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13F-HR filed by Tekla Capital Management LLC

Tekla Capital Management LLC filed this 13F-HR for the quarter ended 2019-09-30, filed 2019-11-13, with 192 holding rows worth $2,292,061,000.

Accession
0001104659-19-063054
Filed
2019-11-13
Accepted by EDGAR
acceptance time not in the bulk data set
Ingested
Source
SEC quarterly data set

Original filing

13F report for Q3 2019

A holdings report, 192 entries on the cover page, a total value of $2,292,061,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $2,292,061,000 with VALUE read as thousands by filing date, 13F file number 028-10950. The quarter's positions are built on this report. The resolved quarter.

The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).

Issuer as filedCUSIPClassAmountValueValue read asType
CELGENE CORP151020104COM1,473,710$146,339,000thousands by filing date
Amgen Inc.031162100COM632,287$122,354,000thousands by filing date
Gilead Sciences,Inc.375558103COM1,833,982$116,238,000thousands by filing date
Johnson & Johnson478160104COM818,227$105,862,000thousands by filing date
Merck & Co.,Inc.58933Y105COM1,211,384$101,974,000thousands by filing date
Vertex Pharmaceuticals Incorporated92532F100COM487,234$82,547,000thousands by filing date
Pfizer Inc.717081103COM2,114,306$75,967,000thousands by filing date
ILLUMINA INC452327109COM241,139$73,359,000thousands by filing date
UnitedHealth Group Inc91324P102COM337,283$73,298,000thousands by filing date
BIOGEN INC COM09062X103Stock257,939$60,053,000thousands by filing date
ALEXION PHARMACEUTICALS INC015351109COM453,887$44,454,000thousands by filing date
REGENERON PHARMACEUTICALS COM75886F107Stock159,658$44,289,000thousands by filing date
Medtronic PlcG5960L103COM399,370$43,380,000thousands by filing date
Bristol-Myers Squibb Company110122108COM738,044$37,426,000thousands by filing date
CVS Health Corporation126650100COM540,286$34,076,000thousands by filing date
ZOETIS INC CL A98978V103Stock249,024$31,026,000thousands by filing date
AbbVie,Inc.00287Y109COM400,016$30,289,000thousands by filing date
Intuitive Surgical,Inc.46120E602COM55,475$29,953,000thousands by filing date
INCYTE CORP COM45337C102Stock393,730$29,227,000thousands by filing date
Elevance Health, Inc.036752103COM121,132$29,084,000thousands by filing date
Abbott Laboratories002824100COM322,513$26,985,000thousands by filing date
Thermo Fisher Scientific Inc.883556102COM89,310$26,013,000thousands by filing date
Stryker Corporation863667101COM118,520$25,636,000thousands by filing date
SEATTLE GENETICS INC812578102COM289,925$24,760,000thousands by filing date
ALLERGAN PLCG0177J108SHS145,281$24,449,000thousands by filing date
Boston Scientific Corporation101137107COM564,950$22,988,000thousands by filing date
Danaher Corporation235851102COM152,376$22,008,000thousands by filing date
NOVARTIS AG SPONSORED ADR66987V109ADR249,447$21,677,000thousands by filing date
HUMANA INC COM444859102Stock84,234$21,536,000thousands by filing date
MYLAN NVN59465109SHS EURO1,038,554$20,543,000thousands by filing date
Cigna Corporation125523100COM124,995$18,973,000thousands by filing date
