13F-HR filed by TWO SIGMA INVESTMENTS, LP
TWO SIGMA INVESTMENTS, LP filed this 13F-HR for the quarter ended 2025-03-31, filed 2025-05-15, with 3,162 holding rows worth $46,785,866,925.
- Accession
- 0000899140-25-000680
- Filer
- CIK 1179392
- Filed
- 2025-05-15
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q1 2025
A holdings report, 3,162 entries on the cover page, a total value of $46,785,866,925 stated on the cover page (in dollars after the unit check, H1), rows summing to $46,785,866,925 with VALUE read as dollars as filed, 13F file number 028-10385. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerTWO SIGMA EQUITY PORTFOLIO LLC028-10704
- included managerTWO SIGMA SPECTRUM PORTFOLIO, LLC028-11144
- included managerTwo Sigma Futures Portfolio, LLC028-16011
- included managerTWO SIGMA HORIZON PORTFOLIO, LLC028-15356
- included managerTwo Sigma Equity Spectrum Portfolio, LLC028-20138
- included managerTwo Sigma Blazar Portfolio, LLC028-23019
- included managerTwo Sigma Navigator Portfolio, LLC028-23021
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| TANGO THERAPEUTICS INC | 87583X109 | COM | 52,902 | $72,476 | dollars as filed | |
| IMMUNITYBIO INC | 45256X103 | COM | 23,800 | $71,638 | dollars as filed | |
| ENGENE HOLDINGS INC | 29286M105 | COM | 15,832 | $70,927 | dollars as filed | |
| Yalla Group Ltd | 98459U103 | COM | 13,561 | $70,788 | dollars as filed | |
| FORTRESS BIOTECH INC | 34960Q307 | COM NEW | 44,799 | $69,886 | dollars as filed | |
| FERROGLOBE PLC | G33856108 | SHS | 18,664 | $69,243 | dollars as filed | |
| WW INTL INC | 98262P101 | COM | 129,709 | $67,786 | dollars as filed | |
| SURO CAP CORP | 86887Q109 | COM NEW | 13,597 | $67,577 | dollars as filed | |
| ATYR PHARMA INC | 002120202 | COM NEW | 22,239 | $67,162 | dollars as filed | |
| BLUEBIRD BIO INC COM NEW | 09609G209 | Stock | 13,745 | $67,076 | dollars as filed | |
| CAMBIUM NETWORKS CORPORATION | G17766109 | COMMON STOCK-FO | 94,529 | $66,690 | dollars as filed | |
| AURORA CANNABIS INC COM | 05156X850 | Stock | 15,098 | $66,280 | dollars as filed | |
| ALUMIS INC | 022307102 | COM | 10,700 | $65,698 | dollars as filed | |
| ENEL CHILE SA SPONSORED ADR | 29278D105 | ADR | 20,025 | $65,482 | dollars as filed | |
| BIOATLA INC | 09077B104 | COM | 188,526 | $65,381 | dollars as filed | |
| PEPGEN INC COM | 713317105 | Stock | 46,194 | $64,903 | dollars as filed | |
| PRECISION BIOSCIENCES INC | 74019P207 | COM NEW | 13,565 | $64,705 | dollars as filed | |
| TRAEGER INC | 89269P103 | COMMON STOCK | 38,269 | $64,292 | dollars as filed | |
| Arbutus Biopharma Corp | 03879J100 | Common Shares, without par value | 18,286 | $63,818 | dollars as filed | |
| ADC THERAPEUTICS SA | H0036K147 | COMMON STOCK | 44,686 | $63,007 | dollars as filed | |
| CELULARITY INC | 151190204 | CL A NEW | 36,380 | $62,937 | dollars as filed | |
| FLEXIBLE SOLUTIONS INTL INC | 33938T104 | COM | 12,424 | $62,741 | dollars as filed | |
| ACCURAY INC DEL | 004397105 | COM | 35,028 | $62,700 | dollars as filed | |
