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13F-HR filed by TWO SIGMA INVESTMENTS, LP

TWO SIGMA INVESTMENTS, LP filed this 13F-HR for the quarter ended 2022-12-31, filed 2023-02-14, with 2,767 holding rows worth $31,850,404,235.

Accession
0000919574-23-001463
Filed
2023-02-14
Accepted by EDGAR
acceptance time not in the bulk data set
Ingested
Source
SEC quarterly data set

Original filing

13F report for Q4 2022

A holdings report, 2,767 entries on the cover page, a total value of $31,850,404,235 stated on the cover page (in dollars after the unit check, H1), rows summing to $31,850,404,235 with VALUE read as dollars as filed, 13F file number 028-10385. The quarter's positions are built on this report. The resolved quarter.

Other managers

The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).

Issuer as filedCUSIPClassAmountValueValue read asType
IHEARTMEDIA INC CLASS A45174J509COMMON STOCK17,200$105,436dollars as filed
BABCOCK & WILCOX ENTERPRISES05614L209COM18,000$103,860dollars as filed
LANNETT COMPANY INCORPORATED516012101COM198,852$103,562dollars as filed
MEDALLION FINANCIAL CORP583928106COMMON STOCK14,447$103,152dollars as filed
HOLLEY INC43538H103COMMON STOCK48,522$102,867dollars as filed
BRILLIANT EARTH GROUP INC109504100CMN23,471$101,160dollars as filed
PERSONALIS INC71535D106COMMON STOCK50,965$100,911dollars as filed
TURKCELL ILETISIM SPON ADR NEW900111204ADR20,955$100,374dollars as filed
DESPEGAR COM CORPG27358103ORD SHS19,300$99,009dollars as filed
EHANG HLDGS LTD ADS26853E102ADR11,500$98,670dollars as filed
COGNITION THERAPEUTICS INC19243B102COM46,620$97,902dollars as filed
ORION GROUP HOLDINGS INC68628V308COMMON STOCK40,548$96,504dollars as filed
CLARIVATE PLCG21810109ORD SHS11,500$95,910dollars as filed
PANGAEA LOGISTICS SOLUTIONSG6891L105COMMON STOCK18,600$95,790dollars as filed
CONSUMER PORTFOLIO SERVICES210502100COMMON STOCK10,802$95,598dollars as filed
LASER PHOTONICS CORP51807Q100COM46,464$94,787dollars as filed
APPLIED MOLECULAR TRANS INC03824M109COM222,987$93,655dollars as filed
USERTESTING INC91734E101COM12,300$92,373dollars as filed
Renovaro Inc29350E104Common Stock89,667$92,357dollars as filed
ROOT INC OH CLASS A77664L207COMMON STOCK20,504$92,063dollars as filed
MIRION TECHNOLOGIES INC60471A119*W EXP 10/20/20281,400$91,168dollars as filed
NATURA &CO HLDG S A63884N108ADR20,700$89,631dollars as filed
PEDEVCO CORP C70532Y303OM PAR80,225$88,248dollars as filed
VIRACTA THERAPEUTICS INC92765F108COM59,774$87,270dollars as filed
KANDI TECHNOLOGIES GROUP INC483709101COM37,629$86,547dollars as filed
CUMBERLAND PHARMACEUTICALS I230770109COM38,430$86,468dollars as filed
ALIGOS THERAPEUTICS INC COM NEW01626L105Stock90,418$86,159dollars as filed
THESEUS PHARMACEUTICALS INC88369M101COM17,175$85,532dollars as filed
RIGETTI COMPUTING INC COMMON STOCK76655K103Stock117,165$85,437dollars as filed
AMTECH SYSTEMS INC032332504COMMON STOCK11,200$85,120dollars as filed
QUANTUM SI INC74765K105COM CL A46,200$84,546dollars as filed
JIANZHI ED TECHNOLOGY GROUP47737L104ADR112,510$83,370dollars as filed
