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13F-HR filed by TWO SIGMA ADVISERS, LP

TWO SIGMA ADVISERS, LP filed this 13F-HR for the quarter ended 2022-03-31, filed 2022-05-16, with 2,714 holding rows worth $37,618,614,000.

Accession
0000919574-22-003430
Filed
2022-05-16
Accepted by EDGAR
acceptance time not in the bulk data set
Ingested
Source
SEC quarterly data set

Original filing

13F report for Q1 2022

A holdings report, 2,714 entries on the cover page, a total value of $37,618,614,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $37,618,614,000 with VALUE read as thousands by filing date, 13F file number 028-14367. The quarter's positions are built on this report. The resolved quarter.

Other managers

The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).

Issuer as filedCUSIPClassAmountValueValue read asType
VOYAGER THERAPEUTICS INC92915B106COMMON STOCK13,500$103,000thousands by filing date
BANCO BBVA ARGENTINA S A058934100SPONSORED ADS28,700$102,000thousands by filing date
THERAVANCE BIOPHARMA INCG8807B106COM10,700$102,000thousands by filing date
SQZ BIOTECHNOLOGIES CO78472W104COM21,000$101,000thousands by filing date
EIGER BIOPHARMACEUTICALS INC28249U105COM12,000$100,000thousands by filing date
CALADRIUS BIOSCIENCES INC128058203COM NEW137,600$99,000thousands by filing date
EASTMAN KODAK CO277461406COM NEW14,900$98,000thousands by filing date
KRONOS BIO INC50107A104COM13,500$98,000thousands by filing date
ELECTROCORE INC28531P103COM166,700$98,000thousands by filing date
DOUGLAS ELLIMAN INC25961D105COM13,300$97,000thousands by filing date
NATIONAL ENERGY SERVICES REUG6375R107SHS11,600$97,000thousands by filing date
AC IMMUNE SAH00263105SHS23,644$95,000thousands by filing date
ACHIEVE LIFE SCIENCES INC004468500COMMON STOCK12,485$95,000thousands by filing date
AVINO SILVER & GOLD MINES LT053906103COM100,100$94,000thousands by filing date
HOEGH LNG PARTNERS LPY3262R100COM UNIT LTD12,700$94,000thousands by filing date
23ANDME HOLDING CO90138Q108CLASS A COM24,500$94,000thousands by filing date
NISUN INTL ENT DVPMT GP CO LG6593L106COM96,000$94,000thousands by filing date
SENSEI BIOTHERAPEUTICS INC81728A108COM40,900$94,000thousands by filing date
IMMATICS N.VN44445109SHS11,300$90,000thousands by filing date
QUMU CORP749063103COM51,200$90,000thousands by filing date
NEXTDOOR HOLDINGS INC65345M108COM CL A14,700$88,000thousands by filing date
MAVERIX METALS INC57776F405COMMON STOCK-FO18,300$88,000thousands by filing date
SURFACE ONCOLOGY INC86877M209COM30,000$88,000thousands by filing date
LESAKA TECHNOLOGIES INC64107N206CMN14,800$87,000thousands by filing date
MARKFORGED HOLDING CORPORATI57064N102COM21,800$87,000thousands by filing date
IMMUNEERING CORP45254E107CLASS A COM13,300$86,000thousands by filing date
9 METERS BIOPHARMA INC654405109COM144,100$86,000thousands by filing date
ZYMERGEN INC98985X100COM29,700$86,000thousands by filing date
ENERGOUS CORP29272C103COM70,500$85,000thousands by filing date
SPIRE GLOBAL, INC.848560108COM39,500$83,000thousands by filing date
VIRACTA THERAPEUTICS INC92765F108COM17,418$83,000thousands by filing date
IRIDEX CORP462684101COM17,600$81,000thousands by filing date
LLOYDS BANKING GROUP PLC SPONSORED ADR539439109ADR33,032$80,000thousands by filing date
