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13F-HR filed by Tekla Capital Management LLC

Tekla Capital Management LLC filed this 13F-HR for the quarter ended 2019-12-31, filed 2020-02-13, with 214 holding rows worth $2,644,201,000.

Accession
0001104659-20-019919
Filed
2020-02-13
Accepted by EDGAR
acceptance time not in the bulk data set
Ingested
Source
SEC quarterly data set

Original filing

13F report for Q4 2019

A holdings report, 214 entries on the cover page, a total value of $2,644,201,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $2,644,201,000 with VALUE read as thousands by filing date, 13F file number 028-10950. The quarter's positions are built on this report. The resolved quarter.

The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).

Issuer as filedCUSIPClassAmountValueValue read asType
Amgen Inc.031162100COM617,427$148,843,000thousands by filing date
Johnson & Johnson478160104COM916,827$133,738,000thousands by filing date
Gilead Sciences,Inc.375558103COM1,890,576$122,850,000thousands by filing date
Merck & Co.,Inc.58933Y105COM1,211,384$110,175,000thousands by filing date
Vertex Pharmaceuticals Incorporated92532F100COM493,789$108,115,000thousands by filing date
ILLUMINA INC452327109COM272,601$90,433,000thousands by filing date
BIOGEN INC COM09062X103Stock285,126$84,605,000thousands by filing date
Pfizer Inc.717081103COM2,085,348$81,704,000thousands by filing date
REGENERON PHARMACEUTICALS COM75886F107Stock201,277$75,575,000thousands by filing date
UnitedHealth Group Inc91324P102COM248,829$73,151,000thousands by filing date
Medtronic PlcG5960L103COM470,812$53,414,000thousands by filing date
Bristol-Myers Squibb Company110122108COM774,862$49,738,000thousands by filing date
ALEXION PHARMACEUTICALS INC015351109COM435,814$47,133,000thousands by filing date
Abbott Laboratories002824100COM471,835$40,984,000thousands by filing date
Thermo Fisher Scientific Inc.883556102COM123,408$40,092,000thousands by filing date
Cigna Corporation125523100COM190,555$38,967,000thousands by filing date
CVS Health Corporation126650100COM497,986$36,995,000thousands by filing date
INCYTE CORP COM45337C102Stock383,230$33,464,000thousands by filing date
SEATTLE GENETICS INC812578102COM276,766$31,623,000thousands by filing date
Elevance Health, Inc.036752103COM102,032$30,817,000thousands by filing date
ALLERGAN PLCG0177J108SHS159,581$30,507,000thousands by filing date
AbbVie,Inc.00287Y109COM340,916$30,185,000thousands by filing date
Eli Lilly and Company532457108COM210,181$27,624,000thousands by filing date
Boston Scientific Corporation101137107COM564,345$25,520,000thousands by filing date
Danaher Corporation235851102COM165,476$25,397,000thousands by filing date
ZOETIS INC CL A98978V103Stock190,384$25,197,000thousands by filing date
Stryker Corporation863667101COM113,667$23,863,000thousands by filing date
SAREPTA THERAPEUTICS INC803607100COM181,623$23,437,000thousands by filing date
BIOMARIN PHARMACEUTICAL INC09061G101COM276,560$23,383,000thousands by filing date
Intuitive Surgical,Inc.46120E602COM38,683$22,867,000thousands by filing date
MYLAN NVN59465109SHS EURO1,038,554$20,875,000thousands by filing date
NEUROCRINE BIOSCIENCES INC64125C109COM193,042$20,750,000thousands by filing date
HUMANA INC COM444859102Stock55,013$20,163,000thousands by filing date
NOVARTIS AG SPONSORED ADR66987V109ADR211,047$19,984,000thousands by filing date
BECTON DICKINSON & CO075887109COM66,257$18,020,000thousands by filing date