| TPI Composites Inc | 87266J104 | Common Stock | 77,521 | $62,482 | dollars as filed | |
| SUTRO BIOPHARMA INC | 869367102 | COM | 95,881 | $62,380 | dollars as filed | |
| NRX PHARMACEUTICALS INC | 629444209 | COM NEW | 30,146 | $61,799 | dollars as filed | |
| VERITONE INC | 92347M100 | COM | 26,260 | $61,055 | dollars as filed | |
| Xilio Therapeutics Inc. | 98422T100 | COM | 84,068 | $60,899 | dollars as filed | |
| GLIMPSE GROUP INC | 37892C106 | COM | 49,461 | $57,375 | dollars as filed | |
| BIOAGE LABS INC COM | 09077V100 | Stock | 15,145 | $56,945 | dollars as filed | |
| BIG 5 SPORTING GOODS CORP | 08915P101 | COM | 58,569 | $56,630 | dollars as filed | |
| WEREWOLF THERAPEUTICS INC | 95075A107 | CMN | 58,132 | $56,516 | dollars as filed | |
| ALTO NEUROSCIENCE INC COM SHS | 02157Q109 | Stock | 26,142 | $56,467 | dollars as filed | |
| BP PRUDHOE BAY RTY TR | 055630107 | TRUS | 100,497 | $55,575 | dollars as filed | |
| CORTEXYME INC | 22053A107 | COM | 41,150 | $54,730 | dollars as filed | |
| GETTY IMAGES HOLDINGS INC | 374275105 | CL A COM | 31,599 | $54,666 | dollars as filed | |
| IMMUNEERING CORP | 45254E107 | CLASS A COM | 35,757 | $54,351 | dollars as filed | |
| IBIO INC | 451033708 | CMN | 13,484 | $54,206 | dollars as filed | |
| RICHTECH ROBOTICS INC | 765504105 | CL B | 26,886 | $53,234 | dollars as filed | |
| Sequans Communications SA | 817323306 | SPONSORED ADS | 24,990 | $52,479 | dollars as filed | |
| SELLAS LIFE SCIENCES GROUP I | 81642T209 | COM NEW | 48,287 | $52,150 | dollars as filed | |
| BINAH CAP GROUP INC | 09032H105 | COM | 26,871 | $51,861 | dollars as filed | |
| THE REAL BROKERAGE INC | 75585H206 | COM NEW | 12,696 | $51,546 | dollars as filed | |
| UNITI GROUP INC | 91325V108 | COM | 10,000 | $50,400 | dollars as filed | put |
| ELEVATION ONCOLOGY INC COM | 28623U101 | Stock | 194,016 | $50,270 | dollars as filed | |
| CEL-SCI CORP | 150837607 | COM PAR NEW | 217,421 | $50,094 | dollars as filed | |
| GRAFTECH INTL LTD | 384313508 | COM | 55,669 | $48,677 | dollars as filed | |
| AIR INDS GROUP | 00912N403 | COM | 13,878 | $48,295 | dollars as filed | |
| BRC INC A | 05601U105 | COMMON STOCK | 23,090 | $48,258 | dollars as filed | |
| GEE GROUP INC | 36165A102 | COM | 235,085 | $47,487 | dollars as filed | |
| KRONOS BIO INC | 50107A104 | COM | 55,935 | $46,146 | dollars as filed | |
| RELMADA THERAPEUTICS INC | 75955J402 | COMMON STOCK | 170,544 | $46,047 | dollars as filed | |
| INTRUSION INC | 46121E304 | COM | 39,999 | $44,799 | dollars as filed | |
| NAVITAS SEMICONDUCTOR CORP COM | 63942X106 | Stock | 21,850 | $44,792 | dollars as filed | |
| MONOGRAM TECHNOLOGIES INC | 609786108 | COM | 15,235 | $44,791 | dollars as filed | |
| NANO DIMENSION LTD | 63008G203 | SPONSORD ADS NEW | 27,642 | $43,951 | dollars as filed | |
| RALLYBIO CORP | 75120L100 | COM | 66,711 | $43,662 | dollars as filed | |
| MARIS TECH LTD | M68057104 | ORDINARY SHARES | 20,235 | $43,505 | dollars as filed | |