LYRA THERAPEUTICS INC55234L105COM20,000$80,000thousands by filing date
INNODATA INC457642205COM NEW11,300$79,000thousands by filing date
PLUS THERAPEUTICS INC72941H400COM79,100$79,000thousands by filing date
WILHELMINA INTL INC968235200COM NEW16,700$78,000thousands by filing date
COGNITION THERAPEUTICS INC19243B102COM28,100$77,000thousands by filing date
Xunlei Ltd-Adr98419E108COM43,900$77,000thousands by filing date
BIOCEPT INC09072V501COM33,000$77,000thousands by filing date
Renalytix PLC75973T101ADS11,000$76,000thousands by filing date
FIVE POINT HOLDINGS LLC33833Q106COM CL A12,300$75,000thousands by filing date
ASPIRA WOMENS HEALTH INC04537Y109COM70,400$73,000thousands by filing date
FORESIGHT AUTONOMOUS HLDGS L345523104SPONSORED ADS65,300$72,000thousands by filing date
CANAAN INC134748102SPONSORED ADS13,100$71,000thousands by filing date
ONTRAK INC683373104COM31,200$71,000thousands by filing date
GENETRON HLDGS LTD37186H100ADS32,600$71,000thousands by filing date
ASTRA SPACE INC04634X103COM CL A18,100$70,000thousands by filing date
ABITS GROUP INCG6S34K105ORDINARY SHARES43,800$70,000thousands by filing date
JOBY AVIATION INCg65163100COMMON STOCK10,400$69,000thousands by filing date
PULSE BIOSCIENCES INC74587B101COMMON STOCK14,298$69,000thousands by filing date
NETSOL TECHNOLOGIES INC64115A402COM PAR $.00118,000$69,000thousands by filing date
TEAM INC878155100COM31,100$69,000thousands by filing date
WHEELER REAL ESTATE INVT TR963025705COM NEW30,100$69,000thousands by filing date
RAIN ONCOLOGY INC75082Q105COM13,500$68,000thousands by filing date
BEYONDSPRING INCG10830100SHS30,000$66,000thousands by filing date
BIODESIX INC09075X108COM39,000$66,000thousands by filing date
TELLURIAN INC NEW87968A104COM12,500$66,000thousands by filing date
VIRIOS THERAPEUTICS INC92829J104COM14,400$65,000thousands by filing date
ZEPP HEALTH CORPORATION SPONSORED ADR98945L105ADR22,067$64,000thousands by filing date
ROVER GROUP INC77936F103COM CL A11,000$63,000thousands by filing date
ENDEAVOUR SILVER CORP29258Y103COM13,400$62,000thousands by filing date
PROTALIX BIOTHERAPEUTICS INC74365A309COMMON STOCK58,900$62,000thousands by filing date
LANDOS BIOPHARMA INC515069102CMN42,300$62,000thousands by filing date
SEMA4 HOLDINGS CORP81663L101COM19,400$60,000thousands by filing date
VISLINK TECHNOLOGIES INC92836Y300COM56,900$60,000thousands by filing date
CAPSTONE GREEN ENERGY CORP.14067D508Common Stock14,403$59,000thousands by filing date
MINERVA SURGICAL INC60343F106COM13,000$59,000thousands by filing date
MIND MEDICINE (MINDMED) INC60255C109COMMON STOCK-FO52,000$58,000thousands by filing date
LARIMAR THERAPEUTICS INC517125100COM13,998$57,000thousands by filing date
SCYNEXIS INC811292200COM NEW14,700$57,000thousands by filing date
LEXINFINTECH HLDGS LTD ADR528877103ADR21,187$56,000thousands by filing date
SMART SAND INC83191H107COM16,300$56,000thousands by filing date
CYTOSORBENTS CORP23283X206CMN17,500$56,000thousands by filing date
ULTRALIFE CORP903899102COM10,400$56,000thousands by filing date
ESS TECH INC26916J106COMMON STOCK10,100$56,000thousands by filing date
EYENOVIA INC30234E104COM18,500$56,000thousands by filing date
ATRECA INC04965G109COM17,600$56,000thousands by filing date
PEDEVCO CORP C70532Y303OM PAR41,700$56,000thousands by filing date