PRA HEALTH SCIENCES INC69354M108COM153,003$17,006,000thousands by filing date
ALNYLAM PHARMACEUTICALS INC COM02043Q107Stock143,795$16,561,000thousands by filing date
EDWARDS LIFESCIENCES CORP COM28176E108Stock69,557$16,227,000thousands by filing date
WELLTOWER INC COM95040Q104REIT191,646$15,673,000thousands by filing date
HCA Healthcare Inc40412C101COM95,833$14,165,000thousands by filing date
ASTRAZENECA PLC SPONSORED ADR046353108ADR276,098$13,766,000thousands by filing date
BEONE MEDICINES LTD SPONSORED ADS07725L102ADR81,089$13,441,000thousands by filing date
NOVO-NORDISK A S ADR670100205ADR221,364$12,813,000thousands by filing date
JAZZ PHARMACEUTICALS PLC SHS USDG50871105Stock85,673$12,789,000thousands by filing date
ESPERION THERAPEUTICS INC NEW COM29664W105Stock213,562$12,735,000thousands by filing date
IONIS PHARMACEUTICALS INC COM462222100Stock209,924$12,682,000thousands by filing date
GLAXOSMITHKLINE PLC-ADR37733W105SPONSORED ADR257,048$12,079,000thousands by filing date
OMEGA HEALTHCARE INVS INC COM681936100REIT284,795$12,061,000thousands by filing date
Milestone Pharmaceuticals Inc59935V107COM746,653$11,954,000thousands by filing date
GLOBAL BLOOD THERAPEUTICS USD37890U108COM147,168$11,698,000thousands by filing date
IDEXX LABS INC COM45168D104Stock43,614$11,389,000thousands by filing date
VENTAS INC COM92276F100REIT191,388$11,051,000thousands by filing date
HORIZON THERAPEUTICS PLCG46188101SHS304,664$11,029,000thousands by filing date
BIO-TECHNE CORP09073M104COM50,091$10,995,000thousands by filing date
BAXTER INTL INC071813109COM129,983$10,869,000thousands by filing date
AGIOS PHARMACEUTICALS INC00847X104COM216,408$10,333,000thousands by filing date
IMMUNOMEDICS INC452907108COM487,103$10,307,000thousands by filing date
MEDICINES CO584688105COM120,670$10,250,000thousands by filing date
SABRA HEALTH CARE REIT INC COM78573L106REIT466,247$9,950,000thousands by filing date
CENCORA INC COM03073E105Stock115,723$9,839,000thousands by filing date
ASCENDIS PHARMA A/S DKK 1.0 AD04351P101SPONSORED ADR69,332$9,645,000thousands by filing date
ZIMMER BIOMET HOLDINGS INC COM98956P102Stock63,671$9,530,000thousands by filing date
CENTENE CORP DEL COM15135B101Stock149,526$9,401,000thousands by filing date
SANOFI SA SPONSORED ADR80105N105ADR186,640$9,369,000thousands by filing date
BLUEPRINT MEDICINES CORP09627Y109COM116,925$9,367,000thousands by filing date
ACADIA PHARMACEUTICALS INC004225108COM218,283$9,338,000thousands by filing date
MCKESSON CORP COM58155Q103Stock67,325$9,312,000thousands by filing date
MIRATI THERAPEUTICS INC60468T105COM70,873$9,133,000thousands by filing date
EXELIXIS INC COM30161Q104Stock515,125$9,077,000thousands by filing date
NOVOCURE LTDG6674U108ORD SHS107,438$9,054,000thousands by filing date
AMARIN CORP PLC023111206SPONS ADR NEW408,120$8,750,000thousands by filing date
EPIZYME INC29428V104COM353,102$8,686,000thousands by filing date
PHYSICIANS REALTY TRUST71943U104COM456,756$8,651,000thousands by filing date
BLUEBIRD BIO INC09609G100COM95,687$8,397,000thousands by filing date
FIBROGEN INC31572Q808COM194,270$8,332,000thousands by filing date
ATRECA INC04965G109COM524,896$8,120,000thousands by filing date
MEDICAL PROPERTIES TRUST INC COM58463J304REIT374,289$7,901,000thousands by filing date
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS881624209ADR785,851$7,701,000thousands by filing date
LTC PPTYS INC COM502175102REIT165,668$7,417,000thousands by filing date
ARGENX SE SPONSORED ADR04016X101ADR44,977$7,220,000thousands by filing date