STARLING ONCOLOGY INC68236X100COMMON STOCK50,492$83,312dollars as filed
BLUE APRON HLDGS INC09523Q200COM97,656$81,054dollars as filed
DIRECT DIGITAL HOLDINGS INC25461T105CLASS A COM33,027$80,090dollars as filed
FAZE HOLDINGS INC31423J102COMMON STOCK42,960$79,476dollars as filed
WILHELMINA INTL INC968235200COM NEW22,377$79,215dollars as filed
INTELLICHECK MOBILISA INC45817G201COM NEW39,524$79,048dollars as filed
GOLD RESOURCE CORP38068T105COMMON STOCK51,187$78,316dollars as filed
LIONS GATE ENTMNT CORP535919401CL A VTG13,600$77,656dollars as filed
LG DISPLAY CO LTD SPONS ADR REP50186V102ADR15,600$77,376dollars as filed
FIVE POINT HOLDINGS LLC33833Q106COM CL A32,616$75,995dollars as filed
ELLINGTON CREDIT COMPANY288578107COM SHS BEN INT10,876$74,609dollars as filed
MIND MEDICINE MINDMED INC60255C885COM NEW33,872$74,518dollars as filed
BIOVENTUS INC09075A108COM CL A28,509$74,408dollars as filed
UPLAND SOFTWARE INC91544A109COMMON STOCK10,400$74,152dollars as filed
DIANTHUS THERAPEUTICS INC COM55910K108Stock186,125$73,519dollars as filed
GRAFTECH INTL LTD384313508COM15,300$72,828dollars as filed
CADIZ INC127537207COM NEW29,032$72,580dollars as filed
EMERALD HOLDING INC29103W104COM20,433$72,333dollars as filed
STEELCASE INC-CLASS A858155203CL A10,200$72,114dollars as filed
ITERIS INC NEW46564T107COM22,960$71,406dollars as filed
LIGHTNING EMOTORS INC53228T101COM194,577$71,312dollars as filed
EMBARK TECHNOLOGY INC29079J202COM NEW21,657$71,252dollars as filed
UNIVERSAL TECHNICAL INST INC913915104COM10,495$70,526dollars as filed
ABSCI CORPORATION00091E109COM32,989$69,277dollars as filed
SPERO THERAPEUTICS INC84833T103COM39,795$68,845dollars as filed
PAYONEER GLOBAL INC70451X112*W EXP 06/25/20266,500$68,495dollars as filed
VISTAGEN THERAPEUTICS INC92840H202COM660,977$68,081dollars as filed
Accelerate Diagnostics00430H102COM94,324$66,593dollars as filed
QUANTUM CORP747906501COM61,091$66,589dollars as filed
BLEND LABS INC09352U108CL A45,100$64,944dollars as filed
MATTERPORT INC577096100COM CL A22,872$64,042dollars as filed
AUTOLUS THERAPEUTICS PLC SPON05280R100COM33,700$64,030dollars as filed
111 INC68247Q102ADR20,900$63,118dollars as filed
CORBUS PHARMACEUTICALS HLDGS21833P103COM570,168$63,004dollars as filed
FORTE BIOSCIENCES INC34962G109COM62,964$62,964dollars as filed
LLOYDS BANKING GROUP PLC SPONSORED ADR539439109ADR28,600$62,920dollars as filed
SYNLOGIC INC87166L100COM81,952$62,284dollars as filed
HCW BIOLOGICS INC40423R105COM32,240$61,733dollars as filed
9 METERS BIOPHARMA INC654405208COM47,617$59,997dollars as filed
TFF PHARMACEUTICALS INC87241J104COM56,954$59,802dollars as filed
CURO GROUP HOLDINGS CORP23131L107COM16,807$59,665dollars as filed
AUDACY INC05070N103COM265,059$59,665dollars as filed
SO YOUNG INTERNATIONAL INC83356Q108SPONSORED ADS45,727$58,988dollars as filed
JOUNCE THERAPEUTICS INC481116101COM52,816$58,626dollars as filed
SACHEM CAP CORP78590A109COM17,363$57,298dollars as filed
WEREWOLF THERAPEUTICS INC95075A107CMN27,185$55,729dollars as filed
TREVI THERAPEUTICS INC COM89532M101Stock28,653$55,300dollars as filed
