103 | COM | 1,021,600 | $146,875,000 | thousands by filing date | |
| ARRAY BIOPHARMA INC COM | 04269X105 | Stock | 16,088,800 | $141,421,000 | thousands by filing date | |
| REGENERON PHARMACEUTICALS COM | 75886F107 | Stock | 355,300 | $130,427,000 | thousands by filing date | |
| EDWARDS LIFESCIENCES CORP COM | 28176E108 | Stock | 1,351,400 | $126,626,000 | thousands by filing date | |
| INTERCEPT PHARMACEUTICALS IN | 45845P108 | COM | 1,120,000 | $121,688,000 | thousands by filing date | |
| Thermo Fisher Scientific Inc. | 883556102 | COM | 799,500 | $112,809,000 | thousands by filing date | |
| SYNERGY PHARMACEUTICALS DEL | 871639308 | COM NEW | 18,241,398 | $111,090,000 | thousands by filing date | |
| IRONWOOD PHARMACEUTICALS INC | 46333X108 | COMMON STOCK | 7,241,300 | $110,719,000 | thousands by filing date | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 1,274,100 | $105,546,000 | thousands by filing date | |
| AETNA INC NEW | 00817Y108 | COM | 805,900 | $99,940,000 | thousands by filing date | |
| Johnson & Johnson | 478160104 | COM | 858,000 | $98,850,000 | thousands by filing date | |
| Intuitive Surgical,Inc. | 46120E602 | COM | 145,500 | $92,272,000 | thousands by filing date | |
| AUDENTES THERAPEUTICS INC. | 05070R104 | Common Stock | 4,801,638 | $87,726,000 | thousands by filing date | |
| Bristol-Myers Squibb Company | 110122108 | COM | 1,493,500 | $87,280,000 | thousands by filing date | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 2,128,774 | $82,384,000 | thousands by filing date | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 5,379,349 | $76,925,000 | thousands by filing date | |
| Gilead Sciences,Inc. | 375558103 | COM | 1,055,100 | $75,556,000 | thousands by filing date | |
| GLAUKOS CORP COM | 377322102 | Stock | 2,180,000 | $74,774,000 | thousands by filing date | |
| Mallinckrodt Plc | G5785G107 | SHS | 1,472,700 | $73,370,000 | thousands by filing date | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 5,301,805 | $70,143,000 | thousands by filing date | |
| PUMA BIOTECHNOLOGY INC | 74587V107 | COMMON STOCK | 2,275,825 | $69,868,000 | thousands by filing date | |
| ALLERGAN PLC | G0177J116 | PFD CONV SER A | 88,200 | $67,249,000 | thousands by filing date | principal |
| MAGELLAN HEALTH SERVICES INC | 559079207 | COM NEW | 801,600 | $60,320,000 | thousands by filing date | |
| AERIE PHARMACEUTICALS INC | 00771V108 | COM | 1,496,000 | $56,624,000 | thousands by filing date | |
| INSYS THERAPEUTICS INC | 45824V209 | COMMON STOCK | 6,071,440 | $55,857,000 | thousands by filing date | |
| LOXO ONCOLOGY INC | 548862101 | COM | 1,728,000 | $55,495,000 | thousands by filing date | |
| TENET HEALTHCARE CORP COM NEW | 88033G407 | Stock | 3,716,700 | $55,156,000 | thousands by filing date | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 2,717,315 | $54,998,000 | thousands by filing date | |
| Medtronic Plc | G5960L103 | COM | 766,600 | $54,605,000 | thousands by filing date | |
| ACHILLION PHARMACEUTICALS IN | 00448Q201 | COM | 13,107,200 | $54,133,000 | thousands by filing date | |
| EAGLE PHARMACEUTICALS INC | 269796108 | COM | 671,000 | $53,237,000 | thousands by filing date | |
| UnitedHealth Group Inc | 91324P102 | COM | 296,400 | $47,436,000 | thousands by filing date | |
| MOMENTA PHARMACEUTICALS INC | 60877T100 | COM | 2,951,968 | $44,427,000 | thousands by filing date | |
| GW PHARMACEUTICALS PLC | 36197T103 | ADS | 396,600 | $44,320,000 | thousands by filing date | |
| THE COOPER COMPANIES | 216648402 | COM NEW | 250,100 | $43,750,000 | thousands by filing date | |
| JAZZ PHARMACEUTICALS PLC SHS USD | G50871105 | Stock | 371,400 | $40,494,000 | thousands by filing date | |
| Stryker Corporation | 863667101 | COM | 316,300 | $37,896,000 | thousands by filing date | |
| INTELLIA THERAPEUTICS INC | 45826J105 | COM | 2,662,180 | $34,901,000 | thousands by filing date | |
