13F-HR filed by PERCEPTIVE ADVISORS LLC
PERCEPTIVE ADVISORS LLC filed this 13F-HR for the quarter ended 2025-03-31, filed 2025-05-15, with 87 holding rows worth $2,838,202,794.
- Accession
- 0001012975-25-000242
- Filer
- CIK 1224962
- Filed
- 2025-05-15
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q1 2025
A holdings report, 87 entries on the cover page, a total value of $2,838,202,794 stated on the cover page (in dollars after the unit check, H1), rows summing to $2,838,202,794 with VALUE read as dollars as filed, 13F file number 028-10438. A later restatement replaced it, so the quarter does not use it. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| VERONA PHARMA PLC | 925050106 | SPONSORED ADS | 6,563,340 | $416,706,457 | dollars as filed | |
| ARCELLX INC COMMON STOCK | 03940C100 | Stock | 2,926,478 | $191,976,957 | dollars as filed | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 21,464,527 | $175,150,540 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 6,547,328 | $144,041,216 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 2,548,445 | $134,991,132 | dollars as filed | |
| NUVALENT INC COM | 670703107 | Stock | 1,633,968 | $115,881,011 | dollars as filed | |
| SOLENO THERAPEUTICS INC | 834203309 | COM | 1,506,602 | $107,646,713 | dollars as filed | |
| INTRA-CELLULAR THERAPIES INC | 46116X101 | COMMON STOCK | 786,358 | $103,736,347 | dollars as filed | |
| MEIRAGTX HOLDINGS PLC | G59665102 | COMMON STOCK | 12,581,103 | $85,254,892 | dollars as filed | |
| ARTIVION INC | 228903100 | COM | 2,793,703 | $68,669,220 | dollars as filed | |
| ALDEYRA THERAPEUTICS INC | 01438T106 | COM | 9,275,851 | $53,336,143 | dollars as filed | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 1,091,271 | $52,773,866 | dollars as filed | |
| EVOLUS INC | 30052C107 | COM | 4,129,142 | $49,673,578 | dollars as filed | |
| IMMUNOVANT INC | 45258J102 | COM | 2,844,072 | $48,605,190 | dollars as filed | |
| SOLID BIOSCIENCES INC | 83422E204 | COMMON STOCK | 11,906,646 | $44,054,590 | dollars as filed | |
| CENTESSA PHARMACEUTICALS PLC | 152309100 | SPONSORED ADS | 3,040,395 | $43,720,880 | dollars as filed | |
| IOVANCE BIOTHERAPEUTICS INC | 462260100 | COM | 12,711,788 | $42,330,254 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 9,383,456 | $42,319,387 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 1,122,767 | $41,946,575 | dollars as filed | |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 355,107 | $41,416,129 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 509,300 | $38,854,497 | dollars as filed | |
| SPYRE THERAPEUTICS INC | 00773J202 | COM NEW | 2,313,272 | $37,324,644 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 980,894 | $37,146,456 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 59,510 | $35,221,886 | dollars as filed | |
| ASTRIA THERAPEUTICS INC COM | 04635X102 | Stock | 6,485,420 | $34,632,142 | dollars as filed | |
| AKERO THERAPEUTICS INC | 00973Y108 | COM | 792,960 | $32,099,021 | dollars as filed | |
| MERUS N V | N5749R100 | COM | 690,485 | $29,062,514 | dollars as filed | |
| AMYLYX PHARMACEUTICALS INC | 03237H101 | COM | 7,874,348 | $27,875,192 | dollars as filed | |
| ADMA BIOLOGICS INC | 000899104 | COM | 1,373,233 | $27,244,943 | dollars as filed | |
| BETA BIONICS INC | 08659B102 | COMMON STOCK | 2,203,840 | $26,975,001 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 706,567 | $26,679,970 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 970,412 | $26,201,124 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 2,313,403 | $24,198,195 | dollars as filed | |
| CELCUITY INC | 15102K100 | COM | 2,362,279 | $23,882,641 | dollars as filed | |
| ZYMEWORKS INC | 98985Y108 | COM | 1,864,672 | $22,208,244 | dollars as filed | |
| Intuitive Surgical,Inc. | 46120E602 | COM | 40,619 | $20,117,372 | dollars as filed | |
| ORCHESTRA BIOMED HOLDINGS IN | 68572M106 | COMMON STOCK | 4,592,556 | $19,656,140 | dollars as filed | |
| INSULET CORP COM | 45784P101 | Stock | 71,597 | $18,802,088 | dollars as filed | |
| REPLIGEN CORP COM | 759916109 | Stock | 129,801 | $16,515,879 | dollars as filed | |
| BRIGHT MINDS BIOSCIENCES INC | 10919W405 | COMMON STOCK | 444,649 | $16,038,489 | dollars as filed | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 46,500 | $15,402,195 | dollars as filed | |
| INHIBRX BIOSCIENCES INC | 45720N103 | COM | 1,064,026 | $14,885,723 | dollars as filed | |
