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13F-HR filed by Tekla Capital Management LLC

Tekla Capital Management LLC filed this 13F-HR for the quarter ended 2020-12-31, filed 2021-02-12, with 200 holding rows worth $2,845,923,000.

Accession
0001104659-21-021559
Filed
2021-02-12
Accepted by EDGAR
acceptance time not in the bulk data set
Ingested
Source
SEC quarterly data set

Original filing

13F report for Q4 2020

A holdings report, 200 entries on the cover page, a total value of $2,845,923,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $2,845,927,000 with VALUE read as thousands by filing date, 13F file number 028-10950. The quarter's positions are built on this report. The resolved quarter.

The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).

Issuer as filedCUSIPClassAmountValueValue read asType
Amgen Inc.031162100COM416,560$95,775,000thousands by filing date
ILLUMINA INC452327109COM257,493$95,272,000thousands by filing date
REGENERON PHARMACEUTICALS COM75886F107Stock179,385$86,663,000thousands by filing date
Johnson & Johnson478160104COM546,805$86,056,000thousands by filing date
Gilead Sciences,Inc.375558103COM1,405,371$81,877,000thousands by filing date
ALEXION PHARMACEUTICALS INC015351109COM501,942$78,423,000thousands by filing date
UnitedHealth Group Inc91324P102COM219,185$76,864,000thousands by filing date
Vertex Pharmaceuticals Incorporated92532F100COM305,310$72,157,000thousands by filing date
AbbVie,Inc.00287Y109COM619,759$66,407,000thousands by filing date
Medtronic PlcG5960L103COM534,914$62,660,000thousands by filing date
Bristol-Myers Squibb Company110122108COM989,908$61,404,000thousands by filing date
BIOGEN INC COM09062X103Stock246,844$60,442,000thousands by filing date
Thermo Fisher Scientific Inc.883556102COM127,553$59,412,000thousands by filing date
SEAGEN INC81181C104COM293,619$51,424,000thousands by filing date
Danaher Corporation235851102COM219,840$48,835,000thousands by filing date
Abbott Laboratories002824100COM431,145$47,206,000thousands by filing date
Merck & Co.,Inc.58933Y105COM560,903$45,882,000thousands by filing date
Eli Lilly and Company532457108COM237,537$40,106,000thousands by filing date
Stryker Corporation863667101COM153,330$37,572,000thousands by filing date
SAREPTA THERAPEUTICS INC803607100COM206,487$35,204,000thousands by filing date
HORIZON THERAPEUTICS PLCG46188101SHS465,016$34,016,000thousands by filing date
HUMANA INC COM444859102Stock82,807$33,973,000thousands by filing date
ZIMMER BIOMET HOLDINGS INC COM98956P102Stock214,014$32,977,000thousands by filing date
BECTON DICKINSON & CO075887109COM131,723$32,960,000thousands by filing date
HCA Healthcare Inc40412C101COM175,097$28,796,000thousands by filing date
Cigna Corporation125523100COM135,712$28,253,000thousands by filing date
NEUROCRINE BIOSCIENCES INC64125C109COM294,234$28,202,000thousands by filing date
RESMED INC COM761152107Stock132,344$28,131,000thousands by filing date
DEXCOM INC COM252131107Stock74,643$27,597,000thousands by filing date
WATERS CORP COM941848103Stock109,510$27,095,000thousands by filing date
Pfizer Inc.717081103COM705,259$25,961,000thousands by filing date
MODERNA INC60770K107COM248,192$25,929,000thousands by filing date
EXELIXIS INC COM30161Q104Stock1,256,520$25,218,000thousands by filing date
