13F-HR filed by TWO SIGMA INVESTMENTS, LP
TWO SIGMA INVESTMENTS, LP filed this 13F-HR for the quarter ended 2025-09-30, filed 2025-11-14, with 3,628 holding rows worth $67,173,960,693.
- Accession
- 0000899140-25-001286
- Filer
- CIK 1179392
- Filed
- 2025-11-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q3 2025
A holdings report, 3,628 entries on the cover page, a total value of $67,173,960,693 stated on the cover page (in dollars after the unit check, H1), rows summing to $67,173,960,693 with VALUE read as dollars as filed, 13F file number 028-10385. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerTWO SIGMA EQUITY PORTFOLIO LLC028-10704
- included managerTWO SIGMA SPECTRUM PORTFOLIO, LLC028-11144
- included managerTwo Sigma Futures Portfolio, LLC028-16011
- included managerTWO SIGMA HORIZON PORTFOLIO, LLC028-15356
- included managerTwo Sigma Equity Spectrum Portfolio, LLC028-20138
- included managerTwo Sigma Blazar Portfolio, LLC028-23019
- included managerTwo Sigma Navigator Portfolio, LLC028-23021
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| Agora Inc-Adr | 00851L103 | COM | 20,000 | $76,400 | dollars as filed | |
| GENERATION BIO CO | 37148K209 | COM NEW | 12,442 | $76,145 | dollars as filed | |
| DAMORA THERAPEUTICS INC | 36322Q206 | COMMON STOCK | 20,296 | $75,501 | dollars as filed | |
| PULMONX CORP | 745848101 | COM | 46,456 | $75,259 | dollars as filed | |
| GLIMPSE GROUP INC | 37892C106 | COM | 45,268 | $74,240 | dollars as filed | |
| Xilio Therapeutics Inc. | 98422T100 | COM | 87,790 | $73,981 | dollars as filed | |
| VYNE THERAPEUTICS INC | 92941V308 | COM | 220,788 | $73,964 | dollars as filed | |
| MYSEUMAI INC | 23816M206 | COM NEW | 31,679 | $71,595 | dollars as filed | |
| GALECTIN THERAPEUTICS INC | 363225202 | COMMON STOCK | 16,647 | $70,500 | dollars as filed | |
| ONKURE THERAPEUTICS INC | 68277Q105 | COM CL A | 25,435 | $69,946 | dollars as filed | |
| LANTERN PHARMA INC | 51654W101 | COM | 16,041 | $69,778 | dollars as filed | |
| DEFI TECHNOLOGIES INC COM | 244916102 | Stock | 32,969 | $69,565 | dollars as filed | |
| KVH INDS INC | 482738101 | COM | 12,363 | $69,233 | dollars as filed | |
| SONNET BIOTHERAPEUTC HLDNG I | 83548R402 | COM NEW | 14,972 | $68,572 | dollars as filed | |
| KOSS CORP | 500692108 | COM | 13,355 | $67,843 | dollars as filed | |
| VIVOSIM LABS INC | 68620A302 | COM | 23,192 | $67,721 | dollars as filed | |
| TWIN VEE POWERCATS CO | 90177C200 | COM NEW | 24,370 | $66,774 | dollars as filed | |
| ABACUS GLOBAL MANAGEMENT INC | 00258Y104 | COMMON STOCK | 11,368 | $65,139 | dollars as filed | |
| FiscalNote Holdings Inc | 337655302 | Common Stock | 13,887 | $64,297 | dollars as filed | |
| ESSA PHARMA INC | 29668H708 | COM NEW | 336,164 | $64,207 | dollars as filed | |
| PANGAEA LOGISTICS SOLUTIONS | G6891L105 | COMMON STOCK | 12,451 | $63,251 | dollars as filed | |
| Q32 BIO INC | 746964105 | Common Stock | 31,506 | $62,382 | dollars as filed | |
| MIRA PHARMACEUTICALS INC | 60458C104 | COM | 45,703 | $62,156 | dollars as filed | |