| Rafael Holdings Inc Class B | 75062E106 | COM | 23,112 | $43,219 | dollars as filed | |
| CAESARSTONE LTD | M20598104 | ORD SHS | 17,717 | $43,052 | dollars as filed | |
| GENERATION BIO CO | 37148K100 | COM | 105,548 | $42,747 | dollars as filed | |
| BRIDGER AEROSPACE GRP HLDGS | 96812F102 | COM | 37,592 | $42,479 | dollars as filed | |
| FTC SOLAR INC | 30320C301 | CMN | 14,285 | $40,998 | dollars as filed | |
| CENTURY THERAPEUTICS INC | 15673T100 | COM | 86,006 | $40,939 | dollars as filed | |
| GOLD RESOURCE CORP | 38068T105 | COMMON STOCK | 79,510 | $40,526 | dollars as filed | |
| XBIOTECH INC | 98400H102 | COM | 12,393 | $40,153 | dollars as filed | |
| KULR TECHNOLOGY GROUP INC | 50125G109 | COM | 30,061 | $39,681 | dollars as filed | |
| GIGAMEDIA LTD | Y2711Y112 | SHS NEW | 24,140 | $39,590 | dollars as filed | |
| VERRICA PHARMACEUTICALS INC | 92511W108 | COM | 88,674 | $39,212 | dollars as filed | |
| GREENLAND TECHNOLOGIES HLDG | G4095T107 | ORD SHS CL A | 22,023 | $38,540 | dollars as filed | |
| Marin Software Inc Ordinary Shares | 56804T304 | COM | 27,605 | $37,267 | dollars as filed | |
| E-HOME HOUSEHOLD SVC HLDGS L | G2952X146 | SHS NEW | 31,573 | $36,940 | dollars as filed | |
| BEYOND MEAT INC | 08862E109 | COM | 12,018 | $36,655 | dollars as filed | |
| COGNITION THERAPEUTICS INC | 19243B102 | COM | 82,544 | $34,735 | dollars as filed | |
| IMMUNOPRECISE ANTIBODIES LTDCOM NEW | 45257F200 | cs | 90,582 | $34,104 | dollars as filed | |
| Biote Corp -A | 090683103 | COM | 10,204 | $33,979 | dollars as filed | |
| NEWEGG COMMERCE INC | G6483G100 | COM | 127,886 | $32,931 | dollars as filed | |
| GOGORO INC | G9491K105 | ORDINARY SHARES | 119,997 | $32,411 | dollars as filed | |
| ITERUM THERAPEUTICS PLC | G6333L200 | COM | 25,245 | $31,051 | dollars as filed | |
| MAISON SOLUTIONS INC | 560667107 | COM CL A | 29,969 | $30,868 | dollars as filed | |
| MILLENNIUM GROUP INTL HLDGS | G6169A104 | ORD SHS | 21,113 | $30,825 | dollars as filed | |
| BUZZFEED INC | 12430A300 | CL A NEW | 13,950 | $29,713 | dollars as filed | |
| CIBUS INC | 17166A101 | CL A COM STK | 15,551 | $29,080 | dollars as filed | |
| ECARX HOLDINGS INC | G29201103 | CMN | 22,269 | $28,059 | dollars as filed | |
| ADAPTIMMUNE THERAPEUTICS PLC | 00653A107 | SPONDS ADR | 135,947 | $26,782 | dollars as filed | |
| PHOENIX MTR INC | 71910P203 | COM NEW | 76,424 | $26,611 | dollars as filed | |
| SKYE BIOSCIENCE INC | 83086J200 | COM NEW | 16,607 | $26,405 | dollars as filed | |
| CELLECTAR BIOSCIENCES INC | 15117F807 | COM | 83,099 | $26,201 | dollars as filed | |
| OUTLOOK THERAPEUTICS INC | 69012T305 | COM | 20,719 | $25,277 | dollars as filed | |
| LYRA THERAPEUTICS INC | 55234L105 | COM | 193,145 | $24,394 | dollars as filed | |
| ARMLOGI HOLDING CORP | 042255109 | COM | 24,102 | $24,102 | dollars as filed | |
| BIOMERICA INC | 09061H307 | COM NEW | 42,362 | $24,019 | dollars as filed | |
| SERES THERAPEUTICS INC | 81750R102 | COM | 32,328 | $22,633 | dollars as filed | |