NEUROCRINE BIOSCIENCES INC64125C109COM206,822$18,637,000thousands by filing date
Eli Lilly and Company532457108COM156,958$17,553,000thousands by filing date
BIOMARIN PHARMACEUTICAL INC09061G101COM245,763$16,564,000thousands by filing date
PRA HEALTH SCIENCES INC69354M108COM153,003$15,182,000thousands by filing date
BECTON DICKINSON & CO075887109COM58,438$14,782,000thousands by filing date
MCKESSON CORP COM58155Q103Stock107,266$14,659,000thousands by filing date
BAXTER INTL INC071813109COM164,958$14,429,000thousands by filing date
CENCORA INC COM03073E105Stock174,338$14,353,000thousands by filing date
EDWARDS LIFESCIENCES CORP COM28176E108Stock65,240$14,347,000thousands by filing date
WELLTOWER INC COM95040Q104REIT152,322$13,808,000thousands by filing date
IDEXX LABS INC COM45168D104Stock49,776$13,536,000thousands by filing date
ALNYLAM PHARMACEUTICALS INC COM02043Q107Stock166,275$13,372,000thousands by filing date
BLUEBIRD BIO INC09609G100COM140,286$12,881,000thousands by filing date
NOVO-NORDISK A S ADR670100205ADR241,000$12,460,000thousands by filing date
ASTRAZENECA PLC SPONSORED ADR046353108ADR276,098$12,306,000thousands by filing date
SAGE THERAPEUTICS INC78667J108COM86,780$12,174,000thousands by filing date
HCA Healthcare Inc40412C101COM98,393$11,848,000thousands by filing date
BEONE MEDICINES LTD SPONSORED ADS07725L102ADR94,289$11,547,000thousands by filing date
OMEGA HEALTHCARE INVS INC COM681936100REIT272,766$11,399,000thousands by filing date
IONIS PHARMACEUTICALS INC COM462222100Stock186,244$11,158,000thousands by filing date
SABRA HEALTH CARE REIT INC COM78573L106REIT466,247$10,705,000thousands by filing date
ZIMMER BIOMET HOLDINGS INC COM98956P102Stock77,571$10,648,000thousands by filing date
SAREPTA THERAPEUTICS INC803607100COM140,279$10,566,000thousands by filing date
VENTAS INC COM92276F100REIT141,119$10,306,000thousands by filing date
GLAXOSMITHKLINE PLC-ADR37733W105SPONSORED ADR231,758$9,891,000thousands by filing date
JAZZ PHARMACEUTICALS PLC SHS USDG50871105Stock74,936$9,602,000thousands by filing date
FIBROGEN INC31572Q808COM233,142$8,622,000thousands by filing date
ESPERION THERAPEUTICS INC NEW COM29664W105Stock213,562$7,829,000thousands by filing date
NOVOCURE LTDG6674U108ORD SHS100,932$7,548,000thousands by filing date
LTC PPTYS INC COM502175102REIT145,421$7,448,000thousands by filing date
ASCENDIS PHARMA A/S DKK 1.0 AD04351P101SPONSORED ADR77,167$7,433,000thousands by filing date
GW PHARMACEUTICALS PLC36197T103ADS64,499$7,419,000thousands by filing date
BLUEPRINT MEDICINES CORP09627Y109COM100,916$7,414,000thousands by filing date
DENTSPLY SIRONA INC24906P109COM136,936$7,300,000thousands by filing date
SPDR SER TR78464A870S&P BIOTECH89,022$6,788,000thousands by filing date
MEDICINES CO584688105COM135,675$6,784,000thousands by filing date
IMMUNOMEDICS INC452907108COM487,103$6,459,000thousands by filing date
MIRATI THERAPEUTICS INC60468T105COM79,687$6,208,000thousands by filing date
BIO-TECHNE CORP09073M104COM30,537$5,975,000thousands by filing date
EXELIXIS INC COM30161Q104Stock331,751$5,867,000thousands by filing date
