13F-HR filed by Tekla Capital Management LLC
Tekla Capital Management LLC filed this 13F-HR for the quarter ended 2018-03-31, filed 2018-05-14, with 187 holding rows worth $2,571,230,000.
- Accession
- 0001104659-18-032830
- Filer
- CIK 1300336
- Filed
- 2018-05-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q1 2018
A holdings report, 187 entries on the cover page, a total value of $2,571,230,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $2,571,230,000 with VALUE read as thousands by filing date, 13F file number 028-10950. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| Gilead Sciences,Inc. | 375558103 | COM | 2,063,699 | $155,582,000 | thousands by filing date | |
| CELGENE CORP | 151020104 | COM | 1,352,842 | $120,687,000 | thousands by filing date | |
| Amgen Inc. | 031162100 | COM | 700,588 | $119,436,000 | thousands by filing date | |
| Johnson & Johnson | 478160104 | COM | 893,082 | $114,448,000 | thousands by filing date | |
| BIOGEN INC COM | 09062X103 | Stock | 378,703 | $103,696,000 | thousands by filing date | |
| Vertex Pharmaceuticals Incorporated | 92532F100 | COM | 614,084 | $100,083,000 | thousands by filing date | |
| UnitedHealth Group Inc | 91324P102 | COM | 352,317 | $75,396,000 | thousands by filing date | |
| Pfizer Inc. | 717081103 | COM | 2,051,943 | $72,823,000 | thousands by filing date | |
| MYLAN NV | N59465109 | SHS EURO | 1,726,967 | $71,099,000 | thousands by filing date | |
| Merck & Co.,Inc. | 58933Y105 | COM | 1,284,022 | $69,941,000 | thousands by filing date | |
| ILLUMINA INC | 452327109 | COM | 294,892 | $69,718,000 | thousands by filing date | |
| ALEXION PHARMACEUTICALS INC | 015351109 | COM | 498,975 | $55,616,000 | thousands by filing date | |
| INCYTE CORP COM | 45337C102 | Stock | 645,442 | $53,785,000 | thousands by filing date | |
| REGENERON PHARMACEUTICALS COM | 75886F107 | Stock | 139,560 | $48,059,000 | thousands by filing date | |
| Abbott Laboratories | 002824100 | COM | 798,619 | $47,853,000 | thousands by filing date | |
| AbbVie,Inc. | 00287Y109 | COM | 450,738 | $42,662,000 | thousands by filing date | |
| Medtronic Plc | G5960L103 | COM | 522,211 | $41,892,000 | thousands by filing date | |
| ALLERGAN PLC | G0177J108 | SHS | 248,836 | $41,877,000 | thousands by filing date | |
| Eli Lilly and Company | 532457108 | COM | 486,865 | $37,669,000 | thousands by filing date | |
| Bristol-Myers Squibb Company | 110122108 | COM | 525,722 | $33,252,000 | thousands by filing date | |
| HUMANA INC COM | 444859102 | Stock | 118,733 | $31,919,000 | thousands by filing date | |
| Thermo Fisher Scientific Inc. | 883556102 | COM | 147,855 | $30,526,000 | thousands by filing date | |
| IDEXX LABS INC COM | 45168D104 | Stock | 153,076 | $29,297,000 | thousands by filing date | |
| NOVARTIS AG SPONSORED ADR | 66987V109 | ADR | 351,020 | $28,380,000 | thousands by filing date | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 378,516 | $28,044,000 | thousands by filing date | |
| CENTENE CORP DEL COM | 15135B101 | Stock | 230,158 | $24,597,000 | thousands by filing date | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 279,419 | $23,172,000 | thousands by filing date | |
