13F-HR filed by Tekla Capital Management LLC
Tekla Capital Management LLC filed this 13F-HR for the quarter ended 2022-12-31, filed 2023-02-10, with 172 holding rows worth $2,647,841,985.
- Accession
- 0001104659-23-018131
- Filer
- CIK 1300336
- Filed
- 2023-02-10
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2022
A holdings report, 172 entries on the cover page, a total value of $2,647,841,985 stated on the cover page (in dollars after the unit check, H1), rows summing to $2,647,841,985 with VALUE read as dollars as filed, 13F file number 028-10950. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| UnitedHealth Group Inc | 91324P102 | COM | 270,546 | $143,438,078 | dollars as filed | |
| Amgen Inc. | 031162100 | COM | 508,676 | $133,598,665 | dollars as filed | |
| Gilead Sciences,Inc. | 375558103 | COM | 1,510,440 | $129,671,274 | dollars as filed | |
| Johnson & Johnson | 478160104 | COM | 639,679 | $112,999,295 | dollars as filed | |
| Eli Lilly and Company | 532457108 | COM | 288,917 | $105,697,395 | dollars as filed | |
| Vertex Pharmaceuticals Incorporated | 92532F100 | COM | 330,343 | $95,396,452 | dollars as filed | |
| REGENERON PHARMACEUTICALS COM | 75886F107 | Stock | 120,862 | $87,200,724 | dollars as filed | |
| AbbVie,Inc. | 00287Y109 | COM | 478,342 | $77,304,851 | dollars as filed | |
| Abbott Laboratories | 002824100 | COM | 693,051 | $76,090,069 | dollars as filed | |
| Pfizer Inc. | 717081103 | COM | 1,457,170 | $74,665,391 | dollars as filed | |
| ASTRAZENECA PLC SPONSORED ADR | 046353108 | ADR | 1,022,255 | $69,308,889 | dollars as filed | |
| ILLUMINA INC | 452327109 | COM | 319,958 | $64,695,508 | dollars as filed | |
| Merck & Co.,Inc. | 58933Y105 | COM | 552,122 | $61,257,936 | dollars as filed | |
| Cigna Corporation | 125523100 | COM | 182,631 | $60,512,956 | dollars as filed | |
| BIOGEN INC COM | 09062X103 | Stock | 195,430 | $54,118,476 | dollars as filed | |
| Thermo Fisher Scientific Inc. | 883556102 | COM | 93,705 | $51,602,406 | dollars as filed | |
| Bristol-Myers Squibb Company | 110122108 | COM | 687,529 | $49,467,712 | dollars as filed | |
| MODERNA INC | 60770K107 | COM | 264,927 | $47,586,188 | dollars as filed | |
| HORIZON THERAPEUTICS PLC | G46188101 | SHS | 415,053 | $47,233,031 | dollars as filed | |
| Stryker Corporation | 863667101 | COM | 164,128 | $40,127,655 | dollars as filed | |
| HUMANA INC COM | 444859102 | Stock | 77,713 | $39,803,821 | dollars as filed | |
| Boston Scientific Corporation | 101137107 | COM | 757,015 | $35,027,084 | dollars as filed | |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 143,214 | $34,034,807 | dollars as filed | |
| ZIMMER BIOMET HOLDINGS INC COM | 98956P102 | Stock | 258,868 | $33,005,670 | dollars as filed | |
| UNITED THERAPEUTICS CORP DEL COM | 91307C102 | Stock | 115,077 | $32,001,763 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 84,021 | $31,829,675 | dollars as filed | |
| Intuitive Surgical,Inc. | 46120E602 | COM | 112,680 | $29,899,638 | dollars as filed | |
| JAZZ PHARMACEUTICALS PLC SHS USD | G50871105 | Stock | 182,782 | $29,119,000 | dollars as filed | |
| Danaher Corporation | 235851102 | COM | 105,690 | $28,052,240 | dollars as filed | |
