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13F-HR filed by MANUFACTURERS LIFE INSURANCE COMPANY, THE

MANUFACTURERS LIFE INSURANCE COMPANY, THE filed this 13F-HR for the quarter ended 2021-12-31, filed 2022-02-16, with 3,106 holding rows worth $163,344,324,000.

Accession
0001145443-22-000046
Filed
2022-02-16
Accepted by EDGAR
acceptance time not in the bulk data set
Ingested
Source
SEC quarterly data set

Original filing

13F report for Q4 2021

A holdings report, 4,931 entries on the cover page, a total value of $163,344,324,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $163,344,324,000 with VALUE read as thousands by filing date, 13F file number 028-04428. The quarter's positions are built on this report. The resolved quarter.

Other managers

The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).

Issuer as filedCUSIPClassAmountValueValue read asType
DADA NEXUS LTD NPV ADR23344D108ADS10,400$137,000thousands by filing date
PASSAGE BIO INC702712100COM21,524$137,000thousands by filing date
CARDIFF ONCOLOGY INC14147L108COM22,619$136,000thousands by filing date
LYELL IMMUNOPHARMA INC55083R104COM17,822$135,000thousands by filing date
ZIOPHARM ONCOLOGY INC98973P101COM123,777$135,000thousands by filing date
OLEMA PHARMACEUTICALS INC68062P106COM14,251$133,000thousands by filing date
CYMABAY THERAPEUTICS INC23257D103COM39,219$133,000thousands by filing date
BRIGHT HEALTH GROUP INC10920V107COM38,321$132,000thousands by filing date
Matrix Service Company576853105COM17,451$131,000thousands by filing date
CENOVUS ENERGY INC15135U117*W EXP 01/01/20217,659$131,000thousands by filing date
AKOUOS INC00973J101COM15,377$131,000thousands by filing date
EPIZYME INC29428V104COM51,916$130,000thousands by filing date
NPK INTERNATIONAL INC651718504COMMON STOCK43,905$129,000thousands by filing date
SPECTRUM PHARMACEUTICALS INC84763A108COM101,415$129,000thousands by filing date
SHATTUCK LABS INC82024L103COMMON STOCK15,056$128,000thousands by filing date
9 METERS BIOPHARMA INC654405109COM130,716$128,000thousands by filing date
PARATEK PHARMACEUTICALS INC699374302Equity28,236$127,000thousands by filing date
CONCRETE PUMPING HOLDINGS IN206704108COMMON STOCK15,394$126,000thousands by filing date
SAFE BULKERS INCY7388L103COMMON STOCK33,440$126,000thousands by filing date
PLAINS ALL AMERN PIPELINE L726503105UNIT LTD PARTN13,357$125,000thousands by filing date
EVOLUS INC30052C107COM19,192$125,000thousands by filing date
DEL TACO RESTAURANTS INC NEW245496104COM10,033$125,000thousands by filing date
SIENTRA INC82621J105COM33,412$123,000thousands by filing date
EASTMAN KODAK CO277461406COM NEW25,842$121,000thousands by filing date
REKOR SYSTEMS INC759419104COM18,440$121,000thousands by filing date
EGAIN CORP28225C806COM NEW12,138$121,000thousands by filing date
SQZ BIOTECHNOLOGIES CO78472W104COM13,552$121,000thousands by filing date
ARCIMOTO INC039587100COM15,415$120,000thousands by filing date
UR-ENERGY INC91688R108COM97,725$119,000thousands by filing date
SHIFT TECHNOLOGIES INC82452T107CL A34,757$119,000thousands by filing date
QUOTIENT LTDG73268107SHS46,073$119,000thousands by filing date
CLEARPOINT NEURO INC18507C103COM10,508$118,000thousands by filing date
VOR BIOPHARMA INC929033108COM10,149$118,000thousands by filing date
GTY TECHNOLOGY HOLDINGS INC362409104COM17,651$118,000thousands by filing date
SYROS PHARMACEUTICALS INC87184Q107COM35,790$117,000thousands by filing date
ADT INC DEL COM00090Q103Stock13,826$116,000thousands by filing date
UROGEN PHARMA LTDM96088105COMMON STOCK11,924$113,000thousands by filing date
INFINITY PHARMACEUTICALS INC45665G303COM50,303$113,000thousands by filing date
ATHERSYS INC04744L106COM125,310$113,000thousands by filing date
ALDEYRA THERAPEUTICS INC01438T106COM27,645$111,000thousands by filing date
MESA AIR GROUP INC590479135COM NEW19,842$111,000thousands by filing date
CECO ENVIRONMENTAL CORP125141101COM17,350$108,000thousands by filing date
CYTOSORBENTS CORP23283X206CMN25,461$107,000thousands by filing date
ASHFORD HOSPITALITY TR INC044103869COM SHS11,078$106,000thousands by filing date
Atossa Therapeutics Inc04962H506Common Stock65,678$105,000thousands by filing date
CASPER SLEEP INC147626105COM15,644$105,000thousands by filing date
NAUTILUS INC63910B102COMMON STOCK16,642$102,000thousands by filing date