| CVS Health Corporation | 126650100 | COM | 366,521 | $22,801,000 | thousands by filing date | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 281,076 | $22,787,000 | thousands by filing date | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 250,460 | $21,973,000 | thousands by filing date | |
| Elevance Health, Inc. | 036752103 | COM | 91,482 | $20,099,000 | thousands by filing date | |
| SAGE THERAPEUTICS INC | 78667J108 | COM | 124,650 | $20,077,000 | thousands by filing date | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 1,083,223 | $18,512,000 | thousands by filing date | |
| JAZZ PHARMACEUTICALS PLC SHS USD | G50871105 | Stock | 122,482 | $18,494,000 | thousands by filing date | |
| SEATTLE GENETICS INC | 812578102 | COM | 346,499 | $18,136,000 | thousands by filing date | |
| SHIRE PLC | 82481R106 | COMMON STOCK-FO | 115,629 | $17,274,000 | thousands by filing date | |
| OMEGA HEALTHCARE INVS INC COM | 681936100 | REIT | 579,785 | $15,677,000 | thousands by filing date | |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 130,376 | $15,528,000 | thousands by filing date | |
| ASTRAZENECA PLC SPONSORED ADR | 046353108 | ADR | 442,600 | $15,478,000 | thousands by filing date | |
| GLAXOSMITHKLINE PLC-ADR | 37733W105 | SPONSORED ADR | 394,749 | $15,423,000 | thousands by filing date | |
| PIERIS PHARMACEUTICALS INC | 720795103 | COM | 2,087,380 | $14,236,000 | thousands by filing date | |
| MCKESSON CORP COM | 58155Q103 | Stock | 98,797 | $13,918,000 | thousands by filing date | |
| ESPERION THERAPEUTICS INC NEW COM | 29664W105 | Stock | 189,287 | $13,691,000 | thousands by filing date | |
| NEKTAR THERAPEUTICS | 640268108 | COM | 124,517 | $13,231,000 | thousands by filing date | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 875,304 | $13,165,000 | thousands by filing date | |
| SABRA HEALTH CARE REIT INC COM | 78573L106 | REIT | 724,606 | $12,789,000 | thousands by filing date | |
| Boston Scientific Corporation | 101137107 | COM | 457,585 | $12,501,000 | thousands by filing date | |
| GW PHARMACEUTICALS PLC | 36197T103 | ADS | 110,784 | $12,482,000 | thousands by filing date | |
| ALKERMES PLC | G01767105 | SHS | 210,182 | $12,182,000 | thousands by filing date | |
| BLUEBIRD BIO INC | 09609G100 | COM | 66,308 | $11,322,000 | thousands by filing date | |
| MEDICAL PROPERTIES TRUST INC COM | 58463J304 | REIT | 858,586 | $11,162,000 | thousands by filing date | |
| WELLTOWER INC 6.50 PFD PREPET | 95040Q203 | CPFD | 200,000 | $11,128,000 | thousands by filing date | |
| ACCELERON PHARMA INC | 00434H108 | COM | 273,098 | $10,678,000 | thousands by filing date | |
| ACADIA HEALTHCARE COMPANY INC COM | 00404A109 | Stock | 272,400 | $10,673,000 | thousands by filing date | |
| Stryker Corporation | 863667101 | COM | 64,258 | $10,340,000 | thousands by filing date | |
| SENIOR HSG PPTYS TR | 81721M109 | SH BEN INT | 646,554 | $10,125,000 | thousands by filing date | |
| AEGERION PHARMACEUTICALS INC | 00767EAB8 | NOTE 2.000 8/1 | 13,000,000 | $10,010,000 | thousands by filing date | principal |
| ADAPTIMMUNE THERAPEUTICS PLC | 00653A107 | SPONDS ADR | 855,468 | $9,607,000 | thousands by filing date | |
