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13F-HR filed by Tekla Capital Management LLC

Tekla Capital Management LLC filed this 13F-HR for the quarter ended 2018-12-31, filed 2019-02-13, with 203 holding rows worth $2,336,202,000.

Accession
0001104659-19-007994
Filed
2019-02-13
Accepted by EDGAR
acceptance time not in the bulk data set
Ingested
Source
SEC quarterly data set

Original filing

13F report for Q4 2018

A holdings report, 203 entries on the cover page, a total value of $2,336,202,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $2,336,202,000 with VALUE read as thousands by filing date, 13F file number 028-10950. The quarter's positions are built on this report. The resolved quarter.

The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).

Issuer as filedCUSIPClassAmountValueValue read asType
Johnson & Johnson478160104COM1,032,628$133,261,000thousands by filing date
Amgen Inc.031162100COM677,855$131,958,000thousands by filing date
BIOGEN INC COM09062X103Stock394,902$118,834,000thousands by filing date
Gilead Sciences,Inc.375558103COM1,889,846$118,210,000thousands by filing date
UnitedHealth Group Inc91324P102COM375,374$93,513,000thousands by filing date
CELGENE CORP151020104COM1,382,006$88,573,000thousands by filing date
ILLUMINA INC452327109COM262,379$78,695,000thousands by filing date
Vertex Pharmaceuticals Incorporated92532F100COM426,248$70,634,000thousands by filing date
Pfizer Inc.717081103COM1,516,793$66,208,000thousands by filing date
Merck & Co.,Inc.58933Y105COM738,108$56,399,000thousands by filing date
REGENERON PHARMACEUTICALS COM75886F107Stock136,422$50,954,000thousands by filing date
ALEXION PHARMACEUTICALS INC015351109COM496,288$48,319,000thousands by filing date
AbbVie,Inc.00287Y109COM492,078$45,365,000thousands by filing date
Medtronic PlcG5960L103COM481,365$43,785,000thousands by filing date
Thermo Fisher Scientific Inc.883556102COM191,895$42,944,000thousands by filing date
INCYTE CORP COM45337C102Stock645,442$41,044,000thousands by filing date
MYLAN NVN59465109SHS EURO1,403,728$38,462,000thousands by filing date
Elevance Health, Inc.036752103COM141,147$37,069,000thousands by filing date
Bristol-Myers Squibb Company110122108COM652,966$33,941,000thousands by filing date
ALLERGAN PLCG0177J108SHS234,720$31,373,000thousands by filing date
CVS Health Corporation126650100COM460,698$30,185,000thousands by filing date
Abbott Laboratories002824100COM391,719$28,333,000thousands by filing date
Stryker Corporation863667101COM160,432$25,148,000thousands by filing date
Eli Lilly and Company532457108COM216,442$25,047,000thousands by filing date
NOVARTIS AG SPONSORED ADR66987V109ADR291,717$25,032,000thousands by filing date
Danaher Corporation235851102COM209,371$21,590,000thousands by filing date
ZOETIS INC CL A98978V103Stock251,415$21,506,000thousands by filing date
SAREPTA THERAPEUTICS INC803607100COM191,837$20,935,000thousands by filing date
HUMANA INC COM444859102Stock68,487$19,620,000thousands by filing date
CENTENE CORP DEL COM15135B101Stock166,869$19,240,000thousands by filing date
Intuitive Surgical,Inc.46120E602COM39,229$18,788,000thousands by filing date
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS881624209ADR1,211,868$18,687,000thousands by filing date