THE LION ELECTRIC COMPANY536221104COMMON STOCK24,542$54,974dollars as filed
PALISADE BIO INC696389204COM10,396$54,059dollars as filed
HELIOGEN INC42329E105COM76,527$53,431dollars as filed
CODEX DNA INC192003101COM44,332$53,198dollars as filed
MOLECULAR TEMPLATES INC608550109COM161,231$52,884dollars as filed
SURO CAP CORP86887Q109COM NEW13,916$52,881dollars as filed
SIENTRA INC82621J105COM257,438$52,234dollars as filed
HUMACYTE INC44486Q103COM24,567$51,836dollars as filed
Zedge Inc98923T104COM29,376$51,702dollars as filed
SMITH MICRO SOFTWARE INC832154207COMMON24,210$50,841dollars as filed
DENISON MINES CORP248356107COM43,800$50,370dollars as filed
POLYMET MNG CORP731916409COM18,945$50,204dollars as filed
ARLO TECHNOLOGIES INC04206A101COMMON STOCK14,284$50,137dollars as filed
APTINYX INC03836N103COM174,225$49,706dollars as filed
ELEDON PHARMACEUTICALS INC28617k101COM21,637$49,332dollars as filed
OMNIAB INC68218J103COM13,700$49,320dollars as filed
NEXTCURE INC65343E108COM33,855$47,736dollars as filed
PYXIS ONCOLOGY INC COMMON STOCK747324101Stock35,477$47,539dollars as filed
VICARIOUS SURGICAL INC92561V109COM23,481$47,432dollars as filed
ARQIT QUANTUM ORDG0567U101COM12,974$46,836dollars as filed
NEUROBO PHARMACEUTICALS INC64132R206COM NEW65,035$46,663dollars as filed
AMERISERV FINL INC03074A102COM11,769$46,370dollars as filed
SENSEI BIOTHERAPEUTICS INC81728A108COM31,076$46,303dollars as filed
IDEANOMICS INC45166V106COM281,717$46,202dollars as filed
APPHARVEST INC03783T103COM81,308$46,134dollars as filed
MUSTANG BIO INC62818Q104COM114,721$45,303dollars as filed
WESTPORT FUEL SYSTEMS INC960908309COM58,100$45,016dollars as filed
MEI PHARMA INC55279B202COM NEW184,405$44,921dollars as filed
LEAP THERAPEUTICS INC52187K101COM98,069$44,131dollars as filed
NTELLIGENT LIVING APPLICATIG4804S101ORD SHS48,948$43,074dollars as filed
ADDVANTAGE TECHNOLOGIES GRP006743306CMN29,316$42,508dollars as filed
CHARLES + COLVARD LTD159765106COM50,543$41,572dollars as filed
ARCIMOTO INC039587209Stock12,513$41,293dollars as filed
NUSCALE PWR CORP67079K118*W EXP 05/02/20225,900$41,181dollars as filed
WHOLE EARTH BRANDS INC96684W100COM CL A10,100$41,107dollars as filed
SCIENCE 37 HOLDINGS INC808644108COM98,773$41,011dollars as filed
LOYALTY VENTURES INC54911Q107COMMON STOCK16,500$39,765dollars as filed
VINTAGE WINE ESTATES INC92747V106COM12,100$39,446dollars as filed
SINGULARITY FUTURE TECH LTD82935V208CMN91,158$38,286dollars as filed
AKSO HEALTH GROUP98422P108ADS101,931$38,285dollars as filed
Atossa Therapeutics Inc04962H506Common Stock71,318$37,692dollars as filed
ZYNERBA PHARMACEUTICALS INC98986X109COM71,070$37,667dollars as filed
SYROS PHARMACEUTICALS INC87184Q206COM NEW10,461$37,555dollars as filed
AEROCENTURY CORP007737109COM21,252$37,404dollars as filed
INVACARE CORP461203101COMMON STOCK88,293$37,083dollars as filed
BRIGHT GREEN CORP10920G100COM78,326$36,774dollars as filed
PARATEK PHARMACEUTICALS INC699374302Equity19,354$36,192dollars as filed
SEMA4 HOLDINGS CORP81663L101COM136,593$36,033dollars as filed
