13F-HR filed by Tekla Capital Management LLC
Tekla Capital Management LLC filed this 13F-HR for the quarter ended 2023-03-31, filed 2023-05-10, with 177 holding rows worth $2,626,615,496.
- Accession
- 0001104659-23-057966
- Filer
- CIK 1300336
- Filed
- 2023-05-10
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q1 2023
A holdings report, 177 entries on the cover page, a total value of $2,626,615,496 stated on the cover page (in dollars after the unit check, H1), rows summing to $2,626,615,496 with VALUE read as dollars as filed, 13F file number 028-10950. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| Amgen Inc. | 031162100 | COM | 555,939 | $134,398,253 | dollars as filed | |
| Gilead Sciences,Inc. | 375558103 | COM | 1,559,884 | $129,423,575 | dollars as filed | |
| REGENERON PHARMACEUTICALS COM | 75886F107 | Stock | 143,053 | $117,542,359 | dollars as filed | |
| Johnson & Johnson | 478160104 | COM | 721,779 | $111,875,745 | dollars as filed | |
| UnitedHealth Group Inc | 91324P102 | COM | 234,173 | $110,667,818 | dollars as filed | |
| Vertex Pharmaceuticals Incorporated | 92532F100 | COM | 330,343 | $104,081,169 | dollars as filed | |
| Eli Lilly and Company | 532457108 | COM | 288,917 | $99,219,876 | dollars as filed | |
| AbbVie,Inc. | 00287Y109 | COM | 511,599 | $81,533,533 | dollars as filed | |
| ILLUMINA INC | 452327109 | COM | 348,079 | $80,945,771 | dollars as filed | |
| Pfizer Inc. | 717081103 | COM | 1,775,076 | $72,423,101 | dollars as filed | |
| ASTRAZENECA PLC SPONSORED ADR | 046353108 | ADR | 992,664 | $68,900,808 | dollars as filed | |
| BIOGEN INC COM | 09062X103 | Stock | 240,926 | $66,984,656 | dollars as filed | |
| Abbott Laboratories | 002824100 | COM | 623,855 | $63,171,557 | dollars as filed | |
| Merck & Co.,Inc. | 58933Y105 | COM | 552,122 | $58,740,260 | dollars as filed | |
| Thermo Fisher Scientific Inc. | 883556102 | COM | 93,705 | $54,008,751 | dollars as filed | |
| Elevance Health, Inc. | 036752103 | COM | 114,070 | $52,450,527 | dollars as filed | |
| MODERNA INC | 60770K107 | COM | 322,217 | $49,486,087 | dollars as filed | |
| Cigna Corporation | 125523100 | COM | 182,631 | $46,667,699 | dollars as filed | |
| Bristol-Myers Squibb Company | 110122108 | COM | 663,796 | $46,007,701 | dollars as filed | |
| SEAGEN INC | 81181C104 | COM | 224,663 | $45,487,518 | dollars as filed | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 285,653 | $39,371,553 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 88,310 | $32,902,540 | dollars as filed | |
| IDEXX LABS INC COM | 45168D104 | Stock | 58,595 | $29,302,188 | dollars as filed | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 300,089 | $29,180,654 | dollars as filed | |
| Intuitive Surgical,Inc. | 46120E602 | COM | 112,680 | $28,786,360 | dollars as filed | |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 143,214 | $28,688,628 | dollars as filed | |
| Boston Scientific Corporation | 101137107 | COM | 565,990 | $28,316,480 | dollars as filed | |
| Medtronic Plc | G5960L103 | COM | 344,517 | $27,774,961 | dollars as filed | |
| Danaher Corporation | 235851102 | COM | 105,690 | $26,638,108 | dollars as filed | |
| DEXCOM INC COM | 252131107 | Stock | 228,747 | $26,575,826 | dollars as filed | |
