13F-HR filed by TWO SIGMA INVESTMENTS, LP
TWO SIGMA INVESTMENTS, LP filed this 13F-HR for the quarter ended 2021-12-31, filed 2022-02-14, with 4,189 holding rows worth $46,809,995,000.
- Accession
- 0000919574-22-001500
- Filer
- CIK 1179392
- Filed
- 2022-02-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2021
A holdings report, 4,189 entries on the cover page, a total value of $46,809,995,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $46,809,995,000 with VALUE read as thousands by filing date, 13F file number 028-10385. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerTWO SIGMA EQUITY PORTFOLIO LLC028-10704
- included managerTWO SIGMA SPECTRUM PORTFOLIO, LLC028-11144
- included managerTwo Sigma Futures Portfolio, LLC028-16011
- included managerTWO SIGMA HORIZON PORTFOLIO, LLC028-15356
- included managerTwo Sigma Options Portfolio, LLC028-17336
- included managerTwo Sigma Equity Spectrum Portfolio, LLC028-20138
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SILVERSUN TECHNOLOGIES INC | 82846H207 | COMMON | 30,641 | $137,000 | thousands by filing date | |
| CENOVUS ENERGY INC | 15135U109 | COM | 11,100 | $136,000 | thousands by filing date | call |
| RAYONIER ADVANCED MATLS INC | 75508B104 | COM | 23,862 | $136,000 | thousands by filing date | |
| BROADMARK RLTY CAP INC | 11135B100 | COM | 14,400 | $136,000 | thousands by filing date | |
| CALADRIUS BIOSCIENCES INC | 128058203 | COM NEW | 160,145 | $135,000 | thousands by filing date | |
| TRECORA RES | 894648104 | COM | 16,736 | $135,000 | thousands by filing date | |
| CIPHER DIGITAL INC COM | 17253J106 | Stock | 28,988 | $134,000 | thousands by filing date | |
| TRAVELZOO | 89421Q205 | CMN | 14,233 | $134,000 | thousands by filing date | |
| AETHLON MED INC | 00808Y307 | COM | 72,256 | $134,000 | thousands by filing date | |
| VINCO VENTURES INC | 927330100 | COM | 55,453 | $132,000 | thousands by filing date | |
| RITHM CAPITAL CORP COM NEW | 64828T201 | REIT | 12,200 | $131,000 | thousands by filing date | call |
| PERDOCEO ED CORP | 71363P106 | COM | 11,128 | $131,000 | thousands by filing date | |
| AERIE PHARMACEUTICALS INC | 00771V108 | COM | 18,358 | $129,000 | thousands by filing date | |
| PHIO PHARMACEUTICALS CORP | 71880W303 | COM | 128,724 | $129,000 | thousands by filing date | |
| CHARAH SOLUTIONS INC | 15957P105 | COM | 27,168 | $129,000 | thousands by filing date | |
| NUVERRA ENVIRONMENTAL SOLUTI | 67091K302 | CMN | 42,214 | $128,000 | thousands by filing date | |
| BIOMEA FUSION INC | 09077A106 | CMN | 17,010 | $127,000 | thousands by filing date | |
| CARPARTS COM INC | 14427M107 | COM | 11,300 | $127,000 | thousands by filing date | |
| SOLENO THERAPEUTIVS, INC. | 834203200 | COMM | 309,546 | $127,000 | thousands by filing date | |
| Xunlei Ltd-Adr | 98419E108 | COM | 62,111 | $125,000 | thousands by filing date | |
| BOLT BIOTHERAPEUTICS INC | 097702104 | COM | 25,500 | $125,000 | thousands by filing date | |
| APTINYX INC | 03836N103 | COM | 46,102 | $123,000 | thousands by filing date | |
| MISSFRESH LTD | 60500F105 | ADS | 24,527 | $123,000 | thousands by filing date | |