BIOMARIN PHARMACEUTICAL INC09061G101COM207,434$17,663,000thousands by filing date
ASTRAZENECA PLC SPONSORED ADR046353108ADR428,024$16,256,000thousands by filing date
Boston Scientific Corporation101137107COM444,991$15,726,000thousands by filing date
BECTON DICKINSON & CO075887109COM69,778$15,722,000thousands by filing date
NEUROCRINE BIOSCIENCES INC64125C109COM216,294$15,446,000thousands by filing date
JAZZ PHARMACEUTICALS PLC SHS USDG50871105Stock115,187$14,279,000thousands by filing date
NOVO-NORDISK A S ADR670100205ADR301,900$13,909,000thousands by filing date
OMEGA HEALTHCARE INVS INC COM681936100REIT380,122$13,361,000thousands by filing date
SEATTLE GENETICS INC812578102COM226,239$12,819,000thousands by filing date
Cigna Corporation125523100COM64,089$12,172,000thousands by filing date
BEONE MEDICINES LTD SPONSORED ADS07725L102ADR85,755$12,028,000thousands by filing date
BAXTER INTL INC071813109COM161,233$10,612,000thousands by filing date
SPDR SER TR78464A870S&P BIOTECH144,424$10,362,000thousands by filing date
FIBROGEN INC31572Q808COM212,763$9,847,000thousands by filing date
BLUEBIRD BIO INC09609G100COM98,429$9,764,000thousands by filing date
AEGERION PHARMACEUTICALS INC00767EAB8NOTE 2.000 8/113,000,000$9,734,000thousands by filing dateprincipal
IDEXX LABS INC COM45168D104Stock51,575$9,594,000thousands by filing date
SAGE THERAPEUTICS INC78667J108COM98,444$9,430,000thousands by filing date
ZIMMER BIOMET HOLDINGS INC COM98956P102Stock89,204$9,252,000thousands by filing date
HCA Healthcare Inc40412C101COM74,335$9,251,000thousands by filing date
ALNYLAM PHARMACEUTICALS INC COM02043Q107Stock126,176$9,199,000thousands by filing date
LAKEFRONT BIOTHERAPEUTICS NV36315X101SPON ADR99,815$9,157,000thousands by filing date
SABRA HEALTH CARE REIT INC COM78573L106REIT542,862$8,946,000thousands by filing date
AMARIN CORP PLC023111206SPONS ADR NEW654,052$8,902,000thousands by filing date
EDWARDS LIFESCIENCES CORP COM28176E108Stock56,798$8,700,000thousands by filing date
MCKESSON CORP COM58155Q103Stock78,720$8,696,000thousands by filing date
AMICUS THERAPEUTICS INC03152W109COM875,304$8,385,000thousands by filing date
GLAXOSMITHKLINE PLC-ADR37733W105SPONSORED ADR218,700$8,357,000thousands by filing date
CENCORA INC COM03073E105Stock111,807$8,318,000thousands by filing date
MEDICINES CO584688105COM428,992$8,211,000thousands by filing date
SANOFI SA SPONSORED ADR80105N105ADR179,900$7,809,000thousands by filing date
LTC PPTYS INC COM502175102REIT178,623$7,445,000thousands by filing date
ACCELERON PHARMA INC00434H108COM170,766$7,437,000thousands by filing date
SMITH & NEPHEW PLC SPDN ADR NEW83175M205ADR185,478$6,933,000thousands by filing date
DIPLOMAT PHARMACY INC25456K101COM505,701$6,807,000thousands by filing date
BLUEPRINT MEDICINES CORP09627Y109COM125,207$6,750,000thousands by filing date
EXELIXIS INC COM30161Q104Stock339,435$6,677,000thousands by filing date
RESMED INC COM761152107Stock58,630$6,676,000thousands by filing date
MEDICAL PROPERTIES TRUST INC COM58463J304REIT413,809$6,654,000thousands by filing date
ESPERION THERAPEUTICS INC NEW COM29664W105Stock142,289$6,545,000thousands by filing date
PRA HEALTH SCIENCES INC69354M108COM70,460$6,480,000thousands by filing date
SHIRE PLC82481R106COMMON STOCK-FO36,216$6,303,000thousands by filing date
PHYSICIANS REALTY TRUST71943U104COM391,016$6,268,000thousands by filing date