| LAKEFRONT BIOTHERAPEUTICS NV | 36315X101 | SPON ADR | 95,635 | $9,541,000 | thousands by filing date | |
| CIGNA CORPORATION | 125509109 | COM | 56,563 | $9,488,000 | thousands by filing date | |
| EDWARDS LIFESCIENCES CORP COM | 28176E108 | Stock | 66,275 | $9,247,000 | thousands by filing date | |
| MEDICINES CO | 584688105 | COM | 278,391 | $9,170,000 | thousands by filing date | |
| ZIMMER BIOMET HOLDINGS INC COM | 98956P102 | Stock | 82,080 | $8,950,000 | thousands by filing date | |
| CELLECTIS ADS | 15117K103 | COM | 283,250 | $8,925,000 | thousands by filing date | |
| HCA Healthcare Inc | 40412C101 | COM | 91,881 | $8,912,000 | thousands by filing date | |
| MERUS N V | N5749R100 | COM | 479,150 | $8,879,000 | thousands by filing date | |
| DIPLOMAT PHARMACY INC | 25456K101 | COM | 439,001 | $8,846,000 | thousands by filing date | |
| AVEXIS INC | 05366U100 | COM | 70,347 | $8,693,000 | thousands by filing date | |
| EPIZYME INC | 29428V104 | COM | 485,325 | $8,615,000 | thousands by filing date | |
| EXELIXIS INC COM | 30161Q104 | Stock | 388,822 | $8,612,000 | thousands by filing date | |
| BEONE MEDICINES LTD SPONSORED ADS | 07725L102 | ADR | 49,496 | $8,315,000 | thousands by filing date | |
| AETNA INC NEW | 00817Y108 | COM | 47,566 | $8,039,000 | thousands by filing date | |
| CENCORA INC COM | 03073E105 | Stock | 92,707 | $7,992,000 | thousands by filing date | |
| LTC PPTYS INC COM | 502175102 | REIT | 209,673 | $7,968,000 | thousands by filing date | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 148,558 | $7,575,000 | thousands by filing date | |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 265,045 | $7,541,000 | thousands by filing date | |
| EXPRESS SCRIPTS HLDG CO | 30219G108 | COM | 106,500 | $7,357,000 | thousands by filing date | |
| Danaher Corporation | 235851102 | COM | 74,847 | $7,328,000 | thousands by filing date | |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 165,677 | $7,303,000 | thousands by filing date | |
| NEW SR INVT GROUP INC | 648691103 | COM | 883,919 | $7,230,000 | thousands by filing date | |
| SANOFI SA SPONSORED ADR | 80105N105 | ADR | 179,900 | $7,210,000 | thousands by filing date | |
| BLUEPRINT MEDICINES CORP | 09627Y109 | COM | 74,221 | $6,806,000 | thousands by filing date | |
| NOVO-NORDISK A S ADR | 670100205 | ADR | 135,900 | $6,693,000 | thousands by filing date | |
| CRISPR THERAPEUTICS AG NAMEN AKT | H17182108 | Stock | 141,191 | $6,454,000 | thousands by filing date | |
| GLOBAL BLOOD THERAPEUTICS USD | 37890U108 | COM | 129,948 | $6,276,000 | thousands by filing date | |
| AVADEL PHARMACEUTICALS, PLC | 05337M104 | COMMON STOCK-FO | 814,588 | $5,938,000 | thousands by filing date | |
| Intuitive Surgical,Inc. | 46120E602 | COM | 14,218 | $5,870,000 | thousands by filing date | |
| VERONA PHARMA PLC | 925050106 | SPONSORED ADS | 275,000 | $5,500,000 | thousands by filing date | |
| ENDO INTL PLC | G30401106 | SHS | 914,548 | $5,432,000 | thousands by filing date | |
| WRIGHT MED GROUP N V | N96617118 | ORD SHS | 266,781 | $5,293,000 | thousands by filing date | |