| CHARLES RIV LABS INTL INC | 159864107 | COM | 118,083 | $23,831,511 | dollars as filed | |
| MCKESSON CORP COM | 58155Q103 | Stock | 66,455 | $23,661,303 | dollars as filed | |
| HCA Healthcare Inc | 40412C101 | COM | 88,703 | $23,389,207 | dollars as filed | |
| ZOETIS INC CL A | 98978V103 | Stock | 136,914 | $22,787,966 | dollars as filed | |
| JAZZ PHARMACEUTICALS PLC SHS USD | G50871105 | Stock | 147,779 | $21,624,501 | dollars as filed | |
| Stryker Corporation | 863667101 | COM | 71,578 | $20,433,372 | dollars as filed | |
| HUMANA INC COM | 444859102 | Stock | 36,794 | $17,862,015 | dollars as filed | |
| NOVO-NORDISK A S ADR | 670100205 | ADR | 111,323 | $17,715,942 | dollars as filed | |
| MOLINA HEALTHCARE INC | 60855R100 | COM | 61,856 | $16,545,861 | dollars as filed | |
| RESMED INC COM | 761152107 | Stock | 73,189 | $16,027,659 | dollars as filed | |
| EDWARDS LIFESCIENCES CORP COM | 28176E108 | Stock | 171,146 | $14,158,909 | dollars as filed | |
| EXELIXIS INC COM | 30161Q104 | Stock | 726,639 | $14,104,063 | dollars as filed | |
| UNITED THERAPEUTICS CORP DEL COM | 91307C102 | Stock | 61,200 | $13,706,352 | dollars as filed | |
| ACADIA HEALTHCARE COMPANY INC COM | 00404A109 | Stock | 186,487 | $13,473,686 | dollars as filed | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 123,791 | $13,272,871 | dollars as filed | |
| UNIQURE NV | N90064101 | SHS | 652,446 | $13,140,262 | dollars as filed | |
| PHYSICIANS REALTY TRUST | 71943U104 | COM | 873,655 | $13,043,669 | dollars as filed | |
| BIONTECH SE SPONSORED ADS | 09075V102 | ADR | 103,858 | $12,937,591 | dollars as filed | |
| IQVIA HLDGS INC COM | 46266C105 | Stock | 63,117 | $12,553,340 | dollars as filed | |
| NOVARTIS AG SPONSORED ADR | 66987V109 | ADR | 136,225 | $12,532,700 | dollars as filed | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 112,908 | $11,428,548 | dollars as filed | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 147,677 | $11,254,464 | dollars as filed | |
| GUARDANT HEALTH INC COM | 40131M109 | Stock | 472,184 | $11,067,993 | dollars as filed | |
| Oculis Holding AG | 952KVL905 | Common | 1,690,741 | $11,047,302 | dollars as filed | |
| RALLYBIO CORP | 75120L100 | COM | 1,727,067 | $9,861,553 | dollars as filed | |
| AVANTOR INC COM | 05352A100 | Stock | 459,488 | $9,713,576 | dollars as filed | |
| KARUNA THERAPEUTICS INC | 48576A100 | COM | 53,452 | $9,709,021 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 418,520 | $9,412,515 | dollars as filed | |
| INTRA-CELLULAR THERAPIES INC | 46116X101 | COMMON STOCK | 172,371 | $9,333,890 | dollars as filed | |
| LABORATORY CORP OF AMERICA | 50540R409 | COM NEW | 40,042 | $9,186,436 | dollars as filed | |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 135,124 | $8,912,779 | dollars as filed | |
| ALKERMES PLC | G01767105 | SHS | 309,613 | $8,727,990 | dollars as filed | |
| ZIMMER BIOMET HOLDINGS INC COM | 98956P102 | Stock | 67,356 | $8,702,395 | dollars as filed | |
| OMEGA HEALTHCARE INVS INC COM | 681936100 | REIT | 306,433 | $8,399,329 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 219,025 | $7,707,490 | dollars as filed | |
| DENALI THERAPEUTICS INC COM | 24823R105 | Stock | 324,829 | $7,484,060 | dollars as filed | |
| CVS Health Corporation | 126650100 | COM | 93,621 | $6,956,977 | dollars as filed | |