| MIRA PHARMACEUTICALS INC | 60458C104 | COM | 22,374 | $21,927 | dollars as filed | |
| SURGEPAYS INC | 86882L204 | COM NEW | 10,449 | $21,629 | dollars as filed | |
| SMITH MICRO SOFTWARE INC | 832154405 | COM SHS | 28,904 | $21,187 | dollars as filed | |
| BIOVIE INC | 09074F405 | CL A | 21,613 | $21,181 | dollars as filed | |
| GALAXY PAYROLL GROUP LTD | G37692103 | SHS CL A | 35,122 | $21,108 | dollars as filed | |
| SNOW LAKE RES LTD | 83336J208 | COM | 40,843 | $21,022 | dollars as filed | |
| NEXALIN TECHNOLOGY INC COM | 65345B201 | Stock | 10,498 | $20,471 | dollars as filed | |
| SO YOUNG INTERNATIONAL INC | 83356Q108 | SPONSORED ADS | 24,473 | $20,315 | dollars as filed | |
| SOW GOOD INC | 84612H106 | cs | 20,090 | $20,291 | dollars as filed | |
| TRILLER GROUP INC | 895970101 | COM | 25,905 | $20,206 | dollars as filed | |
| CHECHE GROUP INC | G20707108 | CMN | 23,758 | $20,194 | dollars as filed | |
| JIADE LIMITED | G7396L103 | USD ORD SHS | 34,357 | $19,924 | dollars as filed | |
| DIGI PWR X INC COM SUB VTG | 25380B102 | Stock | 17,476 | $19,923 | dollars as filed | |
| Reviva Pharmaceuticals Holdings Inc | 76152G100 | Common Stock | 20,670 | $19,715 | dollars as filed | |
| CREATIVE MEDIA & CMNTY TR | 125525527 | TRUS | 76,644 | $19,215 | dollars as filed | |
| FINGERMOTION INC | 31788K108 | COM | 13,934 | $19,090 | dollars as filed | |
| Mersana Therapeutics Inc | 59045L106 | Common Stock | 53,652 | $18,467 | dollars as filed | |
| THE ARENA GROUP HOLDINGS INC | 040044109 | CMN | 10,400 | $17,992 | dollars as filed | |
| ZHONGCHAO INC | G9897X115 | SHS NEW | 13,828 | $17,700 | dollars as filed | |
| PICOCELA INC | 71989C109 | SPONSORED ADS | 31,032 | $17,688 | dollars as filed | |
| FORGE GLOBAL HOLDINGS INC | 34629L103 | COM | 31,412 | $17,654 | dollars as filed | |
| ALLAKOS INC | 01671P100 | COM | 74,270 | $16,904 | dollars as filed | |
| PASSAGE BIO INC | 702712100 | COM | 46,955 | $16,580 | dollars as filed | |
| WALLBOX NV | N94209108 | SHS CL A | 50,327 | $16,492 | dollars as filed | |
| WELLCHANGE HLDGS CO LTD | G9545M115 | SHS CL A | 90,099 | $16,218 | dollars as filed | |
| JIN MED INTL LTD. | G5140V112 | SHS NEW | 20,939 | $15,566 | dollars as filed | |
| Renovaro Inc | 29350E104 | Common Stock | 28,281 | $15,362 | dollars as filed | |
| ODYSSEY MARINE EXPL INC | 676118201 | COM NEW | 36,884 | $14,776 | dollars as filed | |
| USIO INC | 917313108 | CMN | 10,035 | $14,651 | dollars as filed | |
| EON RESOURCES INC | 40472A102 | COM CL A | 28,292 | $13,611 | dollars as filed | |
| PIXELWORKS INC | 72581M305 | COM NEW | 21,639 | $13,563 | dollars as filed | |
| JUPITER NEUROSCIENCES INC | 48208B203 | COM NEW | 21,761 | $13,274 | dollars as filed | |
| GARDEN STAGE LIMITED | G3730L107 | USD ORD SHS | 25,299 | $12,144 | dollars as filed | |
| ROCKET ONE INC | 44148G204 | COM NEW | 11,247 | $11,247 | dollars as filed | |
| FIBROBIOLOGICS INC | 31573L105 | COM SHS | 12,318 | $11,086 | dollars as filed | |