SMITH & NEPHEW PLC SPDN ADR NEW83175M205ADR121,645$5,855,000thousands by filing date
HORIZON THERAPEUTICS PLCG46188101SHS214,730$5,847,000thousands by filing date
SUTRO BIOPHARMA INC869367102COM641,268$5,829,000thousands by filing date
ABIOMED INC003654100COM32,716$5,820,000thousands by filing date
ACADIA PHARMACEUTICALS INC004225108COM160,147$5,764,000thousands by filing date
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS881624209ADR785,851$5,407,000thousands by filing date
PHYSICIANS REALTY TRUST71943U104COM303,908$5,394,000thousands by filing date
LABORATORY CORP OF AMERICA50540R409COM NEW31,424$5,279,000thousands by filing date
NEKTAR THERAPEUTICS640268108COM283,679$5,167,000thousands by filing date
ALIGN TECHNOLOGY INC COM016255101Stock28,278$5,116,000thousands by filing date
PTC THERAPEUTICS INC69366J200COM148,435$5,020,000thousands by filing date
RESMED INC COM761152107Stock37,110$5,014,000thousands by filing date
XENCOR INC98401F105COMMON STOCK148,231$5,000,000thousands by filing date
PIERIS PHARMACEUTICALS INC720795103COM1,449,269$4,942,000thousands by filing date
AGIOS PHARMACEUTICALS INC00847X104COM142,217$4,608,000thousands by filing date
GLOBAL BLOOD THERAPEUTICS USD37890U108COM92,957$4,510,000thousands by filing date
IQVIA HLDGS INC COM46266C105Stock29,857$4,460,000thousands by filing date
LIGAND PHARMACEUTICALS INC53220K504COM NEW44,055$4,385,000thousands by filing date
AMARIN CORP PLC023111206SPONS ADR NEW288,557$4,375,000thousands by filing date
UNITED THERAPEUTICS CORP DEL COM91307C102Stock54,094$4,314,000thousands by filing date
ACADIA HEALTHCARE COMPANY INC COM00404A109Stock136,200$4,233,000thousands by filing date
ULTRAGENYX PHARMACEUTICAL IN90400D108COM97,480$4,170,000thousands by filing date
CRISPR THERAPEUTICS AG NAMEN AKTH17182108Stock101,336$4,154,000thousands by filing date
EPIZYME INC29428V104COM399,604$4,122,000thousands by filing date
SANOFI SA SPONSORED ADR80105N105ADR85,941$3,982,000thousands by filing date
COHERUS ONCOLOGY INC19249H103COM195,146$3,954,000thousands by filing date
MASIMO CORP COM574795100Stock26,436$3,933,000thousands by filing date
REGENXBIO INC75901B107COM109,248$3,889,000thousands by filing date
ARGENX SE SPONSORED ADR04016X101ADR34,048$3,880,000thousands by filing date
ALKERMES PLCG01767105SHS198,048$3,864,000thousands by filing date
BAUSCH HEALTH COS INC COM071734107Stock168,812$3,689,000thousands by filing date
MEDICAL PROPERTIES TRUST INC COM58463J304REIT187,063$3,659,000thousands by filing date
TAKEDA PHARMACEUTICAL CO LTD SPONSORED ADS874060205ADR210,146$3,615,000thousands by filing date
STERIS PLC SHS USDG8473T100Stock24,473$3,536,000thousands by filing date
ACCELERON PHARMA INC00434H108COM86,313$3,410,000thousands by filing date
AVADEL PHARMACEUTICALS, PLC05337M104COMMON STOCK-FO814,588$3,389,000thousands by filing date
EDITAS MEDICINE INC28106W103COM147,939$3,364,000thousands by filing date
CHARLES RIV LABS INTL INC159864107COM25,067$3,318,000thousands by filing date
SENIOR HSG PPTYS TR81721M109SH BEN INT357,720$3,311,000thousands by filing date
ALCON AG ORD SHSH01301128Stock55,369$3,227,000thousands by filing date