Applied Therapeutics Inc03828A101Common Stock11,189$100,000thousands by filing date
CHINDATA GROUP HLDGS LTD16955F107ADS15,100$100,000thousands by filing date
EVELO BIOSCIENCES INC299734103COM16,488$100,000thousands by filing date
METROMILE INC591697107COM45,728$100,000thousands by filing date
NIAGEN BIOSCIENCE INC171077407COM NEW26,377$99,000thousands by filing date
INVIVYD INC00534A102COMMON STOCK12,772$99,000thousands by filing date
PAVMED INC70387R106COM40,053$99,000thousands by filing date
TRANSPORTATION & LOGISTI438083107COM26,719$97,000thousands by filing date
NEOLEUKIN THERAPEUTICS INC64049K104COM20,121$97,000thousands by filing date
IMMUNIC INC4525EP101COM10,029$96,000thousands by filing date
AEGLEA BIOTHERAPEUTICS INC00773J103COM20,139$96,000thousands by filing date
EMCORE CORP290846203COM13,574$95,000thousands by filing date
HUYA INC ADS EACH REP 1 ORD SHS CL A44852D108COM13,600$94,000thousands by filing date
CARLOTZ INC142552108COMMON STOCK41,245$94,000thousands by filing date
HUMANIGEN INC444863203COM NEW25,106$93,000thousands by filing date
RADIANT LOGISTICS INC75025X100COM12,657$92,000thousands by filing date
CURIOSITYSTREAM INC23130Q107COMMON STOCK15,027$89,000thousands by filing date
Accelerate Diagnostics00430H102COM16,864$88,000thousands by filing date
EARGO INC270087109COM17,257$88,000thousands by filing date
CORMEDIX INC COM21900C308Stock19,218$87,000thousands by filing date
GREENLIGHT CAPITAL RE LTD AG4095J109COMMON STOCK11,133$87,000thousands by filing date
CITIUS PHARMACEUTICALS INC17322U207COM55,147$85,000thousands by filing date
SURFACE ONCOLOGY INC86877M209COM17,313$83,000thousands by filing date
COMSCORE INC20564W105COM24,671$82,000thousands by filing date
TECTONIC THERAPEUTIC INC COM05455M100Stock21,176$82,000thousands by filing date
VIEMED HEALTHCARE INC92663R105COM14,593$76,000thousands by filing date
JOBY AVIATION INCg65163100COMMON STOCK10,208$75,000thousands by filing date
LIBERTY TRIPADVISOR HLDGS IN531465102COM SER A34,585$75,000thousands by filing date
SMITH MICRO SOFTWARE INC832154207COMMON14,788$73,000thousands by filing date
THERAPEUTICSMD INC88338N107COM202,077$72,000thousands by filing date
Up Fintech Holding Ltd91531W106COM14,200$70,000thousands by filing date
FORTRESS BIOTECH INC34960Q109COM27,597$69,000thousands by filing date
TCR2 THERAPEUTICS INC87808K106COM14,653$68,000thousands by filing date
TONIX PHARMACEUTICALS HOLDIN890260706COM189,239$68,000thousands by filing date
IBIO INC451033203COM NEW116,483$64,000thousands by filing date
VIRACTA THERAPEUTICS INC92765F108COM16,807$61,000thousands by filing date
ESPERION THERAPEUTICS INC NEW COM29664W105Stock11,917$60,000thousands by filing date
EIGER BIOPHARMACEUTICALS INC28249U105COM11,564$60,000thousands by filing date
CASTLIGHT HEALTH INC CL B14862Q100Stock38,011$59,000thousands by filing date
ASPIRA WOMENS HEALTH INC04537Y109COM32,978$58,000thousands by filing date
ONCOCYTE CORP68235C107COM26,845$58,000thousands by filing date
BROOKLYN IMMUNOTHERAPEUTICS114082100COM13,383$56,000thousands by filing date
NATIONAL CINEMEDIA INC635309107COM19,401$55,000thousands by filing date
ATHENEX INC04685N103COM40,742$55,000thousands by filing date
SEELOS THERAPEUTICS INC81577F109COM32,130$52,000thousands by filing date
CORENERGY INFRASTRUCTURE TR21870U502TRUS16,258$51,000thousands by filing date
DURECT CORP266605104COM47,719$47,000thousands by filing date
ONECONNECT FINL TECHNOLOGY C68248T105ADR18,300$45,000thousands by filing date
MUSTANG BIO INC62818Q104COM27,099$45,000thousands by filing date
MOLECULAR TEMPLATES INC608550109COM10,199$40,000thousands by filing date
Gaotu Techedu Inc36257Y109COM19,600$38,000thousands by filing date
VIRNETX HLDG CORP92823T108COM14,293$37,000thousands by filing date
TEEKAY CORPORATIONY8564W103COM11,022$35,000thousands by filing date
CONTEXTLOGIC INC21077C107COMMON STOCK11,179$35,000thousands by filing date
TREVENA INC89532E109COM60,886$35,000thousands by filing date
Ampio Pharmaceuticals03209T109COM48,637$28,000thousands by filing date
SESEN BIO INC817763105COM26,588$22,000thousands by filing date
ZOMEDICA CORP COM98980M109Stock11,482$4,000thousands by filing date
THERIVA BIOLOGICS INC COM NEW87164U201Stock10,597$3,000thousands by filing date

Amendment chain

FilingRoleFiledAcceptedIngested
13F-HR 0001145443-22-000046this filing2022-02-16acceptance time not in the bulk data set