| IDEXX LABS INC COM | 45168D104 | Stock | 68,065 | $27,767,797 | dollars as filed | |
| Medtronic Plc | G5960L103 | COM | 326,172 | $25,350,088 | dollars as filed | |
| HCA Healthcare Inc | 40412C101 | COM | 105,003 | $25,196,520 | dollars as filed | |
| MCKESSON CORP COM | 58155Q103 | Stock | 66,455 | $24,928,600 | dollars as filed | |
| DEXCOM INC COM | 252131107 | Stock | 218,015 | $24,688,019 | dollars as filed | |
| MOLINA HEALTHCARE INC | 60855R100 | COM | 73,615 | $24,309,145 | dollars as filed | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 230,790 | $23,884,457 | dollars as filed | |
| ZOETIS INC CL A | 98978V103 | Stock | 136,914 | $20,064,747 | dollars as filed | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 140,959 | $18,265,467 | dollars as filed | |
| NOVO-NORDISK A S ADR | 670100205 | ADR | 130,523 | $17,664,983 | dollars as filed | |
| LANTHEUS HLDGS INC | 516544103 | COM | 342,872 | $17,472,757 | dollars as filed | |
| CHARLES RIV LABS INTL INC | 159864107 | COM | 72,675 | $15,835,883 | dollars as filed | |
| BIONTECH SE SPONSORED ADS | 09075V102 | ADR | 103,858 | $15,601,549 | dollars as filed | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 123,791 | $15,118,595 | dollars as filed | |
| UNIQURE NV | N90064101 | SHS | 652,446 | $14,790,951 | dollars as filed | |
| SEAGEN INC | 81181C104 | COM | 112,214 | $14,420,621 | dollars as filed | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 112,908 | $13,485,732 | dollars as filed | |
| IQVIA HLDGS INC COM | 46266C105 | Stock | 63,117 | $12,932,042 | dollars as filed | |
| GUARDANT HEALTH INC COM | 40131M109 | Stock | 472,184 | $12,843,405 | dollars as filed | |
| EDWARDS LIFESCIENCES CORP COM | 28176E108 | Stock | 171,388 | $12,787,259 | dollars as filed | |
| RESMED INC COM | 761152107 | Stock | 60,699 | $12,633,283 | dollars as filed | |
| NOVARTIS AG SPONSORED ADR | 66987V109 | ADR | 136,225 | $12,358,332 | dollars as filed | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 147,677 | $12,257,191 | dollars as filed | |
| ACADIA HEALTHCARE COMPANY INC COM | 00404A109 | Stock | 141,189 | $11,622,678 | dollars as filed | |
| RALLYBIO CORP | 75120L100 | COM | 1,727,067 | $11,346,830 | dollars as filed | |
| ALIGN TECHNOLOGY INC COM | 016255101 | Stock | 50,824 | $10,718,782 | dollars as filed | |
| KARUNA THERAPEUTICS INC | 48576A100 | COM | 53,452 | $10,503,318 | dollars as filed | |
| LABORATORY CORP OF AMERICA | 50540R409 | COM NEW | 44,142 | $10,394,558 | dollars as filed | |
| AVANTOR INC COM | 05352A100 | Stock | 459,488 | $9,690,602 | dollars as filed | |
| INTRA-CELLULAR THERAPIES INC | 46116X101 | COMMON STOCK | 172,371 | $9,121,873 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 418,520 | $8,801,476 | dollars as filed | |
| CVS Health Corporation | 126650100 | COM | 93,621 | $8,724,541 | dollars as filed | |
| OMEGA HEALTHCARE INVS INC COM | 681936100 | REIT | 306,433 | $8,564,802 | dollars as filed | |
| ALKERMES PLC | G01767105 | SHS | 309,613 | $8,090,188 | dollars as filed | |
| BIOCRYST PHARMACEUTICALS INC COM | 09058V103 | Stock | 672,705 | $7,722,653 | dollars as filed | |
| DENALI THERAPEUTICS INC COM | 24823R105 | Stock | 272,520 | $7,578,781 | dollars as filed | |