LINEAGE CELL THERAPEUTICS IN53566P109COMMON STOCK30,662$35,875dollars as filed
MYOMO INC62857J201COM NEW69,606$35,597dollars as filed
ONCOSEC MED INC68234L405COMSTOCK21,111$35,466dollars as filed
MYMD PHARMACEUTICALS INC62856X102COMMON30,084$34,597dollars as filed
APTOSE BIOSCIENCES INC COM03835T200Stock59,265$34,374dollars as filed
GRUPO SUPERVIELLE S.A.40054A108CMN15,836$34,206dollars as filed
BRIGHT HEALTH GROUP INC10920V107COM52,503$34,122dollars as filed
PIERIS PHARMACEUTICALS INC720795103COM32,659$33,965dollars as filed
High Templar Tech Limit747798106COM35,300$33,641dollars as filed
BARNWELL INDS INC068221100COM11,338$33,520dollars as filed
GIGAMEDIA LTDY2711Y112SHS NEW27,620$33,420dollars as filed
HUT 8 MINING CORP44812T102COMMON STOCK-FO38,840$33,014dollars as filed
ADAPTIMMUNE THERAPEUTICS PLC00653A107SPONDS ADR22,600$32,996dollars as filed
CARDIFF ONCOLOGY INC14147L108COM23,309$32,633dollars as filed
NUVVE HOLDING CORP67079Y100COMMON STOCK48,141$32,254dollars as filed
AMERICAN SHARED HOSPITAL SVC029595105COM10,723$31,418dollars as filed
ARQIT QUANTUM INCG0567U119WTS61,000$31,110dollars as filed
SIO GENE THERAPIES INC829399104COM70,925$30,852dollars as filed
NANOVIRICIDES INC630087302COM27,693$30,739dollars as filed
ENSYSCE BIOSCIENCES INC293602207COM39,870$29,903dollars as filed
AYRO INC054748108COM76,712$29,358dollars as filed
GERON CORP374163103COM12,100$29,282dollars as filed
COLOR STAR TECHNOLOGY CO LTDG2287A209USD CL A ORD SHS32,006$29,145dollars as filed
MARKFORGED HOLDING CORPORATI57064N102COM24,711$28,665dollars as filed
TRIVAGO N V SPON ADS A SHS N89686D105ADR20,800$28,080dollars as filed
WIMI HOLOGRAM CLOUD INC97264L100SPON ADS CL B37,068$27,427dollars as filed
FISCALNOTE HOLDINGS INC337655112*W EXP 07/29/20222,200$27,306dollars as filed
ZEPP HEALTH CORPORATION SPONSORED ADR98945L105ADR18,611$26,986dollars as filed
CEL-SCI CORP150837607COM PAR NEW11,225$26,379dollars as filed
INFINITY PHARMACEUTICALS INC45665G303COM44,738$24,830dollars as filed
VICINITY MOTOR CORP925654105COM25,828$24,795dollars as filed
TALKSPACE INC87427V103COM40,500$24,717dollars as filed
SHIFT TECHNOLOGIES INC82452T107CL A164,224$24,453dollars as filed
MARIN SOFTWARE INC56804T205COM NEW24,100$24,100dollars as filed
IBIO INC COM451033609Stock53,463$23,759dollars as filed
CENNTRO ELECTRIC GROUP LIMITQ6519V120COM53,878$23,706dollars as filed
CORE SCIENTIFIC INC21873J108Common Stock314,300$23,604dollars as filed
CURIS INC231269200COM42,328$23,280dollars as filed
SHUTTLE PHARMACTCLS HLDGS IN825693203COM11,772$23,073dollars as filed
SHARECARE INC81948W104COM14,200$22,720dollars as filed
REE AUTOMOTIVE LTDM8287R103CLASS A ORD SHS57,789$22,463dollars as filed
ACORDA THERAPEUTICS INC COM00484M601Stock29,255$22,430dollars as filed
X4 Pharmaceuticals, Inc.98420X103COM22,102$21,947dollars as filed
VOLTA INC92873V102COM CL A60,755$21,592dollars as filed
HIVE BLOCKCHAIN TECHNLGIES L43366H704COM NEW14,906$21,465dollars as filed
SURFACE ONCOLOGY INC86877M209COM26,162$21,453dollars as filed
EXELA TECHNOLOGIES INC30162V706COM258,797$21,221dollars as filed