ALIGN TECHNOLOGY INC COM016255101Stock29,860$6,254,000thousands by filing date
GW PHARMACEUTICALS PLC36197T103ADS63,345$6,169,000thousands by filing date
IMMUNOMEDICS INC452907108COM431,527$6,158,000thousands by filing date
VENTAS INC COM92276F100REIT98,496$5,771,000thousands by filing date
PIERIS PHARMACEUTICALS INC720795103COM2,087,380$5,552,000thousands by filing date
QUEST DIAGNOSTICS INC COM74834L100Stock66,500$5,537,000thousands by filing date
ENDO INTL PLCG30401106SHS717,274$5,236,000thousands by filing date
ARRAY BIOPHARMA INC COM04269X105Stock364,166$5,189,000thousands by filing date
MERUS N VN5749R100COM367,671$5,147,000thousands by filing date
STERIS PLCG84720104SHS USD48,003$5,129,000thousands by filing date
CRISPR THERAPEUTICS AG NAMEN AKTH17182108Stock178,348$5,095,000thousands by filing date
DENTSPLY SIRONA INC24906P109COM125,625$4,675,000thousands by filing date
IQVIA HLDGS INC COM46266C105Stock39,100$4,542,000thousands by filing date
UNITED THERAPEUTICS CORP DEL COM91307C102Stock41,261$4,493,000thousands by filing date
IONIS PHARMACEUTICALS INC COM462222100Stock82,838$4,478,000thousands by filing date
ALKERMES PLCG01767105SHS151,283$4,464,000thousands by filing date
ACADIA HEALTHCARE COMPANY INC COM00404A109Stock173,155$4,452,000thousands by filing date
SENIOR HSG PPTYS TR81721M109SH BEN INT377,220$4,421,000thousands by filing date
ANAPTYSBIO INC032724106COM65,845$4,200,000thousands by filing date
ZOGENIX INC.98978L204Common Stock111,025$4,048,000thousands by filing date
ABIOMED INC003654100COM12,350$4,014,000thousands by filing date
CELLECTIS ADS15117K103COM236,530$3,938,000thousands by filing date
GLOBAL BLOOD THERAPEUTICS USD37890U108COM93,924$3,856,000thousands by filing date
LABORATORY CORP OF AMERICA50540R409COM NEW29,100$3,677,000thousands by filing date
WRIGHT MED GROUP N VN96617118ORD SHS133,391$3,631,000thousands by filing date
LIGAND PHARMACEUTICALS INC53220K504COM NEW26,450$3,589,000thousands by filing date
BAUSCH HEALTH COS INC COM071734107Stock192,000$3,546,000thousands by filing date
LOXO ONCOLOGY INC548862101COM24,595$3,445,000thousands by filing date
ULTRAGENYX PHARMACEUTICAL IN90400D108COM76,958$3,346,000thousands by filing date
WELLTOWER INC COM95040Q104REIT45,560$3,162,000thousands by filing date
NEKTAR THERAPEUTICS640268108COM94,384$3,102,000thousands by filing date
WELLCARE HEALTH PLANS INC94946T106COM13,000$3,069,000thousands by filing date
ALBIREO PHARMA INC01345P106COMMON STOCK125,000$3,066,000thousands by filing date
KONINKLIJKE PHILIPS N V NY REGIS SHS NEW500472303ADR85,400$2,998,000thousands by filing date
VARIAN MED SYS INC92220P105COM26,227$2,972,000thousands by filing date
COHERUS ONCOLOGY INC19249H103COM315,162$2,852,000thousands by filing date
INNOVIVA INC45781M101COM161,603$2,820,000thousands by filing date
SANGAMO THERAPEUTICS INC800677106COM241,538$2,773,000thousands by filing date
NEVRO CORP64157F103COM68,760$2,674,000thousands by filing date
ASCENDIS PHARMA A/S DKK 1.0 AD04351P101SPONSORED ADR42,399$2,656,000thousands by filing date
CHARLES RIV LABS INTL INC159864107COM22,670$2,566,000thousands by filing date
INOVALON HLDGS INC45781D101COM CL A176,163$2,498,000thousands by filing date
VERONA PHARMA PLC925050106SPONSORED ADS275,000$2,475,000thousands by filing date