BIOMARIN PHARMACEUTICAL INC09061G101COM278,330$24,407,000thousands by filing date
EDWARDS LIFESCIENCES CORP COM28176E108Stock264,955$24,172,000thousands by filing date
STERIS PLC SHS USDG8473T100Stock126,779$24,030,000thousands by filing date
ALNYLAM PHARMACEUTICALS INC COM02043Q107Stock174,894$22,731,000thousands by filing date
MCKESSON CORP COM58155Q103Stock130,448$22,688,000thousands by filing date
PRA HEALTH SCIENCES INC69354M108COM175,838$22,057,000thousands by filing date
ARENA PHARMACEUTICALS INC040047607COM NEW252,971$19,436,000thousands by filing date
DENTSPLY SIRONA INC24906P109COM365,927$19,160,000thousands by filing date
MIRATI THERAPEUTICS INC60468T105COM83,784$18,402,000thousands by filing date
ALLAKOS INC01671P100COM130,937$18,331,000thousands by filing date
ARGENX SE SPONSORED ADR04016X101ADR61,687$18,142,000thousands by filing date
ACADIA PHARMACEUTICALS INC004225108COM331,789$17,737,000thousands by filing date
Intuitive Surgical,Inc.46120E602COM21,296$17,422,000thousands by filing date
IDEXX LABS INC COM45168D104Stock34,814$17,402,000thousands by filing date
ASTRAZENECA PLC SPONSORED ADR046353108ADR344,333$17,213,000thousands by filing date
ADAPTIVE BIOTECHNOLOGIES CORP COM00650F109Stock286,013$16,912,000thousands by filing date
BIO-TECHNE CORP09073M104COM51,710$16,421,000thousands by filing date
ASCENDIS PHARMA A/S DKK 1.0 AD04351P101SPONSORED ADR96,246$16,052,000thousands by filing date
SUTRO BIOPHARMA INC869367102COM702,523$15,252,000thousands by filing date
NOVOCURE LTDG6674U108ORD SHS87,918$15,213,000thousands by filing date
GUARDANT HEALTH INC COM40131M109Stock117,852$15,189,000thousands by filing date
FATE THERAPEUTICS INC31189P102COM166,317$15,123,000thousands by filing date
CVS Health Corporation126650100COM219,995$15,026,000thousands by filing date
TURNING PT THERAPEUTICS90041T108COM119,324$14,540,000thousands by filing date
BLUEPRINT MEDICINES CORP09627Y109COM122,699$13,761,000thousands by filing date
NOVARTIS AG SPONSORED ADR66987V109ADR144,525$13,647,000thousands by filing date
IQVIA HLDGS INC COM46266C105Stock76,066$13,629,000thousands by filing date
ULTRAGENYX PHARMACEUTICAL IN90400D108COM97,480$13,494,000thousands by filing date
SYNEOS HEALTH INC87166B102CL A195,136$13,295,000thousands by filing date
SAGE THERAPEUTICS INC78667J108COM152,040$13,153,000thousands by filing date
LABORATORY CORP OF AMERICA50540R409COM NEW64,603$13,150,000thousands by filing date
WELLTOWER INC COM95040Q104REIT203,083$13,123,000thousands by filing date
QUEST DIAGNOSTICS INC COM74834L100Stock109,659$13,068,000thousands by filing date
IOVANCE BIOTHERAPEUTICS INC462260100COM271,073$12,578,000thousands by filing date
APELLIS PHARMACEUTICALS INC03753U106COM216,017$12,356,000thousands by filing date
TRILLIUM THERAPEUTICS INC COM NEW89620X506Stock817,784$12,030,000thousands by filing date
Elevance Health, Inc.036752103COM37,133$11,923,000thousands by filing date
CRISPR THERAPEUTICS AG NAMEN AKTH17182108Stock76,222$11,670,000thousands by filing date
INTRA-CELLULAR THERAPIES INC46116X101COMMON STOCK366,176$11,644,000thousands by filing date
TELADOC HEALTH INC87918A105COM56,520$11,302,000thousands by filing date
METTLER TOLEDO INTERNATIONAL COM592688105Stock9,800$11,169,000thousands by filing date