| Uxin Ltd | 91818X108 | ADS | 77,119 | $122,000 | thousands by filing date | |
| INNODATA INC | 457642205 | COM NEW | 20,521 | $121,000 | thousands by filing date | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 37,898 | $119,000 | thousands by filing date | |
| TIDEWATER INC NEW COM | 88642R109 | Stock | 11,124 | $119,000 | thousands by filing date | |
| SABRE CORP COM | 78573M104 | Stock | 13,900 | $119,000 | thousands by filing date | call |
| WORKSPORT LTD | 98139q209 | COM | 49,295 | $119,000 | thousands by filing date | |
| CENTENNIAL RESOURCE DEV INC | 15136A102 | CL A | 19,900 | $119,000 | thousands by filing date | put |
| COMSTOCK RES INC COM | 205768302 | Stock | 14,600 | $118,000 | thousands by filing date | call |
| ASURE SOFTWARE INC | 04649U102 | COMMON STOCK | 15,077 | $118,000 | thousands by filing date | |
| ULTRALIFE CORP | 903899102 | COM | 19,517 | $118,000 | thousands by filing date | |
| GRUPO AVAL ACCIONES Y VALORE | 40053W101 | SPONSORED ADS | 23,150 | $118,000 | thousands by filing date | |
| ANGI INC CLASS A | 00183L102 | CL A | 12,800 | $118,000 | thousands by filing date | call |
| FRONTLINE PLC F | G3682E192 | ORD SHS | 16,700 | $118,000 | thousands by filing date | call |
| MARCHEX INC | 56624R108 | CMN | 47,016 | $117,000 | thousands by filing date | |
| EFFECTOR THERAPEUTICS INC | 28202V108 | COM | 14,122 | $117,000 | thousands by filing date | |
| FUELCELL ENERGY INC | 35952H601 | COM | 22,300 | $116,000 | thousands by filing date | put |
| ASPEN GROUP INC | 04530L203 | COM NEW | 48,982 | $116,000 | thousands by filing date | |
| HELLO GROUP INC ADS | 423403104 | ADR | 12,800 | $115,000 | thousands by filing date | call |
| MICROVISION INC DEL | 594960304 | COM NEW | 22,900 | $115,000 | thousands by filing date | put |
| U S SILICA HLDGS INC | 90346E103 | COM | 12,200 | $115,000 | thousands by filing date | put |
| REDBOX ENTERTAINMENT INC | 75724T103 | CMN | 15,488 | $115,000 | thousands by filing date | |
| QUMU CORP | 749063103 | COM | 52,998 | $112,000 | thousands by filing date | |
| ARCIMOTO INC | 039587100 | COM | 14,281 | $111,000 | thousands by filing date | |
| ONTRAK INC | 683373104 | COM | 17,300 | $109,000 | thousands by filing date | put |
| PITNEY BOWES INC COM | 724479100 | Stock | 16,300 | $108,000 | thousands by filing date | call |
| ANIXA BIOSCIENCES INC | 03528H109 | COM | 36,350 | $108,000 | thousands by filing date | |
| GAIN THERAPEUTICS INC | 36269B105 | COM | 19,467 | $106,000 | thousands by filing date | |
| OPGEN INC | 68373L307 | COM | 106,332 | $106,000 | thousands by filing date | |
| PLUS THERAPEUTICS INC | 72941H400 | COM | 98,628 | $104,000 | thousands by filing date | |
| MICROVISION INC DEL | 594960304 | COM NEW | 20,300 | $102,000 | thousands by filing date | call |
| NEW FOUND GOLD CORP | 64440N103 | COM | 14,211 | $102,000 | thousands by filing date | |
| CITIZENS INC | 174740100 | COMMON STOCK | 19,200 | $102,000 | thousands by filing date | |
| CONTEXTLOGIC INC | 21077C107 | COMMON STOCK | 32,700 | $102,000 | thousands by filing date | call |
| LIPOCINE INC NEW | 53630X104 | CMN | 102,600 | $102,000 | thousands by filing date | |