TENET HEALTHCARE CORP COM NEW88033G407Stock141,136$2,419,000thousands by filing date
EPIZYME INC29428V104COM385,872$2,377,000thousands by filing date
PTC THERAPEUTICS INC69366J200COM68,652$2,356,000thousands by filing date
AGIOS PHARMACEUTICALS INC00847X104COM49,025$2,261,000thousands by filing date
PORTOLA PHARMACEUTICALS INC COM737010108Stock115,448$2,254,000thousands by filing date
MARINUS PHARMACEUTICALS INC56854Q101COM755,776$2,169,000thousands by filing date
FOAMIX PHARMACEUTICALS LTDM46135105SHS601,205$2,158,000thousands by filing date
AVADEL PHARMACEUTICALS, PLC05337M104COMMON STOCK-FO814,588$2,102,000thousands by filing date
SUTRO BIOPHARMA INC869367102COM229,900$2,074,000thousands by filing date
INTELLIA THERAPEUTICS INC45826J105COM150,290$2,051,000thousands by filing date
WATERS CORP COM941848103Stock10,800$2,037,000thousands by filing date
ARENA PHARMACEUTICALS INC040047607COM NEW52,262$2,036,000thousands by filing date
XENCOR INC98401F105COMMON STOCK56,172$2,031,000thousands by filing date
METTLER TOLEDO INTERNATIONAL COM592688105Stock3,500$1,980,000thousands by filing date
HEALTHCARE RLTY TR421946104COM68,000$1,934,000thousands by filing date
IOVANCE BIOTHERAPEUTICS INC462260100COM216,908$1,920,000thousands by filing date
MYOKARDIA INC62857M105COM38,600$1,886,000thousands by filing date
MASIMO CORP COM574795100Stock17,011$1,826,000thousands by filing date
EDITAS MEDICINE INC28106W103COM76,668$1,744,000thousands by filing date
PUMA BIOTECHNOLOGY INC74587V107COMMON STOCK83,340$1,696,000thousands by filing date
INOGEN INC45780L104COM13,500$1,676,000thousands by filing date
TELEFLEX INCORPORATED879369106COM6,379$1,649,000thousands by filing date
AC IMMUNE SAH00263105SHS171,813$1,624,000thousands by filing date
PERRIGO CO PLC SHSG97822103Stock37,300$1,445,000thousands by filing date
NUVASIVE INC670704105COM28,816$1,428,000thousands by filing date
AERIE PHARMACEUTICALS INC00771V108COM38,770$1,400,000thousands by filing date
DR REDDYS LABS LTD ADR256135203ADR36,500$1,376,000thousands by filing date
CLOVIS ONCOLOGY INC189464100COM75,400$1,354,000thousands by filing date
INTERCEPT PHARMACEUTICALS IN45845P108COM13,348$1,345,000thousands by filing date
PROTAGONIST THERAPEUTICS74366E102COM197,138$1,327,000thousands by filing date
ADAPTIMMUNE THERAPEUTICS PLC00653A107SPONDS ADR228,496$1,314,000thousands by filing date
AERPIO PHARMACEUTICALS INC00810B105COM765,000$1,301,000thousands by filing date
NEW SR INVT GROUP INC648691103COM314,747$1,297,000thousands by filing date
HCP INC40414L109COM45,500$1,271,000thousands by filing date
INTRA-CELLULAR THERAPIES INC46116X101COMMON STOCK110,193$1,255,000thousands by filing date
OVID THERAPEUTICS INC690469101COMMON STOCK496,977$1,203,000thousands by filing date
AKEBIA THERAPEUTICS INC00972D105COMMON STOCK213,942$1,183,000thousands by filing date
HEALTHCARE42225P501CL A NEW46,000$1,164,000thousands by filing date
DERMIRA INC24983L104COM161,579$1,162,000thousands by filing date
ARDELYX INC039697107COM639,370$1,144,000thousands by filing date
NIGHTSTAR THERAPEUTICS PLC65413A101ADR98,929$1,140,000thousands by filing date
AUDENTES THERAPEUTICS INC.05070R104Common Stock52,574$1,121,000thousands by filing date
GENOMIC HEALTH, INC.37244C101COM17,370$1,119,000thousands by filing date