| SELECTA BIOSCIENCES INC | 816212104 | COM | 1,842,797 | $31,604,000 | thousands by filing date | |
| IMMUNOMEDICS INC | 452907AK4 | NOTE 4.750 2/1 | 30,000,000 | $29,769,000 | thousands by filing date | principal |
| OTONOMY INC | 68906L105 | COM | 1,850,094 | $29,416,000 | thousands by filing date | |
| Viewra, Inc | 92672L107 | COM | 9,127,990 | $28,571,000 | thousands by filing date | |
| BEONE MEDICINES LTD SPONSORED ADS | 07725L102 | ADR | 903,700 | $27,436,000 | thousands by filing date | |
| MOLINA HEALTHCARE INC | 60855R100 | COM | 496,200 | $26,924,000 | thousands by filing date | |
| COHERUS ONCOLOGY INC | 19249H103 | COM | 850,100 | $23,930,000 | thousands by filing date | |
| Lion Biotechnologies | 53619R102 | COM | 3,382,900 | $23,511,000 | thousands by filing date | |
| DIMENSION THERAPEUTICS INC | 25433V105 | COM | 5,397,698 | $23,480,000 | thousands by filing date | |
| ILLUMINA INC | 452327109 | COM | 182,200 | $23,329,000 | thousands by filing date | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 614,500 | $22,276,000 | thousands by filing date | |
| XENCOR INC | 98401F105 | COMMON STOCK | 840,237 | $22,115,000 | thousands by filing date | |
| NEWLINK GENETICS CORP | 651511107 | COM | 1,991,700 | $20,475,000 | thousands by filing date | |
| HUMANA INC COM | 444859102 | Stock | 100,000 | $20,403,000 | thousands by filing date | call |
| EHEALTH INC | 28238P109 | COM | 1,820,000 | $19,383,000 | thousands by filing date | |
| LAKEFRONT BIOTHERAPEUTICS NV | 36315X101 | SPON ADR | 283,500 | $18,198,000 | thousands by filing date | |
| BLUEBIRD BIO INC | 09609G100 | COM | 283,800 | $17,510,000 | thousands by filing date | |
| ASSEMBLY BIOSCIENCES INC | 045396108 | COM | 1,397,100 | $16,975,000 | thousands by filing date | |
| SINOVAC BIOTECH LTD | P8696W104 | SHS | 2,667,500 | $15,738,000 | thousands by filing date | |
| NATERA INC COM | 632307104 | Stock | 1,276,190 | $14,944,000 | thousands by filing date | |
| IMMUNOMEDICS INC | 452907108 | COM | 3,802,000 | $13,953,000 | thousands by filing date | |
| BARD C R INC | 067383109 | COM | 58,000 | $13,030,000 | thousands by filing date | |
| DERMIRA INC | 24983L104 | COM | 425,600 | $12,908,000 | thousands by filing date | |
| STANDARD BIOTOOLS INC | 34385P108 | COM | 1,746,100 | $12,712,000 | thousands by filing date | |
| EXACT SCIENCES CORP COM | 30063P105 | Stock | 950,000 | $12,692,000 | thousands by filing date | |
| IMMUNOGEN INC | 45253H101 | COMMON STOCK | 6,095,647 | $12,435,000 | thousands by filing date | |
| PORTOLA PHARMACEUTICALS INC COM | 737010108 | Stock | 551,500 | $12,376,000 | thousands by filing date | |
| ALEXION PHARMACEUTICALS INC | 015351109 | COM | 100,000 | $12,235,000 | thousands by filing date | call |
| DBV TECHNOLOGIES S A | 23306J101 | ADR | 345,700 | $12,144,000 | thousands by filing date | |
| FORWARD PHARMA A/S | 34986J105 | SPONSORED ADR | 798,000 | $11,970,000 | thousands by filing date | |
| VANDA PHARMACEUTICALS INC | 921659108 | COM | 750,000 | $11,963,000 | thousands by filing date | call |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 169,300 | $11,903,000 | thousands by filing date | |
| PROQR THERAPEUTICS NV | N71542109 | SHS EURO | 2,305,446 | $11,297,000 | thousands by filing date | |
| Rocket Pharmaceuticals Inc | 45780V102 | SHS | 1,849,300 | $11,281,000 | thousands by filing date | |
| Eli Lilly and Company | 532457108 | COM | 150,000 | $11,033,000 | thousands by filing date | call |
| SELECT MED HLDGS CORP | 81619Q105 | COM | 831,900 | $11,023,000 | thousands by filing date | |
| PIERIS PHARMACEUTICALS INC | 720795103 | COM | 7,259,620 | $10,201,000 | thousands by filing date | |
| NABRIVA THERAPEUTICS AG | 62957M104 | SPONSORED ADR | 1,677,940 | $10,001,000 | thousands by filing date | |
| Abbott Laboratories | 002824100 | COM | 245,400 | $9,426,000 | thousands by filing date | |
| INCYTE CORP | 45337CAN2 | NOTE 1.250%11/1 | 4,250,000 | $8,670,000 | thousands by filing date | principal |