KANDI TECHNOLOGIES GROUP INC483709101COM17,200$55,000thousands by filing date
SOLENO THERAPEUTIVS, INC.834203200COMM246,400$55,000thousands by filing date
AVEPOINT INC COM CL A053604104Stock10,300$54,000thousands by filing date
METACRINE INC59101E103COM88,900$54,000thousands by filing date
CYCLACEL PHARMACE 6percent PFDCONV23254L603Stock17,800$54,000thousands by filing date
GT BIOPHARMA INC36254L209COM NEW18,500$53,000thousands by filing date
FREQUENCY THERAPEUTICS INC35803L108COM24,500$52,000thousands by filing date
GAMIDA CELL LTDM47364100SHS12,200$51,000thousands by filing date
ALSET EHOME INTERNATIONAL IN02116A104COM110,400$51,000thousands by filing date
REGULUS THERAPEUTICS INC75915K200COM NEW170,500$51,000thousands by filing date
CONTRAFECT CORP212326300COM13,800$50,000thousands by filing date
TYME TECHNOLOGIES INC COM90238J103Stock139,200$49,000thousands by filing date
SOC TELEMED78472F101COM16,400$49,000thousands by filing date
AVALON HLDGS CORP05343P109CL A14,600$48,000thousands by filing date
SALEM MEDIA GROUP INC CLASS A794093104COM14,100$48,000thousands by filing date
DOMA HOLDINGS INC25703A104COM21,900$48,000thousands by filing date
Ohr Pharmaceutical Inc64132K102COM25,350$48,000thousands by filing date
ASTROTECH CORP046484200COM NEW66,200$48,000thousands by filing date
FIVE STAR SENIOR LIVING INC33832D205COM NEW21,500$46,000thousands by filing date
GLOBAL CORD BLOOD CORPG39342103COM11,500$44,000thousands by filing date
SOCIETAL CDMO INC75629F109COM24,600$44,000thousands by filing date
STAR EQUITY HOLDINGS INC85513Q103COMMON38,700$44,000thousands by filing date
PAYSIGN INC70451A104COM21,800$43,000thousands by filing date
Yatra Online Incorporated Ord SHSG98338109Common Stock21,600$43,000thousands by filing date
FORTRESS BIOTECH INC34960Q109COM31,800$43,000thousands by filing date
MOLECULIN BIOTECH INC60855D200COMMON24,200$43,000thousands by filing date
FLEXSHOPPER INC33939J303COM24,800$42,000thousands by filing date
BEST INC08653C106SPONSORED ADS65,700$42,000thousands by filing date
BLUE APRON HLDGS INC09523Q200COM10,400$42,000thousands by filing date
AMERISERV FINL INC03074A102COM10,100$41,000thousands by filing date
PHIO PHARMACEUTICALS CORP71880W303COM46,700$41,000thousands by filing date
DIFFUSION PHARMACEUTICALS IN253748305COM PAR165,000$41,000thousands by filing date
ANIXA BIOSCIENCES INC03528H109COM14,438$40,000thousands by filing date
PHASEBIO PHARMACEUTICALS INC717224109COM30,100$40,000thousands by filing date
THERIVA BIOLOGICS INC COM NEW87164U201Stock140,200$40,000thousands by filing date
SYPRIS SOLUTIONS INC871655106COM14,500$39,000thousands by filing date
SO YOUNG INTERNATIONAL INC83356Q108SPONSORED ADS19,400$38,000thousands by filing date
ONCOLYTICS BIOTECH INC682310875COM NEW24,100$38,000thousands by filing date
TANTECH HLDGS LTDG8675X123SHS NEW79,430$38,000thousands by filing date
Cinedigm Corp CL A172406209COM NEW46,000$37,000thousands by filing date
BRAINSTORM CELL THERAPEUTICS10501E201COM11,000$37,000thousands by filing date
OTONOMO TECHNOLOGIES LTDM7571L103ORDINARY SHARES18,700$37,000thousands by filing date
SIO GENE THERAPIES INC829399104COM55,838$37,000thousands by filing date
AURORA MOBILE LTD051857100ADS34,000$37,000thousands by filing date
CONTEXTLOGIC INC21077C107COMMON STOCK16,000$36,000thousands by filing date