| BIOVIE INC COM CL A NEW | 09074F504 | Stock | 32,505 | $61,760 | dollars as filed | |
| LIVEPERSON, INC. | 538146101 | COM | 103,979 | $60,651 | dollars as filed | |
| COHERUS ONCOLOGY INC | 19249H103 | COM | 35,712 | $58,568 | dollars as filed | |
| ARTIVA BIOTHERAPEUTICS INC | 04317A107 | COM | 20,364 | $58,445 | dollars as filed | |
| INNO HOLDINGS INC | 4576JP208 | COM NEW | 41,938 | $58,294 | dollars as filed | |
| TAOWEAVE INC | 674434303 | COM | 22,584 | $58,267 | dollars as filed | |
| SNOW LAKE RES LTD | 83336J307 | COM | 13,193 | $57,785 | dollars as filed | |
| SMART SH GLOBAL LTD | 83193E102 | ADS | 42,600 | $57,510 | dollars as filed | |
| D-MARKET ELECTR SVCS TRY 0.2 | 23292B104 | SPONSORED ADS | 21,338 | $57,399 | dollars as filed | |
| KOLIBRI GLOBAL ENERGY INC | 50043K406 | COMMON STOCK | 10,300 | $57,165 | dollars as filed | |
| HONEST CO INC | 438333106 | COM | 15,466 | $56,915 | dollars as filed | |
| PURPLE INNOVATION INC | 74640Y106 | CMN | 60,661 | $56,670 | dollars as filed | |
| SMART DIGITAL GROUP LTD | G5006S104 | COM | 30,517 | $56,456 | dollars as filed | |
| CODEXIS INC | 192005106 | COM | 22,745 | $55,498 | dollars as filed | |
| CASI PHARMACEUTICALS INC COM NEW | G1933S101 | Stock | 33,267 | $55,223 | dollars as filed | |
| BIG SKY INDL INC | 911805307 | COM | 45,926 | $54,193 | dollars as filed | |
| KAIROS PHARMA LTD | 48301N104 | COM | 45,789 | $53,573 | dollars as filed | |
| Dawson Geophysical Co Ne | 239360100 | COM | 29,425 | $51,788 | dollars as filed | |
| IMMUNIC INC | 4525EP101 | COM | 58,681 | $51,733 | dollars as filed | |
| ROBIN ENERGY LTD ORD SHS NEW | Y73118104 | Stock | 39,238 | $51,009 | dollars as filed | |
| AC IMMUNE SA | H00263105 | SHS | 16,775 | $48,480 | dollars as filed | |
| AMESITE INC | 031094204 | CMN | 15,851 | $48,346 | dollars as filed | |
| BIG 5 SPORTING GOODS CORP | 08915P101 | COM | 33,489 | $48,224 | dollars as filed | |
| X4 PHARMACEUTICALS INC | 98420X202 | COMMON STOCK | 13,868 | $47,429 | dollars as filed | |
| NINE ENERGY SERVICE INC | 65441V101 | COM | 74,668 | $47,183 | dollars as filed | |
| PSQ HOLDINGS INC | 693691107 | CL A | 24,313 | $46,438 | dollars as filed | |
| BUTTERFLY NETWORK INC | 124155102 | COM CL A | 22,098 | $42,649 | dollars as filed | |
| AMBER INTL HLDG LTD | 45113Y203 | SPON ADS NEW | 12,613 | $42,254 | dollars as filed | |
| AGEAGLE AERIAL SYS INC NEW | 00848K309 | COM SHS | 20,889 | $41,987 | dollars as filed | |
| GCL GLOBAL HLDGS LTD | G3777K103 | SHS | 16,624 | $41,726 | dollars as filed | |
| 374WATER INC | 88583P104 | COM | 143,251 | $41,099 | dollars as filed | |
| TRAWS PHARMA INC | 68232V884 | COM NEW | 22,018 | $40,733 | dollars as filed | |
| WEREWOLF THERAPEUTICS INC | 95075A107 | CMN | 20,139 | $39,674 | dollars as filed | |
| ALTO INGREDIENTS INC | 021513106 | COMMON STOCK | 36,386 | $39,297 | dollars as filed | |
| MEGA MATRIX INC | G6005C108 | CMN | 32,321 | $38,785 | dollars as filed | |