| VERADIGM INC | 01988P108 | COMMON STOCK | 428,580 | $7,560,151 | dollars as filed | |
| Elevance Health, Inc. | 036752103 | COM | 14,644 | $7,511,933 | dollars as filed | |
| HEALTHEQUITY INC COM | 42226A107 | Stock | 110,214 | $6,793,591 | dollars as filed | |
| LTC PPTYS INC COM | 502175102 | REIT | 182,293 | $6,476,870 | dollars as filed | |
| AGILENT TECHNOLOGIES INC COM | 00846U101 | Stock | 43,191 | $6,463,533 | dollars as filed | |
| VECTIVBIO HLDG AG | H9060V101 | COM | 737,704 | $6,351,631 | dollars as filed | |
| SABRA HEALTH CARE REIT INC COM | 78573L106 | REIT | 510,660 | $6,347,504 | dollars as filed | |
| SANOFI SA SPONSORED ADR | 80105N105 | ADR | 123,454 | $5,978,877 | dollars as filed | |
| CATALENT INC USD 0.01 | 148806102 | COM | 125,947 | $5,668,874 | dollars as filed | |
| CEREVEL THERAPEUTICS HLDNG I | 15678U128 | COM | 176,483 | $5,566,274 | dollars as filed | |
| INTELLIA THERAPEUTICS INC | 45826J105 | COM | 154,269 | $5,382,445 | dollars as filed | |
| XENCOR INC | 98401F105 | COMMON STOCK | 200,328 | $5,216,541 | dollars as filed | |
| SMITH & NEPHEW PLC SPDN ADR NEW | 83175M205 | ADR | 181,710 | $4,886,182 | dollars as filed | |
| BEONE MEDICINES LTD SPONSORED ADS | 07725L102 | ADR | 20,952 | $4,608,183 | dollars as filed | |
| MEDICAL PROPERTIES TRUST INC COM | 58463J304 | REIT | 411,743 | $4,586,817 | dollars as filed | |
| ADDUS HOMECARE CORP | 006739106 | COM | 42,380 | $4,216,386 | dollars as filed | |
| PROMETHEUS BIOSCIENCES INC | 74349U108 | COM | 38,237 | $4,206,070 | dollars as filed | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 459,651 | $4,192,017 | dollars as filed | |
| ARROWHEAD PHARMACEUTICALS IN | 04280A100 | COM | 100,422 | $4,073,116 | dollars as filed | |
| HEALTHPEAK PROPERTIES INC COM | 42250P103 | REIT | 150,392 | $3,770,327 | dollars as filed | |
| CARIBOU BIOSCIENCES INC COM | 142038108 | Stock | 567,147 | $3,561,683 | dollars as filed | |
| KURA ONCOLOGY INC COM | 50127T109 | Stock | 283,281 | $3,515,517 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 75,139 | $3,442,869 | dollars as filed | |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 66,426 | $3,434,888 | dollars as filed | |
| CENCORA INC COM | 03073E105 | Stock | 20,417 | $3,383,301 | dollars as filed | |
| HEALTHCARE RLTY TR CL A COM | 42226K105 | REIT | 174,686 | $3,366,199 | dollars as filed | |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 87,840 | $3,317,717 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 83,714 | $3,300,843 | dollars as filed | |
| ADAPTIVE BIOTECHNOLOGIES CORP COM | 00650F109 | Stock | 422,281 | $3,226,227 | dollars as filed | |
| ISHARES TR | 464287556 | ISHARES BIOTECH | 24,569 | $3,225,664 | dollars as filed | |
| MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD | 61559X104 | Stock | 300,000 | $3,150,000 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 67,065 | $3,107,121 | dollars as filed | |
| STERIS PLC SHS USD | G8473T100 | Stock | 16,669 | $3,078,598 | dollars as filed | |
| VENTAS INC COM | 92276F100 | REIT | 66,681 | $3,003,979 | dollars as filed | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 117,717 | $2,995,898 | dollars as filed | |