UNIQURE NVN90064101SHS37,741$1,088,000thousands by filing date
NOVAVAX INC670002104COMMON STOCK571,000$1,051,000thousands by filing date
LIVANOVA PLCG5509L101SHS11,400$1,043,000thousands by filing date
SPECTRUM PHARMACEUTICALS INC84763A108COM114,670$1,003,000thousands by filing date
TETRAPHASE PHARMACEUTICALS INC88165N105COMMON STOCK859,322$971,000thousands by filing date
SYNDAX PHARMACEUTICALS INC87164F105COM200,000$890,000thousands by filing date
Mallinckrodt PlcG5785G107SHS53,600$847,000thousands by filing date
EVOLENT HEALTH INC CL A30050B101Stock42,150$841,000thousands by filing date
NOVOCURE LTDG6674U108ORD SHS24,500$820,000thousands by filing date
IMMUNOGEN INC45253H101COMMON STOCK168,190$807,000thousands by filing date
HOLOGIC INC436440101COM19,546$803,000thousands by filing date
AFFIMED N VN01045108COM254,000$790,000thousands by filing date
TRILLIUM THERAPEUTICS INC COM NEW89620X506Stock446,099$763,000thousands by filing date
MADRIGAL PHARMACEUTICALS INC COM558868105Stock6,670$752,000thousands by filing date
Egalet Corporation28226BAB0Note 5.50% 4/1/207,000,000$700,000thousands by filing dateprincipal
ARQULE INC04269E107COM250,000$693,000thousands by filing date
RHYTHM PHARMACEUTICALS INC76243J105COM24,890$669,000thousands by filing date
GLOBAL MED REIT INC37954A204COM NEW73,400$653,000thousands by filing date
Takeda Pharmaceutical Co. Ltd.687044008Sponsored ADS19,200$649,000thousands by filing date
LEMAITRE VASCULAR INC525558201COM27,150$642,000thousands by filing date
MOLECULAR TEMPLATES INC608550109COM144,110$582,000thousands by filing date
ATHENEX INC04685N103COM45,530$578,000thousands by filing date
MIRATI THERAPEUTICS INC60468T105COM13,590$576,000thousands by filing date
COMMUNITY HEALTH SYSTEMS INC203668108COMMON STOCK203,935$575,000thousands by filing date
CONCERT PHARMACEUTICALS INC206022105COM45,362$569,000thousands by filing date
AGILENT TECHNOLOGIES INC COM00846U101Stock8,200$553,000thousands by filing date
ACHILLION PHARMACEUTICALS IN00448Q201COM318,833$507,000thousands by filing date
LEXICON PHARMACEUTICALS INC528872302COMMON STOCK70,000$465,000thousands by filing date
VIKING THERAPEUTICS INC92686J106COM57,008$436,000thousands by filing date
SPARK THERAPEUTICS INC84652J103COM10,772$422,000thousands by filing date
EIDOS THERAPEUTICS INC.28249H104Common Stock27,900$384,000thousands by filing date
ARROWHEAD PHARMACEUTICALS IN04280A100COM30,700$381,000thousands by filing date
CIDARA THERAPEUTICS INC COM NEW171757107Stock158,784$373,000thousands by filing date
CARDINAL HEALTH INC14149Y108COM6,300$281,000thousands by filing date
ALLIQUA BIOMEDICAL INC019621309COMMON STOCK148,500$278,000thousands by filing date
ARCA BIOPHARMA INC00211Y407COM PAR811,227$271,000thousands by filing date
CLEARSIDE BIOMEDICAL INC185063104COM165,330$177,000thousands by filing date
BELLICUM PHARMACEUTICALS INC079481107COM60,000$175,000thousands by filing date
NUCANA PLC67022C106ADR9,823$142,000thousands by filing date
QUORUM HEALTH CORP74909E106COM23,725$69,000thousands by filing date
JOUNCE THERAPEUTICS INC481116101COM10,127$34,000thousands by filing date
CELLDEX THERAPEUTICS INC NEW15117B103COM105,800$21,000thousands by filing date

Amendment chain

FilingRoleFiledAcceptedIngested
13F-HR 0001104659-19-007994this filing2019-02-13acceptance time not in the bulk data set