| FIBROGEN INC | 31572Q808 | COM | 104,307 | $4,819,000 | thousands by filing date | |
| FOAMIX PHARMACEUTICALS LTD | M46135105 | SHS | 930,398 | $4,773,000 | thousands by filing date | |
| UNIQURE NV | N90064101 | SHS | 199,750 | $4,694,000 | thousands by filing date | |
| UNITED THERAPEUTICS CORP DEL COM | 91307C102 | Stock | 41,261 | $4,636,000 | thousands by filing date | |
| NEVRO CORP | 64157F103 | COM | 52,990 | $4,593,000 | thousands by filing date | |
| EDITAS MEDICINE INC | 28106W103 | COM | 137,801 | $4,568,000 | thousands by filing date | |
| VENTAS INC COM | 92276F100 | REIT | 87,996 | $4,358,000 | thousands by filing date | |
| BIOHAVEN PHARMACEUTICAL HOLDIN | G11196105 | COM | 162,477 | $4,185,000 | thousands by filing date | |
| PHYSICIANS REALTY TRUST | 71943U104 | COM | 265,336 | $4,131,000 | thousands by filing date | |
| ALBIREO PHARMA INC | 01345P106 | COMMON STOCK | 125,000 | $4,071,000 | thousands by filing date | |
| TENET HEALTHCARE CORP COM NEW | 88033G407 | Stock | 164,500 | $3,989,000 | thousands by filing date | |
| CLOVIS ONCOLOGY INC | 189464100 | COM | 75,400 | $3,981,000 | thousands by filing date | |
| PUMA BIOTECHNOLOGY INC | 74587V107 | COMMON STOCK | 55,985 | $3,810,000 | thousands by filing date | |
| OVID THERAPEUTICS INC | 690469101 | COMMON STOCK | 535,824 | $3,788,000 | thousands by filing date | |
| BECTON DICKINSON & CO | 075887109 | COM | 17,254 | $3,739,000 | thousands by filing date | |
| MASIMO CORP COM | 574795100 | Stock | 41,666 | $3,665,000 | thousands by filing date | |
| ALDER BIOPHARMACEUTICALS INC | 014339105 | COM | 279,950 | $3,555,000 | thousands by filing date | |
| INTELLIA THERAPEUTICS INC | 45826J105 | COM | 167,381 | $3,530,000 | thousands by filing date | |
| TRILLIUM THERAPEUTICS INC COM NEW | 89620X506 | Stock | 468,399 | $3,372,000 | thousands by filing date | |
| AFFIMED N V | N01045108 | COM | 1,805,324 | $3,340,000 | thousands by filing date | |
| RESMED INC COM | 761152107 | Stock | 33,819 | $3,330,000 | thousands by filing date | |
| TESARO INC | 881569107 | COM | 57,595 | $3,291,000 | thousands by filing date | |
| ARDELYX INC | 039697107 | COM | 639,370 | $3,229,000 | thousands by filing date | |
| MYOVANT SCIENCES LTD | G637AM102 | COMMON STOCK-FO | 150,471 | $3,201,000 | thousands by filing date | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 38,931 | $3,132,000 | thousands by filing date | |
| PERRIGO CO PLC SHS | G97822103 | Stock | 37,300 | $3,109,000 | thousands by filing date | |
| VALEANT PHARMACEUTICALS INTL | 91911K102 | COM | 192,000 | $3,057,000 | thousands by filing date | |
| PORTOLA PHARMACEUTICALS INC COM | 737010108 | Stock | 89,978 | $2,939,000 | thousands by filing date | |
| KONINKLIJKE PHILIPS N V NY REGIS SHS NEW | 500472303 | ADR | 75,335 | $2,886,000 | thousands by filing date | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 200,000 | $2,846,000 | thousands by filing date | |
| INNOVIVA INC | 45781M101 | COM | 161,603 | $2,694,000 | thousands by filing date | |
| PRA HEALTH SCIENCES INC | 69354M108 | COM | 32,460 | $2,693,000 | thousands by filing date | |