| SCILEX HOLDING CO | 80880W106 | COM | 44,458 | $11,048 | dollars as filed | |
| FLY E GROUP INC | 343927109 | COM | 25,305 | $11,008 | dollars as filed | |
| IPOWER INC | 46265P107 | CL A | 20,558 | $10,279 | dollars as filed | |
| SOL GEL TECHNOLOGIES | M8694L103 | SHS | 18,003 | $9,362 | dollars as filed | |
| MEIHUA INTL MED TECHNOLOGIES | G5966G108 | ORD SHS | 27,834 | $9,336 | dollars as filed | |
| CHECK CAP LTD | M2361E179 | SHS | 11,485 | $9,094 | dollars as filed | |
| IT TECH PACKAGING INC | 46527C209 | COM NEW | 31,461 | $8,617 | dollars as filed | |
| TRINITY BIOTECH INVT LTD | 896438504 | SPONS ADR NEW | 15,073 | $8,592 | dollars as filed | |
| BIONEXUS GENE LAB CORP | 090628207 | COM NEW | 35,532 | $8,400 | dollars as filed | |
| Aethlon Medical Inc OLD | 00808Y406 | COM NEW | 22,720 | $8,134 | dollars as filed | |
| LUCAS GC LTD | G57037106 | SHS | 15,979 | $7,814 | dollars as filed | |
| BOLT PROJS HLDGS INC | 09769B107 | COM | 24,574 | $7,552 | dollars as filed | |
| CHANSON INTL HLDG | G2104U107 | CLASS A ORD | 31,770 | $7,307 | dollars as filed | |
| FORESIGHT AUTONOMOUS HLDGS L | 345523203 | SPONSORED ADR | 10,862 | $6,930 | dollars as filed | |
| SPRUCE BIOSCIENCES INC | 85209E109 | COM | 20,545 | $5,960 | dollars as filed | |
| HERAMBA ELEC PLC | G4411J114 | ORD SHS | 24,428 | $5,904 | dollars as filed | |
| VAXART INC NEW | 92243A200 | COM | 13,824 | $5,626 | dollars as filed | |
| N2OFF INC | 80512Q402 | COM | 18,462 | $4,411 | dollars as filed | |
| EKSO BIONICS HLDGS INC | 282644301 | COM | 10,817 | $4,359 | dollars as filed | |
| Damon Inc | 235750106 | Common Stock | 313,400 | $4,325 | dollars as filed | |
| CYCLACEL PHARMACEUTICALS INC (US) OLD | 23254L801 | COM NEW | 15,286 | $4,268 | dollars as filed | |
| DIGIASIA CORP | G27617102 | SHS | 15,759 | $3,971 | dollars as filed | |
| CYPHERPUNK TECHNOLOGIES INC | 52187K200 | COM NEW | 12,838 | $3,917 | dollars as filed | |
| ORAGENICS INC | 684023500 | COM | 18,231 | $3,829 | dollars as filed | |
| HARRISON GLOBAL HOLDINGS INC | G1180K116 | ORD SHS NEW | 17,270 | $3,523 | dollars as filed | |
| CBDMD INC | 12482W309 | COM | 12,364 | $2,844 | dollars as filed | |
| GRAPHJET TECHNOLOGY | G30449105 | CLASS A ORD SHS | 28,300 | $2,838 | dollars as filed | |
| GREENWAVE TECHNOLOGY SOLUTIO | 57630J403 | COM | 10,093 | $2,379 | dollars as filed | |
| BAIJIAYUN GROUP CL A ORD | G0704V202 | COM | 10,915 | $2,323 | dollars as filed | |
| DIGITAL ALLY INC | 25382T200 | COM NEW | 91,164 | $2,197 | dollars as filed | |
| Treasure Global Inc | 89458T205 | Common Stock | 16,370 | $1,260 | dollars as filed | |
| OCEAN BIOMEDICAL ORD | 67644C104 | COM | 19,871 | $1,073 | dollars as filed | |
| SHARPS TECHNOLOGY INC | 82003F200 | COM NEW | 27,682 | $828 | dollars as filed | |
| LOGICMARK INC | 67091J602 | COM NEW | 12,551 | $249 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0000899140-25-000680 | this filing | 2025-05-15 | acceptance time not in the bulk data set |