| ADVANTAGE SOLUTIONS INC. | 00791N102 | COM CL A | 23,059 | $35,280 | dollars as filed | |
| MESA AIR GROUP INC | 590479135 | COM NEW | 26,290 | $34,177 | dollars as filed | |
| MONTAUK RENEWABLES INC | 61218C103 | COMMON STOCK | 16,955 | $34,080 | dollars as filed | |
| CELULARITY INC | 151190204 | CL A NEW | 16,204 | $33,542 | dollars as filed | |
| BEAMR IMAGING LTD | M1R79L104 | ORDINARY SHS | 10,900 | $33,354 | dollars as filed | |
| KIORA PHARMACEUTICALS INC | 49721T507 | COM | 11,984 | $33,316 | dollars as filed | |
| MARKER THERAPEUTICS INC | 57055L206 | COM NEW | 36,540 | $32,616 | dollars as filed | |
| CYPHERPUNK TECHNOLOGIES INC | 52187K200 | COM NEW | 70,849 | $32,165 | dollars as filed | |
| SUNSHINE BIOPHARMA INC | 867781700 | COM | 21,399 | $31,885 | dollars as filed | |
| CHEETAH NET SUPPLY CHAIN INC | 16307X202 | COM NEW CL A | 17,750 | $31,595 | dollars as filed | |
| VERIFYME INC | 92346X206 | COM NEW | 35,321 | $31,351 | dollars as filed | |
| Cyclerion Therapeutics Inc | 23255M204 | COM | 13,293 | $30,574 | dollars as filed | |
| MURAL ONCOLOGY PUB LTD CO | G63365103 | ORD SHS | 14,706 | $30,441 | dollars as filed | |
| OLAPLEX HLDGS INC | 679369108 | COM | 22,817 | $29,890 | dollars as filed | |
| SUNPOWER INC | 20460L104 | COM | 16,765 | $29,506 | dollars as filed | |
| GALMED PHARMACEUTICALS LTD | M47238148 | SHS | 21,200 | $29,256 | dollars as filed | |
| ADDENTAX GROUP CORP | 00653L301 | COM | 29,206 | $29,206 | dollars as filed | |
| CHECHE GROUP INC | G20707108 | CMN | 23,128 | $29,141 | dollars as filed | |
| ROCKET ONE INC | 44148G204 | COM NEW | 17,346 | $28,101 | dollars as filed | |
| BIOATLA INC | 09077B104 | COM | 40,716 | $28,009 | dollars as filed | |
| CITIUS PHARMACEUTICALS INC | 17322U306 | COM | 21,803 | $27,036 | dollars as filed | |
| NN INC | 629337106 | COM | 13,020 | $26,821 | dollars as filed | |
| STRIVE INC | 862945102 | CL A COM | 10,702 | $26,755 | dollars as filed | |
| NEUROSENSE THERAPEUTICS LTD | M74240108 | FOREIGN | 21,086 | $26,358 | dollars as filed | |
| PASITHEA THERAPEUTICS CORP | 70261F202 | COM NEW | 35,760 | $26,169 | dollars as filed | |
| THERIVA BIOLOGICS INC | 87164U508 | COM NEW | 61,837 | $25,050 | dollars as filed | |
| TRINITY BIOTECH INVT LTD | 896438504 | SPONS ADR NEW | 23,986 | $24,945 | dollars as filed | |
| GEE GROUP INC | 36165A102 | COM | 120,526 | $24,913 | dollars as filed | |
| CORTEXYME INC | 22053A107 | COM | 15,080 | $24,580 | dollars as filed | |
| BATTALION OIL CORP | 07134L107 | COM | 20,196 | $24,437 | dollars as filed | |
| ORIGIN MATERIALS INC | 68622D106 | COM | 46,249 | $23,985 | dollars as filed | |
| BENEFICIENT | 08178Q309 | COM | 23,769 | $22,609 | dollars as filed | |
| Senti Biosciences, Inc. | 81726A209 | COM NEW | 15,968 | $22,515 | dollars as filed | |
| SCANTECH AI SYS INC | 80603V104 | COM | 54,051 | $22,431 | dollars as filed | |
| IOTHREE LTD | G4940T104 | SHS | 57,744 | $22,041 | dollars as filed | |
| FARADAY FUTURE INTLGT ELEC I | 307359885 | COM NEW CL A | 16,915 | $21,990 | dollars as filed | |
