13F-HR filed by TWO SIGMA INVESTMENTS, LP
TWO SIGMA INVESTMENTS, LP filed this 13F-HR for the quarter ended 2024-12-31, filed 2025-02-14, with 3,161 holding rows worth $45,853,263,483.
- Accession
- 0000899140-25-000265
- Filer
- CIK 1179392
- Filed
- 2025-02-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2024
A holdings report, 3,161 entries on the cover page, a total value of $45,853,263,483 stated on the cover page (in dollars after the unit check, H1), rows summing to $45,853,263,483 with VALUE read as dollars as filed, 13F file number 028-10385. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerTWO SIGMA EQUITY PORTFOLIO LLC028-10704
- included managerTWO SIGMA SPECTRUM PORTFOLIO, LLC028-11144
- included managerTwo Sigma Futures Portfolio, LLC028-16011
- included managerTWO SIGMA HORIZON PORTFOLIO, LLC028-15356
- included managerTwo Sigma Equity Spectrum Portfolio, LLC028-20138
- included managerTwo Sigma Blazar Portfolio, LLC028-23019
- included managerTwo Sigma Navigator Portfolio, LLC028-23021
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| HARVARD BIOSCIENCE INC | 416906105 | COM | 35,817 | $75,574 | dollars as filed | |
| AIR INDS GROUP | 00912N403 | COM | 18,260 | $74,318 | dollars as filed | |
| RALLYBIO CORP | 75120L100 | COM | 76,811 | $73,739 | dollars as filed | |
| Marin Software Inc Ordinary Shares | 56804T304 | COM | 33,023 | $72,981 | dollars as filed | |
| FIRY INC | 83067L208 | COM | 14,480 | $72,834 | dollars as filed | |
| IMMUNITYBIO INC | 45256X103 | COM | 28,317 | $72,492 | dollars as filed | |
| HOUSTON AMERN ENERGY CORP | 44183U209 | COM | 55,821 | $72,009 | dollars as filed | |
| PROTARA THERAPEUTICS INC | 74365U107 | COM STK | 13,633 | $71,982 | dollars as filed | |
| KULR TECHNOLOGY GROUP INC | 50125G109 | COM | 20,199 | $71,706 | dollars as filed | |
| ACHILLES THERAPEUTICS PL-ADR | 00449L102 | COM | 61,637 | $70,266 | dollars as filed | |
| BIGBEAR AI HLDGS INC COM | 08975B109 | Stock | 15,753 | $70,101 | dollars as filed | |
| SIGHT SCIENCES INC | 82657M105 | COMMON STOCK | 18,944 | $68,956 | dollars as filed | |
| Canoo Inc | 13803R300 | COM | 48,790 | $68,794 | dollars as filed | |
| CIBUS INC | 17166A101 | CL A COM STK | 24,574 | $68,316 | dollars as filed | |
| CENTURY THERAPEUTICS INC | 15673T100 | COM | 66,797 | $67,465 | dollars as filed | |
| ENEL CHILE SA SPONSORED ADR | 29278D105 | ADR | 23,425 | $67,464 | dollars as filed | |
| RELMADA THERAPEUTICS INC | 75955J402 | COMMON STOCK | 127,579 | $66,341 | dollars as filed | |
| TONIX PHARMACEUTICALS HLDG C | 890260847 | COM NEW | 200,797 | $66,223 | dollars as filed | |
| CAMBIUM NETWORKS CORPORATION | G17766109 | COMMON STOCK-FO | 101,484 | $65,437 | dollars as filed | |
| SIFY TECHNOLOGIES AMERICAN DEPOSIT | 82655M206 | EQUITY | 22,776 | $65,139 | dollars as filed | |
| TENAYA THERAPEUTICS INC | 87990A106 | COM | 44,771 | $64,023 | dollars as filed | |
| CUSTOM TRUCK ONE SOURCE INC | 23204X103 | COM CL A | 13,148 | $63,242 | dollars as filed | |