SYSTEM1 INC87200P117W EXP 01/27/20245,700$21,196dollars as filed
DBV TECHNOLOGIES S A23306J101ADR13,625$20,846dollars as filed
FREELINE THERAPEUTICS HLDGS35655L107SPONSORED ADS43,605$20,717dollars as filed
WAITR HOLDINGS INC930752209COM59,430$20,682dollars as filed
GALECTO INC36322Q107COM17,431$20,046dollars as filed
CohBar Inc19249J307COM NEW11,816$20,027dollars as filed
ONCONETIX INC09610B108COM17,813$19,594dollars as filed
DIAMEDICA THERAPEUTICS INC25253X207COMMON STOCK12,149$19,197dollars as filed
INPIXON45790J867COMMON11,205$19,048dollars as filed
MULTIPLAN CORPORATION62548M100COM16,200$18,630dollars as filed
IT TECH PACKAGING INC46527C209COM NEW40,170$18,486dollars as filed
STAR EQUITY HOLDINGS INC85513Q103COMMON21,587$18,455dollars as filed
ADDENTAX GROUP CORP00653L202COM NEW17,058$18,278dollars as filed
VALLON PHARMACEUTICALS INC92023M101COM62,836$18,222dollars as filed
MOBILE GLOBAL ESPORTS INC607371101COM21,860$18,030dollars as filed
CONTRAFECT CORP212326300COM187,551$18,005dollars as filed
FORGE GLOBAL HOLDINGS INC34629L103COM10,403$17,997dollars as filed
SNAIL INC83301J100CLASS A COM11,833$17,395dollars as filed
CONTEXT THERAPEUTICS INC21077P108COM26,534$17,292dollars as filed
INNOVATIVE EYEWEAR INC45791D109COM12,511$17,140dollars as filed
EFFECTOR THERAPEUTICS INC28202V108COM38,577$16,496dollars as filed
CYCLACEL PHARMACE 6percent PFDCONV23254L603Stock24,060$16,048dollars as filed
AVEANNA HEALTHCARE HLDGS INC05356F105COM20,568$16,043dollars as filed
GREENIDGE GENERATION HLDGS I39531G100COM55,269$15,978dollars as filed
IRONNET INC46323Q105COM69,168$15,909dollars as filed
ONCORUS INC68236R103COM62,792$15,905dollars as filed
GEOVAX LABS INC373678507COM24,939$15,717dollars as filed
SOBR SAFE INC833592207COM NEW16,415$15,593dollars as filed
NANO LABS LTD63011A102ADR13,452$15,470dollars as filed
EQUILLIUM INC29446K106COM14,464$15,332dollars as filed
REGIS CORP758932107COM12,458$15,199dollars as filed
AMERICAN RES CORP02927U208CL A11,211$14,799dollars as filed
WESTWATER RES INC961684206COM NEW18,666$14,746dollars as filed
VASCULAR BIOGENICS LTDM96883109COM120,600$14,472dollars as filed
TOP SHIPS INCY8897Y198SHS NEW11,117$14,119dollars as filed
HEMPACCO CO INC42371L106COM17,091$13,998dollars as filed
PROTALIX BIOTHERAPEUTICS INC74365A309COMMON STOCK10,126$13,873dollars as filed
BETTER THERAPEUTICS INC COMMON08773T104COM12,192$13,472dollars as filed
ALLEGO N VN0796A118WTS133,500$13,350dollars as filed
HEALTHCARE TRIANGLE INC42227W108COM73,007$13,119dollars as filed
TRANSCODE THERAPEUTICS INC89357L105CMN19,407$13,061dollars as filed
INOZYME PHARMA INC45790W108COM12,383$13,002dollars as filed
GOLDEN SUN HEALTH TECH GRP LG4013A107CLASS A ORD11,640$12,804dollars as filed
ADIAL PHARMACEUTICALS INC00688A106COM58,389$12,554dollars as filed
VENUS CONCEPT INC92332W105COM39,000$12,480dollars as filed
PEAR THERAPEUTICS INC704723105COM10,347$12,209dollars as filed
CLENE INC185634102COM11,970$11,970dollars as filed
HUMANIGEN INC444863203COM NEW99,570$11,948dollars as filed