| Boston Scientific Corporation | 101137107 | COM | 130,000 | $13,114,400 | dollars as filed | |
| SIONNA THERAPEUTICS INC | 829401108 | COMMON STOCK | 1,251,101 | $13,086,516 | dollars as filed | |
| INHIBIKASE THERAPEUTICS INC | 45719W205 | COMMON STOCK | 5,925,000 | $12,975,750 | dollars as filed | |
| VIKING THERAPEUTICS INC | 92686J106 | COM | 509,005 | $12,292,471 | dollars as filed | |
| DEXCOM INC COM | 252131107 | Stock | 178,000 | $12,155,620 | dollars as filed | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 100,050 | $11,065,530 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 500,000 | $11,000,000 | dollars as filed | call |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 325,324 | $10,914,620 | dollars as filed | |
| ACRIVON THERAPEUTICS INC | 004890109 | CMN | 5,360,858 | $10,882,542 | dollars as filed | |
| NAUTILUS BIOTECHNOLOGY INC | 63909J108 | COM | 12,594,211 | $10,843,615 | dollars as filed | |
| AQUESTIVE THERAPEUTICS INC COM | 03843E104 | Stock | 3,727,208 | $10,808,903 | dollars as filed | |
| CONTINEUM THERAPEUTICS INC CL A | 21217B100 | Stock | 1,441,249 | $10,059,918 | dollars as filed | |
| CARGO THERAPEUTICS INC COM | 14179K101 | Stock | 2,431,085 | $9,894,515 | dollars as filed | |
| OUTSET MED INC | 690145206 | COM NEW | 833,333 | $9,216,662 | dollars as filed | |
| VIRIDIAN THERAPEUTICS INC | 92790C104 | COM | 659,662 | $8,892,244 | dollars as filed | |
| EYEPOINT INC COM NEW | 30233G209 | Stock | 1,537,274 | $8,332,025 | dollars as filed | |
| Adagio Med Hldgs Inc Com | 00534B100 | Common Stock | 9,812,419 | $7,898,997 | dollars as filed | |
| ANTERIS TECHNOLOGIES GLOBAL | 03675P102 | COMMON STOCK | 2,140,000 | $7,789,600 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 150,000 | $7,446,000 | dollars as filed | |
| ADAPTIVE BIOTECHNOLOGIES CORP COM | 00650F109 | Stock | 930,972 | $6,917,122 | dollars as filed | |
| OCULAR THERAPEUTIX INC | 67576A100 | COM | 915,775 | $6,712,631 | dollars as filed | |
| DELCATH SYSTEMS INC | 24661P807 | COMMON STOCK | 462,422 | $5,886,632 | dollars as filed | |
| RAPT THERAPEUTICS INC | 75382E109 | COM | 4,418,947 | $5,391,115 | dollars as filed | |
| KESTRA MED TECHNOLOGIES LTD | G52441105 | SHS | 200,000 | $4,984,000 | dollars as filed | |
| HELIX ACQUISITION CORP II | G4444H101 | CL A ORD SHS | 398,000 | $4,497,400 | dollars as filed | |
| ONKURE THERAPEUTICS INC | 68277Q105 | COM CL A | 1,004,439 | $4,319,088 | dollars as filed | |
| OPUS GENETICS INC | 67577R102 | COMMON STOCK | 4,325,000 | $4,246,285 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 520,000 | $4,165,200 | dollars as filed | |
| NURIX THERAPEUTICS INC | 67080M103 | COMMON STOCK | 297,553 | $3,534,930 | dollars as filed | |
| MEREO BIOPHARMA GROUP PLC | 589492107 | CMN | 876,961 | $1,973,162 | dollars as filed | |
| LYRA THERAPEUTICS INC | 55234L105 | COM | 12,757,562 | $1,607,453 | dollars as filed | |
| KALA BIO INC | 483119202 | COM NEW | 277,610 | $1,590,705 | dollars as filed | |
| ATHIRA PHARMA INC | 04746L104 | COM | 5,402,964 | $1,539,304 | dollars as filed | |
| BIODESIX INC | 09075X108 | COM | 2,173,880 | $1,358,675 | dollars as filed | |
| SCPHARMACEUTICALS INC | 810648105 | COM | 500,000 | $1,315,000 | dollars as filed | |
| TRAWS PHARMA INC | 68232V884 | COM NEW | 421,781 | $970,096 | dollars as filed | |
| ROCKET PHARMACEUTICALS INC | 77313F106 | COM | 140,726 | $938,642 | dollars as filed | |
| CULLINAN THERAPEUTICS INC | 230031106 | COM | 80,100 | $606,357 | dollars as filed | |
| LEXEO THERAPEUTICS INC | 52886X107 | COMMON STOCK | 139,835 | $485,227 | dollars as filed | |
| Applied Therapeutics Inc | 03828A101 | Common Stock | 860,000 | $420,454 | dollars as filed | |
| NANOBIOTIX | 63009J107 | SPONSORED ADS | 105,053 | $376,090 | dollars as filed | |
| ENSYSCE BIOSCIENCES INC | 293602504 | COM NEW | 86,666 | $221,865 | dollars as filed | |
| APYX MEDICAL CORPORATION | 03837C106 | COM | 150,000 | $205,500 | dollars as filed | |
| REVOLUTION MEDICINES INC | 76155X118 | *W EXP 12/17/202 | 250,000 | $9,500 | dollars as filed | |
| SURROZEN INC | 86889P117 | *W EXP 08/01/203 | 166,666 | $5,000 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001012975-25-000242 | this filing | 2025-05-15 | acceptance time not in the bulk data set | |
| 13F-HR/A 0001012975-25-000422 | base | 2025-08-06 | acceptance time not in the bulk data set |