| YIREN DIGITAL LTD | 98585L100 | SPONSORED ADS | 12,787 | $61,378 | dollars as filed | |
| RIBBON COMMUNICATIONS INC | 762544104 | COMMON STOCK | 14,487 | $60,266 | dollars as filed | |
| KRONOS BIO INC | 50107A104 | COM | 63,261 | $60,098 | dollars as filed | |
| BTC DIGITAL LTD | G6055H155 | SHS NEW | 12,417 | $59,353 | dollars as filed | |
| CHINA AUTOMOTIVE SYS INC | 16936R105 | COM | 14,392 | $59,007 | dollars as filed | |
| CURIOSITYSTREAM INC | 23130Q107 | COMMON STOCK | 38,497 | $58,900 | dollars as filed | |
| BIOVIE INC | 09074F405 | CL A | 28,713 | $57,426 | dollars as filed | |
| HEARTCORE ENTERPRISES INC | 42240Q104 | COM | 31,572 | $57,303 | dollars as filed | |
| CORTEXYME INC | 22053A107 | COM | 30,341 | $56,738 | dollars as filed | |
| Bitfarms Ltd/Canada | 09173B107 | Common Stock | 38,006 | $56,629 | dollars as filed | |
| HYPERFINE INC | 44916K106 | Common Stock | 62,543 | $55,038 | dollars as filed | |
| UNITI GROUP INC | 91325V108 | COM | 10,000 | $55,000 | dollars as filed | put |
| ANNOVIS BIO INC | 03615A108 | COM | 10,923 | $54,943 | dollars as filed | |
| BP PRUDHOE BAY RTY TR | 055630107 | TRUS | 100,999 | $54,943 | dollars as filed | |
| CS DISCO INC | 126327105 | COM | 10,985 | $54,815 | dollars as filed | |
| ALLAKOS INC | 01671P100 | COM | 44,366 | $53,683 | dollars as filed | |
| NINE ENERGY SERVICE INC | 65441V101 | COM | 47,694 | $53,417 | dollars as filed | |
| LITHIUM AMERICAS ARGENTINA C | 53681K100 | COM SHS | 20,313 | $53,220 | dollars as filed | |
| LANTERN PHARMA INC | 51654W101 | COM | 16,545 | $52,779 | dollars as filed | |
| 23ANDME HOLDING CO | 90138Q306 | COM | 16,153 | $52,497 | dollars as filed | |
| ENCORE ENERGY CORP COM NEW | 29259W700 | Stock | 15,102 | $51,498 | dollars as filed | |
| CLEAR CHANNEL OUTDOOR HLDGS | 18453H106 | COM | 37,104 | $50,832 | dollars as filed | |
| MYSEUMAI INC | 23816M206 | COM NEW | 28,456 | $50,652 | dollars as filed | |
| INTELLICHECK MOBILISA INC | 45817G201 | COM NEW | 17,921 | $50,179 | dollars as filed | |
| ILEARNINGENGINES INC | 45175Q106 | COM | 118,490 | $49,766 | dollars as filed | |
| CELLECTIS ADS | 15117K103 | COM | 27,322 | $49,180 | dollars as filed | |
| Inflarx Nv | N44821101 | COM | 19,716 | $48,699 | dollars as filed | |
| DULUTH HLDGS INC | 26443V101 | COM CL B | 15,593 | $48,182 | dollars as filed | |
| INNOVID CORP | 457679108 | COMMON STOCK | 15,553 | $48,059 | dollars as filed | |
| WRAP TECHNOLOGIES INC | 98212N107 | COM | 22,527 | $47,757 | dollars as filed | |
| LAVA THERAPEUTICS NV | N51517105 | SHS | 48,772 | $46,382 | dollars as filed | |
| DIVERSIFIED HEALTHCARE TR | 25525P107 | COM SH BEN INT | 20,116 | $46,267 | dollars as filed | |
| WIMI HOLOGRAM CLOUD INC | 97264L100 | SPON ADS CL B | 24,474 | $45,277 | dollars as filed | |
| ITERUM THERAPEUTICS PLC | G6333L200 | COM | 25,245 | $44,684 | dollars as filed | |
| GALAXY PAYROLL GROUP LTD | G37692103 | SHS CL A | 44,613 | $44,167 | dollars as filed | |
| LYRA THERAPEUTICS INC | 55234L105 | COM | 209,997 | $43,343 | dollars as filed | |