| TETRAPHASE PHARMACEUTICALS INC | 88165N105 | COMMON STOCK | 859,322 | $2,638,000 | thousands by filing date | |
| BAXTER INTL INC | 071813109 | COM | 39,965 | $2,599,000 | thousands by filing date | |
| Egalet Corporation | 28226BAB0 | Note 5.50% 4/1/20 | 7,000,000 | $2,586,000 | thousands by filing date | principal |
| ARRAY BIOPHARMA INC COM | 04269X105 | Stock | 156,056 | $2,547,000 | thousands by filing date | |
| CHARLES RIV LABS INTL INC | 159864107 | COM | 22,670 | $2,420,000 | thousands by filing date | |
| HORIZON PHARMA PLC | G4617B105 | SHS | 162,900 | $2,313,000 | thousands by filing date | |
| ACHILLION PHARMACEUTICALS IN | 00448Q201 | COM | 616,000 | $2,285,000 | thousands by filing date | |
| THERAPEUTICSMD INC | 88338N107 | COM | 468,769 | $2,283,000 | thousands by filing date | |
| CYMABAY THERAPEUTICS INC | 23257D103 | COM | 169,962 | $2,208,000 | thousands by filing date | |
| SCHEIN HENRY INC | 806407102 | COM | 31,400 | $2,110,000 | thousands by filing date | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 93,689 | $2,105,000 | thousands by filing date | |
| QUOTIENT LTD | G73268107 | SHS | 442,461 | $2,084,000 | thousands by filing date | |
| COHERUS ONCOLOGY INC | 19249H103 | COM | 181,023 | $2,000,000 | thousands by filing date | |
| LEXICON PHARMACEUTICALS INC | 528872302 | COMMON STOCK | 231,054 | $1,980,000 | thousands by filing date | |
| ABIOMED INC | 003654100 | COM | 6,514 | $1,896,000 | thousands by filing date | |
| HEALTHCARE RLTY TR | 421946104 | COM | 68,000 | $1,884,000 | thousands by filing date | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 219,042 | $1,882,000 | thousands by filing date | |
| DERMIRA INC | 24983L104 | COM | 234,200 | $1,871,000 | thousands by filing date | |
| TELIGENT INC NEW | 87960W104 | COM | 551,429 | $1,853,000 | thousands by filing date | |
| RA PHARMACEUTICALS INC | 74933V108 | COM | 338,565 | $1,798,000 | thousands by filing date | |
| AC IMMUNE SA | H00263105 | SHS | 171,813 | $1,777,000 | thousands by filing date | |
| EVOLENT HEALTH INC CL A | 30050B101 | Stock | 122,500 | $1,746,000 | thousands by filing date | |
| GLAUKOS CORP COM | 377322102 | Stock | 55,079 | $1,698,000 | thousands by filing date | |
| SMITH & NEPHEW PLC SPDN ADR NEW | 83175M205 | ADR | 44,148 | $1,684,000 | thousands by filing date | |
| STERIS PLC | G84720104 | SHS USD | 16,612 | $1,551,000 | thousands by filing date | |
| NEWLINK GENETICS CORP | 651511107 | COM | 205,026 | $1,486,000 | thousands by filing date | |
| SPARK THERAPEUTICS INC | 84652J103 | COM | 22,046 | $1,468,000 | thousands by filing date | |
| AMARIN CORP PLC | 023111206 | SPONS ADR NEW | 478,149 | $1,439,000 | thousands by filing date | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 280,000 | $1,372,000 | thousands by filing date | |
| REVANCE THERAPEUTICS INC | 761330109 | COM | 43,329 | $1,335,000 | thousands by filing date | |
| AKEBIA THERAPEUTICS INC | 00972D105 | COMMON STOCK | 132,849 | $1,266,000 | thousands by filing date | |
| HEALTHCARE | 42225P501 | CL A NEW | 46,000 | $1,217,000 | thousands by filing date | |
| NOVAVAX INC | 670002104 | COMMON STOCK | 571,000 | $1,199,000 | thousands by filing date | |
