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13F-HR filed by Avoro Capital Advisors LLC

Avoro Capital Advisors LLC filed this 13F-HR for the quarter ended 2021-12-31, filed 2022-02-14, with 41 holding rows worth $5,875,771,000.

Accession
0001104659-22-021801
Filed
2022-02-14
Accepted by EDGAR
acceptance time not in the bulk data set
Ingested
Source
SEC quarterly data set

Original filing

13F report for Q4 2021

A holdings report, 41 entries on the cover page, a total value of $5,875,771,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $5,875,773,000 with VALUE read as thousands by filing date, 13F file number 028-16573. The quarter's positions are built on this report. The resolved quarter.

The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).

Issuer as filedCUSIPClassAmountValueValue read asType
HORIZON THERAPEUTICS PLCG46188101SHS9,295,000$1,001,629,000thousands by filing date
MIRATI THERAPEUTICS INC60468T105COM5,075,000$744,452,000thousands by filing date
UNITED THERAPEUTICS CORP DEL COM91307C102Stock3,035,000$655,803,000thousands by filing date
APELLIS PHARMACEUTICALS INC03753U106COM8,555,555$404,507,000thousands by filing date
ARGENX SE SPONSORED ADR04016X101ADR965,000$337,933,000thousands by filing date
SAREPTA THERAPEUTICS INC803607100COM3,125,000$281,406,000thousands by filing date
ASCENDIS PHARMA A/S DKK 1.0 AD04351P101SPONSORED ADR2,000,000$269,060,000thousands by filing date
BIOMARIN PHARMACEUTICAL INC09061G101COM2,800,000$247,380,000thousands by filing date
AMICUS THERAPEUTICS INC03152W109COM18,500,000$213,675,000thousands by filing date
ALNYLAM PHARMACEUTICALS INC COM02043Q107Stock1,075,000$182,299,000thousands by filing date
IOVANCE BIOTHERAPEUTICS INC462260100COM8,675,000$165,606,000thousands by filing date
XENON PHARMACEUTICALS INC COM98420N105Stock4,985,000$155,731,000thousands by filing date
IVERIC BIO INC46583P102COM7,250,000$121,220,000thousands by filing date
MADRIGAL PHARMACEUTICALS INC COM558868105Stock1,425,000$120,755,000thousands by filing date
SPDR SER TR78464A870S&P BIOTECH1,050,000$117,558,000thousands by filing date
ARENA PHARMACEUTICALS INC040047607COM NEW1,235,000$114,781,000thousands by filing date
MONTE ROSA THERAPEUTICS INC61225M102COM3,311,434$67,619,000thousands by filing date
KURA ONCOLOGY INC COM50127T109Stock4,000,000$56,000,000thousands by filing date
ACADIA PHARMACEUTICALS INC004225108COM2,200,000$51,348,000thousands by filing date
SYNDAX PHARMACEUTICALS INC87164F105COM2,175,000$47,611,000thousands by filing date
WHITEHAWK THERAPEUTICS INC00032Q104CMN1,829,402$44,180,000thousands by filing date
Mersana Therapeutics Inc59045L106Common Stock6,800,000$42,296,000thousands by filing date
MANNKIND CORP COM NEW56400P706Stock8,800,000$38,456,000thousands by filing date
MARINUS PHARMACEUTICALS INC56854Q200COM NEW3,235,000$38,432,000thousands by filing date
PRAXIS PRECISION MEDICINES I74006W108COM1,780,000$35,066,000thousands by filing date
DESIGN THERAPEUTICS INC25056L103COM1,636,100$35,029,000thousands by filing date
KYMERA THERAPEUTICS INC501575104COM550,000$34,920,000thousands by filing date
CYMABAY THERAPEUTICS INC23257D103COM10,300,000$34,814,000thousands by filing date
PMV PHARMACEUTICALS INC69353Y103COM1,465,000$33,842,000thousands by filing date
KRYSTAL BIOTECH INC COM501147102Stock475,000$33,226,000thousands by filing date
AVIDITY BIOSCIENCES INC COM05370A108Stock1,230,000$29,237,000thousands by filing date
AMARIN CORP PLC023111206SPONS ADR NEW6,000,000$20,220,000thousands by filing date
NUVALENT INC COM670703107Stock1,102,671$18,431,000thousands by filing date
TANGO THERAPEUTICS INC87583X109COM1,550,000$16,957,000thousands by filing date
DICE THERAPEUTICS INC23345J104COM562,500$14,237,000thousands by filing date
AVADEL PHARMACEUTICALS, PLC05337M104COMMON STOCK-FO1,670,000$13,494,000thousands by filing date
Adverum Biotechnologies, Inc.00773U108Common Stock6,950,000$12,232,000thousands by filing date
IO BIOTECH INC449778109COM2,055,883$10,243,000thousands by filing date
GENOCEA BIOSCIENCES INC372427401COMMON STOCK5,084,184$5,898,000thousands by filing date
FENNEC PHARMACEUTICALS INC31447P100COMMON STOCK1,200,000$5,280,000thousands by filing date
SAREPTA THERAPEUTICS INC803607100COM300,000$2,910,000thousands by filing datecall

Amendment chain

FilingRoleFiledAcceptedIngested
13F-HR 0001104659-22-021801this filing2022-02-14acceptance time not in the bulk data set