| IPOWER INC | 46265P107 | CL A | 51,789 | $43,130 | dollars as filed | |
| 908 DEVICES INC COM | 65443P102 | Stock | 19,000 | $41,800 | dollars as filed | |
| SMITH MICRO SOFTWARE INC | 832154405 | COM SHS | 31,710 | $41,540 | dollars as filed | |
| ADAPTIMMUNE THERAPEUTICS PLC | 00653A107 | SPONDS ADR | 76,347 | $41,128 | dollars as filed | |
| BOUNDLESS BIO INC | 10170A100 | COM | 13,808 | $40,043 | dollars as filed | |
| Rafael Holdings Inc Class B | 75062E106 | COM | 23,885 | $39,410 | dollars as filed | |
| Reviva Pharmaceuticals Holdings Inc | 76152G100 | Common Stock | 21,159 | $38,298 | dollars as filed | |
| COGNITION THERAPEUTICS INC | 19243B102 | COM | 53,691 | $37,653 | dollars as filed | |
| GIGAMEDIA LTD | Y2711Y112 | SHS NEW | 24,120 | $37,265 | dollars as filed | |
| OMNIAB INC | 68218J103 | COM | 10,292 | $36,434 | dollars as filed | |
| SENSEONICS HLDGS INC | 81727U105 | COM | 68,559 | $35,884 | dollars as filed | |
| REGULUS THERAPEUTICS INC | 75915K309 | COM | 22,264 | $35,177 | dollars as filed | |
| FARADAY FUTURE INTLGT ELEC I | 307359885 | COM NEW CL A | 14,159 | $34,406 | dollars as filed | |
| VAXART INC NEW | 92243A200 | COM | 51,683 | $34,219 | dollars as filed | |
| JIADE LIMITED | G7396L103 | USD ORD SHS | 39,544 | $33,498 | dollars as filed | |
| SPHERE 3D CORP NEW | 84841L407 | COM NEW | 34,595 | $32,665 | dollars as filed | |
| CEL-SCI CORP | 150837607 | COM PAR NEW | 81,589 | $32,627 | dollars as filed | |
| NIKOLA CORP | 654110303 | COM NEW | 27,361 | $32,560 | dollars as filed | |
| NEXALIN TECHNOLOGY INC COM | 65345B201 | Stock | 11,276 | $31,122 | dollars as filed | |
| ONDAS HLDGS INC | 68236H204 | COM NEW | 12,144 | $31,089 | dollars as filed | |
| AMPCO PITTSBURGH CORP | 032037103 | COMMON STOCK | 14,723 | $30,771 | dollars as filed | |
| SYNTEC OPTICS HLDGS INC | 87169M105 | CL A | 12,189 | $30,716 | dollars as filed | |
| MSP Recovery, Inc | 553745308 | CL A | 13,369 | $30,348 | dollars as filed | |
| AEON BIOPHARMA INC | 00791X100 | CL A | 53,018 | $28,630 | dollars as filed | |
| Newbury Str Ii Acquisition C W Exp 06/01/203 | G6439S117 | SPACS Warrant | 187,500 | $28,125 | dollars as filed | |
| SONNET BIOTHERAPEUTC HLDNG I | 83548R402 | COM NEW | 19,203 | $28,036 | dollars as filed | |
| PASSAGE BIO INC | 702712100 | COM | 49,364 | $27,994 | dollars as filed | |
| MIRA PHARMACEUTICALS INC | 60458C104 | COM | 24,317 | $27,721 | dollars as filed | |
| HYCROFT MINING HOLDING CO A | 44862P208 | COMMON STOCK | 12,406 | $27,417 | dollars as filed | |
| PYXIS ONCOLOGY INC COMMON STOCK | 747324101 | Stock | 17,067 | $26,625 | dollars as filed | |
| PRIMECH HOLDINGS LTD. | Y708VV108 | SHS | 39,044 | $26,370 | dollars as filed | |
| CHECHE GROUP INC | G20707108 | CMN | 29,479 | $26,233 | dollars as filed | |
| SCILEX HOLDING CO | 80880W106 | COM | 61,005 | $26,013 | dollars as filed | |
| JIN MED INTL LTD. | G5140V112 | SHS NEW | 32,794 | $25,520 | dollars as filed | |