JAZZ PHARMACEUTICALS PLC SHS USDG50871105Stock67,456$11,134,000thousands by filing date
OMEGA HEALTHCARE INVS INC COM681936100REIT306,433$11,130,000thousands by filing date
IONIS PHARMACEUTICALS INC COM462222100Stock193,201$10,924,000thousands by filing date
GALERA THERAPEUTICS EQUICLASS EQUITY36338D108COMMON STOCK1,041,845$10,658,000thousands by filing date
GENMAB A/S372303206Ordinary Shares, nominal value DKK 1 per share258,672$10,518,000thousands by filing date
VENTAS INC COM92276F100REIT208,108$10,206,000thousands by filing date
ARROWHEAD PHARMACEUTICALS IN04280A100COM132,886$10,196,000thousands by filing date
UNITED THERAPEUTICS CORP DEL COM91307C102Stock63,513$9,641,000thousands by filing date
AMICUS THERAPEUTICS INC03152W109COM405,626$9,366,000thousands by filing date
ZOETIS INC CL A98978V103Stock56,521$9,354,000thousands by filing date
MEDICAL PROPERTIES TRUST INC COM58463J304REIT411,743$8,972,000thousands by filing date
CHEMOCENTRYX INC16383L106COM144,447$8,944,000thousands by filing date
KURA ONCOLOGY INC COM50127T109Stock273,463$8,931,000thousands by filing date
SABRA HEALTH CARE REIT INC COM78573L106REIT510,660$8,870,000thousands by filing date
Boston Scientific Corporation101137107COM246,089$8,847,000thousands by filing date
PHYSICIANS REALTY TRUST71943U104COM495,733$8,824,000thousands by filing date
KARUNA THERAPEUTICS INC48576A100COM85,236$8,659,000thousands by filing date
NOVAVAX INC670002401COM NEW76,585$8,540,000thousands by filing date
MOLINA HEALTHCARE INC60855R100COM39,769$8,458,000thousands by filing date
EXACT SCIENCES CORP COM30063P105Stock63,502$8,413,000thousands by filing date
INCYTE CORP COM45337C102Stock93,257$8,111,000thousands by filing date
THERAVANCE BIOPHARMA INCG8807B106COM456,296$8,108,000thousands by filing date
BEONE MEDICINES LTD SPONSORED ADS07725L102ADR28,280$7,307,000thousands by filing date
FIBROGEN INC31572Q808COM194,270$7,205,000thousands by filing date
ACCENDRA HEALTH INC690732102COM266,023$7,196,000thousands by filing date
LTC PPTYS INC COM502175102REIT182,293$7,093,000thousands by filing date
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS881624209ADR730,051$7,045,000thousands by filing date
CHARLES RIV LABS INTL INC159864107COM28,154$7,035,000thousands by filing date
TG THERAPEUTICS INC COM88322Q108Stock133,269$6,933,000thousands by filing date
XENCOR INC98401F105COMMON STOCK148,231$6,467,000thousands by filing date
ARVINAS INC04335A105COM73,459$6,239,000thousands by filing date
AGILENT TECHNOLOGIES INC COM00846U101Stock52,525$6,224,000thousands by filing date
TELEFLEX INCORPORATED879369106COM15,052$6,195,000thousands by filing date
DENALI THERAPEUTICS INC COM24823R105Stock72,333$6,059,000thousands by filing date
REVANCE THERAPEUTICS INC761330109COM213,808$6,059,000thousands by filing date
COGENT BIOSCIENCES INC19240Q201COM537,742$6,039,000thousands by filing date
ATRECA INC04965G109COM352,424$5,692,000thousands by filing date
AMEDISYS INC023436108COM19,395$5,689,000thousands by filing date
SCHOLAR ROCK HLDG CORP80706P103COM116,094$5,634,000thousands by filing date
ALIGN TECHNOLOGY INC COM016255101Stock10,041$5,366,000thousands by filing date
REVVITY INC714046109COM37,094$5,323,000thousands by filing date
VERONA PHARMA PLC925050106SPONSORED ADS751,905$5,263,000thousands by filing date