| INCYTE CORP | 45337CAM4 | NOTE 0.375%11/1 | 4,250,000 | $8,496,000 | thousands by filing date | principal |
| NUVASIVE INC | 670704105 | COM | 123,500 | $8,319,000 | thousands by filing date | |
| STEADYMED LTD | M84920103 | SHS | 3,072,196 | $7,988,000 | thousands by filing date | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 1,000,000 | $7,700,000 | thousands by filing date | |
| CRISPR THERAPEUTICS AG NAMEN AKT | H17182108 | Stock | 372,191 | $7,541,000 | thousands by filing date | |
| INOTEK PHARMACEUTICALS CORP | 45780VAB8 | NOTE 5.750% 8/0 | 7,000,000 | $7,354,000 | thousands by filing date | principal |
| STANDARD BIOTOOLS INC | 34385PAA6 | NOTE 2.750% 2/0 | 10,000,000 | $7,013,000 | thousands by filing date | principal |
| MINERVA NEUROSCIENCES INC COM NEW | 603380106 | Stock | 556,200 | $6,535,000 | thousands by filing date | |
| TESARO INC | 881569107 | COM | 47,200 | $6,347,000 | thousands by filing date | |
| SIENTRA INC | 82621J105 | COM | 742,574 | $6,327,000 | thousands by filing date | |
| AFFIMED N V | N01045108 | COM | 3,375,000 | $6,075,000 | thousands by filing date | |
| AEGERION PHARMACEUTICALS INC | 00767EAB8 | NOTE 2.000 8/1 | 8,000,000 | $5,976,000 | thousands by filing date | principal |
| CELLECTIS ADS | 15117K103 | COM | 350,000 | $5,933,000 | thousands by filing date | |
| AEGLEA BIOTHERAPEUTICS INC | 00773J103 | COM | 1,360,224 | $5,917,000 | thousands by filing date | |
| REDHILL BIOPHARMA LTD | 757468103 | ADR | 564,900 | $5,909,000 | thousands by filing date | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 757,365 | $5,430,000 | thousands by filing date | |
| ZIMMER BIOMET HOLDINGS INC COM | 98956P102 | Stock | 49,000 | $5,057,000 | thousands by filing date | |
| INFINITY PHARMACEUTICALS INC | 45665G303 | COM | 3,250,300 | $4,388,000 | thousands by filing date | |
| ROKA BIOSCIENCE INC COM NEW | 775431208 | Stock | 893,470 | $3,788,000 | thousands by filing date | |
| INVITAE CORP | 46185L103 | COM | 456,666 | $3,626,000 | thousands by filing date | |
| AMEDISYS INC | 023436108 | COM | 71,500 | $3,048,000 | thousands by filing date | |
| ADAPTIMMUNE THERAPEUTICS PLC | 00653A107 | SPONDS ADR | 724,184 | $2,933,000 | thousands by filing date | |
| VALEANT PHARMACEUTICALS INTL | 91911K102 | COM | 194,900 | $2,830,000 | thousands by filing date | |
| CLEARSIDE BIOMEDICAL INC | 185063104 | COM | 300,000 | $2,682,000 | thousands by filing date | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 204,400 | $2,230,000 | thousands by filing date | |
| SANGAMO THERAPEUTICS INC | 800677106 | COM | 707,400 | $2,158,000 | thousands by filing date | |
| OREXIGEN THERAPEUTICS INC | 686164AB0 | NOTE 2.750%12/0 | 5,210,000 | $1,465,000 | thousands by filing date | principal |
| AMARIN CORP PLC | 023111206 | SPONS ADR NEW | 350,000 | $1,078,000 | thousands by filing date | |
| BIOLINERX LTD-SPONS ADR | 09071M106 | SPON | 1,038,600 | $956,000 | thousands by filing date | |
| NOVELION THERAPEUTICS INC | 67001K202 | COM NEW | 100,000 | $842,000 | thousands by filing date | |
| BIOMARIN PHARMACEUTICAL INC | 09061GAF8 | NOTE 1.500%10/1 | 500,000 | $589,000 | thousands by filing date | principal |
| MARINUS PHARMACEUTICALS INC | 56854Q101 | COM | 567,600 | $573,000 | thousands by filing date | |
| BIOMARIN PHARMACEUTICAL INC | 09061GAE1 | NOTE 0.750%10/1 | 500,000 | $562,000 | thousands by filing date | principal |
| MEDIGUS LTD | 58471G102 | SPONSORED ADR | 600,000 | $339,000 | thousands by filing date | |
| ARALEZ PHARMACEUTICALS INC | 03852X100 | COM | 68,143 | $301,000 | thousands by filing date | |
| ALIMERA SCIENCES INC | 016259103 | COM | 250,000 | $270,000 | thousands by filing date | |
| XTNT | 98420P100 | Common | 475,439 | $261,000 | thousands by filing date |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001172661-17-000766 | this filing | 2017-02-14 | acceptance time not in the bulk data set |