| SANOFI SA SPONSORED ADR | 80105N105 | ADR | 123,454 | $6,718,367 | dollars as filed | |
| LANTHEUS HLDGS INC | 516544103 | COM | 79,495 | $6,563,107 | dollars as filed | |
| LTC PPTYS INC COM | 502175102 | REIT | 182,293 | $6,403,953 | dollars as filed | |
| AGILENT TECHNOLOGIES INC COM | 00846U101 | Stock | 43,191 | $5,975,043 | dollars as filed | |
| STERIS PLC SHS USD | G8473T100 | Stock | 31,072 | $5,943,452 | dollars as filed | |
| SABRA HEALTH CARE REIT INC COM | 78573L106 | REIT | 510,660 | $5,872,590 | dollars as filed | |
| VECTIVBIO HLDG AG | H9060V101 | COM | 682,834 | $5,872,372 | dollars as filed | |
| INTELLIA THERAPEUTICS INC | 45826J105 | COM | 154,269 | $5,749,606 | dollars as filed | |
| VERADIGM INC | 01988P108 | COMMON STOCK | 428,580 | $5,592,969 | dollars as filed | |
| PROMETHEUS BIOSCIENCES INC | 74349U108 | COM | 50,538 | $5,423,738 | dollars as filed | |
| R1 RCM INC | 77634L105 | COM | 356,851 | $5,352,765 | dollars as filed | |
| WEST PHARMACEUTICAL SVSC INC COM | 955306105 | Stock | 15,036 | $5,209,523 | dollars as filed | |
| SMITH & NEPHEW PLC SPDN ADR NEW | 83175M205 | ADR | 181,710 | $5,071,526 | dollars as filed | |
| AMEDISYS INC | 023436108 | COM | 68,949 | $5,071,199 | dollars as filed | |
| ADDUS HOMECARE CORP | 006739106 | COM | 42,380 | $4,524,489 | dollars as filed | |
| BEONE MEDICINES LTD SPONSORED ADS | 07725L102 | ADR | 20,952 | $4,515,785 | dollars as filed | |
| CEREVEL THERAPEUTICS HLDNG I | 15678U128 | COM | 176,483 | $4,304,420 | dollars as filed | |
| BIOCRYST PHARMACEUTICALS INC COM | 09058V103 | Stock | 504,528 | $4,207,764 | dollars as filed | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 459,651 | $4,067,911 | dollars as filed | |
| ADAPTIVE BIOTECHNOLOGIES CORP COM | 00650F109 | Stock | 422,281 | $3,728,741 | dollars as filed | |
| CARDIOVASCULAR SYSTEMS INC | 141619106 | COMMON STOCK | 174,859 | $3,472,700 | dollars as filed | |
| KURA ONCOLOGY INC COM | 50127T109 | Stock | 283,281 | $3,464,527 | dollars as filed | |
| MEDICAL PROPERTIES TRUST INC COM | 58463J304 | REIT | 411,743 | $3,384,527 | dollars as filed | |
| HEALTHCARE RLTY TR CL A COM | 42226K105 | REIT | 174,686 | $3,376,680 | dollars as filed | |
| HEALTHPEAK PROPERTIES INC COM | 42250P103 | REIT | 150,392 | $3,304,112 | dollars as filed | |
| CENCORA INC COM | 03073E105 | Stock | 20,417 | $3,268,966 | dollars as filed | |
| CATALENT INC USD 0.01 | 148806102 | COM | 49,406 | $3,246,468 | dollars as filed | |
| ISHARES TR | 464287556 | ISHARES BIOTECH | 24,569 | $3,173,332 | dollars as filed | |
| MARINUS PHARMACEUTICALS INC | 56854Q200 | COM NEW | 456,780 | $3,151,782 | dollars as filed | |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 87,840 | $3,139,402 | dollars as filed | |
| BLUEPRINT MEDICINES CORP | 09627Y109 | COM | 67,710 | $3,046,273 | dollars as filed | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 12,481 | $3,023,647 | dollars as filed | |
| CARIBOU BIOSCIENCES INC COM | 142038108 | Stock | 567,147 | $3,011,551 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 83,714 | $2,996,124 | dollars as filed | |
| WELLTOWER INC COM | 95040Q104 | REIT | 41,484 | $2,973,988 | dollars as filed | |
| VENTAS INC COM | 92276F100 | REIT | 66,681 | $2,890,621 | dollars as filed | |