HYCROFT MINING HOLDING CORP44862P109COM15,700$36,000thousands by filing date
AMBEV SA SPONSORED ADR02319V103ADR10,700$35,000thousands by filing date
Tempest Therapeutics, Inc.87978U108Common Stock10,100$34,000thousands by filing date
LORDSTOWN MOTORS CORP54405Q100COM10,000$34,000thousands by filing date
TALIS BIOMEDICAL CORP87424L108CMN23,800$34,000thousands by filing date
XERIS BIOPHARMA HOLDINGS INC98422E103COM12,900$33,000thousands by filing date
GOLDMINING INC38149E101COM19,700$33,000thousands by filing date
KALA BIO INC COM483119103Stock23,600$33,000thousands by filing date
REALNETWORKS INC75605L708COM57,000$33,000thousands by filing date
BROADWIND INC11161T207CMN14,700$32,000thousands by filing date
SIERRA METALS INC82639W106COM27,300$32,000thousands by filing date
NEXGEL INC65344E107COM15,900$31,000thousands by filing date
IBIO INC451033203COM NEW72,400$31,000thousands by filing date
RVL PHARMACEUTICALS PLCG6S41R101COM17,800$30,000thousands by filing date
SENSTAR TECHNOLOGIES LTDM8T77E105COM10,900$29,000thousands by filing date
IZEA WORLDWIDE INC COM NEW46604H105Stock17,000$28,000thousands by filing date
AMERICAN SHARED HOSPITAL SVC029595105COM12,000$28,000thousands by filing date
LIVEONE INC53814X102COM34,800$28,000thousands by filing date
CONFORMIS INC20717E101COM44,900$28,000thousands by filing date
FREELINE THERAPEUTICS HLDGS35655L107SPONSORED ADS23,900$27,000thousands by filing date
MARCHEX INC56624R108CMN11,300$26,000thousands by filing date
TITAN MED INC88830X819COM50,100$26,000thousands by filing date
VIRNETX HLDG CORP92823T108COM16,225$26,000thousands by filing date
AYTU BIOPHARMA INC054754874COM23,700$26,000thousands by filing date
EXICURE INC30205M101COM131,700$26,000thousands by filing date
VISIONSYS AI INC876108200SPONSORED ADS10,099$25,000thousands by filing date
GENPREX INC372446104COM11,000$25,000thousands by filing date
OPGEN INC68373L307COM33,700$25,000thousands by filing date
KALTURA INC483467106COMMON STOCK13,400$24,000thousands by filing date
MEREO BIOPHARMA GROUP PLC589492107CMN21,100$24,000thousands by filing date
VIOMI TECHNOLOGY CO LTD92762J103SPONSORED ADS13,800$24,000thousands by filing date
PERSPECTIVE THERAPEUTICS INC46489V104COM65,800$24,000thousands by filing date
RETO ECO SOLUTIONS INCG75271109COM21,100$24,000thousands by filing date
DIGITAL BRANDS GROUP INC25401N101COM12,600$24,000thousands by filing date
VIVEVE MED INC92852W501COM22,300$24,000thousands by filing date
XINYUAN REAL ESTATE CO LTD98417P105SPONS ADR20,900$23,000thousands by filing date
ACORDA THERAPEUTICS INC COM00484M601Stock14,400$23,000thousands by filing date
FEDNAT HOLDING COMPANY31431B109Common Stock16,200$22,000thousands by filing date
BROADWAY FINL CORP DEL111444105COM14,000$22,000thousands by filing date
NUWELLIS INC67113Y108COM22,200$22,000thousands by filing date
RAVE RESTAURANT GROUP INC754198109COM19,500$21,000thousands by filing date
SYNCHRONOSS TECHNOLOGIES INC87157B103COM11,900$21,000thousands by filing date
CBDMD INC12482W101COM20,600$21,000thousands by filing date
BITNILE HOLDINGS INC09175M101CMN25,100$21,000thousands by filing date
DIRTT ENVIRONMENTAL SOLUT LT25490H106COM14,200$19,000thousands by filing date
TALKSPACE INC87427V103COM10,200$18,000thousands by filing date
ZOVIO INC98979V102COMMON STOCK21,700$18,000thousands by filing date