SUTRO BIOPHARMA INC869367102COM641,268$7,054,000thousands by filing date
SAGE THERAPEUTICS INC78667J108COM96,211$6,945,000thousands by filing date
SYNEOS HEALTH INC87166B102CL A115,842$6,890,000thousands by filing date
ALLAKOS INC01671P100COM71,396$6,808,000thousands by filing date
DENTSPLY SIRONA INC24906P109COM119,736$6,776,000thousands by filing date
IOVANCE BIOTHERAPEUTICS INC462260100COM243,483$6,740,000thousands by filing date
ARROWHEAD PHARMACEUTICALS IN04280A100COM105,398$6,685,000thousands by filing date
SPDR SER TR78464A870S&P BIOTECH68,037$6,471,000thousands by filing date
ALIGN TECHNOLOGY INC COM016255101Stock22,378$6,244,000thousands by filing date
AVADEL PHARMACEUTICALS, PLC05337M104COMMON STOCK-FO814,588$6,150,000thousands by filing date
NEKTAR THERAPEUTICS640268108COM283,679$6,123,000thousands by filing date
TELEFLEX INCORPORATED879369106COM15,608$5,875,000thousands by filing date
ZOGENIX INC.98978L204Common Stock107,703$5,615,000thousands by filing date
ABIOMED INC003654100COM32,716$5,581,000thousands by filing date
IQVIA HLDGS INC COM46266C105Stock35,815$5,534,000thousands by filing date
GALERA THERAPEUTICS EQUICLASS EQUITY36338D108COMMON STOCK416,666$5,483,000thousands by filing date
Health Care Select Sector SPDR Fund81369Y209SHS53,773$5,477,000thousands by filing date
REATA PHARMACEUTICALS INC75615P103CL A26,412$5,399,000thousands by filing date
LABORATORY CORP OF AMERICA50540R409COM NEW31,424$5,316,000thousands by filing date
PIERIS PHARMACEUTICALS INC720795103COM1,449,269$5,246,000thousands by filing date
GW PHARMACEUTICALS PLC36197T103ADS50,101$5,239,000thousands by filing date
UNIQURE NVN90064101SHS71,191$5,102,000thousands by filing date
XENCOR INC98401F105COMMON STOCK148,231$5,098,000thousands by filing date
SMITH & NEPHEW PLC SPDN ADR NEW83175M205ADR99,560$4,786,000thousands by filing date
PTC THERAPEUTICS INC69366J200COM99,327$4,771,000thousands by filing date
UNITED THERAPEUTICS CORP DEL COM91307C102Stock54,094$4,765,000thousands by filing date
ROCKET PHARMACEUTICALS INC77313F106COM207,555$4,724,000thousands by filing date
ISHARES TR464287556ISHARES BIOTECH38,834$4,680,000thousands by filing date
CRISPR THERAPEUTICS AG NAMEN AKTH17182108Stock76,222$4,642,000thousands by filing date
ACCELERON PHARMA INC00434H108COM86,313$4,576,000thousands by filing date
ARDELYX INC039697107COM607,698$4,561,000thousands by filing date
ACADIA HEALTHCARE COMPANY INC COM00404A109Stock136,200$4,525,000thousands by filing date
BRISTOL-MYERS SQUIBB CO110122157RIGHT 99/99/99991,473,710$4,436,000thousands by filing date
HEALTHPEAK PROPERTIES INC COM42250P103REIT128,537$4,431,000thousands by filing date
ARQULE INC04269E107COM220,409$4,399,000thousands by filing date
EDITAS MEDICINE INC28106W103COM147,939$4,380,000thousands by filing date
TENET HEALTHCARE CORP COM NEW88033G407Stock113,436$4,314,000thousands by filing date
RESMED INC COM761152107Stock27,775$4,304,000thousands by filing date
LIGAND PHARMACEUTICALS INC53220K504COM NEW40,955$4,271,000thousands by filing date
INTERCEPT PHARMACEUTICALS IN45845P108COM34,414$4,265,000thousands by filing date
ULTRAGENYX PHARMACEUTICAL IN90400D108COM97,480$4,163,000thousands by filing date
BAUSCH HEALTH COS INC COM071734107Stock138,812$4,153,000thousands by filing date
TAKEDA PHARMACEUTICAL CO LTD SPONSORED ADS874060205ADR210,146$4,146,000thousands by filing date
ALKERMES PLCG01767105SHS198,048$4,040,000thousands by filing date
APELLIS PHARMACEUTICALS INC03753U106COM130,999$4,011,000thousands by filing date