| BABYLON HLDGS LTD | G07031100 | CL A SHS | 17,284 | $101,000 | thousands by filing date | |
| RESONANT INC | 76118L102 | COM | 59,187 | $101,000 | thousands by filing date | |
| MISTRAS GROUP INC | 60649T107 | COMMON STOCK | 13,332 | $99,000 | thousands by filing date | |
| AQUA METALS INC | 03837J101 | COM | 80,425 | $99,000 | thousands by filing date | |
| UR-ENERGY INC | 91688R108 | COM | 79,800 | $97,000 | thousands by filing date | |
| ZK INTL GROUP CO LTD SHS NEW | G9892K100 | Stock | 69,658 | $97,000 | thousands by filing date | |
| WISA TECHNOLOGIES INC | 86633R203 | COM NEW | 69,740 | $97,000 | thousands by filing date | |
| EOS ENERGY ENTERPRISES INC COM CL A | 29415C101 | Stock | 12,716 | $96,000 | thousands by filing date | |
| FARMER BROS CO | 307675108 | COM | 12,909 | $96,000 | thousands by filing date | |
| MAIDEN HOLDINGS LTD | G5753U112 | SHS | 31,025 | $95,000 | thousands by filing date | |
| CYMABAY THERAPEUTICS INC | 23257D103 | COM | 28,100 | $95,000 | thousands by filing date | |
| GENPREX INC | 372446104 | COM | 72,290 | $95,000 | thousands by filing date | |
| Up Fintech Holding Ltd | 91531W106 | COM | 19,100 | $94,000 | thousands by filing date | put |
| ARC DOCUMENT SOLUTIONS INC | 00191G103 | COM | 26,436 | $93,000 | thousands by filing date | |
| SAN JUAN BASIN RTY TR | 798241105 | UNIT BEN INT | 15,117 | $92,000 | thousands by filing date | |
| IRIDEX CORP | 462684101 | COM | 15,100 | $92,000 | thousands by filing date | |
| HALLMARK FINL SERVICES INC | 40624Q203 | COM | 21,100 | $92,000 | thousands by filing date | |
| NEXA RES S A | L67359106 | COM | 11,628 | $91,000 | thousands by filing date | |
| SAFEGUARD SCIENTIFICS INC | 786449207 | COMMON STOCK | 12,402 | $91,000 | thousands by filing date | |
| VIRNETX HLDG CORP | 92823T108 | COM | 34,967 | $91,000 | thousands by filing date | |
| SONENDO INC | 835431107 | Common Stocks | 15,657 | $90,000 | thousands by filing date | |
| INTELLICHECK MOBILISA INC | 45817G201 | COM NEW | 19,022 | $88,000 | thousands by filing date | |
| The Very Good Food Company Inc COM | 88340B109 | Common Stock | 119,778 | $88,000 | thousands by filing date | |
| SIGILON THERAPEUTICS INC | 82657L107 | COM | 32,055 | $88,000 | thousands by filing date | |
| Gaotu Techedu Inc | 36257Y109 | COM | 44,922 | $87,000 | thousands by filing date | |
| NULL | 68620A203 | NULL | 23,867 | $87,000 | thousands by filing date | |
| LUCID DIAGNOSTICS INC | 54948X109 | COM | 15,964 | $86,000 | thousands by filing date | |
| ALPHA PRO TECH LTD | 020772109 | COM | 14,400 | $86,000 | thousands by filing date | put |
| EARGO INC | 270087109 | COM | 16,800 | $86,000 | thousands by filing date | call |
| NEXTCURE INC | 65343E108 | COM | 14,114 | $85,000 | thousands by filing date | |
| EXICURE INC | 30205M101 | COM | 421,900 | $85,000 | thousands by filing date | |
| ELOXX PHARMACEUTICALS INC | 29014R103 | COM | 117,729 | $83,000 | thousands by filing date | |
| LMP Automotive Holdings | 53952P101 | COM | 11,905 | $83,000 | thousands by filing date | |
| NISUN INTL ENT DVPMT GP CO L | G6593L106 | COM | 25,465 | $82,000 | thousands by filing date | |