CODIAK BIOSCIENCES INC192010106COM29,453$11,711dollars as filed
VINCERX PHARMA INC92731L106COM NEW10,946$11,165dollars as filed
AEYE INC008183105COM23,101$11,102dollars as filed
AETHLON MED INC00808Y307COM39,883$10,984dollars as filed
ALZAMEND NEURO INC02262M308COM NEW19,313$10,910dollars as filed
Lixte Biotech HLDG539319202COM19,874$10,116dollars as filed
XOS INC98423B108COM22,201$9,833dollars as filed
HEARTCORE ENTERPRISES INC42240Q104COM10,208$9,289dollars as filed
VERB TECHNOLOGY CO INC92337U104COM55,491$9,106dollars as filed
ZEROFOX HLDGS INC98955G111*W EXP 08/03/20259,000$8,939dollars as filed
LION GROUP HOLDING LTD53620U102ADR12,301$8,795dollars as filed
ALPHA TAU MEDICAL LTD WT EXPM0740A116Stock34,500$8,628dollars as filed
ONTRAK INC683373104COM23,469$8,627dollars as filed
THE BEACHBODY COMPANY INC073463101COM16,000$8,416dollars as filed
PHIO PHARMACEUTICALS CORP71880W303COM22,398$8,332dollars as filed
TONIX PHARMACEUTICALS HOLDIN890260862Common Stock21,200$8,264dollars as filed
ORCHARD THERAPEUTICS PLC68570P101ADR21,905$8,127dollars as filed
BRIDGEBIO PHARMA INC09077J107COM43,500$7,839dollars as filed
XWELL INC COM NEW98420U703Stock21,284$7,724dollars as filed
SPHERE 3D CORP NEW84841L308COM26,508$7,303dollars as filed
GREENLANE HLDGS INC CLASS A395330202COM25,245$7,258dollars as filed
FARMMI INCG33277123SHS NEW17,105$6,849dollars as filed
ATHENEX INC04685N103COM44,800$6,608dollars as filed
ALPINE 4 HOLDINGS INC02083E105CL A11,513$6,086dollars as filed
UWM HOLDINGS CORPORATION91823B117*W EXP 01/21/20246,200$5,775dollars as filed
Kelso Technologies Inc48826D201COM17,024$5,107dollars as filed
GROVE COLLABORATIVE HOLD INC39957D102COM CL A12,753$5,088dollars as filed
TROIKA MEDIA GROUP INC89689F305COM43,510$5,047dollars as filed
CAZOO GROUP LTDG2007L105COM31,508$4,940dollars as filed
Benitec Biopharma, Inc.08205P100common28,953$4,922dollars as filed
MARKER THERAPEUTICS INC57055L107COM15,899$4,228dollars as filed
DRIVE SHACK INC262077100COM25,100$4,207dollars as filed
SWVL HOLDINGS CORPG86302109CLASS A COM29,884$4,094dollars as filed
POWERBRIDGE TECHNLOGIES CO LTD ORD SHSG72007100ORD SHS36,600$3,671dollars as filed
CRYPTYDE INC22890A104COM18,070$3,464dollars as filed
PLUS THERAPEUTICS INC72941H400COM10,600$3,360dollars as filed
RUBIUS THERAPEUTICS INC78116T103COM19,200$3,360dollars as filed
FAZE HOLDINGS INC. 11.5000EXP03/01/202831423J110WARR26,300$3,316dollars as filed
P3 Health Partners Inc W Exp 11/19/202744413113SPAC Combination20,700$2,898dollars as filed
AYTU BIOPHARMA INC054754874COM14,917$2,819dollars as filed
FATHOM DIGITAL MFG CORP31189Y111*W EXP 12/22/20232,700$2,714dollars as filed
AGILE THERAPEUTICS INC00847L209COM NEW10,364$2,353dollars as filed
PLX PHARMA INC. XXXBANKRUPTCY EFF: 10/02/2372942A107COMMON STOCK14,086$2,312dollars as filed
MEIWU TECHNOLOGY COMPANY LTDG9604C107ORD SHS10,736$2,051dollars as filed
ROCKLEY PHOTONICS HLDGS LTDG7614L109COM13,983$1,959dollars as filed

Amendment chain

FilingRoleFiledAcceptedIngested
13F-HR 0000919574-23-001463this filing2023-02-14acceptance time not in the bulk data set