INSMED INC COM PAR $.01457669307Stock164,786$3,935,000thousands by filing date
PORTOLA PHARMACEUTICALS INC COM737010108Stock161,899$3,866,000thousands by filing date
DECIPHERA PHARMACEUTICALS IN24344T101COM61,370$3,820,000thousands by filing date
AMICUS THERAPEUTICS INC03152W109COM368,960$3,594,000thousands by filing date
INOGEN INC45780L104COM51,406$3,513,000thousands by filing date
MASIMO CORP COM574795100Stock21,773$3,441,000thousands by filing date
METTLER TOLEDO INTERNATIONAL COM592688105Stock4,223$3,350,000thousands by filing date
FATE THERAPEUTICS INC31189P102COM165,672$3,242,000thousands by filing date
INTRA-CELLULAR THERAPIES INC46116X101COMMON STOCK94,238$3,233,000thousands by filing date
CHARLES RIV LABS INTL INC159864107COM20,967$3,203,000thousands by filing date
ALCON AG ORD SHSH01301128Stock55,369$3,132,000thousands by filing date
THERAVANCE BIOPHARMA INCG8807B106COM117,725$3,048,000thousands by filing date
DIVERSIFIED HEALTHCARE TR25525P107COM SH BEN INT357,720$3,019,000thousands by filing date
HEALTHCARE RLTY TR421946104COM83,629$2,791,000thousands by filing date
RA PHARMACEUTICALS INC74933V108COM55,829$2,620,000thousands by filing date
PACIFIC BIOSCIENCES CALIF INC COM69404D108Stock495,495$2,547,000thousands by filing date
ENDO INTL PLCG30401106SHS531,570$2,493,000thousands by filing date
QUOTIENT LTDG73268107SHS260,030$2,473,000thousands by filing date
HEALTHEQUITY INC COM42226A107Stock31,810$2,356,000thousands by filing date
AGILENT TECHNOLOGIES INC COM00846U101Stock27,325$2,331,000thousands by filing date
STERIS PLC SHS USDG8473T100Stock14,790$2,254,000thousands by filing date
COHERUS ONCOLOGY INC19249H103COM125,146$2,253,000thousands by filing date
QUEST DIAGNOSTICS INC COM74834L100Stock21,025$2,245,000thousands by filing date
HOLOGIC INC436440101COM42,701$2,229,000thousands by filing date
EVOLENT HEALTH INC CL A30050B101Stock231,027$2,091,000thousands by filing date
ALLOGENE THERAPEUTICS INC019770106COM80,280$2,086,000thousands by filing date
KONINKLIJKE PHILIPS N V NY REGIS SHS NEW500472303ADR42,700$2,084,000thousands by filing date
ANAPTYSBIO INC032724106COM118,261$1,922,000thousands by filing date
CELLECTIS ADS15117K103COM110,147$1,886,000thousands by filing date
REVVITY INC714046109COM19,011$1,846,000thousands by filing date
AURINIA PHARMACEUTICALS INC COM05156V102Stock90,788$1,839,000thousands by filing date
AERIE PHARMACEUTICALS INC00771V108COM66,688$1,612,000thousands by filing date
MEDPACE HLDGS INC COM58506Q109Stock18,871$1,586,000thousands by filing date
BIOHAVEN PHARMACEUTICAL HOLDING11196105COM29,125$1,586,000thousands by filing date
VERONA PHARMA PLC925050106SPONSORED ADS275,000$1,581,000thousands by filing date
GLOBAL MED REIT INC37954A204COM NEW118,092$1,562,000thousands by filing date
ZAI LAB LTD ADR98887Q104ADR37,523$1,561,000thousands by filing date
OVID THERAPEUTICS INC690469101COMMON STOCK372,733$1,547,000thousands by filing date
TECTONIC THERAPEUTIC INC COM05455M100Stock74,874$1,507,000thousands by filing date
AC IMMUNE SAH00263105SHS171,813$1,464,000thousands by filing date
REGENXBIO INC75901B107COM35,500$1,454,000thousands by filing date
MYOKARDIA INC62857M105COM19,300$1,407,000thousands by filing date
HERON THERAPEUTICS INC427746102COM59,842$1,406,000thousands by filing date
HEALTHCARE42225P501CL A NEW46,000$1,393,000thousands by filing date
REVANCE THERAPEUTICS INC761330109COM85,840$1,393,000thousands by filing date