CATALYST BIOSCIENCES INC14888D208COM27,000$18,000thousands by filing date
9F INC SPON ADS NEW65442R109ADR20,100$18,000thousands by filing date
CYNERGISTEK INC23258P105COM13,800$18,000thousands by filing date
RICEBRAN TECHNOLOGIES762831204COM NEW37,300$17,000thousands by filing date
RECON TECHNOLOGY LTDG7415M124COMMON15,400$17,000thousands by filing date
ANTELOPE ENTERPRISE HLDGS LTD SHS NEWG041JN106Stock12,100$17,000thousands by filing date
HALL OF FAME RESORT & ENTMT40619L102COM15,100$17,000thousands by filing date
SMART FOR LIFE INC83204U103COMMON STOCK14,600$16,000thousands by filing date
NUCANA PLC67022C106ADR14,800$15,000thousands by filing date
AETERNA ZENTARIS INC007975402COM38,500$14,000thousands by filing date
SINTX TECHNOLOGIES INC829392307COM NEW23,100$14,000thousands by filing date
INVIVO THERAPEUTICS HLDGS CORP COM46186M506Stock39,200$14,000thousands by filing date
SENMIAO TECHNOLOGY LTD817225105COM62,400$14,000thousands by filing date
GREAT PANTHER MINING39115V101COM51,200$13,000thousands by filing date
SCWORX CORP COM78396V109Stock11,600$13,000thousands by filing date
GENOCEA BIOSCIENCES INC372427401COMMON STOCK10,000$13,000thousands by filing date
LUOKUNG TECHNOLOGY CORPG56981106SHS25,800$13,000thousands by filing date
ABEONA THERAPEUTICS INC00289Y107COM39,500$12,000thousands by filing date
SURGALIGN HOLDINGS INC86882C105COM37,900$12,000thousands by filing date
AIR INDS GROUP COM00912N205Stock13,100$11,000thousands by filing date
ORCHARD THERAPEUTICS PLC68570P101ADR15,900$11,000thousands by filing date
CHINA PHARMA HOLDINGS INC16941T104COM28,000$11,000thousands by filing date
DSS INC26253C102COM19,400$11,000thousands by filing date
AMERICAN VRTUAL CLOUD TECH I030382105COM11,700$11,000thousands by filing date
LIMINAL BIOSCIENCES INC53272L103COM10,800$11,000thousands by filing date
STEALTH BIOTHERAPEUTICS CORP SPONSORED ADS85789A105Stock16,400$11,000thousands by filing date
INPIXON45790J800COM41,500$11,000thousands by filing date
CHINA NATURAL RESOURCES INCG2110U109COM10,800$10,000thousands by filing date
NAVIDEA BIOPHARMACEUTICALS INC63937x202COM12,000$9,000thousands by filing date
SENESTECH INC81720R208COM NEW12,400$9,000thousands by filing date
ROCKWELL MED INC774374102COM16,800$8,000thousands by filing date
DYNATRONICS CORP268157401COM NEW11,100$8,000thousands by filing date
GOLDEN MINERALS COMPANY381119106COM14,800$7,000thousands by filing date
CORBUS PHARMACEUTICALS HLDGS21833P103COM14,000$7,000thousands by filing date
NEOVASC INC64065J304COM17,100$7,000thousands by filing date
CELLECTAR BIOSCIENCES INC15117F500COM PAR10,700$7,000thousands by filing date
COCRYSTAL PHARMA INC19188J300CMN13,000$7,000thousands by filing date
PHOENIX NEW MEDIA LTD71910C103SPONSORED ADR10,700$6,000thousands by filing date
GREENLANE HLDGS INC395330103CL A10,900$6,000thousands by filing date
HISTOGEN INC43358Y103COM14,600$4,000thousands by filing date
NOVABAY PHARMACEUTICALS INC66987P201COM NEW11,500$3,000thousands by filing date
POLARITYTE INC731094108COM13,700$3,000thousands by filing date
CHINA JO-JO DRUGSTORES INCG2124G104ORD SHS10,100$3,000thousands by filing date

Amendment chain

FilingRoleFiledAcceptedIngested
13F-HR 0000919574-22-003430this filing2022-05-16acceptance time not in the bulk data set