| ODYSSEY MARINE EXPL INC | 676118201 | COM NEW | 35,122 | $25,288 | dollars as filed | |
| CCSC TECHNOLOGY INTL HLDGS L CL A O | G1993R100 | RD SHS | 15,899 | $24,643 | dollars as filed | |
| EMEREN GROUP LTD | 75971T301 | SPONSORED ADS | 11,900 | $24,157 | dollars as filed | |
| TRIVAGO N V | 89686D303 | SPON ADS A SHS N | 10,656 | $23,230 | dollars as filed | |
| ZHONGCHAO INC | G9897X115 | SHS NEW | 14,028 | $22,725 | dollars as filed | |
| PIXELWORKS INC | 72581M305 | COM NEW | 30,950 | $22,578 | dollars as filed | |
| FORGE GLOBAL HOLDINGS INC | 34629L103 | COM | 24,230 | $22,556 | dollars as filed | |
| LA ROSA HLDGS CORP | 50172T103 | COM | 26,234 | $22,152 | dollars as filed | |
| THE ARENA GROUP HOLDINGS INC | 040044109 | CMN | 16,267 | $21,798 | dollars as filed | |
| TAYSHA GENE THERAPIES INC | 877619106 | COMMON STOCK | 12,300 | $21,279 | dollars as filed | |
| CELLECTAR BIOSCIENCES INC | 15117F807 | COM | 71,119 | $21,265 | dollars as filed | |
| FLY E GROUP INC | 343927109 | COM | 25,305 | $21,256 | dollars as filed | |
| GOLD RESOURCE CORP | 38068T105 | COMMON STOCK | 91,796 | $21,122 | dollars as filed | |
| SURGEPAYS INC | 86882L204 | COM NEW | 11,849 | $21,091 | dollars as filed | |
| SO YOUNG INTERNATIONAL INC | 83356Q108 | SPONSORED ADS | 24,491 | $20,328 | dollars as filed | |
| SERES THERAPEUTICS INC | 81750R102 | COM | 24,412 | $20,286 | dollars as filed | |
| FIBROBIOLOGICS INC | 31573L105 | COM SHS | 10,061 | $20,122 | dollars as filed | |
| OUTLOOK THERAPEUTICS INC | 69012T305 | COM | 10,591 | $20,017 | dollars as filed | |
| NULL | 52178J303 | NULL | 12,707 | $19,950 | dollars as filed | |
| Renovaro Inc | 29350E104 | Common Stock | 23,743 | $19,837 | dollars as filed | |
| Aethlon Medical Inc OLD | 00808Y406 | COM NEW | 22,556 | $19,398 | dollars as filed | |
| WILLOW LANE ACQUISITION CORP | G9675P110 | *W EXP 10/31/203 | 137,500 | $19,250 | dollars as filed | |
| PEDEVCO CORP C | 70532Y303 | OM PAR | 24,200 | $18,828 | dollars as filed | |
| GRAFTECH INTL LTD | 384313508 | COM | 10,329 | $17,869 | dollars as filed | |
| REPARE THERAPEUTICS INC | 760273102 | COM | 13,467 | $17,642 | dollars as filed | |
| GARDEN STAGE LIMITED | G3730L107 | USD ORD SHS | 25,250 | $16,817 | dollars as filed | |
| OMEGA THERAPEUTICS INC | 68217N105 | COMMON STOCK | 21,744 | $16,212 | dollars as filed | |
| NKGen Biotech Inc | 65488A101 | Equity | 22,356 | $14,648 | dollars as filed | |
| SOLIDION TECHNOLOGY INC | 834212102 | COM | 20,133 | $14,027 | dollars as filed | |
| ZAPP ELEC VEHS GROUP LTD | G9889X123 | COM | 10,840 | $13,767 | dollars as filed | |
| APPLIED DNA SCIENCES INC | 03815U409 | COM NEW | 62,508 | $12,752 | dollars as filed | |
| MARINUS PHARMACEUTICALS INC | 56854Q200 | COM NEW | 22,868 | $12,237 | dollars as filed | |
| BOLT PROJS HLDGS INC | 09769B107 | COM | 24,574 | $11,845 | dollars as filed | |
| DIGIASIA CORP | G27617102 | SHS | 15,759 | $11,819 | dollars as filed | |
| GREENWAVE TECHNOLOGY SOLUTIO | 57630J403 | COM | 16,791 | $11,801 | dollars as filed | |