FORMA THERAPEUTICS HLDGS INC34633R104SHS149,825$5,229,000thousands by filing date
ZAI LAB LTD ADR98887Q104ADR37,523$5,078,000thousands by filing date
CENTENE CORP DEL COM15135B101Stock84,145$5,051,000thousands by filing date
REATA PHARMACEUTICALS INC75615P103CL A38,219$4,725,000thousands by filing date
HEALTHPEAK PROPERTIES INC COM42250P103REIT150,392$4,546,000thousands by filing date
NOVO-NORDISK A S ADR670100205ADR64,906$4,534,000thousands by filing date
UNIQURE NVN90064101SHS125,003$4,516,000thousands by filing date
ADDUS HOMECARE CORP006739106COM37,640$4,407,000thousands by filing date
SMITH & NEPHEW PLC SPDN ADR NEW83175M205ADR99,560$4,198,000thousands by filing date
AURINIA PHARMACEUTICALS INC COM05156V102Stock300,611$4,157,000thousands by filing date
AMARIN CORP PLC023111206SPONS ADR NEW849,588$4,154,000thousands by filing date
PRAXIS PRECISION MEDICINES I74006W108COM75,000$4,127,000thousands by filing date
AXONICS INC05465P101COM80,760$4,032,000thousands by filing date
SANOFI SA SPONSORED ADR80105N105ADR81,554$3,963,000thousands by filing date
ARDELYX INC039697107COM607,698$3,932,000thousands by filing date
TAKEDA PHARMACEUTICAL CO LTD SPONSORED ADS874060205ADR210,146$3,825,000thousands by filing date
ENDO INTL PLCG30401106SHS531,570$3,817,000thousands by filing date
Y-mAbs Therapeutics Inc984241109Common Stock76,548$3,790,000thousands by filing date
PIERIS PHARMACEUTICALS INC720795103COM1,449,269$3,623,000thousands by filing date
ABIOMED INC003654100COM10,812$3,505,000thousands by filing date
DECIPHERA PHARMACEUTICALS IN24344T101COM61,370$3,502,000thousands by filing date
ALKERMES PLCG01767105SHS169,930$3,390,000thousands by filing date
TENET HEALTHCARE CORP COM NEW88033G407Stock82,736$3,304,000thousands by filing date
INSMED INC COM PAR $.01457669307Stock98,387$3,275,000thousands by filing date
KONINKLIJKE PHILIPS N V NY REGIS SHS NEW500472303ADR56,927$3,084,000thousands by filing date
HEALTHCARE RLTY TR421946104COM104,024$3,079,000thousands by filing date
NEKTAR THERAPEUTICS640268108COM180,438$3,067,000thousands by filing date
KADMON HLDGS INC48283N106COM714,008$2,963,000thousands by filing date
HERON THERAPEUTICS INC427746102COM131,183$2,776,000thousands by filing date
MOONLAKE IMMUNOTHERAPEUTICSG4444C102COM250,000$2,708,000thousands by filing date
ZYMEWORKS INC98985W102COM55,938$2,644,000thousands by filing date
EIDOS THERAPEUTICS INC.28249H104Common Stock20,000$2,632,000thousands by filing date
MEDPACE HLDGS INC COM58506Q109Stock18,871$2,627,000thousands by filing date
AXSOME THERAPEUTICS INC. COM05464T104Stock31,591$2,574,000thousands by filing date
HOLOGIC INC436440101COM32,564$2,372,000thousands by filing date
MORPHOSYS AG617760202ADR81,867$2,320,000thousands by filing date
INOGEN INC45780L104COM51,406$2,297,000thousands by filing date
PERRIGO CO PLC SHSG97822103Stock51,224$2,291,000thousands by filing date
GLOBAL MED REIT INC37954A204COM NEW174,897$2,284,000thousands by filing date
BAUSCH HEALTH COS INC COM071734107Stock101,412$2,109,000thousands by filing date
NUCANA PLC67022C106ADR460,672$2,068,000thousands by filing date
ALCON AG ORD SHSH01301128Stock31,286$2,064,000thousands by filing date
MOLECULAR TEMPLATES INC608550109COM219,822$2,064,000thousands by filing date
HEALTHCARE42225P501CL A NEW70,662$1,946,000thousands by filing date