| WHEELER REAL ESTATE INVT TR | 963025705 | COM NEW | 42,400 | $82,000 | thousands by filing date | |
| APPLIED UV INC | 03828V105 | COM | 30,262 | $82,000 | thousands by filing date | |
| TASEKO MINES LTD COM | 876511106 | Stock | 39,520 | $81,000 | thousands by filing date | |
| CONNECT BIOPHARMA HLDGS LTD | 207523101 | SHS | 15,632 | $81,000 | thousands by filing date | |
| EVELO BIOSCIENCES INC | 299734103 | COM | 13,330 | $81,000 | thousands by filing date | |
| FREELINE THERAPEUTICS HLDGS | 35655L107 | SPONSORED ADS | 41,073 | $81,000 | thousands by filing date | |
| OSCAR HEALTH INC | 687793109 | CL A | 10,000 | $79,000 | thousands by filing date | put |
| ENDEAVOUR SILVER CORP | 29258Y103 | COM | 18,814 | $79,000 | thousands by filing date | |
| AMERICAN WELL CORP | 03044L105 | CL A | 13,000 | $79,000 | thousands by filing date | call |
| LIVEONE INC | 53814X102 | COM | 61,800 | $79,000 | thousands by filing date | |
| KORU MEDICAL SYSTEMS INC | 759910102 | COMMON STOCK | 26,095 | $78,000 | thousands by filing date | |
| LYRA THERAPEUTICS INC | 55234L105 | COM | 17,731 | $77,000 | thousands by filing date | |
| AIRSPAN NETWORKS HOLDINGS IN | 00951K104 | COM | 20,290 | $77,000 | thousands by filing date | |
| Akoustis Technologies Inc | 00973N102 | COM | 11,200 | $75,000 | thousands by filing date | put |
| ZYNERBA PHARMACEUTICALS INC | 98986X109 | COM | 26,096 | $75,000 | thousands by filing date | |
| WATERDROP INC | 94132V105 | CMN | 53,759 | $74,000 | thousands by filing date | |
| SERVICESOURCE INTL LLC | 81763U100 | COM | 74,696 | $74,000 | thousands by filing date | |
| COEUR MNG INC COM NEW | 192108504 | Stock | 14,200 | $72,000 | thousands by filing date | call |
| WRAP TECHNOLOGIES INC | 98212N107 | COM | 18,009 | $71,000 | thousands by filing date | |
| GREENLAND TECHNOLOGIES HLDG | G4095T107 | ORD SHS CL A | 11,062 | $71,000 | thousands by filing date | |
| SIERRA METALS INC | 82639W106 | COM | 52,502 | $71,000 | thousands by filing date | |
| EDESA BIOTECH INC | 27966L108 | COM | 12,617 | $71,000 | thousands by filing date | |
| SMITH MICRO SOFTWARE INC | 832154207 | COMMON | 14,176 | $70,000 | thousands by filing date | |
| AXIA ENERGIA SA | 15234Q207 | SPONSORED ADR | 11,331 | $69,000 | thousands by filing date | |
| BTCS INC | 05581M404 | CMN | 21,816 | $69,000 | thousands by filing date | |
| NXT-ID INC | 67091J404 | COM NEW | 22,600 | $69,000 | thousands by filing date | put |
| FLEXSHOPPER INC | 33939J303 | COM | 28,508 | $67,000 | thousands by filing date | |
| YUMANITY THERAPEUTICS INC | 98872L102 | COM | 22,738 | $67,000 | thousands by filing date | |
| THERAPEUTICSMD INC | 88338N107 | COM | 183,651 | $65,000 | thousands by filing date | |
| NXT-ID INC | 67091J404 | COM NEW | 21,300 | $65,000 | thousands by filing date | call |
| FIVE STAR SENIOR LIVING INC | 33832D205 | COM NEW | 21,384 | $63,000 | thousands by filing date | |
| AURORA CANNABIS INC-NEW | 05156X884 | COM | 11,647 | $63,000 | thousands by filing date | |
| BRIDGEBIO PHARMA INC | 09077J107 | COM | 10,199 | $63,000 | thousands by filing date | |