| WALLBOX NV | N94209108 | SHS CL A | 22,577 | $11,304 | dollars as filed | |
| SYROS PHARMACEUTICALS INC | 87184Q206 | COM NEW | 48,861 | $11,228 | dollars as filed | |
| CNS Pharmaceuticals Inc (US) Old | 18978H300 | COM | 93,077 | $11,206 | dollars as filed | |
| LUCAS GC LTD | G57037106 | SHS | 18,570 | $11,157 | dollars as filed | |
| BRIACELL THERAPEUTICS CORP | 107930109 | COM | 19,409 | $10,966 | dollars as filed | |
| MEIHUA INTL MED TECHNOLOGIES | G5966G108 | ORD SHS | 30,429 | $10,501 | dollars as filed | |
| Xilio Therapeutics Inc. | 98422T100 | COM | 10,824 | $10,337 | dollars as filed | |
| KAIVAL BRNDS INNOVATNS GRP I | 483104402 | COM | 10,967 | $10,019 | dollars as filed | |
| PREDICTIVE ONCOLOGY INC | 74039M309 | COM | 11,018 | $9,035 | dollars as filed | |
| SPRUCE BIOSCIENCES INC | 85209E109 | COM | 20,616 | $8,659 | dollars as filed | |
| ROCKET ONE INC | 44148G204 | COM NEW | 11,100 | $8,304 | dollars as filed | |
| TWIN VEE POWERCATS CO | 90177C101 | COM | 14,230 | $7,827 | dollars as filed | |
| ORAGENICS INC | 684023500 | COM | 19,671 | $7,265 | dollars as filed | |
| MUSTANG BIO INC | 62818Q203 | COM | 40,683 | $7,201 | dollars as filed | |
| I-80 GOLD CORP | 44955L106 | COM | 14,282 | $6,927 | dollars as filed | |
| IT TECH PACKAGING INC | 46527C209 | COM NEW | 11,461 | $6,893 | dollars as filed | |
| NEWGENIVF GROUP LIMITED | G0544E105 | CL A ORD SHS | 16,400 | $6,642 | dollars as filed | |
| HARRISON GLOBAL HOLDINGS INC | G1180K116 | ORD SHS NEW | 10,378 | $5,947 | dollars as filed | |
| HCW BIOLOGICS INC | 40423R105 | COM | 12,082 | $5,390 | dollars as filed | |
| WINDTREE THERAPEUTICS INC | 97382D501 | COM NEW | 14,449 | $5,047 | dollars as filed | |
| T2 BIOSYSTEMS INC | 89853L302 | COM NEW | 11,936 | $5,013 | dollars as filed | |
| PHOENIX MTR INC | 71910P203 | COM NEW | 16,178 | $4,853 | dollars as filed | |
| N2OFF INC | 80512Q402 | COM | 18,462 | $4,579 | dollars as filed | |
| VENUS CONCEPT INC | 92332W204 | COM NEW | 11,777 | $4,434 | dollars as filed | |
| ENVERIC BIOSCIENCES INC | 29405E208 | COM NEW | 12,145 | $4,353 | dollars as filed | |
| TIVIC HEALTH SYSTEMS INC | 888705209 | COM NEW | 12,147 | $4,205 | dollars as filed | |
| HAOXI HEALTH TECHNOLOGY LTD | G4290F100 | USD CL A ORD SHS | 27,382 | $4,107 | dollars as filed | |
| BIONANO GENOMICS INC | 09075f305 | COM | 13,495 | $3,892 | dollars as filed | |
| Treasure Global Inc | 89458T205 | Common Stock | 19,263 | $3,417 | dollars as filed | |
| LICHEN CHINA LTD | G5479G108 | CL A ORD SHS | 17,286 | $3,070 | dollars as filed | |
| XTI Aerospace Inc OLD | 98423K108 | COM | 67,643 | $2,909 | dollars as filed | |
| CROWN ELECTROKINETICS CORP | 228339404 | COM NEW | 20,060 | $2,853 | dollars as filed | |
| ALGORHYTHM HLDGS INC | 829322403 | COM | 23,912 | $2,104 | dollars as filed | |
| CONDUIT PHARMACEUTICALS INC | 20678X106 | COM | 27,909 | $1,915 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0000899140-25-000265 | this filing | 2025-02-14 | acceptance time not in the bulk data set |