| MIRATI THERAPEUTICS INC | 60468T105 | COM | 65,490 | $2,967,352 | dollars as filed | |
| BLUEPRINT MEDICINES CORP | 09627Y109 | COM | 67,710 | $2,966,375 | dollars as filed | |
| WELLTOWER INC COM | 95040Q104 | REIT | 41,484 | $2,719,276 | dollars as filed | |
| BICYCLE THERAPEUTICS PLC-ADR | 088786108 | SPONSORED ADS | 88,676 | $2,624,810 | dollars as filed | |
| PHYSICIANS REALTY TRUST | 71943U104 | COM | 168,741 | $2,441,682 | dollars as filed | |
| IDEAYA BIOSCIENCES INC COM | 45166A102 | Stock | 133,185 | $2,419,971 | dollars as filed | |
| CARDIOVASCULAR SYSTEMS INC | 141619106 | COMMON STOCK | 174,859 | $2,381,580 | dollars as filed | |
| G1 THERAPEUTICS INC | 3621LQ109 | COM | 423,869 | $2,301,609 | dollars as filed | |
| CRISPR THERAPEUTICS AG NAMEN AKT | H17182108 | Stock | 55,080 | $2,239,002 | dollars as filed | |
| R1 RCM INC | 77634L105 | COM | 202,351 | $2,215,743 | dollars as filed | |
| ARCUTIS BIOTHERAPEUTICS INC | 03969K108 | COM | 148,874 | $2,203,335 | dollars as filed | |
| MEDPACE HLDGS INC COM | 58506Q109 | Stock | 9,435 | $2,004,088 | dollars as filed | |
| NATERA INC COM | 632307104 | Stock | 49,272 | $1,979,256 | dollars as filed | |
| OPTION CARE HEALTH INC COM NEW | 68404L201 | Stock | 64,975 | $1,955,098 | dollars as filed | |
| ICON PUB LTD CO SHS | G4705A100 | Stock | 9,334 | $1,813,130 | dollars as filed | |
| ASSERTIO HOLDINGS INC | 04546C205 | COM NEW | 410,575 | $1,765,473 | dollars as filed | |
| PERRIGO CO PLC SHS | G97822103 | Stock | 51,224 | $1,746,226 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 195,025 | $1,743,524 | dollars as filed | |
| GLOBAL MED REIT INC | 37954A204 | COM NEW | 174,897 | $1,658,024 | dollars as filed | |
| KONINKLIJKE PHILIPS N V NY REGIS SHS NEW | 500472303 | ADR | 109,860 | $1,646,801 | dollars as filed | |
| TAKEDA PHARMACEUTICAL CO LTD SPONSORED ADS | 874060205 | ADR | 105,073 | $1,639,139 | dollars as filed | |
| ARDELYX INC | 039697107 | COM | 539,408 | $1,537,313 | dollars as filed | |
| ARVINAS INC | 04335A105 | COM | 42,998 | $1,470,962 | dollars as filed | |
| GSK PLC SPONSORED ADR | 37733W204 | ADR | 41,852 | $1,470,679 | dollars as filed | |
| MERUS N V | N5749R100 | COM | 92,325 | $1,428,268 | dollars as filed | |
| GALERA THERAPEUTICS EQUICLASS EQUITY | 36338D108 | COMMON STOCK | 898,374 | $1,338,577 | dollars as filed | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 122,271 | $1,333,977 | dollars as filed | |
| ZAI LAB LTD ADR | 98887Q104 | ADR | 43,300 | $1,329,310 | dollars as filed | |
| STEVANATO GROUP S P A ORD SHS | T9224W109 | Stock | 71,190 | $1,279,284 | dollars as filed | |
| MORPHIC HLDG INC | 61775R105 | COM | 44,625 | $1,193,719 | dollars as filed | |
| SUTRO BIOPHARMA INC | 869367102 | COM | 147,531 | $1,192,050 | dollars as filed | |
| MEREO BIOPHARMA GROUP PLC | 589492107 | CMN | 1,551,082 | $1,163,312 | dollars as filed | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 72,225 | $1,149,822 | dollars as filed | |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 108,833 | $984,939 | dollars as filed | |
| PYXIS ONCOLOGY INC COMMON STOCK | 747324101 | Stock | 708,303 | $949,126 | dollars as filed | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 45,861 | $839,256 | dollars as filed | |