| CHINA LIBERAL ED HLDGS LTD | G2161Y109 | ORD | 47,353 | $63,000 | thousands by filing date | |
| SOCKET MOBILE INC | 83368E200 | COM NEW | 15,162 | $62,000 | thousands by filing date | |
| Veru Inc | 92536C103 | Common Stock | 10,582 | $62,000 | thousands by filing date | |
| ORIENTAL CULTURE HOLDING LTD | G6796W107 | ORD SHS | 12,029 | $61,000 | thousands by filing date | |
| NEXIMMUNE INC | 65344D109 | COM | 12,743 | $59,000 | thousands by filing date | |
| EZFILL HOLDINGS INC | 302314208 | COM NEW | 42,050 | $58,000 | thousands by filing date | |
| D-MARKET ELECTR SVCS TRY 0.2 | 23292B104 | SPONSORED ADS | 28,277 | $54,000 | thousands by filing date | |
| SRX HEALTH SOLUTIONS INC. COM NEW | 08771Y303 | Stock | 16,332 | $53,000 | thousands by filing date | |
| EARGO INC | 270087109 | COM | 10,100 | $52,000 | thousands by filing date | put |
| TDH HLDGS INC SHS NEW | G87084102 | Stock | 13,565 | $52,000 | thousands by filing date | |
| TUESDAY MORNING CORP | 89904V101 | COM | 22,800 | $52,000 | thousands by filing date | |
| ONE STOP SYSTEMS INC | 68247W109 | COMMON STOCK | 10,378 | $51,000 | thousands by filing date | |
| NLS PHARMACEUTICS LTD COM NEW | H57830103 | Stock | 45,879 | $51,000 | thousands by filing date | |
| 17 ED & TECHNOLOGY GROUP INC | 81807M205 | ADS | 41,011 | $51,000 | thousands by filing date | |
| MARRONE BIO INNOVATIONS INC | 57165B106 | COM | 70,138 | $51,000 | thousands by filing date | |
| CASI PHARMACEUTICALS INC | 14757U109 | COM | 63,400 | $51,000 | thousands by filing date | |
| SCOPUS BIOPHARMA INC | 809171101 | Equity | 30,403 | $50,000 | thousands by filing date | |
| ANPAC BIO MED SCIENCE CO LTD | 03635R107 | cs | 40,217 | $49,000 | thousands by filing date | |
| AMERISERV FINL INC | 03074A102 | COM | 12,169 | $47,000 | thousands by filing date | |
| ELECTRAMECCANICA VEHS | 284849205 | COM | 19,783 | $45,000 | thousands by filing date | |
| TRANSGLOBE ENERGY CORP | 893662106 | COM | 14,829 | $45,000 | thousands by filing date | |
| SALARIUS PHARMACEUTICALS INC | 79400X107 | COM NEW | 90,471 | $45,000 | thousands by filing date | |
| SmileDirectClub Inc | 83192H106 | COM | 18,100 | $43,000 | thousands by filing date | put |
| CELLECTAR BIOSCIENCES INC | 15117F500 | COM PAR | 65,086 | $43,000 | thousands by filing date | |
| GAMIDA CELL LTD | M47364100 | SHS | 16,394 | $42,000 | thousands by filing date | |
| MY SIZE INC | 62844N208 | COM NEW | 82,689 | $42,000 | thousands by filing date | |
| AGRIFORCE GROWING SYSTEMS LT | C00948106 | COM | 19,538 | $41,000 | thousands by filing date | |
| SIO GENE THERAPIES INC | 829399104 | COM | 30,607 | $39,000 | thousands by filing date | |
| MEDALIST DIVERSIFIED REIT IN | 58403P105 | COM | 32,200 | $39,000 | thousands by filing date | |
| ENVERIC BIOSCIENCES INC | 29405E109 | COM NEW | 42,050 | $39,000 | thousands by filing date | |
| NEW PAC METALS CORP | 64782A107 | COM | 13,000 | $38,000 | thousands by filing date | |
| NEW CONCEPT ENERGY INC | 643611106 | COM | 15,623 | $37,000 | thousands by filing date | |
| AMERICAN SHARED HOSPITAL SVC | 029595105 | COM | 15,130 | $36,000 | thousands by filing date | |