| ALLARITY THERAPEUTICS INC | 016744500 | COM | 13,910 | $21,978 | dollars as filed | |
| LAZYDAYS HLDGS INC | 52110H209 | COM NEW | 10,470 | $21,778 | dollars as filed | |
| IMPACT BIOMEDICAL INC | 45259L205 | COMMON STOCK | 31,500 | $20,941 | dollars as filed | |
| REPARE THERAPEUTICS INC | 760273102 | COM | 10,967 | $19,302 | dollars as filed | |
| ALLIED GAMING & ENTRTNMNT IN | 019170109 | COM | 20,780 | $19,099 | dollars as filed | |
| KALTURA INC | 483467106 | COMMON STOCK | 12,583 | $18,120 | dollars as filed | |
| GREENLAND MINES LTD | 49876K103 | COM | 36,571 | $17,722 | dollars as filed | |
| IPOWER INC | 46265P107 | CL A | 33,061 | $17,112 | dollars as filed | |
| MYOMO INC | 62857J201 | COM NEW | 18,890 | $16,850 | dollars as filed | |
| SMITH MICRO SOFTWARE INC | 832154405 | COM SHS | 22,741 | $16,442 | dollars as filed | |
| INCANNEX HEALTHCARE INC | 45333F109 | EQUITY | 33,859 | $15,721 | dollars as filed | |
| SINGULARITY FUTURE TECH LTD | 82935V307 | COM SHS | 11,595 | $15,537 | dollars as filed | |
| INTEGRATED MEDIA TECHNLOGY L | Q49376124 | SHS NEW | 15,476 | $15,409 | dollars as filed | |
| GOGORO INC | G9491K105 | ORDINARY SHARES | 51,138 | $15,357 | dollars as filed | |
| TRIO PETROLEUM CORP | 89669L207 | COM | 14,510 | $15,236 | dollars as filed | |
| AETHLON MED INC | 00808Y505 | COM NEW | 20,270 | $15,176 | dollars as filed | |
| BARNWELL INDS INC | 068221100 | COM | 11,416 | $14,841 | dollars as filed | |
| TEN HLDGS INC COM USD0.0001 | 880245105 | Stock | 41,404 | $14,761 | dollars as filed | |
| USBC INC. | 499238202 | COM NEW | 10,872 | $14,568 | dollars as filed | |
| MAISON SOLUTIONS INC | 560667107 | COM CL A | 12,729 | $14,511 | dollars as filed | |
| SOCIETY PASS INC | 83370P201 | COM NEW | 12,254 | $14,460 | dollars as filed | |
| KAIVAL BRNDS INNOVATNS GRP I | 483104402 | COM | 32,552 | $13,942 | dollars as filed | |
| CAPSTONE HLDG CORP | 14068E208 | CMN | 10,525 | $13,788 | dollars as filed | |
| AGAPE ATP CORP | 008389207 | COM NEW | 10,836 | $13,708 | dollars as filed | |
| ATLASCLEAR HOLDINGS INC | 128745205 | COM SHS | 24,266 | $12,376 | dollars as filed | |
| OUTLOOK THERAPEUTICS INC | 69012T305 | COM | 11,356 | $12,037 | dollars as filed | |
| ENLIVEX LTD | M4130Y106 | CMN | 10,739 | $11,169 | dollars as filed | |
| RALLYBIO CORP | 75120L100 | COM | 21,453 | $10,705 | dollars as filed | |
| BIOMX INC | 09090D301 | COM | 19,125 | $10,041 | dollars as filed | |
| Reviva Pharmaceuticals Holdings Inc | 76152G100 | Common Stock | 21,773 | $8,026 | dollars as filed | |
| ORIENTAL RISE HLDGS LTD | G6781A102 | COM | 42,334 | $7,925 | dollars as filed | |
| PROMIS NEUROSCIENCES INC | 74346M406 | COM NEW | 18,428 | $7,832 | dollars as filed | |
| HARRISON GLOBAL HOLDINGS INC | G1180K116 | ORD SHS NEW | 11,768 | $2,565 | dollars as filed | |
| LUNAI BIOWORKS INC | 29350E203 | COM SHS | 16,417 | $2,136 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0000899140-25-001286 | this filing | 2025-11-14 | acceptance time not in the bulk data set |