| ALX ONCOLOGY HOLDINGS INC | 00166B105 | COMMON STOCK | 66,211 | $746,198 | dollars as filed | |
| AFFIMED N V | N01045108 | COM | 586,038 | $726,687 | dollars as filed | |
| PLIANT THERAPEUTICS INC | 729139105 | COM | 35,233 | $681,054 | dollars as filed | |
| NOVABRIDGE BIOSCIENCES | 44975P103 | CMN | 162,580 | $679,584 | dollars as filed | |
| NOVAVAX INC | 670002401 | COM NEW | 63,800 | $655,864 | dollars as filed | |
| INTERCEPT PHARMACEUTICALS IN | 45845P108 | COM | 52,067 | $644,069 | dollars as filed | |
| BEAM THERAPEUTICS INC | 07373V105 | COM | 15,817 | $618,603 | dollars as filed | |
| UNIVERSAL HEALTH RLTY INCOME | 91359E105 | REIT | 11,258 | $537,344 | dollars as filed | |
| COMMUNITY USD0.01 | 20369C106 | COM | 14,900 | $533,420 | dollars as filed | |
| NATIONAL HEALTH INVS INC COM | 63633D104 | REIT | 10,038 | $524,184 | dollars as filed | |
| 1LIFE HEALTHCARE INC | 68269G107 | COM | 31,266 | $522,455 | dollars as filed | |
| THESEUS PHARMACEUTICALS INC | 88369M101 | COM | 100,000 | $498,000 | dollars as filed | |
| BIOHAVEN LTD | G1110E107 | COM | 35,087 | $487,008 | dollars as filed | |
| REPARE THERAPEUTICS INC | 760273102 | COM | 29,150 | $428,797 | dollars as filed | |
| FULCRUM THERAPEUTICS INC | 359616109 | COMMON STOCK | 58,537 | $426,149 | dollars as filed | |
| COMMUNITY HEALTH SYSTEMS INC | 203668108 | COMMON STOCK | 88,335 | $381,607 | dollars as filed | |
| ADICET BIO INC | 007002108 | COM | 40,329 | $360,541 | dollars as filed | |
| Tscan Therapeutics Inc | 89854M101 | COM | 200,000 | $326,000 | dollars as filed | |
| CODEXIS INC | 192005106 | COM | 69,125 | $322,123 | dollars as filed | |
| MORPHOSYS AG | 617760202 | ADR | 81,867 | $293,084 | dollars as filed | |
| MALLINCKRODT PLC | G5890A102 | COM | 35,048 | $271,622 | dollars as filed | |
| PRECISION BIOSCIENCES INC | 74019P108 | COM | 224,534 | $267,195 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 5,000 | $239,750 | dollars as filed | |
| BLACK DIAMOND THERAPEUTICS I | 09203E105 | COM | 131,990 | $237,582 | dollars as filed | |
| DIVERSIFIED HEALTHCARE TR | 25525P107 | COM SH BEN INT | 357,720 | $231,373 | dollars as filed | |
| HARPOON THERAPEUTICS INC | 41358P106 | COM | 259,910 | $188,617 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W108 | COM | 75,000 | $178,500 | dollars as filed | |
| NKARTA INC | 65487U108 | COMMON STOCK | 28,988 | $173,638 | dollars as filed | |
| FUSION PHARMACEUTICALS INC | 36118A100 | COM | 43,394 | $136,691 | dollars as filed | |
| ORUKA THERAPEUTICS INC COM | 00211Y506 | Stock | 32,461 | $76,608 | dollars as filed | |
| SPECTRUM PHARMACEUTICALS INC | 84763A108 | COM | 114,670 | $42,256 | dollars as filed | |
| VYNE THERAP. | 92941V209 | COM | 135,395 | $20,309 | dollars as filed | |
| CORBUS PHARMACEUTICALS HLDGS | 21833P103 | COM | 154,310 | $17,051 | dollars as filed | |
| FIVE STAR SENIOR LIVING INC | 33832D205 | COM NEW | 24,237 | $13,330 | dollars as filed | |
| NEXGEL INC | 65344E107 | COM | 4,243 | $5,304 | dollars as filed | |
| BELLICUM PHARMACEUTICALS INC COM NEW | 079481404 | Stock | 6,000 | $4,320 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001104659-23-018131 | this filing | 2023-02-10 | acceptance time not in the bulk data set |