BRIDGEBIO PHARMA INC10806X102COM39,228$1,375,000thousands by filing date
LAKEFRONT BIOTHERAPEUTICS NV36315X101SPON ADR6,543$1,353,000thousands by filing date
DERMIRA INC24983L104COM89,200$1,352,000thousands by filing date
ARENA PHARMACEUTICALS INC040047607COM NEW28,002$1,272,000thousands by filing date
XENON PHARMACEUTICALS INC COM98420N105Stock96,961$1,271,000thousands by filing date
SANGAMO THERAPEUTICS INC800677106COM149,835$1,254,000thousands by filing date
MADRIGAL PHARMACEUTICALS INC COM558868105Stock13,340$1,215,000thousands by filing date
NEW SR INVT GROUP INC648691103COM158,047$1,209,000thousands by filing date
EIDOS THERAPEUTICS INC.28249H104Common Stock20,000$1,148,000thousands by filing date
FOAMIX PHARMACEUTICALS LTDM46135105SHS300,781$1,002,000thousands by filing date
IMMUNOGEN INC45253H101COMMON STOCK168,190$859,000thousands by filing date
INTELLIA THERAPEUTICS INC45826J105COM55,050$808,000thousands by filing date
WAVE LIFE SCIENCES LTD SHSY95308105Stock100,012$802,000thousands by filing date
AXONICS INC05465P101COM28,100$779,000thousands by filing date
MORPHOSYS AG617760202ADR19,390$692,000thousands by filing date
ZYMEWORKS INC98985W102COM15,192$691,000thousands by filing date
UNIVERSAL HEALTH RLTY INCOME91359E105REIT5,742$674,000thousands by filing date
RUBIUS THERAPEUTICS INC78116T103COM68,373$650,000thousands by filing date
COMMUNITY USD0.0120369C106COM14,900$639,000thousands by filing date
PUMA BIOTECHNOLOGY INC74587V107COMMON STOCK71,340$624,000thousands by filing date
CIDARA THERAPEUTICS INC COM NEW171757107Stock158,784$610,000thousands by filing date
MOLECULAR TEMPLATES INC608550109COM42,313$592,000thousands by filing date
COMMUNITY HEALTH SYSTEMS INC203668108COMMON STOCK203,935$591,000thousands by filing date
PERRIGO CO PLC SHSG97822103Stock10,818$559,000thousands by filing date
MYRIAD GENETICS INC62855J104COM18,805$512,000thousands by filing date
CLEARSIDE BIOMEDICAL INC185063104COM165,330$479,000thousands by filing date
TRILLIUM THERAPEUTICS INC COM NEW89620X506Stock446,099$459,000thousands by filing date
SPECTRUM PHARMACEUTICALS INC84763A108COM114,670$417,000thousands by filing date
GENMAB A/S372303206Ordinary Shares, nominal value DKK 1 per share16,520$369,000thousands by filing date
TURNING PT THERAPEUTICS90041T108COM5,677$354,000thousands by filing date
Y-mAbs Therapeutics Inc984241109Common Stock11,326$354,000thousands by filing date
GUARDANT HEALTH INC COM40131M109Stock4,333$339,000thousands by filing date
MERUS N VN5749R100COM21,215$299,000thousands by filing date
DIANTHUS THERAPEUTICS INC COM55910K108Stock16,757$254,000thousands by filing date
ORUKA THERAPEUTICS INC COM00211Y506Stock36,068$206,000thousands by filing date
CYMABAY THERAPEUTICS INC23257D103COM88,102$173,000thousands by filing date
AERPIO PHARMACEUTICALS INC00810B105COM257,554$161,000thousands by filing date
TETRAPHASE PHARMACEUTICALS I88165N204COM NEW42,965$121,000thousands by filing date
Mallinckrodt PlcG5785G107SHS32,980$115,000thousands by filing date
NOVAVAX INC670002401COM NEW28,550$114,000thousands by filing date
ADAPTIMMUNE THERAPEUTICS PLC00653A107SPONDS ADR77,061$92,000thousands by filing date
BELLICUM PHARMACEUTICALS INC079481107COM60,000$77,000thousands by filing date
QUORUM HEALTH CORP74909E106COM23,725$23,000thousands by filing date
CELLDEX THERAPEUTICS INC NEW15117B202COM NEW7,053$16,000thousands by filing date

Amendment chain

FilingRoleFiledAcceptedIngested
13F-HR 0001104659-20-019919this filing2020-02-13acceptance time not in the bulk data set