| PYXIS ONCOLOGY INC COMMON STOCK | 747324101 | Stock | 708,303 | $2,840,295 | dollars as filed | |
| LIVANOVA PLC | G5509L101 | SHS | 63,880 | $2,783,890 | dollars as filed | |
| NATERA INC COM | 632307104 | Stock | 49,272 | $2,735,581 | dollars as filed | |
| BAXTER INTL INC | 071813109 | COM | 67,312 | $2,730,175 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 67,065 | $2,689,307 | dollars as filed | |
| ASSERTIO HOLDINGS INC | 04546C205 | COM NEW | 410,575 | $2,615,363 | dollars as filed | |
| ARDELYX INC | 039697107 | COM | 539,408 | $2,583,764 | dollars as filed | |
| ARROWHEAD PHARMACEUTICALS IN | 04280A100 | COM | 100,422 | $2,550,719 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 150,921 | $2,502,270 | dollars as filed | |
| CRISPR THERAPEUTICS AG NAMEN AKT | H17182108 | Stock | 55,080 | $2,491,268 | dollars as filed | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 117,717 | $2,486,183 | dollars as filed | |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 65,490 | $2,434,918 | dollars as filed | |
| ALIGN TECHNOLOGY INC COM | 016255101 | Stock | 6,925 | $2,313,920 | dollars as filed | |
| GALERA THERAPEUTICS EQUICLASS EQUITY | 36338D108 | COMMON STOCK | 898,374 | $2,299,837 | dollars as filed | |
| OPTION CARE HEALTH INC COM NEW | 68404L201 | Stock | 64,975 | $2,064,256 | dollars as filed | |
| KONINKLIJKE PHILIPS N V NY REGIS SHS NEW | 500472303 | ADR | 109,860 | $2,015,931 | dollars as filed | |
| ICON PUB LTD CO SHS | G4705A100 | Stock | 9,334 | $1,993,649 | dollars as filed | |
| CHINOOK THERAPEUTICS INC | 16961L106 | COM | 83,500 | $1,933,025 | dollars as filed | |
| BICYCLE THERAPEUTICS PLC-ADR | 088786108 | SPONSORED ADS | 88,676 | $1,886,139 | dollars as filed | |
| PERRIGO CO PLC SHS | G97822103 | Stock | 51,224 | $1,837,405 | dollars as filed | |
| IMMUNOVANT INC | 45258J102 | COM | 115,400 | $1,789,854 | dollars as filed | |
| MEDPACE HLDGS INC COM | 58506Q109 | Stock | 9,435 | $1,774,252 | dollars as filed | |
| TAKEDA PHARMACEUTICAL CO LTD SPONSORED ADS | 874060205 | ADR | 105,073 | $1,731,603 | dollars as filed | |
| ARCUTIS BIOTHERAPEUTICS INC | 03969K108 | COM | 148,874 | $1,637,614 | dollars as filed | |
| REATA PHARMACEUTICALS INC | 75615P103 | CL A | 17,850 | $1,622,922 | dollars as filed | |
| 89BIO INC | 282559103 | COM | 105,898 | $1,612,827 | dollars as filed | |
| GLOBAL MED REIT INC | 37954A204 | COM NEW | 174,897 | $1,593,312 | dollars as filed | |
| GSK PLC SPONSORED ADR | 37733W204 | ADR | 41,852 | $1,489,094 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 195,025 | $1,300,817 | dollars as filed | |
| MERUS N V | N5749R100 | COM | 69,025 | $1,270,060 | dollars as filed | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 78,529 | $1,261,176 | dollars as filed | |
| ZAI LAB LTD ADR | 98887Q104 | ADR | 34,640 | $1,152,126 | dollars as filed | |
| G1 THERAPEUTICS INC | 3621LQ109 | COM | 423,869 | $1,135,969 | dollars as filed | |
| MEREO BIOPHARMA GROUP PLC | 589492107 | CMN | 1,551,082 | $1,096,460 | dollars as filed | |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 108,833 | $870,664 | dollars as filed | |
| INTERCEPT PHARMACEUTICALS IN | 45845P108 | COM | 52,067 | $699,260 | dollars as filed | |
| Mersana Therapeutics Inc | 59045L106 | Common Stock | 162,383 | $667,394 | dollars as filed | |