| SEQLL INC | 81734C106 | COM | 19,509 | $36,000 | thousands by filing date | |
| IM CANNABIS CORP | 44969Q208 | COM NEW | 10,603 | $35,000 | thousands by filing date | |
| BAOSHENG MEDIA GROUP HLDNG L | G08908108 | SHS | 39,148 | $35,000 | thousands by filing date | |
| NAVIDEA BIOPHARMACEUTICALS INC | 63937x202 | COM | 33,467 | $33,000 | thousands by filing date | |
| DERMATA THERAPEUTICS INC | 249845108 | COM | 18,697 | $33,000 | thousands by filing date | |
| SUPERIOR DRILLING PRODS INC | 868153107 | COM | 43,516 | $32,000 | thousands by filing date | |
| Sigma Additive Solutions, Inc. | 826598500 | common | 17,636 | $32,000 | thousands by filing date | |
| JIAYIN GROUP INC | 47737C104 | CMN | 14,134 | $31,000 | thousands by filing date | |
| PLURISTEM THERAPEUTICS INC | 72940R300 | COM NEW | 20,859 | $30,000 | thousands by filing date | |
| STAR EQUITY HOLDINGS INC | 85513Q103 | COMMON | 10,000 | $26,000 | thousands by filing date | |
| UPHEALTH INC | 91532B101 | COM | 10,613 | $24,000 | thousands by filing date | |
| BRICKELL BIOTECH INC | 10802T105 | COM | 105,785 | $24,000 | thousands by filing date | |
| THERIVA BIOLOGICS INC COM NEW | 87164U201 | Stock | 84,075 | $23,000 | thousands by filing date | |
| ANTELOPE ENTERPRISE HLDGS LTD SHS NEW | G041JN106 | Stock | 14,411 | $23,000 | thousands by filing date | |
| TIMBER PHARMACEUTICALS INC | 887080109 | COM | 56,291 | $21,000 | thousands by filing date | |
| EBANG INTL HLDGS INC | G3R33A106 | CL A SHS | 19,496 | $20,000 | thousands by filing date | |
| PALISADE BIO INC | 696389105 | COM | 14,477 | $19,000 | thousands by filing date | |
| FIRST HIGH SCH ED GROUP CO L | 320505100 | ADR | 11,436 | $18,000 | thousands by filing date | |
| Kintara Therapeutics, Inc. | 49720K101 | Equities | 34,624 | $18,000 | thousands by filing date | |
| AIR INDS GROUP COM | 00912N205 | Stock | 18,600 | $17,000 | thousands by filing date | |
| INHIBIKASE THERAPEUTICS INC | 45719W106 | COM | 11,500 | $17,000 | thousands by filing date | |
| REGULUS THERAPEUTICS INC | 75915K200 | COM NEW | 55,306 | $17,000 | thousands by filing date | |
| CLEARSIGN TECHNOLOGIES CORP | 185064102 | COM | 11,948 | $16,000 | thousands by filing date | |
| GREAT PANTHER MINING | 39115V101 | COM | 68,188 | $15,000 | thousands by filing date | |
| AURORA MOBILE LTD | 051857100 | ADS | 14,237 | $15,000 | thousands by filing date | |
| PENNSYLVANIA RL ESTATE INVT | 709102107 | SH BEN INT | 12,777 | $13,000 | thousands by filing date | |
| NANOVIBRONIX INC | 63008J108 | COM | 11,244 | $12,000 | thousands by filing date | |
| Kelso Technologies Inc | 48826D201 | COM | 22,428 | $10,000 | thousands by filing date | |
| ONCOSEC MED INC | 68234L306 | COM | 10,395 | $10,000 | thousands by filing date | |
| ELECTROCORE INC | 28531P103 | COM | 14,882 | $9,000 | thousands by filing date | |
| UCOMMUNE INTERNATIONAL LTD | G9449A100 | COM | 10,873 | $8,000 | thousands by filing date | |
| RICEBRAN TECHNOLOGIES | 762831204 | COM NEW | 16,120 | $6,000 | thousands by filing date |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0000919574-22-001500 | this filing | 2022-02-14 | acceptance time not in the bulk data set |