IOVANCE BIOTHERAPEUTICS INC462260100COM175,012$3,185,000thousands by filing date
TENET HEALTHCARE CORP COM NEW88033G407Stock141,136$3,122,000thousands by filing date
PORTOLA PHARMACEUTICALS INC COM737010108Stock115,448$3,096,000thousands by filing date
INOGEN INC45780L104COM61,526$2,948,000thousands by filing date
INSMED INC COM PAR $.01457669307Stock164,786$2,907,000thousands by filing date
QUEST DIAGNOSTICS INC COM74834L100Stock26,012$2,784,000thousands by filing date
CARDINAL HEALTH INC14149Y108COM58,241$2,748,000thousands by filing date
ARDELYX INC039697107COM582,698$2,739,000thousands by filing date
AGILENT TECHNOLOGIES INC COM00846U101Stock34,025$2,607,000thousands by filing date
FATE THERAPEUTICS INC31189P102COM165,672$2,573,000thousands by filing date
WRIGHT MED GROUP N VN96617118ORD SHS124,006$2,558,000thousands by filing date
PACIFIC BIOSCIENCES CALIF INC COM69404D108Stock495,495$2,557,000thousands by filing date
AMICUS THERAPEUTICS INC03152W109COM314,597$2,523,000thousands by filing date
WAVE LIFE SCIENCES LTD SHSY95308105Stock122,551$2,516,000thousands by filing date
ZOGENIX INC.98978L204Common Stock62,074$2,485,000thousands by filing date
SYNEOS HEALTH INC87166B102CL A45,982$2,447,000thousands by filing date
ROCKET PHARMACEUTICALS INC77313F106COM207,555$2,418,000thousands by filing date
APELLIS PHARMACEUTICALS INC03753U106COM98,784$2,380,000thousands by filing date
ANAPTYSBIO INC032724106COM67,496$2,362,000thousands by filing date
INTERCEPT PHARMACEUTICALS IN45845P108COM34,414$2,284,000thousands by filing date
HEALTHCARE RLTY TR421946104COM68,000$2,278,000thousands by filing date
TELEFLEX INCORPORATED879369106COM6,379$2,167,000thousands by filing date
HOLOGIC INC436440101COM42,701$2,156,000thousands by filing date
ATRECA INC04965G109COM167,245$2,047,000thousands by filing date
QUOTIENT LTDG73268107SHS260,030$2,020,000thousands by filing date
KONINKLIJKE PHILIPS N V NY REGIS SHS NEW500472303ADR42,700$1,970,000thousands by filing date
ISHARES TR464287556ISHARES BIOTECH18,914$1,882,000thousands by filing date
HEALTHEQUITY INC COM42226A107Stock31,810$1,818,000thousands by filing date
UNIQURE NVN90064101SHS43,849$1,726,000thousands by filing date
ENDO INTL PLCG30401106SHS531,570$1,706,000thousands by filing date
EVOLENT HEALTH INC CL A30050B101Stock231,027$1,661,000thousands by filing date
HCP INC40414L109COM45,500$1,621,000thousands by filing date
REVVITY INC714046109COM19,011$1,619,000thousands by filing date
LAKEFRONT BIOTHERAPEUTICS NV36315X101SPON ADR9,141$1,395,000thousands by filing date
HEALTHCARE42225P501CL A NEW46,000$1,351,000thousands by filing date
RA PHARMACEUTICALS INC74933V108COM55,829$1,320,000thousands by filing date
ARENA PHARMACEUTICALS INC040047607COM NEW28,002$1,282,000thousands by filing date
AERIE PHARMACEUTICALS INC00771V108COM66,688$1,282,000thousands by filing date
VERONA PHARMA PLC925050106SPONSORED ADS275,000$1,257,000thousands by filing date
BIOHAVEN PHARMACEUTICAL HOLDING11196105COM29,125$1,215,000thousands by filing date
ZAI LAB LTD ADR98887Q104ADR37,523$1,214,000thousands by filing date