| WELLTOWER INC COM | 95040Q104 | REIT | 21,400 | $1,165,000 | thousands by filing date | |
| HCP INC | 40414L109 | COM | 45,500 | $1,057,000 | thousands by filing date | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 137,797 | $992,000 | thousands by filing date | |
| NATERA INC COM | 632307104 | Stock | 103,731 | $962,000 | thousands by filing date | |
| Mallinckrodt Plc | G5785G107 | SHS | 61,900 | $896,000 | thousands by filing date | |
| COMMUNITY HEALTH SYSTEMS INC | 203668108 | COMMON STOCK | 203,935 | $808,000 | thousands by filing date | |
| HOLOGIC INC | 436440101 | COM | 19,546 | $730,000 | thousands by filing date | |
| ARENA PHARMACEUTICALS INC | 040047607 | COM NEW | 16,827 | $665,000 | thousands by filing date | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 24,299 | $658,000 | thousands by filing date | |
| CIDARA THERAPEUTICS INC COM NEW | 171757107 | Stock | 158,784 | $635,000 | thousands by filing date | |
| TELEFLEX INCORPORATED | 879369106 | COM | 2,482 | $633,000 | thousands by filing date | |
| VARIAN MED SYS INC | 92220P105 | COM | 5,065 | $621,000 | thousands by filing date | |
| XENCOR INC | 98401F105 | COMMON STOCK | 20,000 | $600,000 | thousands by filing date | |
| NANOSTRING TECHNOLOGIES INC | 63009R109 | COM | 74,250 | $558,000 | thousands by filing date | |
| RMR GROUP INC | 74967R106 | CL A | 7,441 | $520,000 | thousands by filing date | |
| GLOBAL MED REIT INC | 37954A204 | COM NEW | 73,400 | $510,000 | thousands by filing date | |
| Foundation Medicine Inc | 350465100 | COM | 6,353 | $500,000 | thousands by filing date | |
| NUCANA PLC | 67022C106 | ADR | 24,536 | $464,000 | thousands by filing date | |
| EIGER BIOPHARMACEUTICALS INC | 28249U105 | COM | 45,854 | $452,000 | thousands by filing date | |
| MOLECULAR TEMPLATES INC | 608550109 | COM | 52,891 | $423,000 | thousands by filing date | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 6,214 | $406,000 | thousands by filing date | |
| ARCA BIOPHARMA INC | 00211Y407 | COM PAR | 811,227 | $405,000 | thousands by filing date | |
| ADAMAS PHARMACEUTICALS INC | 00548A106 | COM | 16,699 | $399,000 | thousands by filing date | |
| CARDINAL HEALTH INC | 14149Y108 | COM | 6,300 | $395,000 | thousands by filing date | |
| BELLICUM PHARMACEUTICALS INC | 079481107 | COM | 60,000 | $394,000 | thousands by filing date | |
| NATUS MEDICAL INC | 639050103 | COM | 11,335 | $381,000 | thousands by filing date | |
| ALLIQUA BIOMEDICAL INC | 019621309 | COMMON STOCK | 165,000 | $318,000 | thousands by filing date | |
| CELLDEX THERAPEUTICS INC NEW | 15117B103 | COM | 105,800 | $247,000 | thousands by filing date | |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 2,810 | $230,000 | thousands by filing date | |
| JOUNCE THERAPEUTICS INC | 481116101 | COM | 10,127 | $226,000 | thousands by filing date | |
| THERAVANCE BIOPHARMA INC | G8807B106 | COM | 8,083 | $196,000 | thousands by filing date | |
| QUORUM HEALTH CORP | 74909E106 | COM | 23,725 | $194,000 | thousands by filing date |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001104659-18-032830 | this filing | 2018-05-14 | acceptance time not in the bulk data set |