| THESEUS PHARMACEUTICALS INC | 88369M101 | COM | 75,000 | $666,000 | dollars as filed | |
| ITEOS THERAPEUTICS INC | 46565G104 | COM | 45,735 | $622,453 | dollars as filed | |
| ARCUS BIOSCIENCES INC | 03969F109 | COM | 32,839 | $598,983 | dollars as filed | |
| TACTILE SYSTEMS TECHNOLOGY I | 87357P100 | COMMON STOCK | 34,432 | $565,373 | dollars as filed | |
| NOVABRIDGE BIOSCIENCES | 44975P103 | CMN | 162,580 | $562,527 | dollars as filed | |
| COMMUNITY USD0.01 | 20369C106 | COM | 14,900 | $545,340 | dollars as filed | |
| UNIVERSAL HEALTH RLTY INCOME | 91359E105 | REIT | 11,258 | $541,622 | dollars as filed | |
| NATIONAL HEALTH INVS INC COM | 63633D104 | REIT | 10,038 | $517,760 | dollars as filed | |
| BEAM THERAPEUTICS INC | 07373V105 | COM | 15,817 | $484,317 | dollars as filed | |
| DIVERSIFIED HEALTHCARE TR | 25525P107 | COM SH BEN INT | 357,720 | $482,922 | dollars as filed | |
| BIOHAVEN LTD | G1110E107 | COM | 35,087 | $479,288 | dollars as filed | |
| SUTRO BIOPHARMA INC | 869367102 | COM | 98,354 | $454,395 | dollars as filed | |
| NOVAVAX INC | 670002401 | COM NEW | 63,800 | $442,134 | dollars as filed | |
| AFFIMED N V | N01045108 | COM | 586,038 | $436,950 | dollars as filed | |
| COMMUNITY HEALTH SYSTEMS INC | 203668108 | COMMON STOCK | 88,335 | $432,842 | dollars as filed | |
| Tscan Therapeutics Inc | 89854M101 | COM | 200,000 | $420,000 | dollars as filed | |
| MORPHOSYS AG | 617760202 | ADR | 81,867 | $323,375 | dollars as filed | |
| ALTIMMUNE INC | 02155H200 | COM NEW | 75,000 | $316,500 | dollars as filed | |
| ALX ONCOLOGY HOLDINGS INC | 00166B105 | COMMON STOCK | 66,211 | $299,274 | dollars as filed | |
| REPARE THERAPEUTICS INC | 760273102 | COM | 29,150 | $286,836 | dollars as filed | |
| CODEXIS INC | 192005106 | COM | 69,125 | $286,178 | dollars as filed | |
| MALLINCKRODT PLC | G5890A102 | COM | 35,048 | $255,503 | dollars as filed | |
| BLACK DIAMOND THERAPEUTICS I | 09203E105 | COM | 131,990 | $249,461 | dollars as filed | |
| ADICET BIO INC | 007002108 | COM | 40,329 | $232,295 | dollars as filed | |
| HARPOON THERAPEUTICS INC | 41358P106 | COM | 259,910 | $193,425 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 5,000 | $187,400 | dollars as filed | |
| PRECISION BIOSCIENCES INC | 74019P108 | COM | 224,534 | $169,209 | dollars as filed | |
| FULCRUM THERAPEUTICS INC | 359616109 | COMMON STOCK | 58,537 | $166,830 | dollars as filed | |
| FUSION PHARMACEUTICALS INC | 36118A100 | COM | 43,394 | $163,595 | dollars as filed | |
| NKARTA INC | 65487U108 | COMMON STOCK | 28,988 | $102,907 | dollars as filed | |
| SPECTRUM PHARMACEUTICALS INC | 84763A108 | COM | 114,670 | $86,003 | dollars as filed | |
| ORUKA THERAPEUTICS INC COM | 00211Y506 | Stock | 32,461 | $64,597 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W108 | COM | 75,000 | $60,675 | dollars as filed | |
| CORBUS PHARMACEUTICALS | 21833P301 | COM NEW | 5,143 | $37,390 | dollars as filed | |
| VYNE THERAPEUTICS INC | 92941V308 | COM | 7,520 | $23,162 | dollars as filed | |
| NEXGEL INC | 65344E107 | COM | 4,243 | $5,516 | dollars as filed | |
| BELLICUM PHARMACEUTICALS INC COM NEW | 079481404 | Stock | 6,000 | $1,980 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001104659-23-057966 | this filing | 2023-05-10 | acceptance time not in the bulk data set |