INTERCEPT PHARMACEUTICALS IN45845P108COM77,067$1,904,000thousands by filing date
ZOGENIX INC.98978L204Common Stock88,977$1,779,000thousands by filing date
HARPOON THERAPEUTICS INC41358P106COM106,419$1,768,000thousands by filing date
Milestone Pharmaceuticals Inc59935V107COM253,610$1,699,000thousands by filing date
GRITSTONE BIO INC39868T105COM419,005$1,651,000thousands by filing date
AVADEL PHARMACEUTICALS, PLC05337M104COMMON STOCK-FO233,612$1,561,000thousands by filing date
AFFIMED N VN01045108COM268,019$1,560,000thousands by filing date
DIANTHUS THERAPEUTICS INC COM55910K108Stock192,431$1,509,000thousands by filing date
DICERNA PHARMACEUTICALS INC253031108COM68,150$1,501,000thousands by filing date
MADRIGAL PHARMACEUTICALS INC COM558868105Stock13,340$1,483,000thousands by filing date
DIVERSIFIED HEALTHCARE TR25525P107COM SH BEN INT357,720$1,474,000thousands by filing date
NEW SR INVT GROUP INC648691103COM256,398$1,328,000thousands by filing date
ALLOGENE THERAPEUTICS INC019770106COM48,089$1,214,000thousands by filing date
Health Care Select Sector SPDR Fund81369Y209SHS10,055$1,141,000thousands by filing date
IMMUNOGEN INC45253H101COMMON STOCK168,190$1,085,000thousands by filing date
ESPERION THERAPEUTICS INC NEW COM29664W105Stock41,577$1,081,000thousands by filing date
KARYOPHARM THERAPEUTICS INC48576U106COM65,743$1,018,000thousands by filing date
BRISTOL-MYERS SQUIBB CO110122157RIGHT 99/99/99991,473,710$1,017,000thousands by filing date
REGENXBIO INC75901B107COM21,700$984,000thousands by filing date
AERIE PHARMACEUTICALS INC00771V108COM66,688$901,000thousands by filing date
AC IMMUNE SAH00263105SHS171,813$888,000thousands by filing date
COMMUNITY HEALTH SYSTEMS INC203668108COMMON STOCK117,735$875,000thousands by filing date
GRIFOLS S A398438408SP ADR REP B NVT47,373$874,000thousands by filing date
OVID THERAPEUTICS INC690469101COMMON STOCK372,733$861,000thousands by filing date
VYNE THERAPEUTICS INC92941V100COM NEW541,584$856,000thousands by filing date
UNIVERSAL HEALTH RLTY INCOME91359E105REIT11,258$724,000thousands by filing date
COMMUNITY USD0.0120369C106COM14,900$702,000thousands by filing date
NATIONAL HEALTH INVS INC COM63633D104REIT10,038$694,000thousands by filing date
Indivior Pharmaceuticals Inc04546C106COMMON STOCK1,642,302$587,000thousands by filing date
CORBUS PHARMACEUTICALS HLDGS21833P103COM413,481$517,000thousands by filing date
CYMABAY THERAPEUTICS INC23257D103COM88,102$506,000thousands by filing date
CLEARSIDE BIOMEDICAL INC185063104COM165,330$453,000thousands by filing date
SPECTRUM PHARMACEUTICALS INC84763A108COM114,670$391,000thousands by filing date
CELLECTIS ADS15117K103COM11,955$324,000thousands by filing date
VIATRIS INC COM92556V106Stock13,400$251,000thousands by filing date
FIVE STAR SENIOR LIVING INC33832D205COM NEW24,237$167,000thousands by filing date
ORUKA THERAPEUTICS INC COM00211Y506Stock32,461$130,000thousands by filing date
CELLDEX THERAPEUTICS INC NEW15117B202COM NEW7,053$124,000thousands by filing date
BELLICUM PHARMACEUTICALS INC COM NEW079481404Stock6,000$21,000thousands by filing date
Tetraphase Pharmaceuticals, Inc.881CVR013Common42,965$9,000thousands by filing date

Amendment chain

FilingRoleFiledAcceptedIngested
13F-HR 0001104659-21-021559this filing2021-02-12acceptance time not in the bulk data set