OVID THERAPEUTICS INC690469101COMMON STOCK372,733$1,208,000thousands by filing date
MADRIGAL PHARMACEUTICALS INC COM558868105Stock13,340$1,150,000thousands by filing date
CELLECTIS ADS15117K103COM110,147$1,146,000thousands by filing date
NEW SR INVT GROUP INC648691103COM158,047$1,056,000thousands by filing date
DIPLOMAT PHARMACY INC25456K101COM214,845$1,053,000thousands by filing date
MYOKARDIA INC62857M105COM19,300$1,006,000thousands by filing date
ALLAKOS INC01671P100COM12,207$960,000thousands by filing date
SPECTRUM PHARMACEUTICALS INC84763A108COM114,670$951,000thousands by filing date
MOLECULAR TEMPLATES INC608550109COM144,110$950,000thousands by filing date
FOAMIX PHARMACEUTICALS LTDM46135105SHS300,781$914,000thousands by filing date
THERAVANCE BIOPHARMA INCG8807B106COM46,101$898,000thousands by filing date
ARROWHEAD PHARMACEUTICALS IN04280A100COM30,700$865,000thousands by filing date
AC IMMUNE SAH00263105SHS171,813$850,000thousands by filing date
GLOBAL MED REIT INC37954A204COM NEW73,400$837,000thousands by filing date
Milestone Pharmaceuticals Inc59935V107COM46,940$812,000thousands by filing date
PUMA BIOTECHNOLOGY INC74587V107COMMON STOCK71,340$768,000thousands by filing date
INTELLIA THERAPEUTICS INC45826J105COM55,050$735,000thousands by filing date
COMMUNITY HEALTH SYSTEMS INC203668108COMMON STOCK203,935$734,000thousands by filing date
PERRIGO CO PLC SHSG97822103Stock10,818$605,000thousands by filing date
ARQULE INC04269E107COM76,054$545,000thousands by filing date
MYRIAD GENETICS INC62855J104COM18,805$538,000thousands by filing date
CYMABAY THERAPEUTICS INC23257D103COM88,102$451,000thousands by filing date
IMMUNOGEN INC45253H101COMMON STOCK168,190$407,000thousands by filing date
MERUS N VN5749R100COM21,421$382,000thousands by filing date
ZYMEWORKS INC98985W102COM15,192$377,000thousands by filing date
CIDARA THERAPEUTICS INC COM NEW171757107Stock158,784$317,000thousands by filing date
TECTONIC THERAPEUTIC INC COM05455M100Stock20,176$285,000thousands by filing date
TETRAPHASE PHARMACEUTICALS I88165N204COM NEW42,966$229,000thousands by filing date
INTRA-CELLULAR THERAPIES INC46116X101COMMON STOCK27,548$206,000thousands by filing date
ORUKA THERAPEUTICS INC COM00211Y506Stock36,068$192,000thousands by filing date
AERPIO PHARMACEUTICALS INC00810B105COM257,554$175,000thousands by filing date
DIANTHUS THERAPEUTICS INC COM55910K108Stock16,757$172,000thousands by filing date
NOVAVAX INC670002401COM NEW28,550$143,000thousands by filing date
TRILLIUM THERAPEUTICS INC COM NEW89620X506Stock446,099$137,000thousands by filing date
ADAPTIMMUNE THERAPEUTICS PLC00653A107SPONDS ADR77,061$116,000thousands by filing date
CLEARSIDE BIOMEDICAL INC185063104COM165,330$104,000thousands by filing date
Mallinckrodt PlcG5785G107SHS32,980$79,000thousands by filing date
BELLICUM PHARMACEUTICALS INC079481107COM60,000$63,000thousands by filing date
QUORUM HEALTH CORP74909E106COM23,725$29,000thousands by filing date
CELLDEX THERAPEUTICS INC NEW15117B202COM NEW7,053$15,000thousands by filing date

Amendment chain

FilingRoleFiledAcceptedIngested
13F-HR 0001104659-19-063054this filing2019-11-13acceptance time not in the bulk data set